Early Altered Resting-State Functional Connectivity Predicts the Severity of Post-Traumatic Stress Disorder Symptoms in Acutely Traumatized Subjects
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The goal of this study was to investigate the relationship between resting-state functional connectivity and the severity of post-traumatic stress disorder (PTSD) symptoms in 15 people who developed PTSD following recent trauma. Fifteen participants who experienced acute traumatic events underwent a 7.3-min resting functional magnetic resonance imaging scan within 2 days post-event. All the patients were diagnosed with PTSD within 1 to 6 months after trauma. Brain areas in which activity was correlated with that of the posterior cingulate cortex (PCC) were assessed. To assess the relationship between the severity of PTSD symptoms and PCC connectivity, contrast images representing areas positively correlated with the PCC were correlated with the subject's Clinician-Administered PTSD Scale scores (CAPS) when they were diagnosed. Furthermore, the PCC, medial prefrontal cortex and bilateral amygdala were selected to assess the correlation of the strength of functional connectivity with the CAPS. Resting state connectivity with the PCC was negatively correlated with CAPS scores in the left superior temporal gyrus and right hippocampus/amygdala. Furthermore, the strength of connectivity between the PCC and bilateral amygdala, and even between the bilateral amygdala could predict the severity of PTSD symptoms later. These results suggest that early altered resting-state functional connectivity of the PCC with the left superior temporal gyrus, right hippocampus and amygdala could predict the severity of the disease and may be a major risk factor that predisposes patients to develop PTSD.
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Increased risk of PTSD development is associated with dysregulations of central fear responses prior to and shortly after trauma exposure.
“An increased risk of PTSD development is associated with pre-existing dysregulations of (para)sympathetic [17,18] and hypothalamic-pituitary-adrenal axes [20,21], as well as dysregulations of central fear responses prior to [22] and shortly after trauma exposure [23,24].”
From Efficacy of oxytocin administration early after psychotrauma in preventing the development of PTSD: study protocol of a randomized controlled trial (2014) · cites this paper as [24]
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- Authors
- Zhou, Y., Wang, Z., Qin, L.-D., Wan, J.-Q., Sun, Y.-W., Su, S.-S., Ding, W.-N., & Xu, J.-R.
- Affiliations
- Shanghai Jiao Tong University (CN)
- Corresponding author
- Zhou, Yan
- Wang, Zhen
- ORCID
- Venue
- PLoS ONE
- Publisher
- Public Library of Science (PLoS)
- Published
- 2012-10-02
- Volume
- 7
- Issue
- 10
- Pages
- e46833
- ISSN
- 1932-6203 (ISSN-L)
- PMC
- PMC3462752
- OpenAlex
- W2007059501
- Cited by
- 89
- References
- 36
- Citations by year
- 2025: 5 · 2024: 2 · 2023: 7 · 2022: 2 · 2021: 12 · 2020: 9 · 2019: 2 · 2018: 11 · 2017: 5 · 2016: 7 · 2015: 13 · 2014: 10 · 2013: 4
- FWCI
- 4.41
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- PLoS ONE (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- National Natural Science Foundation of China (S30203, 30800370, 81171325)
- Science and Technology Commission of Shanghai Municipality
- Shanghai Leading Academic Discipline Project (81171325, S30203)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Functional Brain Connectivity Studies
- Social Sciences › Psychology › Clinical Psychology › Posttraumatic Stress Disorder Research
- Health Sciences › Medicine › Epidemiology › Traumatic Brain Injury Research
- Keywords
- post-traumatic stress disorder, resting-state functional connectivity, posterior cingulate cortex, amygdala, hippocampus, superior temporal gyrus, PTSD symptom severity, acute trauma, early biomarkers, medial prefrontal cortex, PTSD risk factors
- MeSH terms
- Adult, Basal Metabolism, Female, Gyrus Cinguli, Humans, Magnetic Resonance Imaging, Male, Nerve Net, Stress Disorders, Post-Traumatic, Time Factors, Stress Disorders, Traumatic, Acute
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