Higher cerebrospinal fluid to plasma ratio of p-cresol sulfate and indoxyl sulfate in patients with Parkinson’s disease

Intestinal microbiota metabolism of l-carnitine, a nutrient in red meat, promotes atherosclerosis

Koeth, R. A., Wang, Z., Levison, B. S., Buffa, J. A., Org, E., Sheehy, B. T., Britt, E. B., Fu, X., Wu, Y., Li, L., et al. (2013) · Nature Medicine · doi:10.1038/nm.3145 · Cited by 4,386 · see citing works

A novel automated direct measurement method for total antioxidant capacity using a new generation, more stable ABTS radical cation

Erel, Ö. (2004) · Clinical Biochemistry · doi:10.1016/j.clinbiochem.2003.11.015 · Cited by 2,940 · see citing works

Gut Microbial Metabolite TMAO Enhances Platelet Hyperreactivity and Thrombosis Risk

Zhu, W., Gregory, J. C., Org, E., Buffa, J. A., Gupta, N., Wang, Z., Li, L., Fu, X., Wu, Y., Mehrabian, M., et al. (2016) · Cell · doi:10.1016/j.cell.2016.02.011 · Cited by 1,968 · see citing works

Penetration of Drugs through the Blood-Cerebrospinal Fluid/Blood-Brain Barrier for Treatment of Central Nervous System Infections

Nau, R., Sörgel, F., & Eiffert, H. (2010) · Clinical Microbiology Reviews · doi:10.1128/cmr.00007-10 · Cited by 1,031 · see citing works

Improved accuracy of clinical diagnosis of Lewy body Parkinson’s disease

Hughes, A. J., Daniel, S. E., & Lees, A. J. (2001) · Neurology · doi:10.1212/wnl.57.8.1497 · Cited by 807 · see citing works

Impact of microbiota on central nervous system and neurological diseases: the gut-brain axis

Ma, Q., Xing, C., Long, W., Wang, H. Y., Liu, Q., & Wang, R. (2019) · Journal of Neuroinflammation · doi:10.1186/s12974-019-1434-3 · Cited by 752 · see citing works

Implication of Trimethylamine N-Oxide (TMAO) in Disease: Potential Biomarker or New Therapeutic Target

Janeiro, M., Ramírez, M., Milagro, F., Martínez, J., & Solas, M. (2018) · Nutrients · doi:10.3390/nu10101398 · Cited by 631 · see citing works

Time-course analysis of hepcidin, serum iron, and plasma cytokine levels in humans injected with LPS

Kemna, E., Pickkers, P., Nemeth, E., van der Hoeven, H., & Swinkels, D. (2005) · Blood · doi:10.1182/blood-2005-03-1159 · Cited by 498 · see citing works

Impact of chronic dietary red meat, white meat, or non-meat protein on trimethylamine N-oxide metabolism and renal excretion in healthy men and women

Wang, Z., Bergeron, N., Levison, B. S., Li, X. S., Chiu, S., Jia, X., Koeth, R. A., Li, L., Wu, Y., Tang, W. H. W., et al. (2019) · European Heart Journal · doi:10.1093/eurheartj/ehy799 · Cited by 496 · see citing works

Age-associated Physiological and Pathological Changes at the Blood-Brain Barrier: A Review

Erdő, F., Denes, L., & de Lange, E. (2017) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1177/0271678x16679420 · Cited by 426 · see citing works

p-Cresyl Sulfate

Gryp, T., Vanholder, R. C., Vaneechoutte, M., & Glorieux, G. (2017) · Toxins · doi:10.3390/toxins9020052 · Cited by 413 · see citing works

Striatal Blood–Brain Barrier Permeability in Parkinson'S Disease

Gray, M. T., & Woulfe, J. M. (2015) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/jcbfm.2015.32 · Cited by 409 · see citing works

Trimethylamine‐ <i>N</i> ‐oxide (TMAO) response to animal source foods varies among healthy young men and is influenced by their gut microbiota composition: A randomized controlled trial

Cho, C. E., Taesuwan, S., Malysheva, O. V., Bender, E., Tulchinsky, N. F., Yan, J., Sutter, J. L., & Caudill, M. A. (2017) · Molecular Nutrition &amp; Food Research · doi:10.1002/mnfr.201600324 · Cited by 405 · see citing works

p -Cresyl sulfate causes renal tubular cell damage by inducing oxidative stress by activation of NADPH oxidase

Watanabe, H., Miyamoto, Y., Honda, D., Tanaka, H., Wu, Q., Endo, M., Noguchi, T., Kadowaki, D., Ishima, Y., Kotani, S., et al. (2013) · Kidney International · doi:10.1038/ki.2012.448 · Cited by 391 · see citing works

Damage to dopaminergic neurons by oxidative stress in Parkinson's disease (Review)

Guo, J., Zhao, X., Li, Y., Li, G., & Liu, X. (2018) · International Journal of Molecular Medicine · doi:10.3892/ijmm.2018.3406 · Cited by 347 · see citing works

Toxic Dimethylarginines: Asymmetric Dimethylarginine (ADMA) and Symmetric Dimethylarginine (SDMA)

Tain, Y., & Hsu, C. (2017) · Toxins · doi:10.3390/toxins9030092 · Cited by 259 · see citing works

Effect of egg ingestion on trimethylamine-N-oxide production in humans: a randomized, controlled, dose-response study , , ,

Miller, C. A., Corbin, K. D., da Costa, K.-A., Zhang, S., Zhao, X., Galanko, J. A., Blevins, T., Bennett, B. J., O’Connor, A., & Zeisel, S. H. (2014) · The American Journal of Clinical Nutrition · doi:10.3945/ajcn.114.087692 · Cited by 240 · see citing works

The production of p-cresol sulfate and indoxyl sulfate in vegetarians versus omnivores

Patel, K. P., Luo, F. J.-G., Plummer, N. S., Hostetter, T. H., & Meyer, T. W. (2012) · Clinical Journal of the American Society of Nephrology · doi:10.2215/cjn.12491211 · Cited by 226 · see citing works

Role of blood–brain barrier organic anion transporter 3 (OAT3) in the efflux of indoxyl sulfate, a uremic toxin: its involvement in neurotransmitter metabolite clearance from the brain

Ohtsuki, S., Asaba, H., Takanaga, H., Deguchi, T., Hosoya, K., Otagiri, M., & Terasaki, T. (2002) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2002.01108.x · Cited by 216 · see citing works

Indoxyl Sulfate Is a Nephro-Vascular Toxin

Niwa, T. (2010) · Journal of Renal Nutrition · doi:10.1053/j.jrn.2010.05.002 · Cited by 207 · see citing works

Impacts of Indoxyl Sulfate and p-Cresol Sulfate on Chronic Kidney Disease and Mitigating Effects of AST-120

Liu, W.-C., Tomino, Y., & Lu, K. (2018) · Toxins · doi:10.3390/toxins10090367 · Cited by 196 · see citing works

Indoxyl Sulfate Affects Glial Function Increasing Oxidative Stress and Neuroinflammation in Chronic Kidney Disease: Interaction between Astrocytes and Microglia

