Phase relationships between core body temperature, melatonin, and sleep are associated with depression severity: Further evidence for circadian misalignment in non-seasonal depression
Open accessAbstract
Misalignment between the timing of sleep and the circadian pacemaker has been linked to depression symptoms. This study sought to extend earlier findings by comparing sleep and circadian markers in healthy controls and individuals with major depression. Two markers of circadian misalignment correlated with depression severity in the depressed group.
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Circadian rhythm disruption is a key biological feature of MDD and often appears to return to normal as symptoms remit.
“It is well known that circadian rhythm disruption is a key biological feature of MDD and it often appears to return to normal as symptoms remit.144”
From Ketamine as an antidepressant: Overview of its mechanisms of action and potential predictive biomarkers (2020) · cites this paper as [144]
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BackgroundHASLER, B. P., GERMAIN, A., NOFZINGER, E. A., KUPFER, D. J., KRAFTY, R. T., ROTHENBERGER, S. D., JAMES, J. A., BI, W., & BUYSSE, D. J. (2012) · Journal of Sleep Research · doi:10.1111/j.1365-2869.2012.01002.x · Cited by 79 · see citing works
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The real-world association between digital markers of circadian disruption and mental health risks
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- Authors
- Hasler, B. P., Buysse, D. J., Kupfer, D. J., & Germain, A.
- Affiliations
- University of Pittsburgh (US)
- Corresponding author
- Germain, Anne
- Venue
- Psychiatry Research
- Publisher
- Elsevier BV
- Published
- 2010-06
- Volume
- 178
- Issue
- 1
- Pages
- 205-207
- ISSN
- 0165-1781 (ISSN-L)
- PMC
- PMC2914120
- OpenAlex
- W2009010658
- Cited by
- 177
- References
- 24
- Citations by year
- 2026: 5 · 2025: 11 · 2024: 11 · 2023: 12 · 2022: 8 · 2021: 13 · 2020: 14 · 2019: 15 · 2018: 12 · 2017: 12 · 2016: 11 · 2015: 13 · 2014: 12 · 2013: 12 · 2012: 12
- FWCI
- 4.07
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Psychiatry Research (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- University of Pittsburgh
- National Institutes of Health (UL1TR000005)
- National Heart, Lung, and Blood Institute (T32HL082610)
- National Institute of Mental Health (R01MH024652, R01-MH24652, R37MH024652)
- National Center for Research Resources (M01RR000056, RR 00056)
- National Center for Advancing Translational Sciences
- Topics
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and related disorders
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and Work-Related Fatigue
- Keywords
- circadian misalignment, non-seasonal depression, major depressive disorder, depression severity, core body temperature, melatonin, sleep timing, circadian pacemaker, sleep-wake cycle
- MeSH terms
- Adult, Body Temperature, Circadian Rhythm, Depression, Female, Humans, Male, Melatonin, Middle Aged, Psychiatric Status Rating Scales, Sleep Wake Disorders, Young Adult
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