Circuit and Plasticity Defects in the Developing Somatosensory Cortex of Fmr1 Knock-Out Mice
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Silencing of the Fmr1 gene causes fragile X syndrome. Although defects in synaptic plasticity in the cerebral cortex have been linked to cognitive impairments in Fmr1 knock-out(ko) mice, the specific cortical circuits affected in the syndrome are unknown. Here, we investigated the development of excitatory projections in the barrel cortex of Fmr1 ko mice. In 2-week-old Fmr1 ko mice, a major ascending projection connecting layer 4 (L4) to L3 (L4→L3), was defective in multiple and independent ways: its strength was reduced, caused by a lower connection probability; the axonal arbors of L4 cells were spatially diffuse in L2/3; the L4→L3 projection did not show experience-dependent plasticity. By 3 weeks, the strength of the L4→L3 projection was similar to that of wild type. Our data indicate that Fmr1 shapes sensory cortical circuits during a developmental critical period.
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Fmr1 mutant mice have a significant delay in the stabilization of dendritic spines and in the maturation of thalamocortical and corticocortical synapses, defects associated with a temporal shift in the critical period for sensory-induced plasticity across different cortical areas.
“Fmr1 mutant mice have a significant delay in the stabilization of dendritic spines and in the maturation of thalamocortical and corticocortical synapses 94-98 , defects associated with a temporal shift in the critical period for sensory-induced plasticity across different cortical areas 94,97,99-101 .”
From Developmental timing and critical windows for the treatment of psychiatric disorders (2016) · cites this paper as [94]
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Cellular Scaling Rules for the Brains of Marsupials: Not as “Primitive” as Expected
Santos, S. E. D., Porfírio, J., Cunha, F., Manger, P. R., Tavares, W. C., Pessôa, L. M., Raghanti, M. A., Sherwood, C. C., & Herculano‐Houzel, S. (2017) · Brain Behavior and Evolution · doi:10.1159/000452856 · Cited by 2,651 · see citing works
NeuN, a neuronal specific nuclear protein in vertebratesxs
Mullen, R. J., Buck, C. R., & Smith, A. M. (1992) · Development · doi:10.1242/dev.116.1.201 · Cited by 2,351 · see citing works
The structural organization of layer IV in the somatosensory region (S I) of mouse cerebral cortex
Woolsey, T. A., & Van der Loos, H. (1970) · Brain Research · doi:10.1016/0006-8993(70)90079-x · Cited by 2,254 · see citing works
The mGluR theory of fragile X mental retardation
Bear, M. F., Huber, K. M., & Warren, S. T. (2004) · Trends in Neurosciences · doi:10.1016/j.tins.2004.04.009 · Cited by 1,580 · see citing works
Altered synaptic plasticity in a mouse model of fragile X mental retardation
Huber, K. M., Gallagher, S. M., Warren, S. T., & Bear, M. F. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.122205699 · Cited by 1,349 · see citing works
Brown, V., Jin, P., Ceman, S., Darnell, J. C., O'Donnell, W. T., Tenenbaum, S. A., Jin, X., Feng, Y., Wilkinson, K. D., Keene, J. D., et al. (2001) · Cell · doi:10.1016/s0092-8674(01)00568-2 · Cited by 1,109 · see citing works
Fmr1 knockout mice: A model to study fragile X mental retardation
THEDUTCHBELGIANFRAGILEXCONSOR (1994) · Cell · doi:10.1016/0092-8674(94)90569-x · Cited by 1,075 · see citing works
Abnormal dendritic spines in fragile X knockout mice: Maturation and pruning deficits
Comery, T. A., Harris, J. B., Willems, P. J., Oostra, B. A., Irwin, S. A., Weiler, I. J., & Greenough, W. T. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.10.5401 · Cited by 1,046 · see citing works
Role for rapid dendritic protein synthesis in hippocampal mGluR-dependent long-term depression.
Huber, K., Kayser, M., & Bear, M. (2000) · Science · doi:10.1126/science.288.5469.1254 · Cited by 1,015 · see citing works
Correction of Fragile X Syndrome in Mice
Dölen, G., Osterweil, E., Rao, B. S. S., Smith, G. B., Auerbach, B. D., Chattarji, S., & Bear, M. F. (2007) · Neuron · doi:10.1016/j.neuron.2007.12.001 · Cited by 979 · see citing works
Experience-dependent plasticity of dendritic spines in the developing rat barrel cortex in vivo
Lendvai, B., Stern, E. A., Chen, B., & Svoboda, K. (2000) · Nature · doi:10.1038/35009107 · Cited by 802 · see citing works
Self-citationFMR1 Protein: Conserved RNP Family Domains and Selective RNA Binding
Ashley, C. T., Wilkinson, K. D., Reines, D., & Warren, S. T. (1993) · Science · doi:10.1126/science.7692601 · Cited by 741 · see citing works
Feldmeyer, D., Lübke, J., Silver, R. A., & Sakmann, B. (2002) · The Journal of Physiology · doi:10.1113/jphysiol.2001.012959 · Cited by 656 · see citing works
Zhang, Y., Bailey, A. M., Matthies, H. J. G., Renden, R., Smith, M. A., Speese, S. D., Rubin, G. M., & Broadie, K. S. (2001) · Cell · doi:10.1016/s0092-8674(01)00589-x · Cited by 641 · see citing works
The protein product of the fragile X gene, FMR1, has characteristics of an RNA-binding protein.
