Sex-dependent control of murine emotional-affective behaviour in health and colitis by peptide YY and neuropeptide Y
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BACKGROUND AND PURPOSE: Peptide YY (PYY) and neuropeptide Y (NPY) are involved in regulating gut and brain function. Because gastrointestinal inflammation is known to enhance anxiety, we explored whether experimental colitis interacts with genetic deletion (knockout) of PYY and NPY to alter emotional-affective behaviour. EXPERIMENTAL APPROACH: Male and female wild-type, NPY (NPY(-/-) ), PYY (PYY(-/-) ) and NPY(-/-) ; PYY(-/-) double knockout mice were studied in the absence and presence of mild colitis induced by ingestion of dextran sulphate sodium (2%) in drinking water. Anxiety-like behaviour was tested on the elevated plus maze and open field, and depression-like behaviour assessed by the forced swim test. KEY RESULTS: In the absence of colitis, anxiety-like behaviour was increased by deletion of NPY but not PYY in a test- and sex-dependent manner, while depression-like behaviour was enhanced in NPY(-/-) and PYY(-/-) mice of either sex. The severity of DSS-induced colitis, assessed by colonic myeloperoxidase content, was attenuated in NPY(-/-) but not PYY(-/-) mice. Colitis modified anxiety- and depression-related behaviour in a sex-, genotype- and test-related manner, and knockout experiments indicated that NPY and PYY were involved in some of these behavioural effects of colitis. CONCLUSIONS AND IMPLICATIONS: These data demonstrate sex-dependent roles of NPY and PYY in regulation of anxiety- and depression-like behaviour in the absence and presence of colitis. Like NPY, the gut hormone PYY has the potential to attenuate depression-like behaviour but does not share the ability of NPY to reduce anxiety-like behaviour.
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Depletion of NPY or PYY in mice prevents the anxiogenic and depressive-like behavior often promoted by colitis.
“For example, depletion of NPY or PYY in mice prevents the anxiogenic and depressive-like behavior often promoted by colitis [210].”
From Anxiety, depression, and the microbiome: A role for gut peptides (2018) · cites this paper as [210]
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- Authors
- Painsipp, E., Herzog, H., Sperk, G., & Holzer, P.
- Affiliations
- Medical University of Graz (AT)
- Garvan Institute of Medical Research (AU)
- Innsbruck Medical University (AT)
- Corresponding author
- Holzer, Peter
- Venue
- British Journal of Pharmacology
- Publisher
- Wiley
- Published
- 2011-06-27
- Volume
- 163
- Issue
- 6
- Pages
- 1302-1314
- ISSN
- 0007-1188 (ISSN-L)
- 1476-5381
- PMC
- PMC3144542
- OpenAlex
- W2146828356
- Cited by
- 93
- References
- 54
- Citations by year
- 2026: 2 · 2025: 4 · 2024: 4 · 2023: 6 · 2022: 5 · 2021: 11 · 2020: 8 · 2019: 7 · 2018: 6 · 2017: 7 · 2016: 9 · 2015: 7 · 2014: 8 · 2013: 4 · 2012: 4
- FWCI
- 2.25
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- British Journal of Pharmacology (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Austrian Science Fund
- Karl-Franzens-Universität Graz
- Medizinische Universität Graz
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
- Life Sciences › Neuroscience › Biological Psychiatry › Tryptophan and brain disorders
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
- Keywords
- peptide YY, neuropeptide Y, inflammatory bowel disease, colitis, anxiety-like behavior, depression-like behavior, sex differences, gut-brain axis, dextran sulfate, knockout mice, gastrointestinal hormones
- MeSH terms
- Animals, Anxiety, Behavior, Animal, Colitis, Depression, Female, Gene Expression Regulation, Male, Peroxidase, Neuropeptide Y, Sex Characteristics, Dextran Sulfate, Mice, Knockout, Peptide YY, Mice
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