A Circadian Genomic Signature Common to Ketamine and Sleep Deprivation in the Anterior Cingulate Cortex
Open accessAbstract
Background Conventional antidepressants usually require several weeks to achieve a full clinical response in patients with major depressive disorder, an illness associated with dysregulated circadian rhythms and a high incidence of suicidality. Two rapid-acting antidepressant strategies, low-dose ketamine (KT) and sleep deprivation (SD) therapies, dramatically reduce depressive symptoms within 24 hours in a subset of major depressive disorder patients. However, it is unknown whether they exert their actions through shared regulatory mechanisms. To address this question, we performed comparative transcriptomics analyses to identify candidate genes and relevant pathways common to KT and SD. Methods We used the forced swim test, a standardized behavioral approach to measure antidepressant-like activity of KT and SD. We investigated gene expression changes using high-density microarrays and pathway analyses (Gene Ontology, Kyoto Encyclopedia of Genes and Genomes, Gene Set Enrichment Analysis) in KT- and SD-treated mice compared with saline-treated control male mice. Results We show that KT and SD elicit common transcriptional responses implicating distinct elements of the circadian clock and processes involved in neuronal plasticity. There is an overlap of 64 genes whose expression is common in KT and SD. Specifically, there is downregulation of clock genes including Ciart, Per2, Npas4, Dbp, and Rorb in both KT- and SD-treated mice. Conclusions We demonstrate a potential involvement of the circadian clock in rapid antidepressant responses. These findings could open new research avenues to help design chronopharmacological strategies to treat major depressive disorder.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Newer preclinical data have shown an overlap between clock gene expression in both sleep deprivation and ketamine, both fast-acting treatments for depression.
“Newer preclinical data have shown an overlap between clock gene expression in both sleep deprivation and ketamine, both fast-acting treatments for depression.148”
From Ketamine as an antidepressant: Overview of its mechanisms of action and potential predictive biomarkers (2020) · cites this paper as [148]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
1 retracted
Larkin, G. L., & Beautrais, A. L. (2011) · The International Journal of Neuropsychopharmacology · doi:10.1017/s1461145711000629 · Cited by 254 · see citing works
RetractedCluster analysis and display of genome-wide expression patterns
Eisen, M. B., Spellman, P. T., Brown, P. O., & Botstein, D. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.25.14863 · Cited by 12,617 · see citing works
KEGG as a reference resource for gene and protein annotation
Kanehisa, M., Sato, Y., Kawashima, M., Furumichi, M., & Tanabe, M. (2016) · Nucleic Acids Research · doi:10.1093/nar/gkv1070 · Cited by 7,387 · see citing works
Antidepressant effects of ketamine in depressed patients
Berman, R. M., Cappiello, A., Anand, A., Oren, D. A., Heninger, G. R., Charney, D. S., & Krystal, J. H. (2000) · Biological Psychiatry · doi:10.1016/s0006-3223(99)00230-9 · Cited by 3,856 · see citing works
