Double dissociations of memory and executive functions in working memory tasks following frontal lobe excisions, temporal lobe excisions or amygdalo-hippocampectomy in man
Abstract
Thirty-two neurosurgical patients with unilateral or bilateral frontal lobe excisions, 41 patients with unilateral temporal lobe lesions and 19 patients who had undergone unilateral amygdalo-hippocampectomy were compared with matched controls on a computerized test of spatial working memory. A significant deficit was observed in the frontal lobe group, even at the least challenging level of task difficulty and this impairment was found to relate to the inefficient use of a particular searching strategy shown to improve performance on this task. In contrast, deficits in the temporal lobe group and the amygdalo-hippocampectomy group were only observed at the most difficult level of the task and in neither group could the deficit be related to the inefficient use of any particular searching strategy. In a follow-up study, the three patient groups were compared on analogous computerized tests of visual and verbal working memory. No deficits were observed in the frontal lobe group. By comparison, both the temporal lobe patients and the amygdalo-hippocampectomy group were significantly impaired in the visual working memory condition but not in the verbal working memory condition. These deficits were clearly evident at all levels of task difficulty and were not related to any particular searching strategy. The data are discussed in terms of the relative contributions of "executive' and "mnemonic' mechanisms to the contrasting, material dependent deficits observed in the frontal and temporal lobe groups.
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In human patients, frontal lesions in either the right or left hemisphere are associated with spatial working memory deficits.
“In human patients, SWM deficits have been associated with frontal lesions in the right (Van Asselen et al., 2006;Owen, Morris, Sahakian, Polkey, & Robbins, 1996) and the left hemisphere (du Boisgueheneuc et al., 2006;Owen et al., 1996).”
From White Matter Microstructure in Superior Longitudinal Fasciculus Associated with Spatial Working Memory Performance in Children (2011) · cites this paper as Owen et al., 1996
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Self-citation
- Authors
- Owen, A. M., Morris, R. G., Sahakian, B. J., Polkey, C. E., & Robbins, T. W.
- Affiliations
- University of Cambridge (GB)
- University of London (GB)
- Maudsley Hospital (GB)
- Corresponding author
- Owen, Adrian M.
- Venue
- Brain
- Publisher
- Oxford University Press (OUP)
- Published
- 1996
- Volume
- 119
- Issue
- 5
- Pages
- 1597-1615
- ISSN
- 0006-8950 (ISSN-L)
- 1460-2156
- OpenAlex
- W2053267868
- Cited by
- 308
- References
- 1
- Citations by year
- 2024: 2 · 2022: 3 · 2021: 5 · 2020: 5 · 2019: 10 · 2018: 2 · 2017: 9 · 2016: 8 · 2015: 12 · 2014: 14 · 2013: 11 · 2012: 15
- FWCI
- 9.43
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Brain (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Wellcome Trust
- Newcastle University
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Cognitive Abilities and Testing
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Cognitive Functions and Memory
- Keywords
- working memory, executive function, temporal lobe lesions, amygdalohippocampectomy, spatial working memory, visual working memory, verbal working memory, frontal lobe, temporal lobe, task difficulty
- MeSH terms
- Adult, Amygdala, Brain Diseases, Female, Frontal Lobe, Hippocampus, Humans, Male, Memory, Middle Aged, Task Performance and Analysis, Temporal Lobe
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