Adesso, S., Magnus, T., Cuzzocrea, S., Campolo, M., Rissiek, B., Paciello, O., Autore, G., Pinto, A., & Marzocco, S. (2017) · Frontiers in Pharmacology · doi:10.3389/fphar.2017.00370 · Cited by 184 · see citing works

NF-κB plays an important role in indoxyl sulfate-induced cellular senescence, fibrotic gene expression, and inhibition of proliferation in proximal tubular cells

Shimizu, H., Bolati, D., Adijiang, A., Muteliefu, G., Enomoto, A., Nishijima, F., Dateki, M., & Niwa, T. (2011) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00471.2010 · Cited by 178 · see citing works

Blood−brain barrier transporters and response to CNS-active drugs

Urquhart, B. L., & Kim, R. B. (2009) · European Journal of Clinical Pharmacology · doi:10.1007/s00228-009-0714-8 · Cited by 175 · see citing works

The Gut Microbial Metabolite Trimethylamine-N-Oxide Is Present in Human Cerebrospinal Fluid

Del Rio, D., Zimetti, F., Caffarra, P., Tassotti, M., Bernini, F., Brighenti, F., Zini, A., & Zanotti, I. (2017) · Nutrients · doi:10.3390/nu9101053 · Cited by 172 · see citing works

TMAO is Associated with Mortality: Impact of Modestly Impaired Renal Function

Gruppen, E. G., Garcia, E., Connelly, M. A., Jeyarajah, E. J., Otvos, J. D., Bakker, S. J. L., & Dullaart, R. P. F. (2017) · Scientific Reports · doi:10.1038/s41598-017-13739-9 · Cited by 146 · see citing works

Cerebro-renal interactions: Impact of uremic toxins on cognitive function

Watanabe, K., Watanabe, T., & Nakayama, M. (2014) · NeuroToxicology · doi:10.1016/j.neuro.2014.06.014 · Cited by 145 · see citing works

Metabolomics of cerebrospinal fluid reveals changes in the central nervous system metabolism in a rat model of multiple sclerosis

Noga, M. J., Dane, A. D., Shi, S., Attali, A., van Aken, H. H. M., Suidgeest, E., Tuinstra, T., Muilwijk, B., Coulier, L., Luider, T. M., et al. (2011) · Metabolomics · doi:10.1007/s11306-011-0306-3 · Cited by 139 · see citing works

Protein-Bound Uremic Toxins: New Insight from Clinical Studies

Liabeuf, S., Drüeke, T. B., & Massy, Z. A. (2011) · Toxins · doi:10.3390/toxins3070911 · Cited by 137 · see citing works

Parkinson disease with constipation: clinical features and relevant factors

Yu, Q.-J., Yu, S., Zuo, L.-J., Lian, T., Hu, Y., Wang, R., Piao, Y., Guo, P. F., Liu, L., Jin, Z. Y., et al. (2018) · Scientific Reports · doi:10.1038/s41598-017-16790-8 · Cited by 136 · see citing works

Trimethylamine N-Oxide, Circulating Endothelial Progenitor Cells, and Endothelial Function in Patients with Stable Angina

Chou, R., Chen, C., Chen, I., Huang, H.-L., Lu, Y., Kuo, C., Chang, C., Huang, P., Chen, J., & Lin, S. (2019) · Scientific Reports · doi:10.1038/s41598-019-40638-y · Cited by 135 · see citing works

Metabolomic search for uremic toxins as indicators of the effect of an oral sorbent AST-120 by liquid chromatography/tandem mass spectrometry

Kikuchi, K., Itoh, Y., Tateoka, R., Ezawa, A., Murakami, K., & Niwa, T. (2010) · Journal of Chromatography B · doi:10.1016/j.jchromb.2010.09.006 · Cited by 121 · see citing works

The Impact of Uremic Toxins on Cerebrovascular and Cognitive Disorders

Assem, M., Lando, M., Grissi, M., Kamel, S., Massy, Z. A., Chillon, J., & Hénaut, L. (2018) · Toxins · doi:10.3390/toxins10070303 · Cited by 118 · see citing works

Associations of current diet with plasma and urine TMAO in the KarMeN study: direct and indirect contributions

Krüger, R., Merz, B., Rist, M. J., Ferrario, P. G., Bub, A., Kulling, S. E., & Watzl, B. (2017) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.201700363 · Cited by 114 · see citing works

Increased Urinary Indoxyl Sulfate (Indican): New Insights into Gut Dysbiosis in Parkinson’s Disease

Cassani, E., Barichella, M., Cancello, R., Cavanna, F., Iorio, L., Cereda, E., Bolliri, C., Zampella Maria, P., Bianchi, F., Cestaro, B., et al. (2015) · Parkinsonism &amp; Related Disorders · doi:10.1016/j.parkreldis.2015.02.004 · Cited by 108 · see citing works

Pathogenic Mechanisms of Neurodegeneration in Parkinson Disease

Mullin, S., & Schapira, A. H. V. (2015) · Neurologic Clinics · doi:10.1016/j.ncl.2014.09.010 · Cited by 108 · see citing works

Hepcidin, an emerging and important player in brain iron homeostasis

Vela, D. (2018) · Journal of Translational Medicine · doi:10.1186/s12967-018-1399-5 · Cited by 104 · see citing works

Altered Gut Microbiome and Intestinal Pathology in Parkinson’s Disease

Chiang, H., & Lin, C. (2019) · Journal of Movement Disorders · doi:10.14802/jmd.18067 · Cited by 104 · see citing works

The nature, consequences, and management of neurological disorders in chronic kidney disease

Jabbari, B., & Vaziri, N. D. (2017) · Hemodialysis International · doi:10.1111/hdi.12587 · Cited by 100 · see citing works

Expression of Iron Transporters and Pathological Hallmarks of Parkinson’s and Alzheimer’s Diseases in the Brain of Young, Adult, and Aged Rats

Lü, L., Qian, Z., Wu, K.-C., Yung, W., & Ke, Y. (2016) · Molecular Neurobiology · doi:10.1007/s12035-016-0067-0 · Cited by 92 · see citing works

Serum prohepcidin concentration: no association with iron absorption in healthy men; and no relationship with iron status in men carrying HFE mutations, hereditary haemochromatosis patients undergoing phlebotomy treatment, or pregnant women

Roe, M. A., Spinks, C. A., Heath, A. M., Harvey, L. J., Foxall, R., Wimperis, J. Z., Wolf, C., & Fairweather‐Tait, S. J. (2007) · British Journal Of Nutrition · doi:10.1017/s0007114507336829 · Cited by 89 · see citing works

Differential urinary metabolites related with the severity of major depressive disorder

Chen, J., Zhou, C., Zheng, P., Cheng, K., Wang, H., Li, J., Zeng, L., & Xie, P. (2017) · Behavioural Brain Research · doi:10.1016/j.bbr.2017.06.012 · Cited by 86 · see citing works

Mood effects of the amino acids tryptophan and tyrosine

Parker, G. B., & Brotchie, H. (2011) · Acta Psychiatrica Scandinavica · doi:10.1111/j.1600-0447.2011.01706.x · Cited by 85 · see citing works

Potential role of gut microbiota and tissue barriers in Parkinson's disease and amyotrophic lateral sclerosis

Fang, X. (2015) · International Journal of Neuroscience · doi:10.3109/00207454.2015.1096271 · Cited by 84 · see citing works

