Implicación del circuito corticoestriadotalámico en pacientes con trastorno obsesivo-compulsivo durante una tarea de control inhibitorio con contingencias de recompensa y castigo
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INTRODUCTION: Recent neuroimaging studies conducted on obsessive-compulsive disorder (OCD) show alterations in the fronto-thalamic-striatal circuit, which would give rise to an executive dysfunction. This could be the neurocognitive substrate underlying the main symptoms of OCD, i.e. obsessions and compulsions. SUBJECTS AND METHODS: Both brain activity and behavioural performance of a group of 13 patients with OCD were compared with a control group of 13 healthy subjects by means of functional magnetic resonance imaging while performing an inhibitory control task with reward and punishment contingencies. The effects of medication were also analysed. RESULTS: The intra-group analyses showed a longer reaction time during the go/no go condition in both groups, although there were no differences between the groups in the performance of the task. With regard to this task, significant activation of large areas of the cerebellum and the occipital, temporal and parietal lobes was observed in the healthy subjects. In comparison with the controls, the obsessive patients showed lower activation in the right-side frontal medial and superior gyri, the anterior cingulate cortex and the caudate nucleus, and greater activation in the inferior parietal convolution and the fusiform gyrus. The effects of medication were found in the frontal cortex and basal structures. CONCLUSIONS: These results agree with the argument claiming that the dysfunction in the corticostriatal system in OCD is associated to diminished brain activity in response to cognitive tasks.
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Pena-Garijo et al. found that individuals with OCD had reduced activity in the ACC and the CN during a reward-learning task.
“Pena-Garijo and colleagues [517] found that individuals with OCD had reduced activity in the ACC and the CN during a reward-learning task.”
From Reward circuitry dysfunction in psychiatric and neurodevelopmental disorders and genetic syndromes: animal models and clinical findings (2012) · cites this paper as [517]
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- Authors
- Pena Garijo, J., Barros Loscertales, A., Ventura Campos, N., Ruipérez Rodríguez, M. Á., Edo Villamón, S., & Ávila Rivera, C.
- Venue
- Revista de Neurología
- Publisher
- IMR Press
- Published
- 2011
- Volume
- 53
- Issue
- 02
- Pages
- 77
- ISSN
- 0210-0010 (ISSN-L)
- OpenAlex
- W26796066
- Cited by
- 12
- References
- 48
- Citations by year
- 2026: 1 · 2022: 1 · 2020: 1 · 2018: 1 · 2017: 1 · 2016: 3 · 2015: 1 · 2014: 1 · 2012: 1
- FWCI
- 1.03
- Type
- journal article
- Language
- es
- Open access
- green
- hdl.handle.net
- Licence
- other-oa
- Locations
- Revista de Neurología (publishedVersion)
- PubMed (publishedVersion)
- LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Científicas) (publishedVersion, other-oa)
- Repositori UJI (Universitat Jaume I) (submittedVersion, public-domain)
- Topics
- Social Sciences › Psychology › Clinical Psychology › Obsessive-Compulsive Spectrum Disorders
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
- Health Sciences › Medicine › Neurology › Neurological disorders and treatments
- Keywords
- obsessive-compulsive disorder, inhibitory control, go/no-go task, executive dysfunction, anterior cingulate cortex, caudate nucleus, frontal cortex, cerebellum, fusiform gyrus, antipsychotic effects, brain activation
- MeSH terms
- Adult, Corpus Striatum, Female, Frontal Lobe, Humans, Inhibition, Psychological, Magnetic Resonance Imaging, Male, Middle Aged, Neural Pathways, Neuropsychological Tests, Obsessive-Compulsive Disorder, Psychomotor Performance, Punishment, Reward, Thalamus
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