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Cited by 187Alzheimer's disease research and treatmentsNeuroinflammation and Neurodegeneration MechanismsEstrogen and related hormone effects

The DOI matches its Crossref record; 45 of the 45 references it cites were found in a registry or an index.

Estradiol or genistein prevent Alzheimer's disease-associated inflammation correlating with an increase PPARγ expression in cultured astrocytes

Valles, Soraya L., Dolz-Gaiton, Pablo, Gambini, Juan, Borras, Consuelo, LLoret, Ana, Pallardo, Federico V., Viña, Jose·2010·Brain Research
DOI 10.1016/j.brainres.2009.11.044
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Abstract

Inflammation has been implicated in neurodegenerative disorders such as Alzheimer's disease (AD). The main inflammatory players in AD are the glial cells which initiate the inflammatory response. One of the earliest neuropathological changes in AD is the accumulation of astrocytes at sites of A beta deposition. It is desirable to find methods of tipping the balance towards anti-inflammatory state. Estrogenic compounds have shown anti-inflammatory and also antioxidant activity. Astrocytes were pretreated with 17-beta estradiol or with genistein, and 48 h later treated with 5 microM amyloid beta (A beta) for 24 h. We found that A beta induces inflammatory mediators, such as cyclooxygenase 2 (COX-2), inducible nitric oxide synthase (iNOS), interleukin 1 beta (IL-1 beta) and tumor necrosis factor alpha (TNF-alpha). All these effects were prevented when cells were pretreated with estradiol or genistein, demonstrating anti-inflammatory effects of estradiol or genistein in astrocytes in primary culture. The A beta-stimulated expression of pro-inflammatory genes in cells is antagonized by the action of the PPARs (peroxisome proliferator activated receptors). Here we detected an increase in PPAR-gamma expression in astrocytes in primary culture treated with A beta and estradiol or soy isoflavone genistein. Thus, some of the anti-inflammatory effects of estrogenic compounds may be mediated and activated by PPARs suppressing a diverse array of inflammatory responses caused by A beta in astrocytes in primary culture.

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Metadata

Authors
Valles, S. L., Dolz-Gaiton, P., Gambini, J., Borras, C., LLoret, A., Pallardo, F. V., & Viña, J.
Affiliations
Universitat de València (ES)
ORCID
Venue
Brain Research
Publisher
Elsevier BV
Published
2010-02
Volume
1312
Pages
138-144
ISSN
0006-8993 (ISSN-L)
DOI
10.1016/j.brainres.2009.11.044
OpenAlex
W2069905837
Cited by
186
References
45
Citations by year
2026: 4 · 2025: 2 · 2024: 10 · 2023: 11 · 2022: 16 · 2021: 14 · 2020: 14 · 2019: 10 · 2018: 11 · 2017: 9 · 2016: 13 · 2015: 9 · 2014: 15 · 2013: 11 · 2012: 18
FWCI
7.95
Type
journal article
Language
en
Open access
closed
Licence
Locations
  • Brain Research (publishedVersion)
  • PubMed (publishedVersion)
Funders
local and national government of Spain (GVcs2007-AP-001, BFU 2005/230, BFU 2007 6583/BFI)
Topics
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Alzheimer's disease research and treatments
  • Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Endocrinology › Estrogen and related hormone effects
Keywords
Alzheimer's disease, astrocytes, estradiol, genistein, amyloid-beta, neuroinflammation, PPARγ, estrogenic compounds, cyclooxygenase-2, inducible nitric oxide synthase, IL-1β, TNF-α, soy isoflavones, anti-inflammatory activity
MeSH terms
Animals, Astrocytes, Cells, Cultured, Cerebral Cortex, Dose-Response Relationship, Drug, Drug Interactions, Enzyme-Linked Immunosorbent Assay, Estradiol, Estrogens, Gene Expression Regulation, Peptide Fragments, Tumor Necrosis Factor-alpha, Amyloid beta-Peptides, Genistein, Protein Kinase Inhibitors, PPAR gamma, Rats, Cyclooxygenase 2, Nitric Oxide Synthase Type II, Interleukin-1beta

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