The uremic toxin indoxyl sulfate interferes with iron metabolism by regulating hepcidin in chronic kidney disease

Hamano, H., Ikeda, Y., Watanabe, H., Horinouchi, Y., Izawa‐Ishizawa, Y., Imanishi, M., Zamami, Y., Takechi, K., Miyamoto, L., Ishizawa, K., et al. (2017) · Nephrology Dialysis Transplantation · doi:10.1093/ndt/gfx252 · Cited by 61 · see citing works

Trimethylamine N-Oxide From Gut Microbiota in Chronic Kidney Disease Patients: Focus on Diet

Moraes, C., Fouque, D. P., Amaral, A. C. F., & Mafra, D. (2015) · Journal of Renal Nutrition · doi:10.1053/j.jrn.2015.06.004 · Cited by 57 · see citing works

Asymmetric dimethylarginine exacerbates Aβ-induced toxicity and oxidative stress in human cell and Caenorhabditis elegans models of Alzheimer disease

Luo, Y., Yue, W., Quan, X., Wang, Y., Zhao, B., & Lu, Z. (2014) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2014.12.002 · Cited by 55 · see citing works

Asymmetrical Dimethylarginine Is Increased in Plasma and Decreased in Cerebrospinal Fluid of Patients with Alzheimer’s Disease

Arlt, S., Schulze, F., Eichenlaub, M., Maas, R., Lehmbeck, J. T., Schwedhelm, E., Jahn, H., & Böger, R. H. (2008) · Dementia and Geriatric Cognitive Disorders · doi:10.1159/000144026 · Cited by 53 · see citing works

Bowel Habits and the Association With Uremic Toxins in Non–Dialysis-Dependent Chronic Kidney Disease Patients

Ramos, C. I., Armani, R. G., Canziani, M. E. F., Dolenga, C. J. R., Nakao, L. S., Campbell, K. L., & Cuppari, L. (2019) · Journal of Renal Nutrition · doi:10.1053/j.jrn.2019.02.004 · Cited by 53 · see citing works

Pesticides, polychlorinated biphenyls and polycyclic aromatic hydrocarbons in cerebrospinal fluid of amyotrophic lateral sclerosis patients: a case-control study

Vinceti, M., Violi, F., Tzatzarakis, M. N., Mandrioli, J., Malagoli, C., Hatch, E. E., Fini, N., Fasano, A., Rakitskii, V. N., Kalantzi, O., et al. (2017) · Environmental Research · doi:10.1016/j.envres.2017.02.025 · Cited by 51 · see citing works

Serum hepcidin but not prohepcidin may be an effective marker for anemia of inflammation (AI)

Sasu, B. J., Li, H., Rose, M. J., Arvedson, T. L., Doellgast, G., & Molineux, G. (2010) · Blood Cells Molecules and Diseases · doi:10.1016/j.bcmd.2010.07.013 · Cited by 43 · see citing works

Cerebrospinal fluid levels of catecholamines and its metabolites in Parkinson's disease: effect of l ‐ DOPA treatment and changes in levodopa‐induced dyskinesia

Andersen, A. D., Blaabjerg, M., Binzer, M., Kamal, A., Thagesen, H., Kjær, T. W., Stenager, E., & Gramsbergen, J. B. (2017) · Journal of Neurochemistry · doi:10.1111/jnc.13997 · Cited by 43 · see citing works

Dimethylarginines, Homocysteine Metabolism, and Cerebrospinal Fluid Markers for Alzheimer's Disease

Arlt, S., Schwedhelm, E., Kölsch, H., Jahn, H., Linnebank, M., Smulders, Y. M., Jessen, F., Böger, R. H., & Popp, J. (2012) · Journal of Alzheimer s Disease · doi:10.3233/jad-2012-112138 · Cited by 39 · see citing works

Indoxyl 3-sulfate stimulates Th17 differentiation enhancing phosphorylation of c-Src and STAT3 to worsen experimental autoimmune encephalomyelitis

Hwang, S., Hwang, Y.-J., Yun, M.-O., Kim, J.-H., Oh, G.-S., & Park, J. (2013) · Toxicology Letters · doi:10.1016/j.toxlet.2013.04.016 · Cited by 38 · see citing works

Serum and cerebrospinal fluid concentrations of homoarginine, arginine, asymmetric and symmetric dimethylarginine, nitrite and nitrate in patients with multiple sclerosis and neuromyelitis optica

Haghikia, A., Kayacelebi, A. A., Beckmann, B., Hanff, E., Gold, R., Haghikia, A., & Tsikas, D. (2015) · Amino Acids · doi:10.1007/s00726-015-2015-0 · Cited by 36 · see citing works

Increased risks of parkinsonism in the 3 years after chronic renal failure

Lin, H., Lin, H.-C., & Chen, Y.-H. (2012) · International Journal of Clinical Practice · doi:10.1111/j.1742-1241.2012.02896.x · Cited by 33 · see citing works

Brain Atrophy and Cognitive Impairment in Chronic Kidney Disease

Tsuruya, K., & Yoshida, H. (2018) · Contributions to nephrology · doi:10.1159/000485694 · Cited by 31 · see citing works

Nitric Oxide Dysregulation in Patients With Heart Failure

Mommersteeg, P. M. C., Schoemaker, R. G., Eisel, U. L. M., Garrelds, I. M., Schalkwijk, C. G., & Kop, W. J. (2015) · Psychosomatic Medicine · doi:10.1097/psy.0000000000000162 · Cited by 30 · see citing works

Motor fluctuations and dyskinesias in advanced/end stage Parkinson’s disease: a study from a population of brain donors

Papapetropoulos, S., & Mash, D. C. (2006) · Journal of Neural Transmission · doi:10.1007/s00702-006-0603-6 · Cited by 20 · see citing works

Correlation of the L-Arginine Pathway with Thrombo-Inflammation May Contribute to the Outcome of Acute Ischemic Stroke

Molnár, T., Pusch, G., Nagy, L., Kéki, S., Berki, T., & Illés, Z. (2016) · Journal of Stroke and Cerebrovascular Diseases · doi:10.1016/j.jstrokecerebrovasdis.2016.05.018 · Cited by 20 · see citing works

Higher serum levels of pro-hepcidin in patients with Parkinson’s disease treated with deep brain stimulation

Kwiatek-Majkusiak, J., Geremek, M., Koziorowski, D., Tomasiuk, R., Szlufik, S., & Friedman, A. (2018) · Neuroscience Letters · doi:10.1016/j.neulet.2018.06.031 · Cited by 19 · see citing works

High asymmetric dimethylarginine, symmetric dimethylarginine and L-arginine levels in migraine patients

Reyhani, A., Çelik, Y., Karadağ, Ç. H., Gündüz, Ö., Asıl, T., & Süt, N. (2017) · Neurological Sciences · doi:10.1007/s10072-017-2970-1 · Cited by 18 · see citing works

Permeability of blood–brain barrier in macaque model of 1‐methyl‐4‐phenyl‐1,2,3,6‐tetrahydropyridine‐induced Parkinson disease

Thiollier, T., Wu, C., Contamin, H., Li, Q., Zhang, J., & Bézard, E. (2016) · Synapse · doi:10.1002/syn.21889 · Cited by 13 · see citing works

