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Exosomes for drug delivery—A novel application for the mesenchymal stem cell
Abstract
Exosomes are the most extensively characterized class of secreted membrane vesicles that carry proteins and RNAs for intercellular communication. They are increasingly seen as possible alternatives to liposomes as drug delivery vehicles. Like liposomes, they could deliver their cargo across the plasma membrane and provide a barrier against premature transformation and elimination. In addition, these naturally-occurring secreted membrane vesicles are less toxic and better tolerated in the body as evidenced by their ubiquitous presence in biological fluids, and have an intrinsic homing ability. They are also amenable to in vivo and in vitro loading of therapeutic agents, and membrane modifications to enhance tissue-specific homing. Here we propose human mesenchymal stem cells as the ideal cell source of exosomes for drug delivery. Mesenchymal stem cell transplantation for various disease indications has been extensively tested and shown to be safe in numerous clinical trials. These cells are also prolific producers of immunologically inert exosomes. Immortalization of these cells does not compromise the quantity or quality of exosome production, thus enabling infinite and reproducible exosome production from a single cell clone.
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“Exosomes could be detected in almost any body fluids (blood, cerebrospinal fluid, saliva, etc.), indicating their transport cargo could go through membrane and be protected from degradations [30].”
From The Therapeutic Potential and Clinical Significance of Exosomes as Carriers of Drug Delivery System (2022) · cites this paper as [30]
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Metadata
- Authors
- Lai, R. C., Yeo, R. W. Y., Tan, K. H., & Lim, S. K.
- Affiliations
- Agency for Science, Technology and Research (SG)
- KK Women's and Children's Hospital (SG)
- Corresponding author
- Lim, Sai Kiang
- Venue
- Biotechnology Advances
- Publisher
- Elsevier BV
- Published
- 2013-09
- Volume
- 31
- Issue
- 5
- Pages
- 543-551
- ISSN
- 0734-9750 (ISSN-L)
- OpenAlex
- W2010746084
- Cited by
- 546
- References
- 136
- Citations by year
- 2026: 17 · 2025: 41 · 2024: 40 · 2023: 50 · 2022: 54 · 2021: 63 · 2020: 62 · 2019: 51 · 2018: 44 · 2017: 32 · 2016: 23 · 2015: 29 · 2014: 21 · 2013: 16
- FWCI
- 1.93
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Biotechnology Advances (publishedVersion)
- PubMed (publishedVersion)
- National University of Singapore (submittedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Extracellular vesicles in disease
- Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Mesenchymal stem cell research
- Keywords
- exosomes, drug delivery, mesenchymal stem cells, membrane vesicles, stem cell transplantation, exosome production, intercellular communication, immunogenicity
- MeSH terms
- Animals, Cells, Cultured, Humans, Drug Delivery Systems, Mesenchymal Stem Cell Transplantation, Exosomes, Mesenchymal Stem Cells
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