CoChat
Sign Up
Cited by 90

The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.

SNX-1 and RME-8 oppose the assembly of HGRS-1/ESCRT-0 degradative microdomains on endosomes

Norris, Anne, Tammineni, Prasad, Wang, Simon, Gerdes, Julianne, Murr, Alexandra, Kwan, Kelvin Y., Cai, Qian, Grant, Barth D.·2017·Proceedings of the National Academy of Sciences
DOI 10.1073/pnas.1612730114
Open this paper in CoChat — free account

Abstract

Significance: Endosomes are membrane-bound organelles that are important for nutrient uptake, protein and lipid sorting, and signal transduction. When integral membrane proteins have reached the endosomal system, they can be sent to the lysosome for degradation or recycled for reuse. Here we provide insight into how the machinery important for reuse controls the machinery that mediates degradation. We show that these opposing functions occupy physically distinct regions of the endosomes, termed microdomains, and that this separation is likely to provide a physical framework for a variety of sorting decisions.

Overview

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Integrity signals

Registry

Crossref · 10.1073/pnas.1612730114

Cites

2 of 2 references verified0 citation errors · 0 not checkable

Statistics

Verification

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

  • Specific endosomal membrane sub-domains are enriched for either degradative components such as ESCRT or recycling machinery including Retromer, Retriever, the CCC complex, and WASH-dependent actin patches.

    “A number of studies have shown that specific endosomal membrane sub-domains are enriched for either degradative components such as ESCRT or recycling machinery including Retromer, Retriever, the CCC complex, and WASH-dependent actin patches9,34–44”

    From Mechanism and regulation of cargo entry into the Commander endosomal recycling pathway (2024) · cites this paper as [42]

    The Results report distinct ESCRT-associated degradative and retromer-associated recycling microdomains on the same endosomes. The Discussion mentions WASH accumulating on endosomal tubules, but does not establish WASH-dependent actin patches as a separate recycling domain; our copy does not support the claim's inclusion of Retriever or the CCC complex. (LLM, conf=0.88)

    Experimental — accuracy not yet measured

  • Core retrieval and recycling complexes localise to specific retrieval sub-domains that are physically distinct from ESCRT-demarcated degradative sub-domains on the same endosome.

    “On the limiting membrane of endosomes, electron and light microscopy has established that core retrieval and recycling complexes localise to specific retrieval sub-domains that, while present on the same endosome, are physically distinct from ESCRT-demarcated degradative sub-domains19,32–37.”

    From Mapping of endosomal proximity proteomes reveals Retromer as a hub for RAB GTPase regulation (2025) · cites this paper as [37]

