The DOI matches its Crossref record; 16 of the 16 references it cites were found in a registry or an index.
3D bioactive composite scaffolds for bone tissue engineering
Open accessAbstract
Bone is the second most commonly transplanted tissue worldwide, with over four million operations using bone grafts or bone substitute materials annually to treat bone defects. However, significant limitations affect current treatment options and clinical demand for bone grafts continues to rise due to conditions such as trauma, cancer, infection and arthritis. Developing bioactive three-dimensional (3D) scaffolds to support bone regeneration has therefore become a key area of focus within bone tissue engineering (BTE). A variety of materials and manufacturing methods including 3D printing have been used to create novel alternatives to traditional bone grafts. However, individual groups of materials including polymers, ceramics and hydrogels have been unable to fully replicate the properties of bone when used alone. Favourable material properties can be combined and bioactivity improved when groups of materials are used together in composite 3D scaffolds. This review will therefore consider the ideal properties of bioactive composite 3D scaffolds and examine recent use of polymers, hydrogels, metals, ceramics and bio-glasses in BTE. Scaffold fabrication methodology, mechanical performance, biocompatibility, bioactivity, and potential clinical translations will be discussed.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Mussel-inspired surface chemistry for multifunctional coatings
Lee, H., Dellatore, S. M., Miller, W. M., & Messersmith, P. B. (2007) · Science · doi:10.1126/science.1147241 · Cited by 10,965
The return of a forgotten polymer—Polycaprolactone in the 21st century
Woodruff, M. A., & Hutmacher, D. W. (2010) · Progress in Polymer Science · doi:10.1016/j.progpolymsci.2010.04.002 · Cited by 4,033
Biomedical applications of biodegradable polymers
Ulery, B. D., Nair, L. S., & Laurencin, C. T. (2011) · Journal of Polymer Science Part B: Polymer Physics · doi:10.1002/polb.22259 · Cited by 2,206
Scaffolding in tissue engineering: general approaches and tissue-specific considerations
Chan, B. P., & Leong, K. W. (2008) · European Spine Journal · doi:10.1007/s00586-008-0745-3 · Cited by 1,708
An Overview of Poly(lactic-co-glycolic) Acid (PLGA)-Based Biomaterials for Bone Tissue Engineering
Gentile, P., Chiono, V., Carmagnola, I., & Hatton, P. (2014) · International Journal of Molecular Sciences · doi:10.3390/ijms15033640 · Cited by 1,593
Markstedt, K., Mantas, A., Tournier, I., Martínez Ávila, H., Hägg, D., & Gatenholm, P. (2015) · Biomacromolecules · doi:10.1021/acs.biomac.5b00188 · Cited by 1,528
Mesenchymal Stem Cell Homing: The Devil Is in the Details
Karp, J. M., & Leng Teo, G. S. (2009) · Cell Stem Cell · doi:10.1016/j.stem.2009.02.001 · Cited by 1,445
Spheroid culture as a tool for creating 3D complex tissues
Fennema, E., Rivron, N., Rouwkema, J., van Blitterswijk, C., & de Boer, J. (2013) · Trends in Biotechnology · doi:10.1016/j.tibtech.2012.12.003 · Cited by 1,054
Electrospun nanostructured scaffolds for bone tissue engineering
Prabhakaran, M. P., Venugopal, J., & Ramakrishna, S. (2009) · Acta Biomaterialia · doi:10.1016/j.actbio.2009.05.007 · Cited by 430 · cited 1×
“niques including 3D printing [80] and electrospinning [127,195].”
BackgroundBone composition: relationship to bone fragility and antiosteoporotic drug effects
Boskey, A. L. (2013) · BoneKEy Reports · doi:10.1038/bonekey.2013.181 · Cited by 424
Cited by
Recent advances in biomaterials for 3D scaffolds: A review
Nikolova, M. P., & Chavali, M. S. (2019) · Bioactive Materials · doi:10.1016/j.bioactmat.2019.10.005 · Cited by 907
Nanocomposite scaffolds for accelerating chronic wound healing by enhancing angiogenesis
Nosrati, H., Aramideh Khouy, R., Nosrati, A., Khodaei, M., Banitalebi-Dehkordi, M., Ashrafi-Dehkordi, K., Sanami, S., & Alizadeh, Z. (2021) · Journal of Nanobiotechnology · doi:10.1186/s12951-020-00755-7 · Cited by 720
The application of hyaluronic acid in bone regeneration
Zhai, P., Peng, X., Li, B., Liu, Y., Sun, H., & Li, X. (2020) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2019.10.169 · Cited by 438
Self-citationAskari, M., Afzali Naniz, M., Kouhi, M., Saberi, A., Zolfagharian, A., & Bodaghi, M. (2021) · Biomaterials Science · doi:10.1039/d0bm00973c · Cited by 369
The role of additive manufacturing for biomedical applications: A critical review
Kumar, R., Kumar, M., & Chohan, J. S. (2021) · Journal of Manufacturing Processes · doi:10.1016/j.jmapro.2021.02.022 · Cited by 367
Metadata
- Authors
- Turnbull, G., Clarke, J., Picard, F., Riches, P., Jia, L., Han, F., Li, B., & Shu, W.
- Venue
- Bioactive Materials
- Publisher
- Elsevier BV
- Published
- 2018-09
- Volume
- 3
- Issue
- 3
- Pages
- 278-314
- ISSN
- 2097-1192 (ISSN-L)
- 2452-199X
- OpenAlex
- W2774085282
- Cited by
- 1,332
- References
- 16
- FWCI
- 35.50
- Type
- journal article
- Language
- en
- Open access
- gold
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: 3D bioactive composite scaffolds for bone tissue engineering. https://app.cochat.ai/papers/10.1016/j.bioactmat.2017.10.001
- The paper
- Turnbull, G., Clarke, J., Picard, F., Riches, P., Jia, L., Han, F., Li, B., & Shu, W. (2018). 3D bioactive composite scaffolds for bone tissue engineering. Bioactive Materials. https://doi.org/10.1016/j.bioactmat.2017.10.001
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
