Cited by 160Fatty Acid Research and HealthNutritional Studies and DietInflammatory mediators and NSAID effects

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Unsaturated fatty acids are inversely associated and n-6/n-3 ratios are positively related to inflammation and coagulation markers in plasma of apparently healthy adults

Kalogeropoulos, Nick, Panagiotakos, Demosthenes B., Pitsavos, Christos, Chrysohoou, Christina, Rousinou, Georgia, Toutouza, Marina, Stefanadis, Christodoulos·2010·Clinica Chimica Acta

DOI 10.1016/j.cca.2010.01.023

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Abstract

Background Blood lipids and inflammatory markers levels have been associated with the development and progression of atherosclerosis. As the association of inflammatory markers with plasma fatty acids has not been extensively evaluated and understood, we sought to investigate the associations between dietary and plasma fatty acids with various inflammation and coagulation markers.Methods High sensitivity C-reactive protein (hsCRP), interleukin-6 (IL-6), tumor necrosis factor-alpha (TNF-alpha), fibrinogen, and homocysteine were measured in serum of 374 free-living, healthy men and women, randomly selected from the ATTICA's study database. Total plasma fatty acids were determined by gas chromatography. Dietary fatty acids were assessed through a semi-quantitative FFQ.Results Multi-adjusted regression analyses revealed that plasma n-3 fatty acids were inversely associated with CRP, IL-6 and TNF-alpha; plasma n-6 fatty acids were inversely associated with CRP, IL-6 and fibrinogen; monounsaturated fatty acids were inversely associated with CRP and IL-6 (all p-values<0.05). Interestingly, the n-6/n-3 ratios exhibited the strongest positive correlations with all the markers studied. No associations were observed between dietary fatty acids and the investigated markers.Conclusions Measurements of total plasma fatty acids could provide insights into the relationships between diet and atherosclerotic disease. Moreover, the n-6/n-3 ratio may constitute a predictor of low-grade inflammation and coagulation.

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Authors: Kalogeropoulos, N., Panagiotakos, D. B., Pitsavos, C., Chrysohoou, C., Rousinou, G., Toutouza, M., & Stefanadis, C.
Affiliations: Harokopio University of Athens (GR)
National and Kapodistrian University of Athens (GR)
Corresponding author: Kalogeropoulos, Nick
ORCID: Kalogeropoulos, Nick
Panagiotakos, Demosthenes B.
Chrysohoou, Christina
Stefanadis, Christodoulos
Venue: Clinica Chimica Acta
Publisher: Elsevier BV
Published: 2010-04
Volume: 411
Issue: 7-8
Pages: 584-591
ISSN: 0009-8981 (ISSN-L)
DOI: 10.1016/j.cca.2010.01.023
OpenAlex: W2022669384
Cited by: 160
References: 33
Citations by year: 2026: 2 · 2025: 5 · 2024: 6 · 2023: 8 · 2022: 9 · 2021: 5 · 2020: 9 · 2019: 8 · 2018: 7 · 2017: 4 · 2016: 17 · 2015: 17 · 2014: 13 · 2013: 22 · 2012: 15
FWCI: 14.56
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Clinica Chimica Acta (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Nursing › Nutrition and Dietetics › Fatty Acid Research and Health
Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Nutritional Studies and Diet
Health Sciences › Medicine › Pharmacology (medical) › Inflammatory mediators and NSAID effects
Keywords: unsaturated fatty acids, n-6/n-3 ratio, plasma fatty acids, dietary fatty acids, inflammatory markers, coagulation markers, C-reactive protein, interleukin-6, TNF-α, fibrinogen, homocysteine, monounsaturated fatty acids, atherosclerosis, ATTICA study
MeSH terms: Adult, Blood Coagulation, C-Reactive Protein, Chromatography, Gas, Female, Fibrinogen, Homocysteine, Humans, Inflammation, Male, Reference Values, Regression Analysis, Sensitivity and Specificity, Tumor Necrosis Factor-alpha, Biomarkers, Fatty Acids, Omega-3, Interleukin-6, Dietary Supplements, Fatty Acids, Omega-6

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Unsaturated fatty acids are inversely associated and n-6/n-3 ratios are positively related to inflammation and coagulation markers in plasma of apparently healthy adults

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