A cAMP-response element binding protein-induced microRNA regulates neuronal morphogenesis

Vo, Ngan; Klein, Matthew E.; Varlamova, Olga; Keller, David M.; Yamamoto, Tadashi; Goodman, Richard H.; Impey, Soren

doi:10.1073/pnas.0508448102

Cited by 696

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A cAMP-response element binding protein-induced microRNA regulates neuronal morphogenesis

Vo, Ngan, Klein, Matthew E., Varlamova, Olga, Keller, David M., Yamamoto, Tadashi, Goodman, Richard H., Impey, Soren·2005·Proceedings of the National Academy of Sciences

DOI 10.1073/pnas.0508448102

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Abstract

MicroRNAs (miRNAs) regulate cellular fate by controlling the stability or translation of mRNA transcripts. Although the spatial and temporal patterning of miRNA expression is tightly controlled, little is known about signals that induce their expression nor mechanisms of their transcriptional regulation. Furthermore, few miRNA targets have been validated experimentally. The miRNA, miR132, was identified through a genome-wide screen as a target of the transcription factor, cAMP-response element binding protein (CREB). miR132 is enriched in neurons and, like many neuronal CREB targets, is highly induced by neurotrophins. Expression of miR132 in cortical neurons induced neurite outgrowth. Conversely, inhibition of miR132 function attenuated neuronal outgrowth. We provide evidence that miR132 regulates neuronal morphogenesis by decreasing levels of the GTPase-activating protein, p250GAP. These data reveal that a CREB-regulated miRNA regulates neuronal morphogenesis by responding to extrinsic trophic cues.

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miR-132 has numerous neuroprotective and neurotrophic regulatory effects in AD.
“Such an approach could also be envisioned for miR-132, considering the numerous neuroprotective and neurotrophic regulatory effects it has in AD [20, 24, 30–32, 34, 92–95].”
From microRNA-132 attenuates inflammation in induced pluripotent stem cell-derived microglia from Alzheimer’s disease patients (2026) · cites this paper as [30]
miR-132 expression affects neuron morphogenesis and enhances neurite outgrowth by suppressing p250GAP.
“its expression has been shown to affect neuron morphogenesis and enhance neurite outgrowth by suppressing the GTPase-activating protein p250GAP (p250GAP/RICS) [36].”
From miR-10b-5p expression in Huntington’s disease brain relates to age of onset and the extent of striatal involvement (2015) · cites this paper as [36]

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Authors: Vo, N., Klein, M. E., Varlamova, O., Keller, D. M., Yamamoto, T., Goodman, R. H., & Impey, S.
Affiliations: Vollum Institute, Oregon Health & Sciences University, 3181 SW Sam Jackson Park Road, Portland, OR 97239; Reed College, 3203 SE Woodstock Boulevard, Portland, OR 97202; and Institute of Medical Science, University of Tokyo, 4-6-1 Shirokane-dai, Minato-ku, Tokyo 108-8639, Japan
Venue: Proceedings of the National Academy of Sciences
Publisher: National Academy of Sciences
Published: 2005-10-31
Volume: 102
Issue: 45
Pages: 16426-16431
ISSN: 0027-8424
1091-6490
DOI: 10.1073/pnas.0508448102
Cited by: 696
References: 4
Language: en
Update notices: correction (2006-01-17)

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A cAMP-response element binding protein-induced microRNA regulates neuronal morphogenesis

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