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Microarray Analysis of Hippocampal CA1 Neurons Implicates Early Endosomal Dysfunction During Alzheimer's Disease Progression
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RAB10 plays a role in endocytosis, which has been implicated in Alzheimer's disease.
“RAB10 plays a role in endocytosis, which has been implicated in AD [56, 57]”
From Linkage, whole genome sequence, and biological data implicate variants in RAB10 in Alzheimer’s disease resilience (2017) · cites this paper as [56]
The Discussion links abnormal endocytosis and endosomal trafficking to AD. The Results mention rab10 but report no differential regulation of it; they do not establish that RAB10 itself plays a role in endocytosis. Thus the paper supports the AD–endocytosis link, but not the RAB10-specific part of the claim. (LLM, conf=0.85)
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Harold, D., Abraham, R., Hollingworth, P., Sims, R., Gerrish, A., Hamshere, M. L., Pahwa, J. S., Moskvina, V., Dowzell, K., Williams, A., et al. (2009) · Nature Genetics · doi:10.1038/ng.440 · Cited by 3,326
Alzheimer's disease: cell-specific pathology isolates the hippocampal formation.
Hyman, B. T., Van Hoesen, G. W., Damasio, A. R., & Barnes, C. L. (1984) · Science · doi:10.1126/science.6474172 · Cited by 2,268
Memory‐related neural systems in Alzheimer's disease: An anatomic study
Hyman, B. T., Hoesen, G. W. V., & Damasio, A. R. (1990) · Neurology · doi:10.1212/wnl.40.11.1721 · Cited by 449 · cited 1×
“Although hippocampal CA1 pyramidal neurons are particularly vulnerable to neurodegeneration during the early stages of AD (3,4), the mechanisms underlying their degeneration are poorly understood.”
Neurodegenerative lysosomal disorders: A continuum from development to late age
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Metadata
- Authors
- Ginsberg, S. D., Alldred, M. J., Counts, S. E., Cataldo, A. M., Neve, R. L., Jiang, Y., Wuu, J., Chao, M. V., Mufson, E. J., Nixon, R. A., & Che, S.
- Venue
- Biological Psychiatry
- Publisher
- Elsevier BV
- Published
- 2010-11
- Volume
- 68
- Issue
- 10
- Pages
- 885-893
- ISSN
- 0006-3223
- PMC
- PMC2965820
- Cited by
- 243
- References
- 5
- Language
- en
- Funders
- National Institutes of Health (AG17617, AG14449, AG10161, AG09466)
- Alzheimer's Association
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