Cited by 173Biosensors and Analytical DetectionElectrochemical sensors and biosensorsAnalytical Chemistry and Sensors

A paper strip based non-invasive glucose biosensor for salivary analysis

Soni, Anuradha, Jha, Sandeep Kumar·2015·Biosensors and Bioelectronics

Abstract

In our present study, we developed an optical biosensor for direct determination of salivary glucose by using immobilized glucose oxidase enzyme on filter paper strip (specific activity 1.4 U/strip) and then reacting it with synthetic glucose samples in presence of co-immobilized color pH indicator. The filter paper changed color based on concentration of glucose in reaction media and hence, by scanning this color change (using RGB profiling) through an office scanner and open source image processing software (GIMP) the concentration of glucose in the reaction medium could be deduced. Once the biosensor was standardized, the synthetic glucose sample was replaced with human saliva from donors. The individual's blood glucose level at the time of obtaining saliva was also measured using an Accuchek(™) active glucometer (Roche Inc.). In this preliminary study, a correlation of nearly 0.64 was found between glucose levels in saliva and blood of healthy individuals and in diabetic patients it was nearly in the order of 0.95, thereby validating the importance of salivary analysis. The RGB profiling method obtained a detection range of 9-1350 mg/dL glucose at a response time of 45 s and LOD of 22.2 mg/dL.

Integrity signals

Registry

Crossref · 10.1016/j.bios.2014.09.042

Cites

12 of 12 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

  • Because saliva can be readily collected, it has been used in connection to in vitro diagnostic biosensors on strips or portable device platforms.

    “Because saliva can be readily collected123-125, it has been used in connection to in vitro diagnostic biosensors on strips or portable device platforms,126-134.”

    From Wearable biosensors for healthcare monitoring (2019) · cites this paper as [126]

  • Soni et al. demonstrated the correlation between blood and saliva glucose concentrations to be R = 0.64 in healthy subjects, whereas diabetic subjects show a much closer relationship with R = 0.95.

    “Soni et al.126 have demonstrated the correlation between blood and saliva glucose concentrations to be R = 0.64 in healthy subjects, whereas diabetic subjects show a much closer relationship with R = 0.95.”

    From Wearable biosensors for healthcare monitoring (2019) · cites this paper as [126]

Cites

Flagged first, then by citations

Cited by

Sorted by citations

Authors
Soni, A., & Jha, S. K.
Affiliations
Indian Institute of Technology Delhi (IN)
Corresponding author
Jha, Sandeep Kumar
Venue
Biosensors and Bioelectronics
Publisher
Elsevier BV
Published
2015-05
Volume
67
Pages
763-768
ISSN
0956-5663 (ISSN-L)
OpenAlex
W2079524492
Cited by
173
References
12
Citations by year
2026: 9 · 2025: 12 · 2024: 15 · 2023: 14 · 2022: 25 · 2021: 21 · 2020: 15 · 2019: 17 · 2018: 15 · 2017: 13 · 2016: 15 · 2015: 2
FWCI
5.19
Type
journal article
Language
en
Open access
closed
Locations
  • Biosensors and Bioelectronics (publishedVersion)
  • PubMed (publishedVersion)
Funders
Indian Institute of Technology Delhi
Topics
  • Physical Sciences › Engineering › Biomedical Engineering › Biosensors and Analytical Detection
  • Physical Sciences › Engineering › Electrical and Electronic Engineering › Electrochemical sensors and biosensors
  • Physical Sciences › Chemical Engineering › Bioengineering › Analytical Chemistry and Sensors
Keywords
salivary glucose, optical biosensors, glucose oxidase immobilization, filter paper strips, image processing, diabetes mellitus, non-invasive glucose monitoring
MeSH terms
Blood Glucose, Diabetes Mellitus, Enzymes, Immobilized, Glucose, Glucose Oxidase, Humans, Paper, Saliva, Biosensing Techniques

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review