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Cited by 265Sleep and Wakefulness ResearchSleep and related disordersMemory and Neural Mechanisms

Impaired Declarative Memory Consolidation During Sleep in Patients With Primary Insomnia: Influence of Sleep Architecture and Nocturnal Cortisol Release

Backhaus, Jutta, Junghanns, Klaus, Born, Jan, Hohaus, Kornelia, Faasch, Frauke, Hohagen, Fritz·2006·Biological Psychiatry
DOI 10.1016/j.biopsych.2006.03.051
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Abstract

Background A central cognitive function of sleep is to consolidate newly acquired memories for long-term storage. Here, we investigated whether the overnight consolidation of declarative memory in patients with chronic sleep disturbances is impaired, owing to less slow wave sleep (SWS) and an increased cortisol release. Methods Polysomnographic recordings, serum cortisol concentrations, and overnight memory consolidation in 16 patients with primary insomnia were compared with those of 13 healthy control subjects. Results Patients displayed distinctly less overnight consolidation of declarative memory (p Conclusions Primary insomnia is associated with a diminished sleep-related consolidation of declarative memory. Efficient overnight consolidation of declarative memory is associated with high amounts of SWS and low serum cortisol levels during the early part of the night. Where SWS is decreased, REM sleep might play a partly compensatory role in the consolidation of declarative memory.

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Crossref · 10.1016/j.biopsych.2006.03.051

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  • Spontaneously increased nocturnal cortisol levels around midnight were correlated with impaired retrieval of declarative memories in healthy subjects and patients with primary insomnia.

    “In addition, spontaneously increased nocturnal cortisol levels around midnight were found to be correlated with impaired retrieval of declarative memories in healthy subjects and patients with primary insomnia (58).”

    From About Sleep's Role in Memory (2013) · cites this paper as [58]

  • Several studies reported correlations between SWS or SWA and overnight retention of declarative memory and procedural motor skills.

    “Several studies reported correlations between SWS or SWA and the overnight retention of declarative memory (55,58,464,1319) as well as procedural motor skills (581, 582).”

    From About Sleep's Role in Memory (2013) · cites this paper as [58]

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Authors
Backhaus, J., Junghanns, K., Born, J., Hohaus, K., Faasch, F., & Hohagen, F.
Affiliations
University of Lübeck (DE)
Corresponding author
Backhaus, Jutta
ORCID
Venue
Biological Psychiatry
Publisher
Elsevier BV
Published
2006-12
Volume
60
Issue
12
Pages
1324-1330
ISSN
0006-3223 (ISSN-L)
DOI
10.1016/j.biopsych.2006.03.051
OpenAlex
W2015976817
Cited by
265
References
13
Citations by year
2026: 6 · 2025: 9 · 2024: 15 · 2023: 11 · 2022: 8 · 2021: 10 · 2020: 14 · 2019: 11 · 2018: 15 · 2017: 12 · 2016: 15 · 2015: 17 · 2014: 21 · 2013: 22 · 2012: 16
FWCI
6.64
Type
journal article
Language
en
Open access
closed
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • Biological Psychiatry (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Sleep and Wakefulness Research
  • Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and related disorders
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
Keywords
primary insomnia, declarative memory consolidation, sleep architecture, slow-wave sleep, REM sleep, serum cortisol, memory retrieval
MeSH terms
Adult, Arousal, Association Learning, Data Interpretation, Statistical, Electroencephalography, Female, Humans, Hydrocortisone, Sleep Initiation and Maintenance Disorders, Male, Memory, Psychomotor Performance, Surveys and Questionnaires, Reaction Time, Sleep, Sleep Stages, Sleep, REM, Verbal Learning, Polysomnography

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