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Citations

Cites

Flagged first, then by citations

Research works printed but not linked: 95

  1. 10.1038/nrc2521 · DOI
  2. 10.1083/jcb.137.1.79 · DOI · Paper page
  3. 10.1038/nature06216 · DOI · Paper page
  4. 10.1083/jcb.200312055 · DOI · Paper page
  5. 10.1371/journal.pone.0020420 · DOI · Paper page
  6. 10.4161/cib.16855 · DOI
  7. 10.1038/ncb2281 · DOI · Paper page
  8. 10.1091/mbc.8.8.1529 · DOI
  9. 10.1091/mbc.e11-11-0915 · DOI
  10. 10.1242/jcs.03302 · DOI · Paper page
  11. 10.1091/mbc.e10-09-0756 · DOI
  12. 10.1016/j.cub.2004.09.077 · DOI · Paper page
  13. 10.1038/emboj.2012.283 · DOI · Paper page
  14. 10.1111/j.1600-0854.2011.01201.x · DOI
  15. 10.1038/emboj.2009.272 · DOI
  16. 10.1111/j.1600-0854.2009.00993.x · DOI
  17. 10.1247/csf.07045 · DOI
  18. 10.1091/mbc.12.7.2011 · DOI
  19. 10.1038/sj.embor.7400172 · DOI
  20. 10.1038/378632a0 · DOI
  21. 10.1038/35055137 · DOI
  22. 10.1074/jbc.M115.644757 · DOI
  23. CL Freeman, G Hesketh, MN Seaman, RME-8 coordinates the activity of the WASH complex with the function of the retromer SNX dimer to control endosomal tubulation. J Cell Sci 127, 2053–2070 (2014).
  24. 10.3109/10409238.2010.502516 · DOI
  25. 10.1016/j.ceb.2011.04.008 · DOI
  26. 10.1016/j.devcel.2011.05.015 · DOI
  27. 10.1038/416451a · DOI · Paper page
  28. 10.1083/jcb.200112080 · DOI
  29. 10.1016/S0968-0004(01)01835-7 · DOI
  30. 10.1247/csf.27.403 · DOI
  31. 10.1038/ncb791 · DOI · Paper page
  32. 10.1242/jcs.114.12.2255 · DOI
  33. 10.1083/jcb.149.4.901 · DOI · Paper page
  34. 10.1091/mbc.01-10-0525 · DOI · Paper page
  35. 10.1111/j.1398-9219.2004.00204.x · DOI
  36. 10.1007/s00018-010-0594-1 · DOI
  37. 10.1002/j.1460-2075.1994.tb06381.x · DOI · Paper page
  38. 10.1091/mbc.e05-08-0787 · DOI · Paper page
  39. 10.1091/mbc.e11-04-0279 · DOI
  40. 10.7554/eLife.00190 · DOI
  41. 10.1091/mbc.e02-06-0338 · DOI
  42. 10.1083/jcb.142.4.923 · DOI
  43. 10.1073/pnas.1418651112 · DOI
  44. 10.1016/j.devcel.2007.12.003 · DOI
  45. 10.1038/ncb1678 · DOI
  46. 10.1016/j.devcel.2007.12.001 · DOI
  47. 10.1016/j.devcel.2007.12.004 · DOI
  48. 10.1038/ncb1687 · DOI
  49. 10.1083/jcb.200312034 · DOI · Paper page
  50. 10.1038/35078543 · DOI · Paper page
  51. 10.1016/j.ejcb.2009.10.021 · DOI
  52. 10.1128/MCB.00156-06 · DOI
  53. 10.1093/emboj/20.17.5008 · DOI
  54. 10.1074/jbc.M004129200 · DOI
  55. 10.1895/wormbook.1.77.2 · DOI
  56. 10.1093/genetics/159.1.133 · DOI
  57. 10.1038/ng0501-64 · DOI
  58. 10.1091/mbc.e05-12-1120 · DOI
  59. 10.1074/jbc.271.16.9347 · DOI
  60. 10.1379/1466-1268(1998)003<0028:SFAEOD>2.3.CO;2 · DOI
  61. 10.1128/MCB.19.11.7751 · DOI
  62. 10.1073/pnas.0809541106 · DOI
  63. 10.1038/ncb791 · DOI · Paper page
  64. 10.1242/jcs.02978 · DOI
  65. 10.1073/pnas.1319947111 · DOI
  66. 10.1242/jcs.112904 · DOI
  67. 10.1038/nprot.2011.336 · DOI
  68. 10.1186/1471-2105-11-372 · DOI
  69. 10.1186/1471-2105-14-349 · DOI
  70. 10.1038/35096054 · DOI
  71. 10.1016/j.cell.2010.10.003 · DOI · Paper page
  72. SD Hunt, AK Townley, CM Danson, PJ Cullen, DJ Stephens, Microtubule motors mediate endosomal sorting by maintaining functional domain organization. J Cell Sci 126, 2493–2501 (2013).
  73. 10.1002/j.1460-2075.1983.tb01640.x · DOI
  74. 10.4161/21592780.2014.954441 · DOI
  75. 10.1101/cshperspect.a016857 · DOI
  76. 10.1615/CritRevOncog.v12.i3-4.70 · DOI
  77. 10.1016/j.devcel.2011.08.019 · DOI · Paper page
  78. 10.1074/jbc.M110.185363 · DOI
  79. 10.1371/journal.pone.0039774 · DOI · Paper page
  80. 10.1016/bs.mcb.2015.03.025 · DOI
  81. 10.1083/jcb.200311084 · DOI
  82. 10.1016/j.febslet.2008.02.042 · DOI
  83. 10.1074/jbc.M505036200 · DOI
  84. 10.1242/jcs.02978 · DOI
  85. 10.4161/cib.29483 · DOI
  86. 10.1093/genetics/77.1.71 · DOI
  87. 10.1038/27579 · DOI
  88. 10.1016/S1046-2023(03)00050-1 · DOI
  89. 10.1038/nmeth.1768 · DOI
  90. 10.1038/nmeth0510-339 · DOI
  91. 10.1038/ng.248 · DOI
  92. 10.1093/genetics/157.3.1217 · DOI
  93. PJ Schweinsberg, BD Grant, C. elegans gene transformation by microparticle bombardment. WormBook Dec 30, 1–10
  94. 10.1038/nmeth.2641 · DOI
  95. 10.1371/journal.pone.0053419 · DOI

Cited by

Sorted by citations

Metadata

Authors
Norris, A., Tammineni, P., Wang, S., Gerdes, J., Murr, A., Kwan, K. Y., Cai, Q., & Grant, B. D.
Venue
Proceedings of the National Academy of Sciences
Publisher
National Academy of Sciences
Published
2017-01-04
Volume
114
Issue
3
ISSN
  • 0027-8424
  • 1091-6490
DOI
10.1073/pnas.1612730114
Cited by
90
References
2
Language
en
Licence
www.pnas.org/site/misc/userlicense.xhtml (vor, 181 d)
Funders
HHS | NIH | National Institute of General Medical Sciences (GM067237, GM103995, 5F32GM096599)

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review