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Actin-dependent endosomal receptor recycling

Simonetti, Boris, Cullen, Peter J·2019·Current Opinion in Cell Biology

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Crossref · 10.1016/j.ceb.2018.08.006

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  • SNX17-dependent recycling requires the Retriever complex, the CCC complex, and the actin-regulatory WASH complex.

    “SNX17-dependent recycling requires the Retriever complex (VPS35L, VPS26C, and VPS29), the CCC complex (COMMD/CCDC22/CCDC93), and the actin-regulatory WASH complex”

    From PI(3)P coordinates SNX17- and SNX27-dependent protein recycling for long-term synaptic plasticity (2025) · cites this paper as Simonetti and Cullen, 2019

    The Introduction (p. 3) identifies Retriever and CCC as regulators of SNX17-associated cargo recycling, and Figure 2 (p. 21) says Retriever binds SNX17 and associates with CCC and WASH. The paper describes these relationships but does not establish that all three complexes are required for SNX17-dependent recycling; Figure 2 also names two Retriever subunits as C16orf62 and DSCR3 rather than the aliases in the citing sentence. (LLM, conf=0.85)

    Experimental — accuracy not yet measured
  • Endosomal recycling by Commander requires dynamic organization of actin-rich domains on the endosomal surface.

    “Endosomal recycling by Commander requires dynamic organization of actin-rich domains on the endosomal surface.4”

    From Structure of the endosomal Commander complex linked to Ritscher-Schinzel syndrome (2023) · cites this paper as [4]

    The Figure 4 caption (p. 23) says regulated receptor recycling depends on actin dynamics at the endosomal surface and involves actin-enriched subdomains. The section “Actin and WASH in the organization of the retrieval subdomains” (p. 6) links WASH-mediated domain organization to the retriever complex via the CCC complex. The paper does not name Commander or establish that recycling by Commander specifically requires this organization. (LLM, conf=0.83)

    Experimental — accuracy not yet measured
  • Endosome-associated branched actin is nucleated by Arp2/3 following activation by the WASH complex, which interacts with Commander subunits.

    “Endosome-associated branched actin is nucleated by Arp2/3 following activation by the WASH complex, which interacts with Commander subunits.4,6,13,21,65,78”

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Metadata

Authors
Simonetti, B., & Cullen, P. J.
Venue
Current Opinion in Cell Biology
Publisher
Elsevier BV
Published
2019-02
Volume
56
Pages
22-33
ISSN
0955-0674
Cited by
139
References
2
Language
en
Funders
  • MRC (MR/L007363/1, MR/P018807/1)
  • Wellcome Trust (104568/Z/14/2)
  • Wellcome Trust PhD Studentship (083474)

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