Reversible parkinsonism with lentiform fork sign as an initial and dominant manifestation of uremic encephalopathy

Park, J., Kim, S.-U., Choi, J., Jung, J., Kwon, D., & Park, M. H. (2015) · Journal of the Neurological Sciences · doi:10.1016/j.jns.2015.08.002 · Cited by 7 · see citing works

Evaluation of serum hepcidin concentrations in Parkinson’s disease patients

Manolov, V., Hadjidekova, S. P., Petrova, J., Vasilev, V., Petrova, M., Kunchev, T., Jelev, Y., Jeliazkov, P., Gramatikova, Z., Voleva, S., et al. (2018) · Parkinsonism & Related Disorders · doi:10.1016/j.parkreldis.2017.11.257 · Cited by 1 · see citing works

Microbiota–gut–brain axis and its therapeutic applications in neurodegenerative diseases

Loh, J. S., Mak, W. Q., Tan, L. K. S., Ng, C. X., Chan, H. H., Yeow, S. H., Foo, J. B., Ong, Y. S., How, C. W., & Khaw, K. Y. (2024) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-024-01743-1 · Cited by 1,193 · see citing works

A gut-derived metabolite alters brain activity and anxiety behaviour in mice

Needham, B. D., Funabashi, M., Adame, M. D., Wang, Z., Boktor, J. C., Haney, J., Wu, W.-L., Rabut, C., Ladinsky, M. S., Hwang, S.-J., et al. (2022) · Nature · doi:10.1038/s41586-022-04396-8 · Cited by 489 · see citing works

Microbiota-derived metabolites as drivers of gut–brain communication

Ahmed, H., Leyrolle, Q., Koistinen, V., Kärkkäinen, O., Layé, S., Delzenne, N., & Hanhineva, K. (2022) · Gut Microbes · doi:10.1080/19490976.2022.2102878 · Cited by 462 · see citing works

The microbiome–gut–brain axis in Parkinson disease — from basic research to the clinic

Tan, A. H., Lim, S. Y., & Lang, A. E. (2022) · Nature Reviews Neurology · doi:10.1038/s41582-022-00681-2 · Cited by 392 · see citing works

Comprehensive metabolic profiling of Parkinson’s disease by liquid chromatography-mass spectrometry

Shao, Y., Li, T., Liu, Z., Wang, X., Xu, X., Li, S., Xu, G., & Le, W. (2021) · Molecular Neurodegeneration · doi:10.1186/s13024-021-00425-8 · Cited by 226 · see citing works

The Role of Gut Bacterial Metabolites in Brain Development, Aging and Disease

Tran, S. M.-S., & Mohajeri, M. H. (2021) · Nutrients · doi:10.3390/nu13030732 · Cited by 207 · see citing works

Microbial-derived metabolites as a risk factor of age-related cognitive decline and dementia

Connell, E., Le Gall, G., Pontifex, M. G., Sami, S., Cryan, J. F., Clarke, G., Müller, M., & Vauzour, D. (2022) · Molecular Neurodegeneration · doi:10.1186/s13024-022-00548-6 · Cited by 208 · see citing works

Gut Microbial Ecosystem in Parkinson Disease: New Clinicobiological Insights from Multi‐Omics

Tan, A. H., Chong, C. W., Lim, S., Yap, I. K. S., Teh, C. S. J., Loke, M. F., Song, S., Tan, J. Y., Ang, B. H., Tan, Y. Q., et al. (2021) · Annals of Neurology · doi:10.1002/ana.25982 · Cited by 196 · see citing works

Parkinson’s disease and gut microbiota: from clinical to mechanistic and therapeutic studies

Zhang, X., Tang, B., & Guo, J. (2023) · Translational Neurodegeneration · doi:10.1186/s40035-023-00392-8 · Cited by 205 · see citing works

Implications of Gut Microbiota in Neurodegenerative Diseases

Zhang, H., Chen, Y., Wang, Z., Xie, G., Liu, M., Yuan, B., Chai, H., Wang, W., & Cheng, P. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.785644 · Cited by 157 · see citing works

Boundaries and integration between microbiota, the nervous system, and immunity

Macpherson, A. J., Pachnis, V., & Prinz, M. (2023) · Immunity · doi:10.1016/j.immuni.2023.07.011 · Cited by 117 · see citing works

The Role of a Gut Microbial-Derived Metabolite, Trimethylamine N-Oxide (TMAO), in Neurological Disorders

Praveenraj, S. S., Sonali, S., Anand, N., Hediyal, T. A., Vichitra, C., Kalyan, M., Kanna, P. V., Chandana, K. A., Paneyala, S., Mahalakshmi, A. M., et al. (2022) · Molecular Neurobiology · doi:10.1007/s12035-022-02990-5 · Cited by 111 · see citing works

Chronic kidney disease and neurological disorders: are uraemic toxins the missing piece of the puzzle?

Liabeuf, S., Pépin, M., Franssen, C. F. M., Viggiano, D., Carriazo, S. M., Gansevoort, R. T., Gesualdo, L., Hafez, G., Małyszko, J., Mayer, C. C., et al. (2021) · Nephrology Dialysis Transplantation · doi:10.1093/ndt/gfab223 · Cited by 105 · see citing works

Bacterial neurotoxic metabolites in multiple sclerosis cerebrospinal fluid and plasma

Ntranos, A., Park, H.-J., Wentling, M., Tolstikov, V., Amatruda, M., Inbar, B., Kim‐Schulze, S., Frazier, C., Button, J., Kiebish, M. A., et al. (2021) · Brain · doi:10.1093/brain/awab320 · Cited by 101 · see citing works

Multi-omic evaluation of metabolic alterations in multiple sclerosis identifies shifts in aromatic amino acid metabolism

Fitzgerald, K. C., Smith, M. D., Kim, S., Sotirchos, E. S., Kornberg, M. D., Douglas, M., Nourbakhsh, B., Graves, J. S., Rattan, R., Poisson, L., et al. (2021) · Cell Reports Medicine · doi:10.1016/j.xcrm.2021.100424 · Cited by 99 · see citing works

p-Cresol Sulfate Caused Behavior Disorders and Neurodegeneration in Mice with Unilateral Nephrectomy Involving Oxidative Stress and Neuroinflammation

Sun, C., Li, J., Wang, Y., Lin, S., Ou, Y., Lin, C., Wang, J., Liao, S., & Chen, C. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21186687 · Cited by 98 · see citing works

Untargeted serum metabolomics reveals novel metabolite associations and disruptions in amino acid and lipid metabolism in Parkinson’s disease

Paul, K. C., Zhang, K., Walker, D. I., Sinsheimer, J. S., Yu, Y., Kusters, C., Rosario, I. D., Folle, A. D., Keener, A. M., Bronstein, J. M., et al. (2023) · Molecular Neurodegeneration · doi:10.1186/s13024-023-00694-5 · Cited by 92 · see citing works

The gut microbiota derived metabolite trimethylamine N-oxide: Its important role in cancer and other diseases

Zhou, Y., Zhang, Y., Jin, S., Lv, J., Li, M., & Feng, N. (2024) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2024.117031 · Cited by 92 · see citing works

Indoxyl sulfate caused behavioral abnormality and neurodegeneration in mice with unilateral nephrectomy

