Cited by 95Neuropeptides and Animal PhysiologyNeurotransmitter Receptor Influence on BehaviorNeuroendocrine regulation and behavior

Effect of Y1 receptor deficiency on motor activity, exploration, and anxiety

Karl, Tim, Burne, Thomas H.J., Herzog, Herbert·2006·Behavioural Brain Research

Abstract

Neuropeptide Y (NPY) in the CNS plays an important regulatory role in anxiety-related responses as exogenous administration of NPY exerts an anxiolytic-like effect in rodents. This effect is believed to be mediated by the Y(1) receptor system as pharmacological modulation of this Y(1) receptor system results in an increase in anxiety. Here we present a comprehensive phenotyping strategy for characterizing Y(1) receptor knockout animals at different times of the circadian rhythm using several motor activity-, exploration-, and anxiety-related behavioural tasks including open field, elevated plus maze, light-dark, and hole board test. We show that Y(1) deficiency has an important effect on motor activity and explorative-like behaviours and that it results in marked alterations in anxiety-related behaviours. Importantly, the behavioural phenotype of the Y(1) receptor knockout mice is circadian rhythm-dependent and also influenced by stimuli such as restraint stress. In addition, we found evidence for increases in working memory. Taken together, these findings suggest an important role of Y(1) receptors in the regulation of motor activity, exploration, and anxiety-related behaviours. This role is also influenced by several factors such as circadian rhythm and stress exposure confirming the importance of a comprehensive strategy and of using genetic animal models in behavioural neuroscience.

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Crossref · 10.1016/j.bbr.2005.08.019

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Authors
Karl, T., Burne, T. H. J., & Herzog, H.
Affiliations
  • Garvan Institute of Medical Research (AU)
  • Griffith University (AU)
Corresponding author
Karl, Tim
Venue
Behavioural Brain Research
Publisher
Elsevier BV
Published
2006-02
Volume
167
Issue
1
Pages
87-93
ISSN
0166-4328 (ISSN-L)
OpenAlex
W2011869246
Cited by
95
References
50
Citations by year
2025: 1 · 2024: 1 · 2023: 2 · 2022: 3 · 2021: 4 · 2020: 3 · 2019: 4 · 2018: 2 · 2017: 3 · 2016: 3 · 2015: 7 · 2014: 2 · 2013: 3 · 2012: 7
FWCI
2.89
Type
journal article
Language
en
Open access
closed
Locations
  • Behavioural Brain Research (publishedVersion)
  • PubMed (publishedVersion)
  • Griffith Research Online (submittedVersion)
Funders
  • Sylvia and Charles Viertel Charitable Foundation
  • Deutsche Forschungsgemeinschaft
Topics
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
  • Social Sciences › Psychology › Social Psychology › Neuroendocrine regulation and behavior
Keywords
Y1 receptor, neuropeptide Y, receptor knockout mice, anxiety-like behavior, motor activity, exploratory behavior, circadian rhythm, restraint stress, working memory, elevated plus maze, open field, light/dark test, hole board test
MeSH terms
Analysis of Variance, Animals, Anxiety, Behavior, Animal, Circadian Rhythm, Exploratory Behavior, Motor Activity, Receptors, Neuropeptide Y, Mice, Knockout, Maze Learning, Mice

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