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Memory formation and retention are affected in adult miR-132/212 knockout mice

Hernandez-Rapp, Julia, Smith, Pascal Y., Filali, Mohammed, Goupil, Claudia, Planel, Emmanuel, Magill, Stephen T., Goodman, Richard H., Hébert, Sébastien S.·2015·Behavioural Brain Research
DOI 10.1016/j.bbr.2015.03.032
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Abstract

The miR-132/212 family is thought to play an important role in neural function and plasticity, while its misregulation has been observed in various neurodegenerative disorders. In this study, we analyzed 6-month-old miR-132/212 knockout mice in a battery of cognitive and non-cognitive behavioral tests. No significant changes were observed in reflexes and basic sensorimotor functions as determined by the SHIRPA primary screen. Accordingly, miR-132/212 knockout mice did not differ from wild-type controls in general locomotor activity in an open-field test. Furthermore, no significant changes of anxiety were measured in an elevated plus maze task. However, the mutant mice showed retention phase defects in a novel object recognition test and in the T-water maze. Moreover, the learning and probe phases in the Barnes maze were clearly altered in knockout mice when compared to controls. Finally, changes in BDNF, CREB, and MeCP2 were identified in the miR-132/212-deficient mice, providing a potential mechanism for promoting memory loss. Taken together, these results further strengthen the role of miR-132/212 in memory formation and retention, and shed light on the potential consequences of its deregulation in neurodegenerative diseases.

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Research works printed but not linked: 59

