Stress, genetics and epigenetic effects on the neurobiology of suicidal behavior and depression

Mann, J.J.; Currier, D.M.

doi:10.1016/j.eurpsy.2010.01.009

Cited by 169Suicide and Self-Harm StudiesStress Responses and CortisolNeurotransmitter Receptor Influence on Behavior

Stress, genetics and epigenetic effects on the neurobiology of suicidal behavior and depression

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Mann, J.J., Currier, D.M.·2010·European Psychiatry

DOI 10.1016/j.eurpsy.2010.01.009PMC PMC2896004

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Abstract

Alterations in a number of neurobiological systems have been associated with suicidal behavior including the serotonergic and noradrenergic systems and the hypothalamic-pituitary-adrenal axis. Altered functioning of these systems may stem from both genetic and developmental causes. Adversity in early-life has developmental consequences on these systems that persist into adulthood. Genetic differences may also contribute to alterations in functioning of neurobiological systems. Moreover, the interaction of early-life experiences of adversity and genetic vulnerability is increasingly thought to play a role, including via epigenetic mechanisms.

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Stress affects human society by increasing suicide and reducing work efficiency.
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[17]Mann JJ Currier D Stanley B Oquendo MA Amsel LV Ellis SP Can biological tests assist prediction of suicide in mood disorders? Int J Neuropsychopharmacol 2006 9 465 74 15967058

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Authors: Mann, J. J., & Currier, D. M.
Affiliations: Columbia University (US)
Corresponding author: Mann, J.J.
ORCID: Mann, J.J.
Currier, D.M.
Venue: European Psychiatry
Publisher: Cambridge University Press (CUP)
Published: 2010-06
Volume: 25
Issue: 5
Pages: 268-271
ISSN: 0924-9338 (ISSN-L)
1778-3585
DOI: 10.1016/j.eurpsy.2010.01.009
PMC: PMC2896004
OpenAlex: W2034761715
Cited by: 169
References: 29
Citations by year: 2026: 2 · 2025: 8 · 2024: 4 · 2023: 6 · 2022: 11 · 2021: 16 · 2020: 4 · 2019: 9 · 2018: 14 · 2017: 13 · 2016: 13 · 2015: 13 · 2014: 20 · 2013: 11 · 2012: 16
FWCI: 12.68
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.cambridge.org/core/terms (unspecified, 3607 d)
Locations: European Psychiatry (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
Funders: National Institute of Mental Health (MH 62185, R10MH056390, MH48514, R01MH082041, MH56390, R01MH048514, MH82041, R01MH056390, P50MH062185)
Topics: Social Sciences › Psychology › Clinical Psychology › Suicide and Self-Harm Studies
Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
Keywords: suicidal behavior, depression, stress, epigenetics, genetics, neurobiology, serotonergic system, noradrenergic system, hypothalamic-pituitary-adrenal axis, childhood adversity, genetic susceptibility, gene-environment interaction
MeSH terms: Depressive Disorder, Humans, Stress, Psychological, Suicide, Epigenesis, Genetic

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Stress, genetics and epigenetic effects on the neurobiology of suicidal behavior and depression

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