Siomi, H., Siomi, M. C., Nussbaum, R. L., & Dreyfuss, G. (1993) · Cell · doi:10.1016/0092-8674(93)90420-u · Cited by 641 · see citing works
Dendritic Spine Structural Anomalies in Fragile-X Mental Retardation Syndrome
Irwin, S. A. (2000) · Cerebral Cortex · doi:10.1093/cercor/10.10.1038 · Cited by 626 · see citing works
Map Plasticity in Somatosensory Cortex
Feldman, D. E., & Brecht, M. (2005) · Science · doi:10.1126/science.1115807 · Cited by 587 · see citing works
(1994) · PubMed · Cited by 565 · see citing works
Abnormal Development of Dendritic Spines in<i>FMR1</i>Knock-Out Mice
Nimchinsky, E. A., Oberlander, A. M., & Svoboda, K. (2001) · The Journal of Neuroscience · doi:10.1523/jneurosci.21-14-05139.2001 · Cited by 560 · see citing works
Self-citationFeng, Y., Absher, D., Eberhart, D. E., Brown, V., Malter, H. E., & Warren, S. T. (1997) · Molecular Cell · doi:10.1016/s1097-2765(00)80012-x · Cited by 511 · see citing works
A Decade of Molecular Studies of Fragile X Syndrome
O'Donnell, W. T., & Warren, S. T. (2002) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.25.112701.142909 · Cited by 481 · see citing works
A critical period for experience-dependent synaptic plasticity in rat barrel cortex
Fox, K. D. (1992) · Journal of Neuroscience · doi:10.1523/jneurosci.12-05-01826.1992 · Cited by 420 · see citing works
Koekkoek, S. K. E., Yamaguchi, K., Milojkovic, B. A., Dortland, B. R., Ruigrok, T. J. H., Maex, R., Graaf, W. D., Smit, A. E., VanderWerf, F., Bakker, C. E., et al. (2005) · Neuron · doi:10.1016/j.neuron.2005.07.005 · Cited by 417 · see citing works
Two Coincidence Detectors for Spike Timing-Dependent Plasticity in Somatosensory Cortex
Bender, V. A., Bender, K. J., Brasier, D. J., & Feldman, D. E. (2006) · Journal of Neuroscience · doi:10.1523/jneurosci.0176-06.2006 · Cited by 373 · see citing works
Understanding the molecular basis of fragile X syndrome
Jin, P. (2000) · Human Molecular Genetics · doi:10.1093/hmg/9.6.901 · Cited by 368 · see citing works
Spencer, C. M., Alekseyenko, O., Serysheva, E., Yuva‐Paylor, L. A., & Paylor, R. (2005) · Genes, Brain and Behavior · doi:10.1111/j.1601-183x.2005.00123.x · Cited by 349 · see citing works
Fragile X mice develop sensory hyperreactivity to auditory stimuli
Chen, L., & Toth, M. (2001) · Neuroscience · doi:10.1016/s0306-4522(01)00036-7 · Cited by 345 · see citing works
A developmental switch in the signaling cascades for LTP induction
Yasuda, H., Barth, A. L., Stellwagen, D., & Malenka, R. C. (2003) · Nature Neuroscience · doi:10.1038/nn985 · Cited by 325 · see citing works
Circuit analysis of experience-dependent plasticity in the developing rat barrel cortex
Shepherd, G. M. G., Pologruto, T. A., & Svoboda, K. (2003) · Neuron · doi:10.1016/s0896-6273(03)00152-1 · Cited by 322 · see citing works
Self-citationDecreased expression of the GABAA receptor in fragile X syndrome
D'Hulst, C., De Geest, N., Reeve, S. P., Van Dam, D., De Deyn, P. P., Hassan, B. A., & Kooy, R. F. (2006) · Brain Research · doi:10.1016/j.brainres.2006.08.115 · Cited by 318 · see citing works
Synaptic regulation of protein synthesis and the fragile X protein
Greenough, W. T., Klintsova, A. Y., Irwin, S. A., Galvez, R., Bates, K. E., & Weiler, I. J. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.141145998 · Cited by 317 · see citing works
Paradee, W., Melikian, H. E., Rasmussen, D. L., Kenneson, A., Conn, P. J., & Warren, S. T. (1999) · Neuroscience · doi:10.1016/s0306-4522(99)00285-7 · Cited by 305 · cited 2× · see citing works
“Fmr1 ko mice have learning deficits (Dutch–Belgian Fragile X Consortium, 1994; Paradee et al., 1999; Peier et al., 2000), abnormal social behaviors (Spencer et al., 2005; Mineur et al., 2006), and audiogenic seizures (Musumeci et al., 2000; Chen and Toth, 2001; Yan et al., 2004).”
BackgroundAudiogenic Seizures Susceptibility in Transgenic Mice with Fragile X Syndrome
Musumeci, S. A., Bosco, P., Calabrese, G., Bakker, C., De Sarro, G. B., Elia, M., Ferri, R., & Oostra, B. A. (2000) · Epilepsia · doi:10.1111/j.1528-1157.2000.tb01499.x · Cited by 289 · see citing works
Darnell, J. C., Fraser, C. E., Mostovetsky, O., Stefani, G., Jones, T. A., Eddy, S. R., & Darnell, R. B. (2005) · Genes & Development · doi:10.1101/gad.1276805 · Cited by 287 · see citing works
(Over)correction of FMR1 deficiency with YAC transgenics: behavioral and physical features
Peier, A. M. (2000) · Human Molecular Genetics · doi:10.1093/hmg/9.8.1145 · Cited by 285 · see citing works
Todd, P. K., Mack, K. J., & Malter, J. S. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2336265100 · Cited by 280 · see citing works
Rapid Development and Plasticity of Layer 2/3 Maps in Rat Barrel Cortex In Vivo
Stern, E. A., Maravall, M., & Svoboda, K. (2001) · Neuron · doi:10.1016/s0896-6273(01)00360-9 · Cited by 276 · see citing works
Self-citationInterdigitated Paralemniscal and Lemniscal Pathways in the Mouse Barrel Cortex
Bureau, I., Paul, F. V. S., & Svoboda, K. (2006) · PLoS Biology · doi:10.1371/journal.pbio.0040382 · Cited by 274 · see citing works