Gene Ontology Consortium: going forward
The Gene Ontology Consortium (2015) · Nucleic Acids Research · doi:10.1093/nar/gku1179 · Cited by 3,492 · see citing works
Essential role of BDNF in the mesolimbic dopamine pathway in social defeat stress
Berton, O., McClung, C. A., DiLeone, R. J., Krishnan, V., Renthal, W., Russo, S. J., Graham, D., Tsankova, N. M., Bolanos, C. A., Rios, M., et al. (2006) · Science · doi:10.1126/science.1120972 · Cited by 2,129 · see citing works
Animal models of neuropsychiatric disorders
Nestler, E. J., & Hyman, S. E. (2010) · Nature Neuroscience · doi:10.1038/nn.2647 · Cited by 2,023 · see citing works
A Serum Shock Induces Circadian Gene Expression in Mammalian Tissue Culture Cells
Balsalobre, A., Damiola, F., & Schibler, U. (1998) · Cell · doi:10.1016/s0092-8674(00)81199-x · Cited by 2,001 · see citing works
NMDA receptor blockade at rest triggers rapid behavioural antidepressant responses
Autry, A. E., Adachi, M., Nosyreva, E., Na, E. S., Los, M. F., Cheng, P.-F., Kavalali, E. T., & Monteggia, L. M. (2011) · Nature · doi:10.1038/nature10130 · Cited by 1,926 · see citing works
Synaptic Dysfunction in Depression: Potential Therapeutic Targets
Duman, R. S., & Aghajanian, G. K. (2012) · Science · doi:10.1126/science.1222939 · Cited by 1,651 · see citing works
MAPK cascade signalling and synaptic plasticity
Thomas, G. M., & Huganir, R. L. (2004) · Nature Reviews Neuroscience · doi:10.1038/nrn1346 · Cited by 1,454 · see citing works
The subgenual anterior cingulate cortex in mood disorders
Drevets, W. C., Savitz, J., & Trimble, M. (2008) · CNS Spectrums · doi:10.1017/s1092852900013754 · Cited by 1,109 · see citing works
Neuregulin 1 in neural development, synaptic plasticity and schizophrenia
Mei, L., & Xiong, W.-C. (2008) · Nature Reviews Neuroscience · doi:10.1038/nrn2392 · Cited by 1,030 · see citing works
Targeting abnormal neural circuits in mood and anxiety disorders: from the laboratory to the clinic
Ressler, K. J., & Mayberg, H. S. (2007) · Nature Neuroscience · doi:10.1038/nn1944 · Cited by 1,007 · see citing works
Zarate, C. A., Brutsche, N. E., Ibrahim, L., Franco-Chaves, J., Diazgranados, N., Cravchik, A., Selter, J., Marquardt, C. A., Liberty, V., & Luckenbaugh, D. A. (2012) · Biological Psychiatry · doi:10.1016/j.biopsych.2011.12.010 · Cited by 811 · see citing works
Can, A., Dao, D. T., Arad, M., Terrillion, C. E., Piantadosi, S. C., & Gould, T. D. (2011) · Journal of Visualized Experiments · doi:10.3791/3638 · Cited by 616 · see citing works
Price, R. B., Nock, M. K., Charney, D. S., & Mathew, S. J. (2009) · Biological Psychiatry · doi:10.1016/j.biopsych.2009.04.029 · Cited by 600 · see citing works
Circadian patterns of gene expression in the human brain and disruption in major depressive disorder
Li, J. Z., Bunney, B. G., Meng, F., Hagenauer, M. H., Walsh, D. M., Vawter, M. P., Evans, S. J., Choudary, P. V., Cartagena, P., Barchas, J. D., et al. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1305814110 · Cited by 589 · see citing works
Self-citationNotch signaling in the mammalian central nervous system: insights from mouse mutants
