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Memory formation and retention are affected in adult miR-132/212 knockout mice

Hernandez-Rapp, Julia, Smith, Pascal Y., Filali, Mohammed, Goupil, Claudia, Planel, Emmanuel, Magill, Stephen T., Goodman, Richard H., Hébert, Sébastien S.·2015·Behavioural Brain Research
DOI 10.1016/j.bbr.2015.03.032
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Abstract

The miR-132/212 family is thought to play an important role in neural function and plasticity, while its misregulation has been observed in various neurodegenerative disorders. In this study, we analyzed 6-month-old miR-132/212 knockout mice in a battery of cognitive and non-cognitive behavioral tests. No significant changes were observed in reflexes and basic sensorimotor functions as determined by the SHIRPA primary screen. Accordingly, miR-132/212 knockout mice did not differ from wild-type controls in general locomotor activity in an open-field test. Furthermore, no significant changes of anxiety were measured in an elevated plus maze task. However, the mutant mice showed retention phase defects in a novel object recognition test and in the T-water maze. Moreover, the learning and probe phases in the Barnes maze were clearly altered in knockout mice when compared to controls. Finally, changes in BDNF, CREB, and MeCP2 were identified in the miR-132/212-deficient mice, providing a potential mechanism for promoting memory loss. Taken together, these results further strengthen the role of miR-132/212 in memory formation and retention, and shed light on the potential consequences of its deregulation in neurodegenerative diseases.

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Metadata

Authors
Hernandez-Rapp, J., Smith, P. Y., Filali, M., Goupil, C., Planel, E., Magill, S. T., Goodman, R. H., & Hébert, S. S.
Venue
Behavioural Brain Research
Publisher
Elsevier BV
Published
2015-07
Volume
287
Pages
15-26
ISSN
0166-4328
DOI
10.1016/j.bbr.2015.03.032
Cited by
81
References
13
Language
en
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Funders
  • Canadian Institutes of Health Research
  • Alzheimer Society

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