Self-citationSiomi, M. C., Zhang, Y., Siomi, H., & Dreyfuss, G. (1996) · Molecular and Cellular Biology · doi:10.1128/mcb.16.7.3825 · Cited by 271 · see citing works
Long-term depression induced by sensory deprivation during cortical map plasticity in vivo
Allen, C. B., Celikel, T., & Feldman, D. E. (2003) · Nature Neuroscience · doi:10.1038/nn1012 · Cited by 270 · see citing works
Li, J., Pelletier, M. R., Perez-Velazquez, J. L., & Carlen, P. L. (2002) · Molecular and Cellular Neuroscience · doi:10.1006/mcne.2001.1085 · Cited by 268 · see citing works
Sensory experience modifies the short-term dynamics of neocortical synapses
Finnerty, G. T., Roberts, L., & Connors, B. W. (1999) · Nature · doi:10.1038/22553 · Cited by 264 · see citing works
Cerebellar LTD and Learning-Dependent Timing of Conditioned Eyelid Responses
Koekkoek, S. K. E., Hulscher, H. C., Dortland, B. R., Hensbroek, R. A., Elgersma, Y., Ruigrok, T. J. H., & Zeeuw, C. I. D. (2003) · Science · doi:10.1126/science.1088383 · Cited by 263 · see citing works
Antar, L. N., Li, C., Zhang, H., Carroll, R. C., & Bassell, G. J. (2006) · Molecular and Cellular Neuroscience · doi:10.1016/j.mcn.2006.02.001 · Cited by 259 · see citing works
Deficits in trace fear memory and long-term potentiation in a mouse model for fragile X syndrome
Zhao, M.-G., Toyoda, H., Ko, S. W., Ding, H.-K., Wu, L.-J., & Zhuo, M. (2005) · The Journal of Neuroscience · doi:10.1523/jneurosci.1520-05.2005 · Cited by 258 · see citing works
Geometric and functional organization of cortical circuits
Shepherd, G. M., Stepanyants, A., Bureau, I., Chklovskii, D. B., & Svoboda, K. (2005) · Nature Neuroscience · doi:10.1038/nn1447 · Cited by 257 · see citing works
Self-citationHigh-Probability Uniquantal Transmission at Excitatory Synapses in Barrel Cortex
Silver, R. A., Lübke, J. H. R., Sakmann, B. J., & Feldmeyer, D. (2003) · Science · doi:10.1126/science.1087160 · Cited by 247 · see citing works
Selby, L., Zhang, C., & Sun, Q.-Q. (2007) · Neuroscience Letters · doi:10.1016/j.neulet.2006.11.062 · Cited by 245 · see citing works
Shepherd, G. M. (2005) · Journal of Neuroscience · doi:10.1523/jneurosci.1173-05.2005 · Cited by 236 · see citing works
Self-citationGalvez, R., & Greenough, W. T. (2005) · American Journal of Medical Genetics Part A · doi:10.1002/ajmg.a.30709 · Cited by 231 · see citing works
Canepari, M., Nelson, L., Papageorgiou, G., Corrie, J. E. T., & Ogden, D. (2001) · Journal of Neuroscience Methods · doi:10.1016/s0165-0270(01)00451-4 · Cited by 216 · see citing works
A phenotypic and molecular characterization of the <i>fmr1‐tm1Cgr</i> Fragile X mouse
Yan, Q. J., Asafo‐Adjei, P. K., Arnold, H. M., Brown, R. E., & Bauchwitz, R. P. (2004) · Genes, Brain and Behavior · doi:10.1111/j.1601-183x.2004.00087.x · Cited by 213 · see citing works
Decreased GABAA receptor expression in the seizure-prone fragile X mouse
Idrissi, A. E., Ding, X., Scalia, J., Trenkner, E., Brown, W. T., & Dobkin, C. (2004) · Neuroscience Letters · doi:10.1016/j.neulet.2004.11.087 · Cited by 210 · see citing works
Grossman, A. W., Elisseou, N. M., McKinney, B. C., & Greenough, W. T. (2006) · Brain Research · doi:10.1016/j.brainres.2006.02.044 · Cited by 204 · see citing works
Lübke, J. H. R. (2003) · Cerebral Cortex · doi:10.1093/cercor/13.10.1051 · Cited by 202 · see citing works
Immunocytochemical and Biochemical Characterization of FMRP, FXR1P, and FXR2P in the Mouse
Bakker, C. E., de Diego‐Otero, Y., Bontekoe, C. J. M., Raghoe, P., Luteijn, T., Hoogeveen, A. T., Oostra, B. A., & Willemsen, R. (2000) · Experimental Cell Research · doi:10.1006/excr.2000.4932 · Cited by 193 · see citing works
Dendritic spine abnormalities in the occipital cortex of C57BL/6Fmr1 knockout mice
McKinney, B. C., Grossman, A. W., Elisseou, N. M., & Greenough, W. T. (2005) · American Journal of Medical Genetics Part B: Neuropsychiatric Genetics · doi:10.1002/ajmg.b.30183 · Cited by 184 · see citing works
Nosyreva, E. D., & Huber, K. M. (2005) · Journal of Neuroscience · doi:10.1523/jneurosci.3652-04.2005 · Cited by 182 · see citing works
Social behavior deficits in the Fmr1 mutant mouse
Mineur, Y. S., Huynh, L. X., & Crusio, W. E. (2006) · Behavioural Brain Research · doi:10.1016/j.bbr.2005.11.004 · Cited by 177 · see citing works
Crozier, R. A., Wang, Y., Liu, C.-H., & Bear, M. F. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0609596104 · Cited by 163 · see citing works
Pfeiffer, B. E., & Huber, K. M. (2007) · The Journal of Neuroscience · doi:10.1523/jneurosci.0054-07.2007 · Cited by 154 · see citing works
Precise Development of Functional and Anatomical Columns in the Neocortex
Bureau, I., Shepherd, G. M., & Svoboda, K. (2004) · Neuron · doi:10.1016/j.neuron.2004.05.002 · Cited by 149 · see citing works
Self-citationFMRP Involvement in Formation of Synapses among Cultured Hippocampal Neurons
Braun, K. A. (2000) · Cerebral Cortex · doi:10.1093/cercor/10.10.1045 · Cited by 149 · see citing works
Michel, C. I., Kraft, R., & Restifo, L. L. (2004) · Journal of Neuroscience · doi:10.1523/jneurosci.1102-04.2004 · Cited by 145 · see citing works
