Aging-related episodic-like memory decline in dogs
Open accessAbstract
Episodic memory, in humans, is the memory most affected by age-related deterioration or the constitution of neurodegenerative pathologies, such as Alzheimer's disease. However, it is unknown whether this relationship is also present in nonhuman animals. Since studies in birds, rats, primates, and dogs have been shown to have episodic-like memory, more studies aiming to improve the present understanding of this relationship in nonhuman animals are important to aid the development of new translational models for neurodegenerative disorders. Knowing that dogs (Canis familiaris) represent a promising experimental model for neurodegenerative disorders, a memory retrieval test was conducted with 90 clinically healthy domestic dogs of different ages, both sexes, and distinct breeds, for the purpose of evaluating episodic-like memory. The present study adapted a test that corroborates episodic memory requirements through incidental codification of experienced events. We performed a test with two exposure phases, with different characteristics between them, so that in the third phase it was necessary to integrate previous experiences in order to achieve success in the test. In our study, it was possible to verify the decline of episodic memory in elderly dogs, even clinically healthy, regardless of the dogs' sex and size. This episodic-like memory decline observed in elderly dogs may be related to the physiological process of aging or preclinical pathological manifestation of cognitive impairment, similar as reported in humans. More studies should be carried out evaluating episodic-like memory in dogs with suspected of canine cognitive dysfunction syndrome in order to better understand the physiological and pathological behavior of this type of memory in canine species.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Older dogs and apes show lower performances in an incidental encoding and what-where-when test, respectively, compared with younger conspecifics.
“Furthermore, older dogs and apes who were otherwise healthy showed lower performances in an incidental encoding and what–where–when test, respectively, compared with younger conspecifics [75,146].”
From Is episodic-like memory <i>like</i> episodic memory? (2024) · cites this paper as [146]
Cites
Albert, M. S., DeKosky, S. T., Dickson, D., Dubois, B., Feldman, H. H., Fox, N. C., Gamst, A., Holtzman, D. M., Jagust, W. J., Petersen, R. C., et al. (2011) · Alzheimer's & Dementia · doi:10.1016/j.jalz.2011.03.008 · Cited by 10,152 · see citing works
Episodic memory: from mind to brain
Tulving, E. (2002) · Annual Review of Psychology · doi:10.1146/annurev.psych.53.100901.135114 · Cited by 4,950 · see citing works
Zerbino, D. R., Achuthan, P., Akanni, W., Amode, M. R., Barrell, D., Bhai, J., Billis, K., Cummins, C., Gall, A., Girón, C. G., et al. (2018) · Nucleic Acids Research · doi:10.1093/nar/gkx1098 · Cited by 2,605 · see citing works
The Medial Temporal Lobe and Recognition Memory
Eichenbaum, H., Yonelinas, A. P., & Ranganath, C. (2007) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.30.051606.094328 · Cited by 2,580 · see citing works
Episodic-like memory during cache recovery by scrub jays
Clayton, N. S., & Dickinson, A. (1998) · Nature · doi:10.1038/26216 · Cited by 1,464 · see citing works
Critical role of the hippocampus in memory for sequences of events
Fortin, N. J., Agster, K. L., & Eichenbaum, H. B. (2002) · Nature Neuroscience · doi:10.1038/nn834 · Cited by 881 · see citing works
Prefrontal–hippocampal interactions in episodic memory
Eichenbaum, H. (2017) · Nature Reviews Neuroscience · doi:10.1038/nrn.2017.74 · Cited by 870 · see citing works
Episodic memory loss is related to hippocampal-mediated -amyloid deposition in elderly subjects
Mormino, E. C., Kluth, J. T., Madison, C. M., Rabinovici, G. D., Baker, S. L., Miller, B. L., Koeppe, R. A., Mathis, C. A., Weiner, M. W., Jagust, W. J., et al. (2009) · Brain · doi:10.1093/brain/awn320 · Cited by 684 · see citing works
Changes in memory processing with age
Grady, C. (2000) · Current Opinion in Neurobiology · doi:10.1016/s0959-4388(00)00073-8 · Cited by 635 · see citing works
Tulving, E. (1993) · Current Directions in Psychological Science · doi:10.1111/1467-8721.ep10770899 · Cited by 634 · see citing works
Age, APOE and sex: triad of risk of Alzheimer’s disease.