  1. Ambros, 2011, MicroRNAs and developmental timing, Curr Opin Genet Dev, 21, 511, 10.1016/j.gde.2011.04.003 · DOI · Paper page
  2. Thomas, 2010, Desperately seeking microRNA targets, Nat Struct Mol Biol, 17, 1169, 10.1038/nsmb.1921 · DOI
  3. Dorval, 2012, Gene network and pathway analysis of mice with conditional ablation of Dicer in post-mitotic neurons, PLoS ONE, 7, e44060, 10.1371/journal.pone.0044060 · DOI
  4. Konopka, 2011, The microRNA contribution to learning and memory, Neuroscientist, 17, 468, 10.1177/1073858411411721 · DOI
  5. Kosik, 2006, The neuronal microRNA system, Nat Rev Neurosci, 7, 911, 10.1038/nrn2037 · DOI
  6. Fineberg, 2009, MicroRNAs potentiate neural development, Neuron, 64, 303, 10.1016/j.neuron.2009.10.020 · DOI
  7. Magill, 2010, MicroRNA-132 regulates dendritic growth and arborization of newborn neurons in the adult hippocampus, Proc Natl Acad Sci USA, 107, 20382, 10.1073/pnas.1015691107 · DOI · Paper page
  8. Tognini, 2012, MicroRNA212/132 family: molecular transducer of neuronal function and plasticity, Int J Biochem Cell Biol, 44, 6, 10.1016/j.biocel.2011.10.015 · DOI
  9. Vo, 2005, A cAMP-response element binding protein-induced microRNA regulates neuronal morphogenesis, Proc Natl Acad Sci USA, 102, 16426, 10.1073/pnas.0508448102 · DOI · Paper page
  10. Wayman, 2008, An activity-regulated microRNA controls dendritic plasticity by down-regulating p250GAP, Proc Natl Acad Sci USA, 105, 9093, 10.1073/pnas.0803072105 · DOI · Paper page
  11. Lambert, 2010, MicroRNA132 modulates short-term synaptic plasticity but not basal release probability in hippocampal neurons, PLoS ONE, 5, e15182, 10.1371/journal.pone.0015182 · DOI · Paper page
  12. Remenyi, 2013, miR-132/212 knockout mice reveal roles for these miRNAs in regulating cortical synaptic transmission and plasticity, PLoS ONE, 8, e62509, 10.1371/journal.pone.0062509 · DOI · Paper page
  13. Nudelman, 2010, Neuronal activity rapidly induces transcription of the CREB-regulated microRNA-132, in vivo, Hippocampus, 20, 492, 10.1002/hipo.20646 · DOI
  14. Hansen, 2010, Transgenic miR132 alters neuronal spine density and impairs novel object recognition memory, PLoS ONE, 5, e15497, 10.1371/journal.pone.0015497 · DOI
  15. Hansen, 2013, miRNA-132: a dynamic regulator of cognitive capacity, Brain Struct Funct, 218, 817, 10.1007/s00429-012-0431-4 · DOI · Paper page
  16. Wang, 2013, In vivo knockdown of hippocampal miR-132 expression impairs memory acquisition of trace fear conditioning, Hippocampus, 23, 625, 10.1002/hipo.22123 · DOI
  17. Wanet, 2012, miR-212/132 expression and functions: within and beyond the neuronal compartment, Nucleic Acids Res, 40, 4742, 10.1093/nar/gks151 · DOI
  18. Hebert, 2013, A study of small RNAs from cerebral neocortex of pathology-verified Alzheimer's disease, dementia with lewy bodies, hippocampal sclerosis, frontotemporal lobar dementia, and non-demented human controls, J Alzheimers Dis, 35, 335, 10.3233/JAD-122350 · DOI · Paper page
  19. Wong, 2013, De-repression of FOXO3a death axis by microRNA-132 and -212 causes neuronal apoptosis in Alzheimer's disease, Human Mol Genet, 22, 3077, 10.1093/hmg/ddt164 · DOI · Paper page
  20. Lau, 2014, Variance in the identification of microRNAs deregulated in Alzheimer's disease and possible role of lincRNAs in the pathology: the need of larger datasets, Ageing Res Rev, 17, 43, 10.1016/j.arr.2014.02.006 · DOI
  21. Johnson, 2008, A microRNA-based gene dysregulation pathway in Huntington's disease, Neurobiol Dis, 29, 438, 10.1016/j.nbd.2007.11.001 · DOI · Paper page
  22. Burgos, 2014, Profiles of extracellular miRNA in cerebrospinal fluid and serum from patients with Alzheimer's and Parkinson's diseases correlate with disease status and features of pathology, PLoS ONE, 9, e94839, 10.1371/journal.pone.0094839 · DOI · Paper page
  23. Chen-Plotkin, 2012, TMEM106B, the risk gene for frontotemporal dementia, is regulated by the microRNA-132/212 cluster and affects progranulin pathways, J Neurosci, 32, 11213, 10.1523/JNEUROSCI.0521-12.2012 · DOI · Paper page
  24. Smith, 2011, MicroRNA-132 loss is associated with tau exon 10 inclusion in progressive supranuclear palsy, Human Mol Genet, 20, 4016, 10.1093/hmg/ddr330 · DOI · Paper page
  25. Filali, 2009, Age-related cognitive decline and nesting behavior in an APPswe/PS1 bigenic model of Alzheimer's disease, Brain Res, 1292, 93, 10.1016/j.brainres.2009.07.066 · DOI · Paper page
  26. Filali, 2012, Cognitive and non-cognitive behaviors in the triple transgenic mouse model of Alzheimer's disease expressing mutated APP, PS1, and Mapt (3xTg-AD), Behav Brain Res, 234, 334, 10.1016/j.bbr.2012.07.004 · DOI
  27. Terzian, 2011, The dopamine and cannabinoid interaction in the modulation of emotions and cognition: assessing the role of cannabinoid CB1 receptor in neurons expressing dopamine D1 receptors, Front Behav Neurosci, 5, 49, 10.3389/fnbeh.2011.00049 · DOI
  28. Walker, 2011, Spatial learning and memory impairment and increased locomotion in a transgenic amyloid precursor protein mouse model of Alzheimer's disease, Behav Brain Res, 222, 169, 10.1016/j.bbr.2011.03.049 · DOI
  29. Filali, 2013, The effects of subchronic d-serine on left-right discrimination learning, social interaction, and exploratory activity in APPswe/PS1 mice, Eur J Pharmacol, 701, 152, 10.1016/j.ejphar.2012.12.018 · DOI
  30. Remenyi, 2010, Regulation of the miR-212/132 locus by MSK1 and CREB in response to neurotrophins, Biochem J, 428, 281, 10.1042/BJ20100024 · DOI