Kemp, N. M. (1999) · Neuropharmacology · doi:10.1016/s0028-3908(98)00222-6 · Cited by 140 · see citing works
Synaptic basis for developmental plasticity in somatosensory cortex
Foeller, E., & Feldman, D. E. (2004) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2004.01.011 · Cited by 136 · see citing works
Larson, J., Jessen, R. E., Kim, D., Fine, A.-K. S., & du Hoffmann, J. (2005) · The Journal of Neuroscience · doi:10.1523/jneurosci.2638-05.2005 · Cited by 135 · see citing works
Synaptic basis for whisker deprivation-induced synaptic depression in rat somatosensory cortex
Bender, K. J., Allen, C. B., Bender, V. A., & Feldman, D. E. (2006) · The Journal of Neuroscience · doi:10.1523/jneurosci.0175-06.2006 · Cited by 126 · see citing works
Axonal trajectories between mouse somatosensory thalamus and cortex
Bernardo, K. L., & Woolsey, T. A. (1987) · The Journal of Comparative Neurology · doi:10.1002/cne.902580406 · Cited by 121 · see citing works
Absence of metabotropic glutamate receptor-mediated plasticity in the neocortex of fragile X mice
Wilson, B. M., & Cox, C. L. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0610875104 · Cited by 121 · see citing works
Wang, H. (2003) · Human Molecular Genetics · doi:10.1093/hmg/ddh009 · Cited by 117 · see citing works
Bender, K. J., Rangel, J., & Feldman, D. E. (2003) · Journal of Neuroscience · doi:10.1523/jneurosci.23-25-08759.2003 · Cited by 108 · see citing works
Hanson, J. E., & Madison, D. V. (2007) · Journal of Neuroscience · doi:10.1523/jneurosci.4717-06.2007 · Cited by 103 · see citing works
Guerrini, R., Carrozzo, R., Rinaldi, R., & Bonanni, P. (2003) · Pediatric Drugs · doi:10.2165/00148581-200305100-00001 · Cited by 99 · see citing works
Early Postnatal Plasticity in Neocortex of <i>Fmr1</i> Knockout Mice
Desai, N. S., Casimiro, T. M., Gruber, S. M., & Vanderklish, P. W. (2006) · Journal of Neurophysiology · doi:10.1152/jn.00221.2006 · Cited by 92 · see citing works
Bannister, N., Benke, T., Mellor, J., Scott, H. L., Gürdal, E., Crabtree, J., & Isaac, J. (2005) · Journal of Neuroscience · doi:10.1523/jneurosci.0827-05.2005 · Cited by 50 · see citing works
The Neurobiology of Tuberous Sclerosis Complex
Ess, K. C. (2006) · Seminars in Pediatric Neurology · doi:10.1016/j.spen.2006.01.009 · Cited by 48 · see citing works
Ha, D. H., Robertson, R. T., Ribak, C. E., & Weiss, J. H. (1996) · The Journal of Comparative Neurology · doi:10.1002/(sici)1096-9861(19960923)373:3 · Cited by 36 · see citing works
Long‐term potentiation in the hippocampus of fragile X knockout mice
Godfraind, J., Reyniers, E., Boulle, K. D., D’Hooge, R., Deyn, P. P. D., Bakker, C. E., Oostra, B. A., Kooy, R. F., & Willems, P. J. (1996) · American Journal of Medical Genetics · doi:10.1002/(sici)1096-8628(19960809)64:2 · Cited by 16 · see citing works
Clinical consult: developmental delay/fragile X syndrome
Wiesner, G. L., Cassidy, S. B., Grimes, S. J., Matthews, A. L., & Acheson, L. S. (2004) · Primary Care Clinics in Office Practice · doi:10.1016/j.pop.2004.04.008 · Cited by 7 · see citing works
Medical records in the governmental hospitals, Gaza Strip, Palestine.
Ah, R. (2000) · PubMed · Cited by 3 · see citing works
Irwin (2001) · doi:10.1002/1096-8628(20010115)98:2
Flagged first, then by citations
Cited by
Sorted by citations
Fragile X Syndrome: Loss of Local mRNA Regulation Alters Synaptic Development and Function
Bassell, G. J., & Warren, S. T. (2008) · Neuron · doi:10.1016/j.neuron.2008.10.004 · Cited by 1,051 · see citing works
Excitatory/Inhibitory Balance and Circuit Homeostasis in Autism Spectrum Disorders
Nelson, S. B., & Valakh, V. (2015) · Neuron · doi:10.1016/j.neuron.2015.07.033 · Cited by 1,001 · see citing works
Gibson, J. R., Bartley, A. F., Hays, S. A., & Huber, K. M. (2008) · Journal of Neurophysiology · doi:10.1152/jn.90752.2008 · Cited by 529 · see citing works
Altered Neuronal and Circuit Excitability in Fragile X Syndrome
Contractor, A., Klyachko, V. A., & Portera‐Cailliau, C. (2015) · Neuron · doi:10.1016/j.neuron.2015.06.017 · Cited by 425 · see citing works
Developmental timing and critical windows for the treatment of psychiatric disorders
Marín, O. (2016) · Nature Medicine · doi:10.1038/nm.4225 · Cited by 374 · see citing works
Development and critical period plasticity of the barrel cortex
Erzurumlu, R. S., & Gaspar, P. (2012) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2012.08075.x · Cited by 344 · see citing works
Delayed Stabilization of Dendritic Spines in Fragile X Mice
Cruz-Martin, A., Crespo, M., & Portera-Cailliau, C. (2010) · Journal of Neuroscience · doi:10.1523/jneurosci.0577-10.2010 · Cited by 321 · see citing works
Olmos-Serrano, J. L., Paluszkiewicz, S. M., Martin, B. S., Kaufmann, W. E., Corbin, J. G., & Huntsman, M. M. (2010) · Journal of Neuroscience · doi:10.1523/jneurosci.1714-10.2010 · Cited by 309 · see citing works
Somatosensory processing in neurodevelopmental disorders
Cascio, C. J. (2010) · Journal of Neurodevelopmental Disorders · doi:10.1007/s11689-010-9046-3 · Cited by 285 · see citing works
