Cited by 243Tryptophan and brain disordersStress Responses and CortisolNeuroinflammation and Neurodegeneration Mechanisms

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Diet-induced obesity progressively alters cognition, anxiety-like behavior and lipopolysaccharide-induced depressive-like behavior: Focus on brain indoleamine 2,3-dioxygenase activation

André, Caroline, Dinel, Anne-Laure, Ferreira, Guillaume, Layé, Sophie, Castanon, Nathalie·2014·Brain Behavior and Immunity

DOI 10.1016/j.bbi.2014.03.012

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Abstract

Obesity is associated with a high prevalence of mood symptoms and cognitive dysfunctions that emerges as significant risk factors for important health complications such as cardiovascular diseases and type 2 diabetes. It is therefore important to identify the dynamic of development and the pathophysiological mechanisms underlying these neuropsychiatric symptoms. Obesity is also associated with peripheral low-grade inflammation and increased susceptibility to immune-mediated diseases. Excessive production of proinflammatory cytokines and the resulting activation of the brain tryptophan catabolizing enzyme indoleamine 2,3-dioxygenase (IDO) have been shown to promote neurobehavioral complications, particularly depression. In that context, questions arise about the impact of diet-induced obesity on the onset of neuropsychiatric alterations and the increased susceptibility to immune-mediated diseases displayed by obese patients, particularly through brain IDO activation. To answer these questions, we used C57Bl/6 mice exposed to standard diet or western diet (WD; consisting of palatable energy-dense food) since weaning and for 20 weeks. We then measured inflammatory and behavioral responses to a systemic immune challenge with lipopolysaccharide (LPS) in experimental conditions known to alter cognitive and emotional behaviors independently of any motor impairment. We first showed that in absence of LPS, 9 weeks of WD is sufficient to impair spatial recognition memory (in the Y-maze). On the other hand, 18 weeks of WD increased anxiety-like behavior (in the elevated plus-maze), but did not affect depressive-like behavior (in the tail-suspension and forced-swim tests). However, 20 weeks of WD altered LPS-induced depressive-like behavior compared to LPS-treated lean mice and exacerbated hippocampal and hypothalamic proinflammatory cytokine expression and brain IDO activation. Taken together, these results show that WD exposure alters cognition and anxiety in unstimulated conditions and enhances activation of neurobiological mechanisms underlying depression after immune stimulation. They suggest therefore that obesity, and possibly obesity-associated inflammatory priming, may represent a vulnerability state to immune-mediated depressive symptoms.

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Authors: André, C., Dinel, A.-L., Ferreira, G., Layé, S., & Castanon, N.
Affiliations: Université de Bordeaux (FR)
Corresponding author: Castanon, Nathalie
ORCID: André, Caroline
Dinel, Anne-Laure
Ferreira, Guillaume
Layé, Sophie
Castanon, Nathalie
Venue: Brain Behavior and Immunity
Publisher: Elsevier BV
Published: 2014-10
Volume: 41
Pages: 10-21
ISSN: 0889-1591 (ISSN-L)
DOI: 10.1016/j.bbi.2014.03.012
OpenAlex: W2034355214
Cited by: 241
References: 84
Citations by year: 2026: 8 · 2025: 16 · 2024: 22 · 2023: 20 · 2022: 13 · 2021: 27 · 2020: 28 · 2019: 25 · 2018: 15 · 2017: 16 · 2016: 27 · 2015: 19 · 2014: 5
FWCI: 6.87
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
Locations: Brain Behavior and Immunity (publishedVersion)
PubMed (publishedVersion)
HAL (submittedVersion)
Topics: Life Sciences › Neuroscience › Biological Psychiatry › Tryptophan and brain disorders
Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
Keywords: diet-induced obesity, Western diet, indoleamine 2,3-dioxygenase, lipopolysaccharide, depression-like behavior, anxiety-like behavior, spatial recognition memory, inflammatory cytokines, neuroinflammation, hippocampus, hypothalamus, tryptophan metabolism, cognitive impairment
MeSH terms: Animals, Anxiety, Behavior, Animal, Brain, Cognition Disorders, Depression, Endotoxins, Enzyme Activation, Gene Expression Regulation, Hormones, Male, Memory Disorders, Mice, Inbred C57BL, Nerve Tissue Proteins, Obesity, Neuroimmunomodulation, Cytokines, Maze Learning, Indoleamine-Pyrrole 2,3,-Dioxygenase, Mice, Diet, Western

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Diet-induced obesity progressively alters cognition, anxiety-like behavior and lipopolysaccharide-induced depressive-like behavior: Focus on brain indoleamine 2,3-dioxygenase activation

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