Sun, C., Li, J., Wang, Y., Lin, S., Ou, Y., Lin, C., Wang, J., Liao, S., & Chen, C. (2021) · Aging · doi:10.18632/aging.202523 · Cited by 78 · see citing works

Gut Microbiota-Derived Metabolite Trimethylamine N-Oxide as a Biomarker in Early Parkinson’s Disease

Chung, S. J., Rim, J. H., Ji, D., Lee, S., Yoo, H. S., Jung, J. H., Baik, K., Choi, Y., Ye, B. S., Sohn, Y. H., et al. (2021) · Nutrition · doi:10.1016/j.nut.2020.111090 · Cited by 74 · see citing works

Gut microenvironmental changes as a potential trigger in Parkinson’s disease through the gut–brain axis

Chen, S., & Lin, C. (2022) · Journal of Biomedical Science · doi:10.1186/s12929-022-00839-6 · Cited by 81 · see citing works

Clinical significance and potential role of trimethylamine N-oxide in neurological and neuropsychiatric disorders

Mudimela, S., Vishwanath, N. K., Pillai, A., Morales, R., Marrelli, S. P., Barichello, T., & Giridharan, V. V. (2022) · Drug Discovery Today · doi:10.1016/j.drudis.2022.08.002 · Cited by 70 · see citing works

The Gut Metabolite Trimethylamine N‐oxide Is Associated With Parkinson's Disease Severity and Progression

Chen, S., Kuo, C., Kuo, H., Chen, C., Wu, W., Liou, J., Wu, M., & Lin, C. (2020) · Movement Disorders · doi:10.1002/mds.28246 · Cited by 65 · see citing works

Balancing the Equation: A Natural History of Trimethylamine and Trimethylamine-N-oxide

Loo, R. L., Chan, Q. M., Nicholson, J. K., & Holmes, E. C. (2022) · Journal of Proteome Research · doi:10.1021/acs.jproteome.1c00851 · Cited by 60 · see citing works

The Impact of Gut Microbiota-Derived Metabolites in Autism Spectrum Disorders

Marzal, L. N. P., Prince, N., Bajić, D., Roussin, L., Naudon, L., Rabot, S., Garssen, J., Kraneveld, A. D., & Perez‐Pardo, P. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms221810052 · Cited by 63 · see citing works

The Role of Bacterial-Derived Aromatic Amino Acids Metabolites Relevant in Autism Spectrum Disorders: A Comprehensive Review

Zheng, Y., Bek, M. K., Prince, N., Marzal, L. N. P., Garssen, J., Perez‐Pardo, P., & Kraneveld, A. D. (2021) · Frontiers in Neuroscience · doi:10.3389/fnins.2021.738220 · Cited by 58 · see citing works

Trimethylamine N-Oxide Exacerbates Neuroinflammation and Motor Dysfunction in an Acute MPTP Mice Model of Parkinson’s Disease

Quan, W., Qiao, C.-M., Niu, G.-Y., Wu, J., Zhao, L.-P., Cui, C., Zhao, W.-J., & Shen, Y.-Q. (2023) · Brain Sciences · doi:10.3390/brainsci13050790 · Cited by 49 · see citing works

Stroke and Vascular Cognitive Impairment: The Role of Intestinal Microbiota Metabolite TMAO

Tu, R., & Xia, J. (2024) · CNS &amp; Neurological Disorders - Drug Targets · doi:10.2174/1871527322666230203140805 · Cited by 47 · see citing works

Effect of uremic toxins on hippocampal cell damage: analysis in vitro and in rat model of chronic kidney disease

Watanabe, K., Sato, E., Mishima, E., Watanabe, M., Abe, T., Takahashi, N., & Nakayama, M. (2021) · Heliyon · doi:10.1016/j.heliyon.2021.e06221 · Cited by 43 · see citing works

Orally Induced High Serum Level of Trimethylamine N-oxide Worsened Glial Reaction and Neuroinflammation on MPTP-Induced Acute Parkinson’s Disease Model Mice

Qiao, C.-M., Quan, W., Zhou, Y., Niu, G.-Y., Hong, H., Wu, J., Zhao, L.-P., Li, T., Cui, C., Zhao, W.-J., et al. (2023) · Molecular Neurobiology · doi:10.1007/s12035-023-03392-x · Cited by 45 · see citing works

Gut-brain axis: gut dysbiosis and psychiatric disorders in Alzheimer’s and Parkinson’s disease

Denman, C. R., Park, S. M., & Jo, J. (2023) · Frontiers in Neuroscience · doi:10.3389/fnins.2023.1268419 · Cited by 43 · see citing works

The metabolite p ‐cresol impairs dendritic development, synaptogenesis, and synapse function in hippocampal neurons: Implications for autism spectrum disorder

Guzmán‐Salas, S., Weber, A., Malci, A., Lin, X., Herrera‐Molina, R., Cerpa, W. F., Dorador, C., Signorelli, J. R., & Zamorano, P. L. (2022) · Journal of Neurochemistry · doi:10.1111/jnc.15604 · Cited by 39 · see citing works

The Metabolomic Approach Reveals the Alteration in Human Serum and Cerebrospinal Fluid Composition in Parkinson’s Disease Patients

Plewa, S., Popławska-Domaszewicz, K., Florczak‐Wyspianska, J., Klupczyńska, A., Sokół, B., Miltyk, W., Jankowski, R., Kozubski, W. P., Kokot, Z. J., & Matysiak, J. (2021) · Pharmaceuticals · doi:10.3390/ph14090935 · Cited by 35 · see citing works

Targeted metabolomic analysis in Parkinson’s disease brain frontal cortex and putamen with relation to cognitive impairment

Kalecký, K., & Bottiglieri, T. (2023) · npj Parkinson's Disease · doi:10.1038/s41531-023-00531-y · Cited by 32 · see citing works

Clostridioides difficile infection dysregulates brain dopamine metabolism

Vinithakumari, A. A., Padhi, P., Hernandez, B., Lin, S. J.-H., Dunkerson-Kurzhumov, A., Showman, L., Breitzman, M., Stokes, C., Sulaiman, Y., Tangudu, C., et al. (2022) · Microbiology Spectrum · doi:10.1128/spectrum.00073-22 · Cited by 31 · see citing works

The Autism Spectrum Disorder-Associated Bacterial Metabolite p-Cresol Derails the Neuroimmune Response of Microglial Cells Partially via Reduction of ADAM17 and ADAM10

Zheng, Y., Prince, N., Marzal, L. N. P., Ahmed, S., Garssen, J., Perez‐Pardo, P., & Kraneveld, A. D. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms231911013 · Cited by 30 · see citing works

Plasma metabolites of aromatic amino acids associate with clinical severity and gut microbiota of Parkinson’s disease

Chen, S., Wu, Y., Chen, C., Wu, Y., Liou, J., Wu, M., Kuo, C., & Lin, C. (2023) · npj Parkinson s Disease · doi:10.1038/s41531-023-00612-y · Cited by 28 · see citing works

The relationship between Parkinson’s disease and gastrointestinal diseases

Zeng, J., Wang, X., Pan, F., & Mao, Z. (2022) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2022.955919 · Cited by 26 · see citing works