Circuit level defects in the developing neocortex of fragile X mice
Gonçalves, J. T., Anstey, J. E., Golshani, P., & Portera-Cailliau, C. (2013) · Nature Neuroscience · doi:10.1038/nn.3415 · Cited by 279 · see citing works
Ephus: multipurpose data acquisition software for neuroscience experiments
Suter, B. A. (2010) · Frontiers in Neural Circuits · doi:10.3389/fncir.2010.00100 · Cited by 255 · see citing works
Critical period plasticity is disrupted in the barrel cortex of FMR1 knockout mice
Harlow, E. G., Till, S. M., Russell, T. A., Wijetunge, L. S., Kind, P., & Contractor, A. (2010) · Neuron · doi:10.1016/j.neuron.2010.01.024 · Cited by 252 · see citing works
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He, Q., Nomura, T., Xu, J., & Contractor, A. (2014) · The Journal of Neuroscience · doi:10.1523/jneurosci.4447-13.2014 · Cited by 230 · see citing works
Dendritic channelopathies contribute to neocortical and sensory hyperexcitability in Fmr1−/y mice
Zhang, Y., Bonnan, A., Bony, G., Férézou, I., Pietropaolo, S., Ginger, M. R., Sans, N., Rossier, J., Oostra, B. A., LeMasson, G., et al. (2014) · Nature Neuroscience · doi:10.1038/nn.3864 · Cited by 227 · see citing works
Meredith, R. M. (2014) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2014.12.001 · Cited by 237 · see citing works
The State of Synapses in Fragile X Syndrome
Pfeiffer, B. E., & Huber, K. M. (2009) · The Neuroscientist · doi:10.1177/1073858409333075 · Cited by 214 · see citing works
Spatially restricting gene expression by local translation at synapses
Wang, D. O., Martin, K. C., & Zukin, R. S. (2010) · Trends in Neurosciences · doi:10.1016/j.tins.2010.01.005 · Cited by 187 · see citing works
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Paluszkiewicz, S. M., Martin, B. S., & Huntsman, M. M. (2011) · Developmental Neuroscience · doi:10.1159/000329420 · Cited by 177 · see citing works
Early postnatal development of pyramidal neurons across layers of the mouse medial prefrontal cortex
Kroon, T., van Hugte, E., van Linge, L., Mansvelder, H. D., & Meredith, R. M. (2019) · Scientific Reports · doi:10.1038/s41598-019-41661-9 · Cited by 161 · see citing works
Thalamic Network Oscillations Synchronize Ontogenetic Columns in the Newborn Rat Barrel Cortex
Yang, J., An, S., Sun, J., Reyes‐Puerta, V., Kindler, J., Berger, T. K., Kilb, W., & Luhmann, H. J. (2012) · Cerebral Cortex · doi:10.1093/cercor/bhs103 · Cited by 171 · see citing works
Hays, S. A., Huber, K. M., & Gibson, J. R. (2011) · Journal of Neuroscience · doi:10.1523/jneurosci.3157-11.2011 · Cited by 167 · see citing works
Sidhu, H., Dansie, L. E., Hickmott, P. W., Ethell, D. W., & Ethell, I. M. (2014) · Journal of Neuroscience · doi:10.1523/jneurosci.1162-14.2014 · Cited by 155 · see citing works
He, C. X., Cantu, D. A., Mantri, S. S., Zeiger, W., Goel, A., & Portera‐Cailliau, C. (2017) · Journal of Neuroscience · doi:10.1523/jneurosci.0651-17.2017 · Cited by 140 · see citing works
Moy, J. K., Khoutorsky, A., Asiedu, M. N., Black, B., Kuhn, J. L., Barragán‐Iglesias, P., Megat, S., Burton, M. D., Burgos-Vega, C., Melemedjian, O. K., et al. (2017) · Journal of Neuroscience · doi:10.1523/jneurosci.0220-17.2017 · Cited by 142 · see citing works
Shifting Developmental Trajectories During Critical Periods of Brain Formation
Dehorter, N., & del Pino, I. (2020) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2020.00283 · Cited by 134 · see citing works
Cytoplasmic RNA-Binding Proteins and the Control of Complex Brain FunctionPreprint
Darnell, J. C., & Richter, J. D. (2012) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a012344 · Cited by 124 · see citing works
Sasaki, Y., Welshhans, K., Wen, Z., Yao, J., Xu, M. F., Goshima, Y., Zheng, J. Q., & Bassell, G. J. (2010) · Journal of Neuroscience · doi:10.1523/jneurosci.0499-10.2010 · Cited by 124 · see citing works
Pyronneau, A., He, Q., Hwang, J.-Y., Porch, M., Contractor, A., & Zukin, R. S. (2017) · Science Signaling · doi:10.1126/scisignal.aan0852 · Cited by 122 · see citing works
Dani, V. S., & Nelson, S. B. (2009) · Journal of Neuroscience · doi:10.1523/jneurosci.1019-09.2009 · Cited by 121 · see citing works
A metabolomic and systems biology perspective on the brain of the fragile X syndrome mouse model
Davidovic, L., Navratil, V., Bonaccorso, C. M., Catania, M. V., Bardoni, B., & Dumas, M.-E. (2011) · Genome Research · doi:10.1101/gr.116764.110 · Cited by 118 · see citing works
Experience-Dependent Retinogeniculate Synapse Remodeling Is Abnormal in MeCP2-Deficient Mice
Noutel, J., Hong, Y. K., Leu, B., Kang, E., & Chen, C. (2011) · Neuron · doi:10.1016/j.neuron.2011.03.001 · Cited by 103 · see citing works
CYFIP family proteins between autism and intellectual disability: links with Fragile X syndrome
Abekhoukh, S., & Bardoni, B. (2014) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2014.00081 · Cited by 110 · see citing works
Sensitive time-windows for susceptibility in neurodevelopmental disorders
Meredith, R. M., Dawitz, J., & Kramvis, I. (2012) · Trends in Neurosciences · doi:10.1016/j.tins.2012.03.005 · Cited by 104 · see citing works
