Cited by 183Visual perception and processing mechanismsSchizophrenia research and treatmentHallucinations in medical conditions

Processing of global, but not local, motion direction is deficient in schizophrenia

Chen, Y·2003·Schizophrenia Research

Abstract

Visual motion processing is compromised in a substantial proportion of schizophrenic patients, but precise neural mechanisms underlying the motion-processing deficit have not yet been elaborated. The visual motion pathway includes a local and a global processing stage, each of which has distinct neural substrates. Here, we attempt to identify the stage(s) that are implicated in impaired motion processing of schizophrenia-local, global, or both. For schizophrenia patients (n=23) and normal controls (n=26), we measured (1) the thresholds for detecting the motion direction of a random dot pattern, a task that requires global motion processing, and (2) the thresholds for detecting the motion direction of a grating, a task that requires only local motion processing, using psychophysical methods. Schizophrenia patients showed elevated thresholds for detecting the direction of coherent motion, particularly for the high dot-density target. In contrast, schizophrenia patients showed normal thresholds for detecting the direction of motion of a grating. The results indicate that the global, but not the local, processing stage of the visual motion system is compromised in schizophrenia patients, thus implicating motion-sensitive brain areas that possess large receptive fields for spatial and temporal integration, such as Middle Temporal Area/Medial Superior Temporal Area.

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Crossref · 10.1016/s0920-9964(02)00222-0

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  • Numerous studies have shown motion processing deficits in schizophrenia.

    “As discussed in the preceding text, numerous studies have shown motion processing deficits in schizophrenia (28,30–32,81).”

    From Visual perception and its impairment in schizophrenia (2008) · cites this paper as [81]

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Authors
Chen, Y.
Affiliations
Harvard University (US)
Corresponding author
Chen, Y
ORCID
Chen, Y
Venue
Schizophrenia Research
Publisher
Elsevier BV
Published
2003-06-01
Volume
61
Issue
2-3
Pages
215-227
ISSN
0920-9964 (ISSN-L)
OpenAlex
W2144806037
Cited by
183
References
51
Citations by year
2026: 1 · 2025: 2 · 2024: 6 · 2023: 4 · 2022: 3 · 2021: 5 · 2020: 7 · 2019: 5 · 2018: 6 · 2017: 6 · 2016: 5 · 2015: 8 · 2014: 10 · 2013: 9 · 2012: 8
FWCI
9.31
Type
journal article
Language
en
Open access
closed
Locations
  • Schizophrenia Research (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • Harvard University
  • Roy A. Hunt Foundation
  • National Institute of Mental Health (MH 61824, R01MH049487, MH01020, MH 31340, P01MH031154, MH-31154, MH 49487, R01MH031340, R01MH061824)
Topics
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Visual perception and processing mechanisms
  • Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Hallucinations in medical conditions
Keywords
schizophrenia, visual motion processing
MeSH terms
Adult, Attention, Female, Field Dependence-Independence, Humans, Male, Middle Aged, Motion Perception, Neuropsychological Tests, Orientation, Pattern Recognition, Visual, Psychophysics, Pursuit, Smooth, Schizophrenia, Schizophrenic Psychology, Sensory Thresholds

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