Processing of global, but not local, motion direction is deficient in schizophrenia
Abstract
Visual motion processing is compromised in a substantial proportion of schizophrenic patients, but precise neural mechanisms underlying the motion-processing deficit have not yet been elaborated. The visual motion pathway includes a local and a global processing stage, each of which has distinct neural substrates. Here, we attempt to identify the stage(s) that are implicated in impaired motion processing of schizophrenia-local, global, or both. For schizophrenia patients (n=23) and normal controls (n=26), we measured (1) the thresholds for detecting the motion direction of a random dot pattern, a task that requires global motion processing, and (2) the thresholds for detecting the motion direction of a grating, a task that requires only local motion processing, using psychophysical methods. Schizophrenia patients showed elevated thresholds for detecting the direction of coherent motion, particularly for the high dot-density target. In contrast, schizophrenia patients showed normal thresholds for detecting the direction of motion of a grating. The results indicate that the global, but not the local, processing stage of the visual motion system is compromised in schizophrenia patients, thus implicating motion-sensitive brain areas that possess large receptive fields for spatial and temporal integration, such as Middle Temporal Area/Medial Superior Temporal Area.
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Numerous studies have shown motion processing deficits in schizophrenia.
“As discussed in the preceding text, numerous studies have shown motion processing deficits in schizophrenia (28,30–32,81).”
From Visual perception and its impairment in schizophrenia (2008) · cites this paper as [81]
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- Authors
- Chen, Y.
- Affiliations
- Harvard University (US)
- Corresponding author
- Chen, Y
- ORCID
- Chen, Y
- Venue
- Schizophrenia Research
- Publisher
- Elsevier BV
- Published
- 2003-06-01
- Volume
- 61
- Issue
- 2-3
- Pages
- 215-227
- ISSN
- 0920-9964 (ISSN-L)
- OpenAlex
- W2144806037
- Cited by
- 183
- References
- 51
- Citations by year
- 2026: 1 · 2025: 2 · 2024: 6 · 2023: 4 · 2022: 3 · 2021: 5 · 2020: 7 · 2019: 5 · 2018: 6 · 2017: 6 · 2016: 5 · 2015: 8 · 2014: 10 · 2013: 9 · 2012: 8
- FWCI
- 9.31
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Schizophrenia Research (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Harvard University
- Roy A. Hunt Foundation
- National Institute of Mental Health (MH 61824, R01MH049487, MH01020, MH 31340, P01MH031154, MH-31154, MH 49487, R01MH031340, R01MH061824)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Visual perception and processing mechanisms
- Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
- Life Sciences › Neuroscience › Cognitive Neuroscience › Hallucinations in medical conditions
- Keywords
- schizophrenia, visual motion processing
- MeSH terms
- Adult, Attention, Female, Field Dependence-Independence, Humans, Male, Middle Aged, Motion Perception, Neuropsychological Tests, Orientation, Pattern Recognition, Visual, Psychophysics, Pursuit, Smooth, Schizophrenia, Schizophrenic Psychology, Sensory Thresholds
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
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