He, L.-J., Liu, N., Cheng, T.-L., Chen, X.-J., Li, Y.-D., Shu, Y.-S., Qiu, Z.-L., & Zhang, X.-H. (2014) · Nature Communications · doi:10.1038/ncomms6036 · Cited by 107 · see citing works
RNA-binding proteins balance brain function in health and disease
Schieweck, R., Ninkovic, J., & Kiebler, M. A. (2020) · Physiological Reviews · doi:10.1152/physrev.00047.2019 · Cited by 104 · see citing works
Qiu, S., Anderson, C. T., Levitt, P., & Shepherd, G. M. G. (2011) · The Journal of Neuroscience · doi:10.1523/jneurosci.6569-10.2011 · Cited by 106 · see citing works
Self-citationTherapeutic Strategies in Fragile X Syndrome: Dysregulated mGluR Signaling and Beyond
Groß, C., Berry‐Kravis, E., & Bassell, G. J. (2011) · Neuropsychopharmacology · doi:10.1038/npp.2011.137 · Cited by 103 · see citing works
Klemmer, P., Meredith, R. M., Holmgren, C. D., Klychnikov, O. I., Stahl-Zeng, J., Loos, M., van der Schors, R. C., Wortel, J., de Wit, H., Spijker, S., et al. (2011) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.210260 · Cited by 104 · see citing works
Pilpel, Y., Kolleker, A., Berberich, S., Ginger, M., Frick, A., Mientjes, E., Oostra, B. A., & Seeburg, P. H. (2009) · The Journal of Physiology · doi:10.1113/jphysiol.2008.160929 · Cited by 91 · see citing works
A Subset of Autism-Associated Genes Regulate the Structural Stability of Neurons
Lin, Y., Frei, J. A., Kilander, M. B. C., Shen, W., & Blatt, G. J. (2016) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2016.00263 · Cited by 91 · see citing works
Altered maturation of the primary somatosensory cortex in a mouse model of fragile X syndrome
Till, S. M., Wijetunge, L. S., Seidel, V. G., Harlow, E., Wright, A. K., Bagni, C., Contractor, A., Gillingwater, T. H., & Kind, P. C. (2012) · Human Molecular Genetics · doi:10.1093/hmg/dds030 · Cited by 91 · see citing works
Haberl, M. G., Zerbi, V., Veltien, A. A., Ginger, M. R., Heerschap, A., & Frick, A. (2015) · Science Advances · doi:10.1126/sciadv.1500775 · Cited by 91 · see citing works
BDNF and TrkB in neuronal differentiation of Fmr1-knockout mouse
Louhivuori, V., Vicario, A., Uutela, M., Rantamäki, T., Louhivuori, L. M., Ċastrén, E., Tongiorgi, E., Åkerman, K. E. O., & Castrén, M. L. (2010) · Neurobiology of Disease · doi:10.1016/j.nbd.2010.10.018 · Cited by 89 · see citing works
Doll, C. A., & Broadie, K. S. (2014) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2014.00030 · Cited by 81 · see citing works
Syndromic autism: causes and pathogenetic pathways
Benvenuto, A., Moavero, R., Alessandrelli, R., Manzi, B., & Curatolo, P. (2009) · World Journal of Pediatrics · doi:10.1007/s12519-009-0033-2 · Cited by 88 · see citing works
Kalmbach, B. E., Johnston, D., & Brager, D. H. (2015) · eNeuro · doi:10.1523/eneuro.0114-15.2015 · Cited by 82 · see citing works
Shamay-Ramot, A., Khermesh, K., Porath, H. T., Barak, M., Pinto, Y., Wachtel, C., Zilberberg, A., Lerer‐Goldshtein, T., Efroni, S., Levanon, E. Y., et al. (2015) · PLoS Genetics · doi:10.1371/journal.pgen.1005702 · Cited by 83 · see citing works
Lai, J., Sobala-Drozdowski, M., Zhou, L., Doering, L. C., Faure, P. A., & Foster, J. A. (2013) · Behavioural Brain Research · doi:10.1016/j.bbr.2013.10.049 · Cited by 84 · see citing works
Cheng, C., Lau, S. K. M., & Doering, L. C. (2016) · Molecular Brain · doi:10.1186/s13041-016-0256-9 · Cited by 84 · see citing works
Patel, A. B., Hays, S. A., Bureau, I., Huber, K. M., & Gibson, J. R. (2013) · Journal of Neuroscience · doi:10.1523/jneurosci.2447-12.2013 · Cited by 82 · see citing works
Self-citationScotto-Lomassese, S., Nissant, A., Mota, T., Néant-Féry, M., Oostra, B. A., Greer, C. A., Lledo, P.-M., Trembleau, A., & Caillé, I. (2011) · The Journal of Neuroscience · doi:10.1523/jneurosci.5514-10.2011 · Cited by 80 · see citing works
Shepherd, G. M., & Katz, D. M. (2011) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2011.06.006 · Cited by 75 · see citing works
Self-citationO’Donnell, C., Gonçalves, J. T., Portera‐Cailliau, C., & B, T. J. S. A. (2017) · eLife · doi:10.7554/elife.26724 · Cited by 69 · see citing works
He, Q., Arroyo, E. D., Smukowski, S. N., Xu, J., Piochon, C., Savas, J. N., Portera‐Cailliau, C., & Contractor, A. (2018) · Molecular Psychiatry · doi:10.1038/s41380-018-0048-y · Cited by 73 · see citing works
Making and breaking synapses through local mRNA regulation
Swanger, S. A., & Bassell, G. J. (2011) · Current Opinion in Genetics & Development · doi:10.1016/j.gde.2011.04.002 · Cited by 72 · see citing works
Effect of Prenatal Valproic Acid Exposure on Cortical Morphology in Female Mice
Hara, Y., Maeda, Y., Kataoka, S., Ago, Y., Takuma, K., & Matsuda, T. (2012) · Journal of Pharmacological Sciences · doi:10.1254/jphs.12025sc · Cited by 72 · see citing works
Coffee, R. L., Tessier, C. R., Woodruff, E. A., & Broadie, K. S. (2010) · Disease Models & Mechanisms · doi:10.1242/dmm.004598 · Cited by 71 · see citing works
Activity-dependent FMRP requirements in development of the neural circuitry of learning and memory