Review of Elevated Para-Cresol in Autism and Possible Impact on Symptoms

Flynn, C. K., Adams, J. B., Krajmalnik‐Brown, R., Khoruts, A., Sadowsky, M. J., Nirmalkar, K., Takyi, E., & Whiteley, P. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26041513 · Cited by 25 · see citing works

Neuroactive metabolites and bile acids are altered in extremely premature infants with brain injury

Pristner, M., Wasinger, D., Seki, D., Klebermaß-Schrehof, K., Berger, A., Berry, D., Wisgrill, L., & Warth, B. (2024) · Cell Reports Medicine · doi:10.1016/j.xcrm.2024.101480 · Cited by 22 · see citing works

Causal effect of gut‐microbiota‐derived metabolite trimethylamine N‐oxide on Parkinson's disease: A Mendelian randomization study

Zhou, H., Luo, Y., Zhang, W., Xie, F., Deng, C., Zheng, W., Zhu, S., & Wang, Q. (2023) · European Journal of Neurology · doi:10.1111/ene.15702 · Cited by 21 · see citing works

Neuroinflammation in kidney disease and dialysis

Chagas, Y. E. W., de Castro, P. A. S. V., & Silva, A. C. S. E. (2025) · Behavioural Brain Research · doi:10.1016/j.bbr.2025.115465 · Cited by 19 · see citing works

Relationship between Excreted Uremic Toxins and Degree of Disorder of Children with ASD

Osredkar, J., Gantar, B. Ž. B., Finderle, P., Bobrowska‐Korczak, B., Gątarek, P., Rosiak, A., Giebułtowicz, J., Vrhovšek, M. J., & Kałużna‐Czaplińska, J. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24087078 · Cited by 19 · see citing works

Elevation of Gut-Derived p-Cresol During Spaceflight and its Effect on Drug Metabolism and Performance in AstronautsPreprint

Schmidt, M. A., Meydan, C., Schmidt, C. M., Afshinnekoo, E., & Mason, C. E. (2020) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2020.11.10.374645 · Cited by 19 · see citing works

Trimethylamine N-Oxide as a Mediator Linking Peripheral to Central Inflammation: An In Vitro Study

Janeiro, M. H., Solas, M., Orbe, J., Rodríguez, J. A., de Muniain, L. S., Escalada, P., Yip, P. K., & Ramírez, M. J. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms242417557 · Cited by 18 · see citing works

α-synuclein overexpression and the microbiome shape the gut and brain metabolome in mice

Morais, L. H., Boktor, J. C., MahmoudianDehkordi, S., Kaddurah-Daouk, R. F., & Mazmanian, S. K. (2024) · npj Parkinson s Disease · doi:10.1038/s41531-024-00816-w · Cited by 18 · see citing works

Assessment of trimethylamine-N-oxide at the blood-cerebrospinal fluid barrier: Results from 290 lumbar punctures

Enko, D., Zelzer, S., Niedrist, T., Holasek, S. J., Baranyi, A., Schnedl, W. J., Herrmann, M., & Meinitzer, A. (2020) · EXCLI journal · doi:10.17179/excli2020-2763 · Cited by 17 · see citing works

Comparative plasma metabolomic analysis to identify biomarkers for lead-induced cognitive impairment

Wang, Y., Nong, Y., Zhang, X., Mai, T., Cai, J., Liu, J., Lai, K. P., & Zhang, Z. (2022) · Chemico-Biological Interactions · doi:10.1016/j.cbi.2022.110143 · Cited by 17 · see citing works

TMAO promotes dementia progression by mediating the PI3K/Akt/mTOR pathway

Hu, X., Zhang, Y., Gu, C., Gu, C., Yao, Y., Yao, Y., Luo, L., & Zhang, Y. (2023) · Tissue and Cell · doi:10.1016/j.tice.2023.102034 · Cited by 17 · see citing works

Decoding TMAO in the Gut-Organ Axis: From Biomarkers and Cell Death Mechanisms to Therapeutic Horizons

Liu, J., Ge, P., Luo, Y., Sun, Z., Luo, X., Li, H., Pei, B., Xun, L., Zhang, X., Jiang, Y., et al. (2025) · Drug Design Development and Therapy · doi:10.2147/dddt.s512207 · Cited by 19 · see citing works

High levels of Bifidobacteriaceae are associated with the pathogenesis of Parkinson’s disease

Zuo, S., Wang, H., Zhao, Q., Tang, J., Wang, M., Zhang, Y., Sang, M., Tian, J., & Wang, P. (2023) · Frontiers in Integrative Neuroscience · doi:10.3389/fnint.2022.1054627 · Cited by 15 · see citing works

DDAH-1 maintains endoplasmic reticulum-mitochondria contacts and protects dopaminergic neurons in Parkinson’s disease

Zhao, Y., Shen, W., Zhang, M., Guo, M., Dou, Y., Han, S., Yu, J., Cui, M., & Zhao, Y. (2024) · Cell Death and Disease · doi:10.1038/s41419-024-06772-w · Cited by 15 · see citing works

Trimethylamine-N-oxide aggravated the sympathetic excitation in D-galactose induced aging rats by down-regulating P2Y12 receptor in microglia

Wang, P., Mi, Y., Yu, H. N., Teng, X., Jin, S., Xiao, L., Xue, H., Tian, D., Guo, Q., & Wu, Y. (2024) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2024.116549 · Cited by 14 · see citing works

Effects of p-Cresol on Senescence, Survival, Inflammation, and Odontoblast Differentiation in Canine Dental Pulp Stem Cells

Zayed, M., & Iohara, K. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21186931 · Cited by 13 · see citing works

A metabolomics study in aqueous humor discloses altered arginine metabolism in Parkinson’s disease

Serrano‐Marín, J., Marín, S., Bernal‐Casas, D., Lillo, A., González‐Subías, M., Navarro, G., Cascante, M., Sánchez-Navés, J., & Franco, R. (2023) · Fluids and Barriers of the CNS · doi:10.1186/s12987-023-00494-5 · Cited by 13 · see citing works

Determination of Trimethylamine N-oxide and Betaine in Serum and Food by Targeted Metabonomics

He, M., Yu, H., Peng, L., Huang, S., Ren, J., Fan, W., Han, L., Yu, H., Wang, Y., Ren, M. Q., et al. (2021) · Molecules · doi:10.3390/molecules26051334 · Cited by 13 · see citing works

Implications of Gut Microbiota-Derived Metabolites in Neurological Disorders

Dalal, N., Jaiswal, J., Kushwaha, M., Verma, H., Rana, P., Gupta, S., Panwar, R., Janmeda, P., Jain, P., Singh, A. K., et al. (2025) · ACS Chemical Neuroscience · doi:10.1021/acschemneuro.5c00414 · Cited by 12 · see citing works

Integrative Metabolome and Proteome Analysis of Cerebrospinal Fluid in Parkinson’s Disease

Kim, S. G., Hwang, J. S., George, N. P., Jang, Y. E., Kwon, M., Lee, S. S., & Lee, G. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms252111406 · Cited by 12 · see citing works

Impact of Alterations in Homocysteine, Asymmetric Dimethylarginine and Vitamins-Related Pathways in Some Neurodegenerative Diseases: A Narrative Review

Saija, C., Currò, M., Ientile, R., Caccamo, D., & Bertuccio, M. P. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26083672 · Cited by 11 · see citing works