Yoon, K., & Gaiano, N. (2005) · Nature Neuroscience · doi:10.1038/nn1475 · Cited by 587 · see citing works
DiazGranados, N., Ibrahim, L. A., Brutsche, N. E., Ameli, R., Henter, I. D., Luckenbaugh, D. A., Machado-Vieira, R., & Zarate, C. A. (2010) · The Journal of Clinical Psychiatry · doi:10.4088/jcp.09m05327blu · Cited by 564 · see citing works
Disruption of circadian clocks has ramifications for metabolism, brain, and behavior
Karatsoreos, I. N., Bhagat, S., Bloss, E. B., Morrison, J. H., & McEwen, B. S. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1018375108 · Cited by 547 · see citing works
GeneCodis3: a non-redundant and modular enrichment analysis tool for functional genomics
Tabas‐Madrid, D., Nogales‐Cadenas, R., & Pascual-Montano, A. (2012) · Nucleic Acids Research · doi:10.1093/nar/gks402 · Cited by 537 · see citing works
Petryszak, R., Keays, M., Tang, A., Fonseca, N. A., Barrera, E., Burdett, T., Füllgrabe, A., Fuentes, A. M.-P., Jupp, S., Koskinen, S., et al. (2015) · Nucleic Acids Research · doi:10.1093/nar/gkv1045 · Cited by 530 · see citing works
Not(ch) just development: Notch signalling in the adult brain
Ables, J. L., Breunig, J. J., Eisch, A. J., & RAKIC, P. T. (2011) · Nature reviews. Neuroscience · doi:10.1038/nrn3024 · Cited by 460 · see citing works
Garcia, L. S. B., Comim, C. M., Valvassori, S. S., Réus, G. Z., Barbosa, L. M., Andreazza, A. C., Stertz, L., Fries, G. R., Gavioli, E. C., Kapczinski, F., et al. (2008) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2007.07.027 · Cited by 454 · see citing works
Mineur, Y. S., Obayemi, A., Wigestrand, M. B., Fote, G. M., Calarco, C. A., Li, A. M., & Picciotto, M. R. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1219731110 · Cited by 375 · see citing works
Homer1a is a core brain molecular correlate of sleep loss
Maret, S., Dorsaz, S., Gurcel, L., Pradervand, S., Petit, B., Pfister, C., Hagenbüchle, O., O’Hara, B. F., Franken, P., & Tafti, M. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0710131104 · Cited by 366 · see citing works
Price, R. B., Iosifescu, D. V., Murrough, J. W., Chang, L. C., Al Jurdi, R. K., Iqbal, S. Z., Soleimani, L., Charney, D. S., Foulkes, A. L., & Mathew, S. J. (2014) · Depression and Anxiety · doi:10.1002/da.22253 · Cited by 345 · see citing works
A Role for MAP Kinase Signaling in Behavioral Models of Depression and Antidepressant Treatment
Duman, C. H., Schlesinger, L., Kodama, M., Russell, D., & Duman, R. S. (2006) · Biological Psychiatry · doi:10.1016/j.biopsych.2006.05.047 · Cited by 338 · see citing works
The circadian molecular clock creates epidermal stem cell heterogeneity
Janich, P., Pascual, G., Merlos-Suárez, A., Batlle, E., Ripperger, J., Albrecht, U., Cheng, H.-Y. M., Obrietan, K., Di Croce, L., & Benitah, S. A. (2011) · Nature · doi:10.1038/nature10649 · Cited by 326 · see citing works
Sleep and waking modulate spine turnover in the adolescent mouse cortex
Maret, S., Faraguna, U., Nelson, A. B., Cirelli, C., & Tononi, G. (2011) · Nature Neuroscience · doi:10.1038/nn.2934 · Cited by 315 · see citing works
Ketamine for rapid reduction of suicidal ideation: a randomized controlled trial
