Cited by 45Birth, Development, and HealthRegulation of Appetite and ObesityNeurotransmitter Receptor Influence on Behavior

Increased palatable food intake and response to food cues in intrauterine growth-restricted rats are related to tyrosine hydroxylase content in the orbitofrontal cortex and nucleus accumbens

Alves, Márcio Bonesso, Dalle Molle, Roberta, Desai, Mina, Ross, Michael G., Silveira, Patrícia Pelufo·2015·Behavioural Brain Research

Abstract

Intrauterine growth restriction (IUGR) is associated with altered food preferences, which may contribute to increased risk of obesity. We evaluated the effects of IUGR on attention to a palatable food cue, as well as tyrosine hydroxylase (TH) content in the orbitofrontal cortex (OFC) and nucleus accumbens (NAcc) in response to sweet food intake. From day 10 of gestation and through lactation, Sprague-Dawley rats received either an ad libitum (Adlib) or a 50% food-restricted (FR) diet. At birth, pups were cross-fostered, generating four groups (gestation/lactation): Adlib/Adlib (control), FR/Adlib (intrauterine growth-restricted), Adlib/FR, and FR/FR. Adult attention to palatable food cues was measured using the Attentional Set-Shifting Task (ASST), which uses a sweet pellet as reward. TH content in the OFC and NAcc was measured at baseline and in response to palatable food intake. At 90 days of age, FR/Adlib males ate more sweet food than controls, without differences in females. However, when compared to Controls, FR/Adlib females needed fewer trials to reach criterion in the ASST (p=0.04) and exhibited increased TH content in the OFC in response to sweet food (p=0.03). In the NAcc, there was a differential response of TH content after sweet food intake in both FR/Adlib males and females (p<0.05). Fetal programming of adult food preferences involves the central response to palatable food cues and intake, affecting dopamine release in select structures of the brain reward system.

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Crossref · 10.1016/j.bbr.2015.03.019

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  • IUGR is associated with an increase in impulsive behavior due to an altered dopamine signaling in the PFC.

    “Recently it has become clear that IUGR is associated with an increase in impulsive behavior due to an altered dopamine signaling in the PFC [357, 358].”

    From Development of prefrontal cortex (2022) · cites this paper as [358]

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Authors
Alves, M. B., Dalle Molle, R., Desai, M., Ross, M. G., & Silveira, P. P.
Affiliations
  • Universidade Federal do Rio Grande do Sul (BR)
  • University of California, Los Angeles (US)
Corresponding author
Alves, Márcio Bonesso
Venue
Behavioural Brain Research
Publisher
Elsevier BV
Published
2015-07
Volume
287
Pages
73-81
ISSN
0166-4328 (ISSN-L)
OpenAlex
W1980298089
Cited by
45
References
84
Citations by year
2026: 4 · 2025: 4 · 2024: 2 · 2023: 4 · 2022: 1 · 2021: 5 · 2020: 3 · 2019: 5 · 2018: 6 · 2017: 7 · 2016: 2 · 2015: 2
FWCI
5.64
Type
journal article
Language
en
Open access
closed
Locations
  • Behavioural Brain Research (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • Fundo de Incentivo à Pesquisa e Eventos do Hospital de Clínicas de Porto Alegre
  • Pró-Pesquisa/PROPESQ/UFRGS
  • Coordination for the Improvement of Higher Education Personnel
  • Fundação de Amparo à Pesquisa do Estado do Rio Grande do Sul
Topics
  • Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Birth, Development, and Health
  • Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
Keywords
fetal growth restriction, palatable food intake, food cues, tyrosine hydroxylase, orbitofrontal cortex, nucleus accumbens, sweet foods, food preferences, fetal programming, dopamine, brain reward system, obesity risk, sex differences
MeSH terms
Animals, Attention, Body Weight, Cues, Eating, Female, Fetal Growth Retardation, Male, Maternal Behavior, Motor Activity, Nucleus Accumbens, Pregnancy, Prenatal Exposure Delayed Effects, Tyrosine 3-Monooxygenase, Rats, Sprague-Dawley, Prefrontal Cortex, Prenatal Nutritional Physiological Phenomena, Rats

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