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De-repression of FOXO3a death axis by microRNA-132 and -212 causes neuronal apoptosis in Alzheimer's disease

Wong, Hon-Kit Andus, Veremeyko, Tatiana, Patel, Nehal, Lemere, Cynthia A., Walsh, Dominic M., Esau, Christine, Vanderburg, Charles, Krichevsky, Anna M.·2013·Human Molecular Genetics
DOI 10.1093/hmg/ddt164
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Abstract

Alzheimer's disease (AD) is a multifactorial and fatal neurodegenerative disorder for which the mechanisms leading to profound neuronal loss are incompletely recognized. MicroRNAs (miRNAs) are recently discovered small regulatory RNA molecules that repress gene expression and are increasingly acknowledged as prime regulators involved in human brain pathologies. Here we identified two homologous miRNAs, miR-132 and miR-212, downregulated in temporal cortical areas and CA1 hippocampal neurons of human AD brains. Sequence-specific inhibition of miR-132 and miR-212 induces apoptosis in cultured primary neurons, whereas their overexpression is neuroprotective against oxidative stress. Using primary neurons and PC12 cells, we demonstrate that miR-132/212 controls cell survival by direct regulation of PTEN, FOXO3a and P300, which are all key elements of AKT signaling pathway. Silencing of these three target genes by RNAi abrogates apoptosis caused by the miR-132/212 inhibition. We further demonstrate that mRNA and protein levels of PTEN, FOXO3a, P300 and most of the direct pro-apoptotic transcriptional targets of FOXO3a are significantly elevated in human AD brains. These results indicate that the miR-132/miR-212/PTEN/FOXO3a signaling pathway contributes to AD neurodegeneration.

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Metadata

Authors
Wong, H.-K. A., Veremeyko, T., Patel, N., Lemere, C. A., Walsh, D. M., Esau, C., Vanderburg, C., & Krichevsky, A. M.
Affiliations
  • Brigham and Women's Hospital and Harvard Medical School, Harvard Institutes of Medicine 1   Center for Neurologic Diseases , , Boston, MA 02115 , ,
  • Harvard NeuroDiscovery Center, Massachusetts General Hospital and Harvard Medical School 2   , Building 114, Charlestown, MA 02129 , ,
  • Brigham and Women's Hospital, Harvard Institutes of Medicine 3   Laboratory for Neurodegenerative Research, Center for Neurologic Diseases , , Boston, MA , and
  • 4  Regulus Therapeutics, 3545 John Hopkins Ct, San Diego, CA 92121, USA
Venue
Human Molecular Genetics
Publisher
Oxford University Press (OUP)
Published
2013-04-11
Volume
22
Issue
15
Pages
3077-3092
ISSN
  • 1460-2083
  • 0964-6906
DOI
10.1093/hmg/ddt164
Cited by
271
References
17
Language
en
Licence
academic.oup.com/journals/pages/open_access/funder_policies/chorus/standard_publication_model (vor)
Funders
  • Alzheimer’s Association (NIRG-09-132844)
  • NIH

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