The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Green tea catechin, epigallocatechin-3-gallate (EGCG): Mechanisms, perspectives and clinical applications
Open accessAbstract
An expanding body of preclinical evidence suggests EGCG, the major catechin found in green tea (Camellia sinensis), has the potential to impact a variety of human diseases. Apparently, EGCG functions as a powerful antioxidant, preventing oxidative damage in healthy cells, but also as an antiangiogenic and antitumor agent and as a modulator of tumor cell response to chemotherapy. Much of the cancer chemopreventive properties of green tea are mediated by EGCG that induces apoptosis and promotes cell growth arrest by altering the expression of cell cycle regulatory proteins, activating killer caspases, and suppressing oncogenic transcription factors and pluripotency maintain factors. In vitro studies have demonstrated that EGCG blocks carcinogenesis by affecting a wide array of signal transduction pathways including JAK/STAT, MAPK, PI3K/AKT, Wnt and Notch. EGCG stimulates telomere fragmentation through inhibiting telomerase activity. Various clinical studies have revealed that treatment by EGCG inhibits tumor incidence and multiplicity in different organ sites such as liver, stomach, skin, lung, mammary gland and colon. Recent work demonstrated that EGCG reduced DNMTs, proteases, and DHFR activities, which would affect transcription of TSGs and protein synthesis. EGCG has great potential in cancer prevention because of it’s safety, low cost and bioavailability. In this review, we discuss its cancer preventive properties and it’s mechanism of action at numerous points regulating cancer cell growth, survival, angiogenesis and metastasis. Therefore, non-toxic natural agent could be useful either alone or in combination with conventional therapeutics for the prevention of tumor progression and/or treatment of human malignancies.
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Tea catechins and polyphenols: Health effects, metabolism, and antioxidant functions
Higdon, J. V., & Frei, B. (2003) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408690390826464 · Cited by 1,854
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Phenolic content and antioxidant capacity in algal food products
Machu, L., Misurcova, L., Vavra Ambrozova, J., Orsavova, J., Mlcek, J., Sochor, J., & Jurikova, T. (2015) · Molecules · doi:10.3390/molecules20011118 · Cited by 437
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A review: using nanoparticles to enhance absorption and bioavailability of phenolic phytochemicals
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Tong, X., Cao, J., Tian, T., Lyu, B., Miao, L., Lian, Z., Cui, W., Liu, S., Wang, H., & Jiang, L. (2022) · Food Hydrocolloids · doi:10.1016/j.foodhyd.2021.107084 · Cited by 318
Zeng, J., Bao, T., Yang, K., Zhu, X., Wang, S., Xiang, W., Ge, A., Zeng, L., & Ge, J. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2022.1047550 · Cited by 175
Gào, X., & Schöttker, B. (2017) · Oncotarget · doi:10.18632/oncotarget.17128 · Cited by 147
Luo, K.-W., Chen, W., Lung, W.-Y., Wei, X.-Y., Cheng, B.-H., Cai, Z.-M., & Huang, W.-R. (2017) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2016.12.004 · Cited by 137
Wang, J., Man, G. C. W., Chan, T. H., Kwong, J., & Wang, C. C. (2018) · Cancer Letters · doi:10.1016/j.canlet.2017.09.054 · Cited by 127
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DYRK1A BAC Transgenic Mouse: A New Model of Thyroid Dysgenesis in Down Syndrome
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Metadata
- Authors
- Singh, B. N., Shankar, S., & Srivastava, R. K.
- Venue
- Biochemical Pharmacology
- Publisher
- Elsevier BV
- Published
- 2011-12
- Volume
- 82
- Issue
- 12
- Pages
- 1807-1821
- ISSN
- 0006-2952 (ISSN-L)
- OpenAlex
- W2070785261
- Cited by
- 1,602
- References
- 1
- FWCI
- 44.01
- Type
- journal article
- Language
- en
- Open access
- green
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