Doll, C. A., & Broadie, K. S. (2015) · Development · doi:10.1242/dev.117127 · Cited by 68 · see citing works
Patel, A. B., Loerwald, K. W., Huber, K. M., & Gibson, J. R. (2014) · Journal of Neuroscience · doi:10.1523/jneurosci.2921-13.2014 · Cited by 67 · see citing works
Altered dendritic spine function and integration in a mouse model of fragile X syndrome
Booker, S. A., Domanski, A. P. F., Dando, O., Jackson, A. D., Isaac, J. T. R., Hardingham, G. E., Wyllie, D. J. A., & Kind, P. C. (2019) · Nature Communications · doi:10.1038/s41467-019-11891-6 · Cited by 70 · see citing works
The contribution of inhibitory interneurons to circuit dysfunction in Fragile X Syndrome
Rio, C. A. C.-D., & Huntsman, M. M. (2014) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2014.00245 · Cited by 67 · see citing works
Portera‐Cailliau, C. (2011) · The Neuroscientist · doi:10.1177/1073858410395322 · Cited by 68 · see citing works
Castrén, M. L., & Ċastrén, E. (2013) · Neuropharmacology · doi:10.1016/j.neuropharm.2013.05.018 · Cited by 68 · see citing works
Li, C. (2009) · Frontiers in Neural Circuits · doi:10.3389/neuro.04.011.2009 · Cited by 67 · see citing works
Booker, S. A., de Oliveira, L. S., Anstey, N. J., Kozić, Z., Dando, O., Jackson, A. D., Baxter, P. S., Isom, L. L., Sherman, D. L., Hardingham, G. E., et al. (2020) · Cell Reports · doi:10.1016/j.celrep.2020.107988 · Cited by 66 · see citing works
Wilson, S. M., Xiong, W., Wang, Y., Ping, X., Head, J., Brittain, J. M., Gagare, P. D., Ramachandran, P. V., Jin, X., & Khanna, R. (2012) · Neuroscience · doi:10.1016/j.neuroscience.2012.02.038 · Cited by 65 · see citing works
PTEN Regulation of Local and Long-Range Connections in Mouse Auditory Cortex
Xiong, Q., Oviedo, H. V., Trotman, L. C., & Zador, A. M. (2012) · Journal of Neuroscience · doi:10.1523/jneurosci.4480-11.2012 · Cited by 60 · see citing works
What we can learn from a genetic rodent model about autism
Möhrle, D., Fernández, M. C., Peñagarikano, O., Frick, A., Allman, B. L., & Schmid, S. (2019) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2019.12.015 · Cited by 59 · see citing works
Bray, S., Hirt, M., Jo, B., Hall, S. S., Lightbody, A. A., Walter, E., Chen, K. S., Patnaik, S., & Reiss, A. L. (2011) · Biological Psychiatry · doi:10.1016/j.biopsych.2011.05.038 · Cited by 58 · see citing works
Juczewski, K., von Richthofen, H. J., Bagni, C., Celikel, T., Fisone, G., & Krieger, P. (2016) · Neurobiology of Disease · doi:10.1016/j.nbd.2016.09.007 · Cited by 59 · see citing works
Pathological plasticity in fragile X syndrome.
Martin, B. S., & Huntsman, M. M. (2012) · Neural Plasticity · doi:10.1155/2012/275630 · Cited by 57 · see citing works
Anastasiades, P. G., & Butt, S. J. B. (2012) · The Journal of Neuroscience · doi:10.1523/jneurosci.1262-12.2012 · Cited by 49 · see citing works
Domanski, A. P. F., Booker, S. A., Wyllie, D. J. A., Isaac, J. T. R., & Kind, P. C. (2019) · Nature Communications · doi:10.1038/s41467-019-12736-y · Cited by 53 · see citing works
Wood, L., & Shepherd, G. M. (2010) · Neurobiology of Disease · doi:10.1016/j.nbd.2010.01.018 · Cited by 55 · see citing works
Self-citationHyperexcitability and homeostasis in fragile X Syndrome.
Liu, X., Kumar, V., Tsai, N.-P., & Auerbach, B. D. (2022) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2021.805929 · Cited by 53 · see citing works
Molecular Advances Leading to Treatment Implications for Fragile X Premutation Carriers
Hagerman, R. J. (2014) · Brain Disorders & Therapy · doi:10.4172/2168-975x.1000119 · Cited by 52 · see citing works
Coffee, R. L., Williamson, A. J., Adkins, C. M., Gray, M. C., Page, T. L., & Broadie, K. S. (2011) · Human Molecular Genetics · doi:10.1093/hmg/ddr527 · Cited by 51 · see citing works
Interneuron Dysfunction and Inhibitory Deficits in Autism and Fragile X Syndrome
Nomura, T. (2021) · Cells · doi:10.3390/cells10102610 · Cited by 48 · see citing works
Gatto, C. L. (2009) · Frontiers in Neural Circuits · doi:10.3389/neuro.04.008.2009 · Cited by 50 · see citing works
Pan, L., Zheng, L., Wu, X., Zhu, Z., Wang, S., Lu, Y., He, Y., Yang, Q., Ma, X., Wang, X., et al. (2022) · Molecular Psychiatry · doi:10.1038/s41380-022-01692-7 · Cited by 49 · see citing works
Doll, C. A., Vita, D. J., & Broadie, K. S. (2017) · Current Biology · doi:10.1016/j.cub.2017.06.046 · Cited by 43 · see citing works
Development of White Matter Circuitry in Infants With Fragile X Syndrome
Swanson, M. R., Wolff, J. J., Shen, M. D., Styner, M. A., Estes, A. M., Gerig, G., McKinstry, R. C., Botteron, K. N., Piven, J., Hazlett, H. C., et al. (2018) · JAMA Psychiatry · doi:10.1001/jamapsychiatry.2018.0180 · Cited by 47 · see citing works
Transient Potassium Channels: Therapeutic Targets for Brain Disorders
Noh, W., Pak, S., Choi, G., Yang, S., & Yang, S. (2019) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2019.00265 · Cited by 46 · see citing works
Fragile X Mental Retardation Protein in Learning-Related Synaptic Plasticity
Mercaldo, V., Descalzi, G., & Zhuo, M. (2009) · Molecules and Cells · doi:10.1007/s10059-009-0193-x · Cited by 44 · see citing works