  31. Im, 2010, MeCP2 controls BDNF expression and cocaine intake through homeostatic interactions with microRNA-212, Nat Neurosci, 13, 1120, 10.1038/nn.2615 · DOI · Paper page
  32. Wang, 2012, MicroRNAs in learning, memory, and neurological diseases, Learn Mem, 19, 359, 10.1101/lm.026492.112 · DOI
  33. Mellios, 2011, miR-132, an experience-dependent microRNA, is essential for visual cortex plasticity, Nat Neurosci, 14, 1240, 10.1038/nn.2909 · DOI · Paper page
  34. Vidigal, 2015, The biological functions of miRNAs: lessons from in vivo studies, Trends Cell Biol, 25, 137, 10.1016/j.tcb.2014.11.004 · DOI
  35. Nunez, 2013, Positively correlated miRNA-mRNA regulatory networks in mouse frontal cortex during early stages of alcohol dependence, BMC Genomics, 14, 725, 10.1186/1471-2164-14-725 · DOI
  36. Ritchie, 2009, Conserved expression patterns predict microRNA targets, PLoS Comput Biol, 5, e1000513, 10.1371/journal.pcbi.1000513 · DOI
  37. Kida, 2014, Functional roles of CREB as a positive regulator in the formation and enhancement of memory, Brain Res Bull, 105, 17, 10.1016/j.brainresbull.2014.04.011 · DOI
  38. Li, 2011, Loss of activity-induced phosphorylation of MeCP2 enhances synaptogenesis, LTP and spatial memory, Nat Neurosci, 14, 1001, 10.1038/nn.2866 · DOI
  39. Heldt, 2007, Hippocampus-specific deletion of BDNF in adult mice impairs spatial memory and extinction of aversive memories, Mol Psychiatry, 12, 656, 10.1038/sj.mp.4001957 · DOI · Paper page
  40. Hsiao, 1996, Correlative memory deficits, Abeta elevation, and amyloid plaques in transgenic mice, Science, 274, 99, 10.1126/science.274.5284.99 · DOI · Paper page
  41. Ambree, 2009, Levodopa ameliorates learning and memory deficits in a murine model of Alzheimer's disease, Neurobiol Aging, 30, 1192, 10.1016/j.neurobiolaging.2007.11.010 · DOI · Paper page
  42. Gortz, 2008, Effects of environmental enrichment on exploration, anxiety, and memory in female TgCRND8 Alzheimer mice, Behav Brain Res, 191, 43, 10.1016/j.bbr.2008.03.006 · DOI
  43. Clinton, 2007, Age-dependent sexual dimorphism in cognition and stress response in the 3xTg-AD mice, Neurobiol Dis, 28, 76, 10.1016/j.nbd.2007.06.013 · DOI · Paper page
  44. Oules, 2012, Ryanodine receptor blockade reduces amyloid-beta load and memory impairments in Tg2576 mouse model of Alzheimer disease, J Neurosci, 32, 11820, 10.1523/JNEUROSCI.0875-12.2012 · DOI
  45. Dumont, 2004, Spatial learning and exploration of environmental stimuli in 24-month-old female APP23 transgenic mice with the Swedish mutation, Brain Res, 1024, 113, 10.1016/j.brainres.2004.07.052 · DOI
  46. Hyde, 2005, Age-progressing cognitive impairments and neuropathology in transgenic CRND8 mice, Behav Brain Res, 160, 344, 10.1016/j.bbr.2004.12.017 · DOI
  47. Carroll, 2007, Progesterone and estrogen regulate Alzheimer-like neuropathology in female 3xTg-AD mice, J Neurosci, 27, 13357, 10.1523/JNEUROSCI.2718-07.2007 · DOI
  48. Ohno, 2004, BACE1 deficiency rescues memory deficits and cholinergic dysfunction in a mouse model of Alzheimer's disease, Neuron, 41, 27, 10.1016/S0896-6273(03)00810-9 · DOI · Paper page
  49. Prut, 2007, Aged APP23 mice show a delay in switching to the use of a strategy in the Barnes maze, Behav Brain Res, 179, 107, 10.1016/j.bbr.2007.01.017 · DOI
  50. Stewart, 2011, Which memory task for my mouse? A systematic review of spatial memory performance in the Tg2576 Alzheimer's mouse model, J Alzheimers Dis, 26, 105, 10.3233/JAD-2011-101827 · DOI
  51. Yassine, 2013, Detecting spatial memory deficits beyond blindness in tg2576 Alzheimer mice, Neurobiol Aging, 34, 716, 10.1016/j.neurobiolaging.2012.06.016 · DOI
  52. Elder, 2010, Transgenic mouse models of Alzheimer's disease, Mt Sinai J Med, 77, 69, 10.1002/msj.20159 · DOI · Paper page
  53. Platt, 2013, Transgenic models of Alzheimer's disease: better utilization of existing models through viral transgenesis, Biochim Biophys Acta, 1832, 1437, 10.1016/j.bbadis.2013.04.017 · DOI
  54. Clement, 2007, Anxiety in mice: a principal component analysis study, Neural Plast, 2007, 35457, 10.1155/2007/35457 · DOI
  55. Meshorer, 2006, Virtues and woes of AChE alternative splicing in stress-related neuropathologies, Trends Neurosci, 29, 216, 10.1016/j.tins.2006.02.005 · DOI
  56. Shaltiel, 2013, Hippocampal microRNA-132 mediates stress-inducible cognitive deficits through its acetylcholinesterase target, Brain Struct Funct, 218, 59, 10.1007/s00429-011-0376-z · DOI
  57. Taylor, 2010, Behavioral phenotyping of mouse models of Parkinson's disease, Behav Brain Res, 211, 1, 10.1016/j.bbr.2010.03.004 · DOI
  58. Menalled, 2009, Systematic behavioral evaluation of Huntington's disease transgenic and knock-in mouse models, Neurobiol Dis, 35, 319, 10.1016/j.nbd.2009.05.007 · DOI
  59. Heikkinen, 2012, Characterization of neurophysiological and behavioral changes, MRI brain volumetry and 1H MRS in zQ175 knock-in mouse model of Huntington's disease, PLoS ONE, 7, e50717, 10.1371/journal.pone.0050717 · DOI

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Metadata

Authors
Hernandez-Rapp, J., Smith, P. Y., Filali, M., Goupil, C., Planel, E., Magill, S. T., Goodman, R. H., & Hébert, S. S.
Venue
Behavioural Brain Research
Publisher
Elsevier BV
Published
2015-07
Volume
287
Pages
15-26
ISSN
0166-4328
DOI
10.1016/j.bbr.2015.03.032
Cited by
81
References
13
Language
en
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Funders
  • Canadian Institutes of Health Research
  • Alzheimer Society

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