Murrough, J. W., Soleimani, L., DeWilde, K. E., Collins, K. A., Lapidus, K. A., Iacoviello, B. M., Lener, M., Kautz, M., Kim, J., Stern, J. B., et al. (2015) · Psychological Medicine · doi:10.1017/s0033291715001506 · Cited by 297 · see citing works
A role for cryptochromesin sleep regulation
Wisor, J. P., O’Hara, B. F., Terao, A., Selby, C. P., Kilduff, T. S., Sancar, A., Edgar, D. M., & Franken, P. (2002) · BMC Neuroscience · doi:10.1186/1471-2202-3-20 · Cited by 286 · see citing works
Salvadore, G., Cornwell, B. R., Colon-Rosario, V., Coppola, R., Grillon, C., Zarate, C. A., & Manji, H. K. (2009) · Biological Psychiatry · doi:10.1016/j.biopsych.2008.08.014 · Cited by 277 · see citing works
Involvement of the MAP kinase cascade in resetting of the mammalian circadian clockPreprint
Akashi, M., & Nishida, E. (2000) · Genes & Development · doi:10.1101/gad.14.6.645 · Cited by 269 · see citing works
Bunney, W. E. (2000) · Neuropsychopharmacology · doi:10.1016/s0893-133x(99)00145-1 · Cited by 268 · see citing works
Self-citationWu, J. C., Kelsoe, J. R., Schachat, C., Bunney, B. G., DeModena, A., Golshan, S., Gillin, J. C., Potkin, S. G., & Bunney, W. E. (2009) · Biological Psychiatry · doi:10.1016/j.biopsych.2009.02.018 · Cited by 263 · see citing works
Self-citationSynaptic Mechanisms Underlying Rapid Antidepressant Action of Ketamine
Kavalali, E. T., & Monteggia, L. M. (2012) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2012.12040531 · Cited by 258 · see citing works
Liu, R.-J., Fuchikami, M., Dwyer, J. M., Lepack, A. E., Duman, R. S., & Aghajanian, G. K. (2013) · Neuropsychopharmacology · doi:10.1038/npp.2013.128 · Cited by 256 · see citing works
Circadian rhythms and memory formation
Gerstner, J. R., & Yin, J. C. P. (2010) · Nature reviews. Neuroscience · doi:10.1038/nrn2881 · Cited by 253 · see citing works
Serchov, T., Clement, H.-W., Schwarz, M. K., Iasevoli, F., Tosh, D. K., Idzko, M., Jacobson, K. A., de Bartolomeis, A., Normann, C., Biber, K., et al. (2015) · Neuron · doi:10.1016/j.neuron.2015.07.010 · Cited by 210 · see citing works
KETAMINE'S MECHANISM OF ACTION: A PATH TO RAPID‐ACTING ANTIDEPRESSANTS
Abdallah, C. G., Adams, T. G., Kelmendi, B., Esterlis, I., Sanacora, G., & Krystal, J. H. (2016) · Depression and Anxiety · doi:10.1002/da.22501 · Cited by 206 · see citing works
Alberi, L. A., Liu, S., Wang, Y. J., Badie, R., Smith‐Hicks, C. L., Wu, J., Pierfelice, T. J., Abazyan, B. N., Mattson, M. P., Kuhl, D., et al. (2011) · Neuron · doi:10.1016/j.neuron.2011.01.004 · Cited by 199 · see citing works
Surget, A., Wang, Y., Leman, S., Ibargüen-Vargas, Y., Edgar, N. M., Griebel, G., Belzung, C., & Sibille, E. L. (2008) · Neuropsychopharmacology · doi:10.1038/npp.2008.76 · Cited by 195 · see citing works
Cedernaes, J., Osler, M. E., Voisin, S., Broman, J.-E., Vogel, H., Dickson, S. L., Zierath, J. R., Schiöth, H. B., & Benedict, C. (2015) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2015-2284 · Cited by 188 · see citing works
Souêtre, E., Salvati, E., Wehr, T. A., Sack, D. A., Krebs, B., & DARCOURT, G. (1988) · American Journal of Psychiatry · doi:10.1176/ajp.145.9.1133 · Cited by 188 · see citing works
Circadian dysregulation of clock genes: clues to rapid treatments in major depressive disorder
