Cited by 85Transcranial Magnetic Stimulation StudiesAttention Deficit Hyperactivity DisorderNeural and Behavioral Psychology Studies

Transcranial direct current stimulation modulates neuronal networks in attention deficit hyperactivity disorder

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Sotnikova, Anna, Soff, Cornelia, Tagliazucchi, Enzo, Becker, Katja, Siniatchkin, Michael·2017·Brain Topography

Abstract

Anodal transcranial direct current stimulation (tDCS) of the prefrontal cortex has been repeatedly shown to improve working memory (WM). Since patients with attention deficit hyperactivity disorder (ADHD) are characterized by both underactivation of the prefrontal cortex and deficits in WM, the modulation of prefrontal activity with tDCS in ADHD patients may increase their WM performance as well as improve the activation and connectivity of the WM network. In the present study, this hypothesis was tested using a double-blind sham-controlled experimental design. After randomization, sixteen adolescents with ADHD underwent either anodal tDCS over the left dorsolateral prefrontal cortex (DLPFC, 1 mA, 20 min) or sham stimulation with simultaneous fMRI during n-back WM task. Both in one-back and two-back conditions, tDCS led to a greater activation (compared with sham stimulation) of the left DLPFC (under the electrode), left premotor cortex, left supplementary motor cortex, and precuneus. The effects of tDCS were long-lasting and influenced resting state functional connectivity even 20 min after the stimulation, with patterns of strengthened DLPFC connectivity after tDCS outlining the WM network. In summary, anodal tDCS caused increased neuronal activation and connectivity, not only in the brain area under the stimulating electrode (i.e. left DLPFC) but also in other, more remote brain regions. Because of moderate behavioral effects of tDCS, the significance of this technique for ADHD treatment has to be investigated in further studies.

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Crossref · 10.1007/s10548-017-0552-4

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  • In the same cognitive WM/attention task, ADHD adolescents improved in reaction time and its variability but became worse in omission and commission errors after stimulation compared to sham.

    “In the same cognitive WM/attention task, ADHD adolescents improved in reaction time and its variability but became worse in omission and commission errors after stimulation compared to sham (Sotnikova et al., 2017).”

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Authors
Sotnikova, A., Soff, C., Tagliazucchi, E., Becker, K., & Siniatchkin, M.
Affiliations
  • Philipps University of Marburg (DE)
  • Christian-Albrechts-Universität zu Kiel (DE)
Corresponding author
Siniatchkin, Michael
Venue
Brain Topography
Published
2017-02-17
Volume
30
Issue
5
Pages
656-672
ISSN
  • 0896-0267 (ISSN-L)
  • 1573-6792
OpenAlex
W2588471851
Cited by
85
References
90
Citations by year
2026: 3 · 2025: 10 · 2024: 11 · 2023: 8 · 2022: 10 · 2021: 18 · 2020: 14 · 2019: 3 · 2018: 6 · 2017: 1 · 2016: 1
FWCI
3.27
Type
journal article
Language
en
Open access
Locations
  • Brain Topography (publishedVersion)
  • PubMed (publishedVersion)
  • CONICET Digital (CONICET) (submittedVersion, cc-by-nc-sa)
Topics
  • Life Sciences › Neuroscience › Neurology › Transcranial Magnetic Stimulation Studies
  • Health Sciences › Medicine › Psychiatry and Mental health › Attention Deficit Hyperactivity Disorder
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
Keywords
transcranial direct current stimulation, attention deficit hyperactivity disorder, working memory, dorsolateral prefrontal cortex, resting-state functional connectivity, n-back task, adolescents, non-invasive brain stimulation, premotor cortex, supplementary motor area, precuneus
MeSH terms
Adolescent, Attention Deficit Disorder with Hyperactivity, Child, Double-Blind Method, Female, Humans, Magnetic Resonance Imaging, Male, Memory, Short-Term, Nerve Net, Prefrontal Cortex, Transcranial Direct Current Stimulation

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