Effect of Y1 receptor deficiency on motor activity, exploration, and anxiety
Abstract
Neuropeptide Y (NPY) in the CNS plays an important regulatory role in anxiety-related responses as exogenous administration of NPY exerts an anxiolytic-like effect in rodents. This effect is believed to be mediated by the Y(1) receptor system as pharmacological modulation of this Y(1) receptor system results in an increase in anxiety. Here we present a comprehensive phenotyping strategy for characterizing Y(1) receptor knockout animals at different times of the circadian rhythm using several motor activity-, exploration-, and anxiety-related behavioural tasks including open field, elevated plus maze, light-dark, and hole board test. We show that Y(1) deficiency has an important effect on motor activity and explorative-like behaviours and that it results in marked alterations in anxiety-related behaviours. Importantly, the behavioural phenotype of the Y(1) receptor knockout mice is circadian rhythm-dependent and also influenced by stimuli such as restraint stress. In addition, we found evidence for increases in working memory. Taken together, these findings suggest an important role of Y(1) receptors in the regulation of motor activity, exploration, and anxiety-related behaviours. This role is also influenced by several factors such as circadian rhythm and stress exposure confirming the importance of a comprehensive strategy and of using genetic animal models in behavioural neuroscience.
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Alterations in neuropeptide Y receptors produce anxiety-like phenotypes.
“Alterations in neuroeptide Y receptors produce anxiety-like phenotypes (Karl et al 2006)”
From Biological rhythms, higher brain function, and behavior: Gaps, opportunities, and challenges (2009) · cites this paper as Karl et al 2006
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- Authors
- Karl, T., Burne, T. H. J., & Herzog, H.
- Affiliations
- Garvan Institute of Medical Research (AU)
- Griffith University (AU)
- Corresponding author
- Karl, Tim
- Venue
- Behavioural Brain Research
- Publisher
- Elsevier BV
- Published
- 2006-02
- Volume
- 167
- Issue
- 1
- Pages
- 87-93
- ISSN
- 0166-4328 (ISSN-L)
- OpenAlex
- W2011869246
- Cited by
- 95
- References
- 50
- Citations by year
- 2025: 1 · 2024: 1 · 2023: 2 · 2022: 3 · 2021: 4 · 2020: 3 · 2019: 4 · 2018: 2 · 2017: 3 · 2016: 3 · 2015: 7 · 2014: 2 · 2013: 3 · 2012: 7
- FWCI
- 2.89
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Behavioural Brain Research (publishedVersion)
- PubMed (publishedVersion)
- Griffith Research Online (submittedVersion)
- Funders
- Sylvia and Charles Viertel Charitable Foundation
- Deutsche Forschungsgemeinschaft
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Social Sciences › Psychology › Social Psychology › Neuroendocrine regulation and behavior
- Keywords
- Y1 receptor, neuropeptide Y, receptor knockout mice, anxiety-like behavior, motor activity, exploratory behavior, circadian rhythm, restraint stress, working memory, elevated plus maze, open field, light/dark test, hole board test
- MeSH terms
- Analysis of Variance, Animals, Anxiety, Behavior, Animal, Circadian Rhythm, Exploratory Behavior, Motor Activity, Receptors, Neuropeptide Y, Mice, Knockout, Maze Learning, Mice
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