Riedel, B. C., Thompson, P. M., & Brinton, R. D. (2016) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/j.jsbmb.2016.03.012 · Cited by 627 · see citing works
Conversion of Mild Cognitive Impairment to Alzheimer Disease Predicted by Hippocampal Atrophy Maps
Apostolova, L. G., Dutton, R. A., Dinov, I. D., Hayashi, K. M., Toga, A. W., Cummings, J. L., & Thompson, P. M. (2006) · Archives of Neurology · doi:10.1001/archneur.63.5.693 · Cited by 553 · see citing works
Gaffan, D. (1994) · Journal of Cognitive Neuroscience · doi:10.1162/jocn.1994.6.4.305 · Cited by 484 · see citing works
Grober, E. H., Hall, C. B., Lipton, R. B., Zonderman, A. B., Resnick, S. M., & Kawas, C. H. (2008) · Journal of the International Neuropsychological Society · doi:10.1017/s1355617708080302 · Cited by 424 · see citing works
Integrated Memory for Object, Place, and Context in Rats: A Possible Model of Episodic-Like Memory?
Eacott, M. J., & Norman, G. (2004) · Journal of Neuroscience · doi:10.1523/jneurosci.2975-03.2004 · Cited by 344 · see citing works
Small, B. J., Fratiglioni, L., Viitanen, M., Winblad, B., & Bäckman, L. (2000) · Archives of Neurology · doi:10.1001/archneur.57.6.839 · Cited by 329 · see citing works
Episodic-like Memory in the Rat
Babb, S. J., & Crystal, J. D. (2006) · Current Biology · doi:10.1016/j.cub.2006.05.025 · Cited by 308 · see citing works
The canine as an animal model of human aging and dementia
Cummings, B. J., Head, E., Ruehl, W. W., Milgram, N. W., & Cotman, C. W. (1996) · Neurobiology of Aging · doi:10.1016/0197-4580(95)02060-8 · Cited by 280 · see citing works
Cognitive Dysfunction Syndrome
Landsberg, G. M., Nichol, J., & Araujo, J. A. (2012) · Veterinary Clinics of North America Small Animal Practice · doi:10.1016/j.cvsm.2012.04.003 · Cited by 260 · see citing works
Keeping track of time: evidence for episodic-like memory in great apes
Martin-Ordas, G., Haun, D., Colmenares, F., & Call, J. (2010) · Animal Cognition · doi:10.1007/s10071-009-0282-4 · Cited by 244 · see citing works
β-Amyloid Accumulation Correlates with Cognitive Dysfunction in the Aged Canine
Cummings, B. J., Head, E., Afagh, A., Milgram, N. W., & Cotman, C. W. (1996) · Neurobiology of Learning and Memory · doi:10.1006/nlme.1996.0039 · Cited by 243 · see citing works
Cognitive functions and aging in the dog: Acquisition of nonspatial visual tasks.
Milgram, N. W., Head, E., Weiner, E., et al. (1994) · Behavioral Neuroscience · doi:10.1037/0735-7044.108.1.57 · Cited by 203 · see citing works
Prevalence, comorbidity, and breed differences in canine anxiety in 13,700 Finnish pet dogs
Salonen, M., Sulkama, S., Mikkola, S., Puurunen, J., Hakanen, E., Tiira, K., Araujo, C., & Lohi, H. (2020) · Scientific Reports · doi:10.1038/s41598-020-59837-z · Cited by 182 · see citing works
Discrimination of what, when, and where: Implications for episodic-like memory in rats
Babb, S. J., & Crystal, J. D. (2005) · Learning and Motivation · doi:10.1016/j.lmot.2005.02.009 · Cited by 181 · see citing works
Brain structural alterations before mild cognitive impairment
Smith, C. D., Chebrolu, H., Wekstein, D. R., Schmitt, F. A., Jicha, G. A., Cooper, G., & Markesbery, W. R. (2007) · Neurology · doi:10.1212/01.wnl.0000259542.54830.34 · Cited by 161 · see citing works
Maďari, A., Farbáková, J., Katina, S., Smolek, T., Novák, P., Weissova, T., Novák, M., & Žilka, N. (2015) · Applied Animal Behaviour Science · doi:10.1016/j.applanim.2015.08.034 · Cited by 158 · see citing works
Spatial learning and memory as a function of age in the dog.