Bunney, B. G., Li, J. Z., Walsh, D. M. A., Stein, R., Vawter, M. P., Cartagena, P. M., Barchas, J. D., Schatzberg, A. F., Myers, R., Watson, S. J., et al. (2014) · Molecular Psychiatry · doi:10.1038/mp.2014.138 · Cited by 185 · see citing works
Self-citationBunney, B. G., & Bunney, W. E. (2013) · Biological Psychiatry · doi:10.1016/j.biopsych.2012.07.020 · Cited by 181 · see citing works
Self-citationHasler, B. P., Buysse, D. J., Kupfer, D. J., & Germain, A. (2010) · Psychiatry Research · doi:10.1016/j.psychres.2010.04.027 · Cited by 177 · see citing works
Bagot, R. C., Cates, H. M., Purushothaman, I., Vialou, V., Heller, E. A., Yieh, L., Labonté, B., Peña, C. J., Shen, L., Wittenberg, G. M., et al. (2016) · Biological Psychiatry · doi:10.1016/j.biopsych.2016.06.012 · Cited by 171 · see citing works
Antidepressant effects of sleep deprivation require astrocyte-dependent adenosine mediated signaling
Hines, D. J., Schmitt, L. I., Hines, R. M., Moss, S. J., & Haydon, P. G. (2013) · Translational Psychiatry · doi:10.1038/tp.2012.136 · Cited by 160 · see citing works
The circadian clock: a framework linking metabolism, epigenetics and neuronal function
Masri, S., & Sassone‐Corsi, P. (2012) · Nature reviews. Neuroscience · doi:10.1038/nrn3393 · Cited by 154 · see citing works
Self-citationA Novel Protein, CHRONO, Functions as a Core Component of the Mammalian Circadian Clock
Goriki, A., Hatanaka, F., Myung, J., Kim, J. K., Yoritaka, T., Tanoue, S., Abe, T., Kiyonari, H., Fujimoto, K., Kato, Y., et al. (2014) · PLoS Biology · doi:10.1371/journal.pbio.1001839 · Cited by 154 · see citing works
Prediction of treatment response in major depression: Integration of concepts
Mulert, C., Juckel, G., Brunnmeier, M., Karch, S., Leicht, G., Mergl, R., Möller, H., Hegerl, U., & Pogarell, O. M. (2006) · Journal of Affective Disorders · doi:10.1016/j.jad.2006.07.021 · Cited by 146 · see citing works
Wisor, J. P., Pasumarthi, R. K., Gerashchenko, D., Thompson, C. L., Pathak, D. S., Sancar, A., Franken, P., Lein, E. S., & Kilduff, T. S. (2008) · Journal of Neuroscience · doi:10.1523/jneurosci.1150-08.2008 · Cited by 145 · see citing works
Troxel, W., Kupfer, D. J., Reynolds, C. F., Frank, E., Thase, M. E., Miewald, J. M., & Buysse, D. J. (2011) · The Journal of Clinical Psychiatry · doi:10.4088/jcp.11m07184 · Cited by 145 · see citing works
Afferents to anterior cingulate areas 24a and 24b and midcingulate areas 24a′ and 24b′ in the mouse
Fillinger, C., Yalçın, İ., Barrot, M., & Veinante, P. (2016) · Brain Structure and Function · doi:10.1007/s00429-016-1290-1 · Cited by 139 · see citing works
The Circadian Clock Gates the Intestinal Stem Cell Regenerative State
Karpowicz, P. A., Zhang, Y., Hogenesch, J. B., Emery, P., & Perrimon, N. (2013) · Cell Reports · doi:10.1016/j.celrep.2013.03.016 · Cited by 126 · see citing works
Mongrain, V., La Spada, F., Curie, T., & Franken, P. (2011) · PLoS ONE · doi:10.1371/journal.pone.0026622 · Cited by 118 · see citing works
Molecular and anatomical signatures of sleep deprivation in the mouse brain
Thompson, C. L. (2010) · Frontiers in Neuroscience · doi:10.3389/fnins.2010.00165 · Cited by 111 · see citing works
MAPK signaling correlates with the antidepressant effects of ketamine.
