Shorter Leukocyte Telomere Length in Midlife Women with Poor Sleep Quality
Open accessAbstract
Background . Accumulating evidence supports leukocyte telomere length (LTL) as a biological marker of cellular aging. Poor sleep is a risk factor for age-related disease; however, the extent to which sleep accounts for variation in LTL is unknown. Methods . The present study examined associations of self-reported sleep duration, onset latency, and subjective quality with LTL in a community-dwelling sample of 245 healthy women in midlife (aged 49–66 years). Results . While sleep duration and onset latency were unrelated to LTL, women reporting poorer sleep quality displayed shorter LTL ( r = 0.14 , P = 0.03 ), independent of age, BMI, race, and income ( b = 55.48 , SE = 27.43 , P = 0.04 ). When analyses were restricted to participants for whom sleep patterns were chronic, poorer sleep quality predicted shorter LTL independent of covariates and perceived psychological stress. Conclusions . This study provides the first evidence that poor sleep quality explains significant variation in LTL, a marker of cellular aging.
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Among women with chronic poor sleep quality, poorer sleep quality predicted shorter leukocyte telomere length.
“Moreover, among those women for whom poor sleep quality was chronic, poorer sleep quality predicted shorter leukocyte telomere length.”
From Sleep health: Reciprocal regulation of sleep and innate immunity (2017) · cites this paper as Prather et al, 2011
Sleep duration was unrelated to leukocyte telomere length in midlife women.
“Similar to the observations between sleep duration and inflammation, sleep duration was unrelated to leukocyte telomere length.”
From Sleep health: Reciprocal regulation of sleep and innate immunity (2017) · cites this paper as Prather et al, 2011
Poor sleep quality was associated with shorter leukocyte telomere length, independent of age, BMI, race, and income.
“However, poor sleep quality was associated with shorter leukocyte telomere length, independent of age, BMI, race, and income.”
From Sleep health: Reciprocal regulation of sleep and innate immunity (2017) · cites this paper as Prather et al, 2011
Shorter leukocyte telomere length has been linked with markers of sleep disturbances (PSQI) in a sample of 245 healthy midlife women and of 87 obese adults, with the latter study reporting a link with telomere length of CD8 and CD4 T cells in particular.
“shorter leukocyte telomere length, a proposed marker of cellular senescence, has been linked with markers of sleep disturbances (assessed by the PSQI) in a sample of 245 healthy midlife women (451) and of 87 obese adults (446), with the latter study reporting a link with telomere length of CD8 and CD4 T cells in particular”
From The Sleep-Immune Crosstalk in Health and Disease (2019) · cites this paper as [451]
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Self-citation
- Authors
- Prather, A. A., Puterman, E., Lin, J., O'Donovan, A., Krauss, J., Tomiyama, A. J., Epel, E. S., & Blackburn, E. H.
- Affiliations
- University of California, San Francisco (US)
- Department of Psychiatry, University of California, San Francisco, CA 94143, USA
- Rutgers, The State University of New Jersey (US)
- Corresponding author
- Prather, Aric A.
- ORCID
- Venue
- Journal of Aging Research
- Publisher
- Wiley
- Published
- 2011
- Volume
- 2011
- Pages
- 1-6
- ISSN
- 2090-2204 (ISSN-L)
- 2090-2212
- PMC
- PMC3199186
- OpenAlex
- W2088868199
- Cited by
- 100
- References
- 38
- Citations by year
- 2026: 2 · 2025: 6 · 2024: 2 · 2023: 5 · 2022: 5 · 2021: 7 · 2020: 3 · 2019: 12 · 2018: 5 · 2017: 9 · 2016: 10 · 2015: 8 · 2014: 11 · 2013: 10 · 2012: 5
- FWCI
- 5.67
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- Journal of Aging Research (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
- eScholarship (California Digital Library) (submittedVersion)
- Funders
- Robert Wood Johnson Foundation
- Topics
- Health Sciences › Medicine › Physiology › Telomeres, Telomerase, and Senescence
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and related disorders
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
- Keywords
- leukocyte telomere length, sleep quality, cellular aging, middle-aged women, sleep duration, sleep latency, subjective sleep quality, psychological stress
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