Head, E., Mehta, R., Hartley, J., Kameka, M., Cummings, B. J., Cotman, C. W., Ruehl, W. W., & Milgram, N. W. (1995) · Behavioral Neuroscience · doi:10.1037/0735-7044.109.5.851 · Cited by 155 · see citing works
Evidence of episodic-like memory in cuttlefish
Jozet-Alves, C., Bertin, M., & Clayton, N. S. (2013) · Current Biology · doi:10.1016/j.cub.2013.10.021 · Cited by 154 · see citing works
2019 AAHA Canine Life Stage Guidelines*
Creevy, K. E., Grady, J. G., Little, S. E., Moore, G. E., Strickler, B. G., Thompson, S., & Webb, J. A. (2019) · Journal of the American Animal Hospital Association · doi:10.5326/jaaha-ms-6999 · Cited by 152 · see citing works
Azkona, G., García‐Belenguer, S., Chacón, G., et al. (2009) · Journal of Small Animal Practice · doi:10.1111/j.1748-5827.2008.00718.x · Cited by 149 · see citing works
Fast, R., Schütt, T., Toft, N., Møller, A., & Berendt, M. (2013) · Journal of Veterinary Internal Medicine · doi:10.1111/jvim.12109 · Cited by 117 · see citing works
Use of a delayed non-matching to position task to model age-dependent cognitive decline in the dog
Adams, B. (2000) · Behavioural Brain Research · doi:10.1016/s0166-4328(99)00132-1 · Cited by 113 · see citing works
Memory for Distant Past Events in Chimpanzees and Orangutans
Martín-Ordás, G., Berntsen, D., & Call, J. (2013) · Current Biology · doi:10.1016/j.cub.2013.06.017 · Cited by 103 · see citing works
Episodic-like memory in zebrafish
Hamilton, T. J., Myggland, A., Duperreault, E., May, Z., Gallup, J., Powell, R. A., Schalomon, M., & Digweed, S. M. (2016) · Animal Cognition · doi:10.1007/s10071-016-1014-1 · Cited by 100 · see citing works
Looking for episodic memory in animals and young children: Prospects for a new minimalism
Clayton, N. S., & Russell, J. A. (2008) · Neuropsychologia · doi:10.1016/j.neuropsychologia.2008.10.011 · Cited by 99 · see citing works
Rats Answer an Unexpected Question after Incidental Encoding
Zhou, W., Hohmann, A. G., & Crystal, J. D. (2012) · Current Biology · doi:10.1016/j.cub.2012.04.040 · Cited by 98 · see citing works
Episodic Memory in Nonhuman Animals
Templer, V. L., & Hampton, R. R. (2013) · Current Biology · doi:10.1016/j.cub.2013.07.016 · Cited by 94 · see citing works
The progression of β-amyloid deposition in the frontal cortex of the aged canine
Satou, T., Cummings, B. J., Head, E., Nielson, K. A., Hahn, F. F., Milgram, N. W., Velázquez, P., Cribbs, D. H., Tenner, A. J., & Cotman, C. W. (1997) · Brain Research · doi:10.1016/s0006-8993(97)81684-8 · Cited by 88 · see citing works
Absolute brain size predicts dog breed differences in executive function
Horschler, D. J., Hare, B., Call, J., Kaminski, J., Miklósi, Á., & MacLean, E. L. (2019) · Animal Cognition · doi:10.1007/s10071-018-01234-1 · Cited by 87 · see citing works
Elements of episodic-like memory in animal models
Crystal, J. D. (2009) · Behavioural Processes · doi:10.1016/j.beproc.2008.09.009 · Cited by 86 · see citing works
Episodic-like memory: Pigeons can report location pecked when unexpectedly asked
Zentall, T. R., Singer, R. A., & Stagner, J. P. (2008) · Behavioural Processes · doi:10.1016/j.beproc.2008.05.003 · Cited by 84 · see citing works
Recall of Others’ Actions after Incidental Encoding Reveals Episodic-like Memory in Dogs
Fugazza, C., Pogány, Á., & Miklósi, Á. (2016) · Current Biology · doi:10.1016/j.cub.2016.09.057 · Cited by 74 · see citing works
Singer, R. A., & Zentall, T. R. (2007) · Learning & Behavior · doi:10.3758/bf03193054 · Cited by 60 · see citing works
Validation of a rodent model of episodic memory
Zhou, W., & Crystal, J. D. (2011) · Animal Cognition · doi:10.1007/s10071-010-0367-0 · Cited by 60 · see citing works
Binder, S., Dere, E., & Zlomuzica, A. (2015) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2015.04.002 · Cited by 53 · see citing works
McDonough, I. M., Festini, S. B., & Wood, M. M. (2020) · Ageing Research Reviews · doi:10.1016/j.arr.2020.101133 · Cited by 49 · see citing works
Canine separation anxiety: strategies for treatment and management