Réus, G. Z., Vieira, F. G., Abelaira, H. M., Michels, M., Tomaz, D. B., dos Santos, M. A. D., Carlessi, A. S., Neotti, M. V., Matias, B. I., Luz, J. R., et al. (2014) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2014.04.010 · Cited by 106 · see citing works
Homeostatic and circadian contribution to EEG and molecular state variables of sleep regulation
Curie, T., Mongrain, V., Dorsaz, S., Mang, G. M., Emmenegger, Y., & Franken, P. (2013) · SLEEP · doi:10.5665/sleep.2440 · Cited by 94 · see citing works
Epigenetic control and the circadian clock: Linking metabolism to neuronal responses
Orozco-Solis, R., & Sassone-Corsi, P. (2014) · Neuroscience · doi:10.1016/j.neuroscience.2014.01.043 · Cited by 94 · see citing works
Self-citationRapid-acting antidepressant strategies: mechanisms of action
Bunney, B. G., & Bunney, W. E. (2012) · The International Journal of Neuropsychopharmacology · doi:10.1017/s1461145711000927 · Cited by 79 · see citing works
Self-citationNocturnal sweating and temperature in depression
Aver, D. H., Shah, S. H., Eder, D. N., & Wildschindtz, G. (1999) · Acta Psychiatrica Scandinavica · doi:10.1111/j.1600-0447.1999.tb10864.x · Cited by 73 · see citing works
Annayev, Y., Adar, S., Chiou, Y., Lieb, J. D., Sancar, A., & Ye, R. (2014) · Journal of Biological Chemistry · doi:10.1074/jbc.m113.534651 · Cited by 73 · see citing works
Ketamine Influences CLOCK:BMAL1 Function Leading to Altered Circadian Gene Expression
Bellet, M. M., Vawter, M. P., Bunney, B. G., Bunney, W. E., & Sassone-Corsi, P. (2011) · PLoS ONE · doi:10.1371/journal.pone.0023982 · Cited by 70 · see citing works
Self-citationChronobiological Therapy for Mood Disorders
Dallaspezia, S., Suzuki, M., & Benedetti, F. (2015) · Current Psychiatry Reports · doi:10.1007/s11920-015-0633-6 · Cited by 68 · see citing works
Antidepressant mechanism of ketamine: perspective from preclinical studies
Scheuing, L., Chiu, C., Liao, H., & Chuang, D. (2015) · Frontiers in Neuroscience · doi:10.3389/fnins.2015.00249 · Cited by 65 · see citing works
Orozco-Solís, R., Ramadori, G., Coppari, R., & Sassone‐Corsi, P. (2015) · Endocrinology · doi:10.1210/en.2014-1805 · Cited by 64 · see citing works
Self-citationNilsson, E., Boström, A. E. D., Mwinyi, J., & Schiöth, H. B. (2016) · OMICS A Journal of Integrative Biology · doi:10.1089/omi.2016.0041 · Cited by 61 · see citing works
Papadopoulou, A., Siamatras, T., Delgado‐Morales, R., Amin, N. D., Shukla, V. K., Zheng, Y.-L., Pant, H. C., Almeida, O. F. X., & Kino, T. (2015) · Translational Psychiatry · doi:10.1038/tp.2015.72 · Cited by 54 · see citing works
Weckmann, K., Labermaier, C., Asara, J. M., Müller, M. B., & Turck, C. W. (2014) · Translational Psychiatry · doi:10.1038/tp.2014.119 · Cited by 53 · see citing works
Total sleep deprivation decreases immobility in the forced-swim test
Lopez-Rodriguez, F., Kim, J., & Poland, R. E. (2004) · Neuropsychopharmacology · doi:10.1038/sj.npp.1300406 · Cited by 49 · see citing works
Benedetti, F., Dallaspezia, S., Lorenzi, C., Pirovano, A., Radaelli, D., Locatelli, C., Poletti, S., Colombo, C., & Smeraldi, E. (2011) · Journal of Affective Disorders · doi:10.1016/j.jad.2011.10.039 · Cited by 49 · see citing works
Molecular profile of dissociative drug ketamine in relation to its rapid antidepressant action
Ficek, J., Zygmunt, M., Piechota, M., Hoinkis, D., Rodriguez Parkitna, J., Przewlocki, R., & Korostynski, M. (2016) · BMC Genomics · doi:10.1186/s12864-016-2713-3 · Cited by 42 · see citing works
Current Status of Ketamine and Related Compounds for Depression