LC-MS/MS Determination of Modified Nucleosides in The Urine of Parkinson’s Disease and Parkinsonian Syndromes Patients

Gątarek, P., Kałużna‐Czaplińska, J., Pawelczyk, M., Jastrzębski, K., Giebułtowicz, J., Glabinski, A. R., & Bobrowska‐Korczak, B. (2020) · Molecules · doi:10.3390/molecules25214959 · Cited by 11 · see citing works

Gut microbiota and Parkinson’s disease: exploring pathogenesis and potential therapeutic strategies from a gut-brain axis perspective

Jin, X., Wei, J., Min, X., Fan, Y., Yuan, Z., Du, Z., Su, Z., Xun, T., Du, Q., Liang, T., et al. (2025) · iScience · doi:10.1016/j.isci.2025.114185 · Cited by 10 · see citing works

Indoxyl Sulfate and Autism Spectrum Disorder: A Literature Review

Hill, Z. R., Flynn, C. K., & Adams, J. B. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms252312973 · Cited by 10 · see citing works

CuO nanoparticles adorned anodic WO3 nanosheets: Facile synthesis and electrochemical sensing of tyrosine biomarker

Ghazi, R., Ali, G., Cho, S. O., Al‐Zaqri, N., & Rehman, Z. (2025) · Journal of Molecular Structure · doi:10.1016/j.molstruc.2025.141980 · Cited by 10 · see citing works

The interaction between intestinal bacterial metabolites and phosphatase and tensin homolog in autism spectrum disorder

Zheng, Y., Prince, N., van Hattem, C., Garssen, J., Perez‐Pardo, P., & Kraneveld, A. D. (2022) · Molecular and Cellular Neuroscience · doi:10.1016/j.mcn.2022.103805 · Cited by 10 · see citing works

Gut microbiota dysbiosis and neurologic diseases: New Horizon with potential diagnostic and therapeutic impact

Keshavarzian, A., & Sisodia, S. S. (2024) · Neurotherapeutics · doi:10.1016/j.neurot.2024.e00478 · Cited by 10 · see citing works

Trimethylamine-N-oxide damages astrocytes and lymphatic endothelial cells in the cerebral lymphatic system

Su, M., Duan, H.-S., Wang, Q.-L., Zhang, Y., Shi, X.-M., Zeng, J., Tan, W.-N., Chang, Y., & Wang, S. (2025) · IBRO Neuroscience Reports · doi:10.1016/j.ibneur.2025.09.001 · Cited by 8 · see citing works

Para-Cresol and the Brain: Emerging Role in Neurodevelopmental and Neurodegenerative Disorders and Therapeutic Perspectives

Bertarini, L., Imbeni, F., Brighenti, V., Martusciello, I., Pellati, F., & Alboni, S. (2025) · ACS Pharmacology & Translational Science · doi:10.1021/acsptsci.5c00289 · Cited by 8 · see citing works

Enrichment of gut-derived metabolites in a Parkinson’s disease subtype with REM sleep behavior disorder

Lee, S., Kim, J. H., Baek, J. W., Jung, K.-Y., Lee, Y., Koh, A., & Kim, H. (2025) · npj Parkinson s Disease · doi:10.1038/s41531-025-01040-w · Cited by 7 · see citing works

Plasma Metabolomics Profiles in Prodromal and Clinical Parkinson's Disease

Flores‐Torres, M. H., Peng, X., Jeanfavre, S., Clish, C. B., Wang, Y., McCullough, M. L., Healy, B. C., Schwarzschild, M. A., Bjørnevik, K., & Ascherio, A. (2025) · Movement Disorders · doi:10.1002/mds.30308 · Cited by 7 · see citing works

The role of neuroimmune and inflammation in pediatric uremia-induced neuropathy

Zhu, L., Tong, G., Yang, F., Zhao, Y., & Chen, G. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.1013562 · Cited by 7 · see citing works

Small phenolic and indolic gut-dependent molecules in the primate central nervous system: levels vs. bioactivity

Jaskiw, G. E., Xu, D., Obrenovich, M. E., & Donskey, C. J. (2022) · Metabolomics · doi:10.1007/s11306-021-01866-4 · Cited by 7 · see citing works

Circulatory dietary and gut-derived metabolites predict early cognitive decline

Connell, E., Sami, S. A. K., Khondoker, M. R., Minihane, A. M., Pontifex, M. G., Müller, M. M., McArthur, S., Gall, G. L., & Vauzour, D. (2026) · Gut Microbes · doi:10.1080/19490976.2026.2649487 · Cited by 6 · see citing works

The role of indole metabolites derived from gut microbiota in Parkinson's disease: A comprehensive review

Meng, S. (2026) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2026.111775 · Cited by 6 · see citing works

The measured CSF/plasma donepezil concentration ratio but not individually measured CSF and plasma concentrations significantly increase over 24 h after donepezil treatment in patients with Alzheimer’s disease

Vališ, M., Dlabková, A., Hort, J., Angelucci, F., Pejchal, J., Kuča, K., Pavelek, Z., Karasová, J. Ž., & Novotný, M. (2023) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2023.114223 · Cited by 5 · see citing works

Total analysis system for the determination of uremic toxins in human plasma based on bead injection solid phase extraction hyphenated to mass spectrometry

Fernandes, S. R., Barreiros, L., Sampaio‐Maia, B., Miró, M., & Segundo, M. A. (2023) · Analytica Chimica Acta · doi:10.1016/j.aca.2023.341668 · Cited by 4 · see citing works

Gut Microbes in Parkinson's Disease

Markidi, A., Elford, J. D., Berkers, C. R., Kraneveld, A. D., & Perez‐Pardo, P. (2024) · Elsevier eBooks · doi:10.1016/b978-0-323-99971-7.00002-3 · Cited by 4 · see citing works

Plasma and Visceral Organ Kynurenine Metabolites Correlate in the Multiple Sclerosis Cuprizone Animal Model

Polyák, H., Galla, Z., Rajda, C., Monostori, P. B., Klivènyi, P., & Vécsei, L. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26030976 · Cited by 4 · see citing works

β-Cyclodextrin with Sodium Alginate based Nanosponges Preparation and Characterization in the Removal of Organic Toxin: p-Cresol in the Simulated Biological Fluids

Azeez, S. A., Sultana, A., & Hajera, A. (2022) · Asian Journal of Research in Pharmaceutical Sciences · doi:10.52711/2231-5659.2022.00045 · Cited by 4 · see citing works

Circulatory dietary and gut-derived metabolites predict preclinical Alzheimer’s diseasePreprint

Connell, E., Sami, S. A. K., Khondoker, M. R., Minihane, A. M., Pontifex, M. G., Müller, M. M., McArthur, S., Gall, G. L., & Vauzour, D. (2024) · medRxiv · doi:10.1101/2024.05.10.24307050 · Cited by 4 · see citing works

Higher p-Cresol sulfate and tumor necrosis factor (TNF)-α levels are associated with cognitive improvement through increased TNF receptor 2 in individuals with mild cognitive impairment: A cross-sectional mediation analysis

Azargoonjahromi, A., Nasiri, H., & Initiative, A. D. N. (2025) · Journal of Alzheimer s Disease Reports · doi:10.1177/25424823251362483 · Cited by 3 · see citing works

