CoChat
Sign Up
Cited by 73Adipokines, Inflammation, and Metabolic DiseasesAntioxidant Activity and Oxidative StressRegulation of Appetite and Obesity

The DOI matches its Crossref record; 516 of the 516 references it cites were found in a registry or an index.

Towards a comprehensive theory of obesity and a healthy diet: The causal role of oxidative stress in food addiction and obesity

Tobore, Tobore Onojighofia·2020·Behavioural Brain Research
DOI 10.1016/j.bbr.2020.112560
Open this paper in CoChat — free account

Abstract

Background Obesity is a major public health problem whose prevalence has been rapidly increasing in the United States (U.S), and globally. It is one of the leading causes of preventable deaths globally and contributes to the development of many diseases.Methods The search was limited to studies published in English and other languages involving both animal and human subjects. Articles selected included preclinical studies, randomized clinical trials RCTs, observational studies, meta-analyses, narrative and systemic reviews providing primary quantitative data with a measure of obesity or food addiction as an outcome. Over 5000 articles were found in the first round of search which was filtered to 506 articles.Results Oxidative stress plays a critical role in food addiction and is both a cause and mediator of obesity. Reactive oxygen species play a direct role in adipogenesis and oxidative stress modulates all factors involved in obesity including genetics, sleep, gut microbiome, insulin, ghrelin, inflammation, adipokines, leptin, stress, HPA axis, and the hypothalamus.Conclusions The idea of thinking of combating obesity from the lens of calorie count, low carbohydrate, high or low-fat, vegetarian, vegan, plant-based, or animal-based diet is fundamentally wrong. The best way to look at obesity is through the framework of systemic redox homeostasis. Since redox homeostasis is tilted towards increased reactive oxygen species production, and excessive antioxidant intake can result in oxidative stress, an antioxidant and prooxidant food ratio of 2:3 per meal is the ideal nutritional ratio for good health and ideal weight. A ratio of 3:4 is ideal for obese individuals because of their state of chronic oxidative stress and inflammation. Physical activity, sleep quality, psychological stress, maternal prenatal diet and oxidative stress promoting disease conditions are important modulators of oxidative stress and obesity.

Overview

Integrity signals

Registry

Crossref · 10.1016/j.bbr.2020.112560

Cites

516 of 516 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Verification

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Citations

Cites

1 retracted

Items 201–400 of 516

Flagged first, then by citations

Research works printed but not linked: 4

  1. Sadek, 2018, Parent perceptions of behavior change in their child with autism spectrum disorder following high antioxidant cacao consumption, Integr. Med. (Encinitas, Calif.), 17, 31
  2. Sunil, 2011, Int. Med. J. Malaysia, 10
  3. Raya-Farías, 2019, Avocado inhibits oxidative stress and endothelial dysfunction induced by the intake of a hamburger in patients with metabolic syndrome, Medicina Interna de México, 34, 840
  4. De, 2020, Quinoa or corn flakes to prevent peripheral inflammation after menopause?, J. Obes. Eating Disord., 1, 1

Cited by

Sorted by citations

See all 73

Related

See all

Metadata

Authors
Tobore, T. O.
Corresponding author
Tobore, Tobore Onojighofia
ORCID
Tobore, Tobore Onojighofia
Venue
Behavioural Brain Research
Publisher
Elsevier BV
Published
2020-04
Volume
384
Pages
112560
ISSN
0166-4328 (ISSN-L)
DOI
10.1016/j.bbr.2020.112560
OpenAlex
W3008749930
Cited by
73
References
516
Citations by year
2026: 2 · 2025: 6 · 2024: 9 · 2023: 14 · 2022: 14 · 2021: 22 · 2020: 6
FWCI
2.05
Type
journal article
Language
en
Open access
closed
Licence
Locations
  • Behavioural Brain Research (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adipokines, Inflammation, and Metabolic Diseases
  • Health Sciences › Medicine › Biochemistry (medical) › Antioxidant Activity and Oxidative Stress
  • Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
Keywords
obesity, food addiction, oxidative stress, reactive oxygen species, redox homeostasis, antioxidant intake, adipogenesis, gut microbiota, insulin, ghrelin, leptin, inflammation, hypothalamic-pituitary-adrenal axis, sleep quality, psychological stress, healthy eating
MeSH terms
Gastrointestinal Microbiome, Diet, Healthy, Food Addiction, Animals, Humans, Hypothalamo-Hypophyseal System, Hypothalamus, Inflammation, Insulin, Obesity, Pituitary-Adrenal System, Sleep, Stress, Psychological, Exercise, Reactive Oxygen Species, Oxidative Stress, Adipogenesis, Adipokines, Ghrelin

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review