Mathews, D. C., & Zarate, C. A. (2013) · The Journal of Clinical Psychiatry · doi:10.4088/jcp.13ac08382 · Cited by 36 · see citing works
Antle, M. C., Tse, F., Koke, S. J., et al. (2008) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2008.06533.x · Cited by 26 · see citing works
Flagged first, then by citations
Research works printed but not linked: 2
- [68]Chiba S 2006 Notch signaling in stem cell systems Stem Cells 24 2437 2447 16888285
- [78]Berger M Riemann D Höchli D Spiegel R 1989 The cholinergic rapid eye movement sleep induction test with rs-86: State or trait marker of depression? Arch Gen Psychiatry 46 421 428 2712660
Cited by
Sorted by citations
The future of rodent models in depression research
Gururajan, A., Reif, A., Cryan, J. F., & Slattery, D. A. (2019) · Nature Reviews Neuroscience · doi:10.1038/s41583-019-0221-6 · Cited by 269 · see citing works
Matveychuk, D., Thomas, R. K., Swainson, J., Khullar, A., MacKay, M.-A., Baker, G. B., & Dursun, S. M. (2020) · Therapeutic Advances in Psychopharmacology · doi:10.1177/2045125320916657 · Cited by 209 · see citing works
Gottlieb, J. F., Benedetti, F., Geoffroy, P. A., Henriksen, T. E. G., Lam, R. W., Murray, G., Phelps, J., Sit, D., Swartz, H. A., Crowe, M., et al. (2019) · Bipolar Disorders · doi:10.1111/bdi.12847 · Cited by 196 · see citing works
McCarthy, M. J., Gottlieb, J. F., Gonzalez, R., McClung, C. A., Alloy, L. B., Cain, S., Dulcis, D., Etain, B., Frey, B. N., Garbazza, C., et al. (2022) · Bipolar Disorders · doi:10.1111/bdi.13165 · Cited by 136 · see citing works
Benedetti, F., Poletti, S., Locatelli, C., Mazza, E., Lorenzi, C., Vitali, A., Riberto, M., Brioschi, S., Vai, B., Bollettini, I., et al. (2018) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2017.10.011 · Cited by 64 · see citing works
Circadian and epigenetic control of depression-like behaviors
Sato, S., & Sassone-Corsi, P. (2019) · Current Opinion in Behavioral Sciences · doi:10.1016/j.cobeha.2018.05.010 · Cited by 10 · see citing works
Self-citation
- Authors
- Orozco-Solis, R., Montellier, E., Aguilar-Arnal, L., Sato, S., Vawter, M. P., Bunney, B. G., Bunney, W. E., & Sassone-Corsi, P.
- Affiliations
- University of California, Irvine (US)
- Venue
- Biological Psychiatry
- Publisher
- Elsevier BV
- Published
- 2017-09
- Volume
- 82
- Issue
- 5
- Pages
- 351-360
- ISSN
- 0006-3223 (ISSN-L)
- PMC
- PMC5660920
- OpenAlex
- W2594064947
- Cited by
- 119
- References
- 78
- Citations by year
- 2026: 12 · 2025: 18 · 2024: 6 · 2023: 8 · 2022: 13 · 2021: 18 · 2020: 14 · 2019: 20 · 2018: 8 · 2017: 2
- FWCI
- 8.40
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Biological Psychiatry (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- eScholarship (California Digital Library) (submittedVersion, cc-by)
- Funders
- Novo Nordisk Fonden
- National Institutes of Health
- University of California, Irvine
- National Institute of Mental Health (R01MH085801)
- Topics
- Health Sciences › Medicine › Pharmacology › Treatment of Major Depression
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Keywords
- ketamine, sleep deprivation, major depressive disorder, circadian clock, anterior cingulate cortex, rapid-acting antidepressants, clock genes, gene expression, neuroplasticity, chronopharmacology, forced swim test, antidepressant-like effects
- MeSH terms
- Animals, Antidepressive Agents, Depressive Disorder, Disease Models, Animal, Gyrus Cinguli, Ketamine, Male, Mice, Inbred C57BL, Sleep Deprivation, Gene Expression, Computational Biology, Microarray Analysis, Circadian Rhythm Signaling Peptides and Proteins, Transcriptome
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