Tessier, C. R., & Broadie, K. S. (2010) · Neurobiology of Disease · doi:10.1016/j.nbd.2010.09.002 · Cited by 44 · see citing works
Khalfallah, O., Jarjat, M., Davidovic, L., Nottet, N., Cestèle, S., Mantegazza, M., & Bardoni, B. (2016) · Stem Cells · doi:10.1002/stem.2505 · Cited by 44 · see citing works
Cruz‐Martín, A., Crespo, M., & Portera‐Cailliau, C. (2012) · PLoS ONE · doi:10.1371/journal.pone.0032446 · Cited by 44 · see citing works
Defects in translational regulation contributing to human cognitive and behavioral disease
Darnell, J. (2011) · Current Opinion in Genetics & Development · doi:10.1016/j.gde.2011.05.002 · Cited by 43 · see citing works
Kroon, T., Sierksma, M. C., & Meredith, R. (2013) · Frontiers in Systems Neuroscience · doi:10.3389/fnsys.2013.00075 · Cited by 56 · see citing works
The developmental roles of FMRP
Till, S. M. (2010) · Biochemical Society Transactions · doi:10.1042/bst0380507 · Cited by 43 · see citing works
Sensory hypo-excitability in a rat model of fetal development in Fragile X Syndrome
Berzhanskaya, J., Phillips, M. A., Shen, J., & Colonnese, M. T. (2016) · Scientific Reports · doi:10.1038/srep30769 · Cited by 41 · see citing works
Heads‐up: New roles for the fragile X mental retardation protein in neural stem and progenitor cells
Callan, M. A., & Zarnescu, D. C. (2011) · genesis · doi:10.1002/dvg.20745 · Cited by 39 · see citing works
Zhang, P., Abdelmohsen, K., Liu, Y., Tominaga, K., Yoon, J., Grammatikakis, I., Martindale, J. L., Zhang, Y., Becker, K. G., Yang, I. H., et al. (2015) · Nature Communications · doi:10.1038/ncomms9888 · Cited by 38 · see citing works
Wallingford, J., Scott, A. L., Rodrigues, K., & Doering, L. C. (2017) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2017.00268 · Cited by 38 · see citing works
Sears, J. C., & Broadie, K. S. (2018) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2017.00440 · Cited by 38 · see citing works
Presynaptic protein synthesis and brain plasticity: From physiology to neuropathology
Perrone‐Capano, C., Volpicelli, F., Penna, E., Chun, J. T., & Crispino, M. (2021) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2021.102051 · Cited by 36 · see citing works
The Fragile X Mental Retardation Protein in Circadian Rhythmicity and Memory Consolidation
Gatto, C. L., & Broadie, K. S. (2009) · Molecular Neurobiology · doi:10.1007/s12035-009-8057-0 · Cited by 38 · see citing works
Functional rescue of excitatory synaptic transmission in the developing hippocampus in Fmr1-KO mouse
Meredith, R. M., de Jong, R., & Mansvelder, H. D. (2010) · Neurobiology of Disease · doi:10.1016/j.nbd.2010.08.026 · Cited by 35 · see citing works
Axonal mRNA translation in neurological disorders
Lin, J. Q., van Tartwijk, F. W., & Holt, C. E. (2020) · RNA Biology · doi:10.1080/15476286.2020.1822638 · Cited by 33 · see citing works
Circuit-level theories for sensory dysfunction in autism: convergence across mouse models
Monday, H. R., Wang, H. C., & Feldman, D. E. (2023) · Frontiers in Neurology · doi:10.3389/fneur.2023.1254297 · Cited by 31 · see citing works
- Authors
- Bureau, I., Shepherd, G. M. G., & Svoboda, K.
- Affiliations
- Howard Hughes Medical Institute (US)
- Corresponding author
- Bureau, Ingrid
- Venue
- The Journal of Neuroscience
- Publisher
- Society for Neuroscience
- Published
- 2008-05-14
- Volume
- 28
- Issue
- 20
- Pages
- 5178-5188
- ISSN
- 0270-6474 (ISSN-L)
- 1529-2401
- PMC
- PMC2696604
- OpenAlex
- W1966371094
- Cited by
- 201
- References
- 82
- Citations by year
- 2026: 3 · 2025: 6 · 2024: 8 · 2023: 8 · 2022: 6 · 2021: 14 · 2020: 14 · 2019: 8 · 2018: 8 · 2017: 11 · 2016: 8 · 2015: 13 · 2014: 14 · 2013: 12 · 2012: 17
- FWCI
- 9.69
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Journal of Neuroscience (publishedVersion, cc-by-nc-sa)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Cold Spring Harbor Laboratory Institutional Repository (Cold Spring Harbor Laboratory) (acceptedVersion)
- HAL (submittedVersion)
- Funders
- Howard Hughes Medical Institute
- FRAXA Research Foundation
- National Institutes of Health
- National Institute of Neurological Disorders and Stroke (R01NS038259)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetics and Neurodevelopmental Disorders
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Neuroscience › Cognitive Neuroscience › Autism Spectrum Disorder Research
- Keywords
- FMR1 gene, fragile X syndrome, Fmr1 knockout mice, barrel cortex, somatosensory cortex, cortical circuit development, synaptic plasticity, axonal arbors, experience-dependent plasticity, critical period, connection probability
- MeSH terms
- Animals, Disease Models, Animal, Fragile X Syndrome, Male, Mice, Inbred C57BL, Nervous System Malformations, Neural Pathways, Synaptic Transmission, Neuronal Plasticity, Organ Culture Techniques, Sensation, Somatosensory Cortex, Mice, Knockout, Gene Expression Regulation, Developmental, Excitatory Postsynaptic Potentials, Genetic Predisposition to Disease, Growth Cones, Mice, Fragile X Messenger Ribonucleoprotein 1
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