Communication Theoretical Analysis of P-Cresol Signaling in Gut-Brain Axis with Autism Spectrum Disorder

Ortlek, B. E., & Akan, Ö. B. (2023) · International Conference on Communications · doi:10.1109/icc45041.2023.10279237 · Cited by 3 · see citing works

Expansion of a versatile pathogen: Clostridioides difficile

Lucas, T., & Brown, B. (2024) · Hygiene and Environmental Health Advances · doi:10.1016/j.heha.2024.100108 · Cited by 2 · see citing works

Gut bacteria composition in animal models of Parkinson’s disease: a systematic review and meta-analysis

Elford, J. D., Heesbeen, E. J., van der Plaats, N. A., Garssen, J., Kraneveld, A. D., Groenink, L., & Perez‐Pardo, P. (2026) · npj Parkinson s Disease · doi:10.1038/s41531-025-01236-0 · Cited by 2 · see citing works

Immunology and microbiome: Implications for motor systems

Mahjoub, Y., & Martino, D. (2023) · Handbook of clinical neurology · doi:10.1016/b978-0-323-98818-6.00001-7 · Cited by 2 · see citing works

Mendelian randomization analysis of the causal relationship between trimethylamine N oxide and its precursors and Parkinson’s disease

Zhang, B., Zhang, R., Ren, H., Guan, Q., Fan, W., & Han, L. (2024) · Archives of Medical Science · doi:10.5114/aoms/184128 · Cited by 2 · see citing works

Untargeted Plasma Metabolomics Unveils Distinct Metabolite Profiles in Parkinson’s Disease Subtypes: A Focus on idiopathic REM Sleep Behavior DisordersPreprint

Lee, S., Kim, J. H., Baek, J., Jung, K., Lee, Y., Koh, A., & Kim, H. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.05.02.592293 · Cited by 2 · see citing works

Extracorporeal hemoadsorption and neurological disorders: A challenging perspective

Ramírez‐Guerrero, G., Ferri-Cortés, A., Cabrera-Aguilar, J. S., & Ronco, C. (2025) · Journal of Translational Critical Care Medicine · doi:10.1097/jtccm-d-25-00015 · Cited by 1 · see citing works

Therapeutic potential of phytochemicals and role of gut microbiota in neurodegenerative diseases

Gupta, S. K., & Sharma, R. (2025) · Elsevier eBooks · doi:10.1016/b978-0-443-36372-6.00014-8 · Cited by 1 · see citing works

The gut–brain axis and trimethylamine N-oxide: an emergent biomarker in neurological diseases

Arangia, A., Paola, R. D., Cuzzocrea, S., Siracusa, R., D’Amico, R., & Impellizzeri, D. (2026) · Neuroscience · doi:10.1016/j.neuroscience.2026.05.005 · Cited by 1 · see citing works

Parkinson’s disease and inflammatory bowel disease: exploring the connection between the two

Zhou, X., Zhang, X., Liang, H., & Bi, Y. (2026) · Ageing and Neurodegenerative Diseases · doi:10.20517/and.2026.01 · Cited by 1 · see citing works

The microbiome: what a neurologist needs to know

Dehghanizai, A. B., Stewart, C. J., & Thomas, R. H. (2025) · Practical Neurology · doi:10.1136/pn-2024-004400 · Cited by 1 · see citing works

Age-related microbiome metabolites alter RNA splicing and chromatin accessibility in the brainPreprint

Chakraborty, M., Shi, S. M., Porter, I. E., Richard, D. J., Marinov, G. K., Murthy, M. N., Moore, A. A., Blum, J. L. E., Natarajan, A., Jahng, J. W. S., et al. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.10.03.680371 · Cited by 2 · see citing works

Cuantificación del p-cresol sérico y su relación con la masa muscular en pacientes en hemodiálisis

Rojas, M., & Ximena, M. (2020)

Trimethylamine N-Oxide levels increase in patients with severe and non-severe COVID-19

Yasak, İ. H., Yılmaz, M., Ceylan, M. R., Koyuncu, İ., & ŞEYHANLI, E. S. (2023) · The Annals of Clinical and Analytical Medicine · doi:10.4328/acam.21403

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Bidin, M. Z., Shah, A. M., Stanslas, J., Ghani, F. B. A., Goh, B. L., & Lim, C. T. S. (2023) · Nephrology Dialysis Transplantation · doi:10.1093/ndt/gfad063c_5438

Full Validation and Application to Clinical Research of a High-Performance Liquid Chromatography Method for the Assessment of Urinary 3-Indoxyl Sulfate in Pediatric Patients with Hematopoietic Stem Cell Transplant

Olivetti, C. E., Fernández, M. F., Stojanova, J., Ruvinsky, S., Mangano, A. M., & Schaiquevich, P. S. (2024) · Methods and Protocols · doi:10.3390/mps7040064

Research Progress on the Relationship between Gut Microbiome and Parkinson’s Disease

力比奴尔·塞地尔丁, 克. (2024) · Advances in Clinical Medicine · doi:10.12677/acm.2024.14123217

Dual flow-path HPLC method for time-optimised quantification of physicochemically different metabolite classes in human serum samples using a single mass spectrometer

Faist, C., Tacke, E., Eierhoff, T., Oberhuber, A., & Hayen, H. (2025) · Journal of Chromatography A · doi:10.1016/j.chroma.2025.466636

Additional file 1 of Comprehensive metabolic profiling of Parkinson’s disease by liquid chromatography-mass spectrometry

Shao, Y., Li, T., Liu, Z., Wang, X., Xu, X., Li, S., Xu, G., & Le, W. (2021) · Figshare · doi:10.6084/m9.figshare.13634334

Additional file 1 of A metabolomics study in aqueous humor discloses altered arginine metabolism in Parkinson’s disease

Serrano‐Marín, J., Marín, S., Bernal‐Casas, D., Lillo, A., González-Subías, M., Navarro, G., Cascante, M., Sánchez-Navés, J., & Franco, R. (2023) · Figshare · doi:10.6084/m9.figshare.24741892

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Jiménez-Jiménez, F. J., Alonso‐Navarro, H., García‐Martín, E., & Agúndez, J. A. G. (2014) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2014.00369 · Cited by 83 · see citing works

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Shukla, R., RAJANI, M., SRIVASTAVA, N., Barthwal, M. K., & Dikshit, M. (2006) · International Journal of Neuroscience · doi:10.1080/00207450500513989 · Cited by 40 · see citing works

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Björkhem, I., Lövgren‐Sandblom, A., Leoni, V., Meaney, S., Brodin, L., Salveson, L., Winge, K., Pålhagen, S., & Svenningsson, P. (2013) · Neuroscience Letters · doi:10.1016/j.neulet.2013.09.003 · Cited by 112 · see citing works

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Cerebrospinal fluid levels of oxidative stress measured using diacron-reactive oxygen metabolites and biological antioxidant potential in patients with Parkinson’s disease and progressive supranuclear palsy

Takahashi, K., Iwaoka, K., Takahashi, K., Suzuki, Y., Taguchi, K., Yamahara, K., & Maeda, T. (2021) · Neuroscience Letters · doi:10.1016/j.neulet.2021.135975 · Cited by 12 · see citing works