Sargisson, R. J. (2014) · Veterinary Medicine Research and Reports · doi:10.2147/vmrr.s60424 · Cited by 48 · see citing works
Fujita, K., Morisaki, A., Takaoka, A., Maeda, T., & Hori, Y. (2012) · Animal Cognition · doi:10.1007/s10071-012-0529-3 · Cited by 46 · see citing works
Risk factors for canine cognitive dysfunction syndrome in Slovakia
Katina, S., Farbáková, J., Maďari, A., et al. (2015) · Acta veterinaria Scandinavica · doi:10.1186/s13028-016-0196-5 · Cited by 44 · see citing works
Cognitive mechanisms of memory for order in rhesus monkeys (Macaca mulatta)
Templer, V. L., & Hampton, R. R. (2012) · Hippocampus · doi:10.1002/hipo.22082 · Cited by 36 · see citing works
Clinical feasibility of cognitive testing in dogs (Canis lupus familiaris)
Heckler, M. C. T., Tranquilim, M. V., Svicero, D. J., et al. (2013) · Journal of Veterinary Behavior · doi:10.1016/j.jveb.2013.09.002 · Cited by 29 · see citing works
Staging the cognitive continuum in prodromal Alzheimer's disease with episodic memory
Moscoso, A., Silva‐Rodríguez, J., Aldrey, J. M., Cortés, J., Fernández‐Ferreiro, A., Gómez‐Lado, N., Ruibal, Á., & Aguiar, P. (2019) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2019.07.014 · Cited by 23 · see citing works
Use of incidentally encoded memory from a single experience in cats
Takagi, S., Tsuzuki, M., Chijiiwa, H., Arahori, M., Watanabe, A., Saito, A., & Fujita, K. (2017) · Behavioural Processes · doi:10.1016/j.beproc.2016.12.014 · Cited by 19 · see citing works
Dogs (Canis familiaris) use odor cues to show episodic-like memory for what, where, and when.
Lo, K. H., & Roberts, W. A. (2019) · Journal of comparative psychology · doi:10.1037/com0000174 · Cited by 15 · see citing works
&NA; (1978) · Nursing Research · doi:10.1097/00006199-197801000-00063 · Cited by 8 · see citing works
Applicability of tactile memory examination as an option to visual- and verbal-based batteries
Arambula, O. G., Padovani, F. H. P., Corrente, J. E., Schelp, A. B., Sanches, F. J., Amorim, R. M., & Schelp, A. O. (2021) · Dementia & Neuropsychologia · doi:10.1590/1980-57642021dn15-030010 · Cited by 3 · see citing works
Self-citationMental Time Travel: Can Animals Recall the Past and Plan for the Future?
Clayton, N. S., & Dickinson, A. (2010) · Elsevier eBooks · doi:10.1016/b978-0-12-813251-7.00094-8 · Cited by 3 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Is episodic-like memory <i>like</i> episodic memory?
Davies, J. R., & Clayton, N. S. (2024) · Philosophical Transactions of the Royal Society B: Biological Sciences · doi:10.1098/rstb.2023.0397 · Cited by 27 · see citing works
- Authors
- Sanches, F. J., de Melo, J. C., Ferreira, S. P., Trinca, L. A., Arambula, O. G., Padovani, F. H. P., Schelp, A. O., & Amorim, R. M.
- Affiliations
- Universidade Estadual Paulista (Unesp) (BR)
- Corresponding author
- Amorim, Rogério Martins
- ORCID
- Venue
- Behavioural Brain Research
- Publisher
- Elsevier BV
- Published
- 2022-03
- Volume
- 422
- Pages
- 113762
- ISSN
- 0166-4328 (ISSN-L)
- OpenAlex
- W4206993327
- Cited by
- 10
- References
- 57
- Citations by year
- 2026: 2 · 2025: 3 · 2024: 1 · 2023: 3 · 2022: 1
- FWCI
- 1.21
- Type
- journal article
- Language
- en
- Open access
- green
- hdl.handle.net
- Licence
- Locations
- Behavioural Brain Research (publishedVersion)
- PubMed (publishedVersion)
- LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Científicas) (submittedVersion, other-oa)
- Funders
- CAPES
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Human-Animal Interaction Studies
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory Processes and Influences
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Keywords
- episodic-like memory, memory decline, aging, dogs, canine cognitive dysfunction, neurodegenerative diseases, translational animal model, cognitive impairment
- MeSH terms
- Age Factors, Aging, Animals, Behavior, Animal, Dogs, Female, Male, Memory Disorders, Cognitive Dysfunction, Memory, Episodic
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
