Mitochondria, Oxidants, and Aging

Superoxide Dismutase

McCord, J. M., & Fridovich, I. (1969) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)63504-5 · Cited by 12,952

Aging: a theory based on free radical and radiation chemistry

Harman, D. (1956) · Journal of Gerontology · doi:10.1093/geronj/11.3.298 · Cited by 8,567

Hydroperoxide metabolism in mammalian organs.

Chance, B., Sies, H., & Boveris, A. (1979) · Physiological Reviews · doi:10.1152/physrev.1979.59.3.527 · Cited by 5,827

Oncogenic ras provokes premature cell senescence associated with accumulation of p53 and p16INK4a

Serrano, M., Lin, A. W., McCurrach, M. E., Beach, D., & Lowe, S. W. (1997) · Cell · doi:10.1016/s0092-8674(00)81902-9 · Cited by 5,218

Mitochondrial formation of reactive oxygen species

Turrens, J. F. (2003) · The Journal of Physiology · doi:10.1113/jphysiol.2003.049478 · Cited by 5,084

Intrinsic signal changes accompanying sensory stimulation: functional brain mapping with magnetic resonance imaging.

Ogawa, S., Tank, D. W., Menon, R., Ellermann, J. M., Kim, S. G., Merkle, H., & Ugurbil, K. (1992) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.89.13.5951 · Cited by 3,681

Protein Oxidation in Aging, Disease, and Oxidative Stress

Berlett, B. S., & Stadtman, E. R. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.33.20313 · Cited by 3,379

Stress-dependent regulation of FOXO transcription factors by the SIRT1 deacetylase

Brunet, A., Sweeney, L. B., Sturgill, J. F., Chua, K. F., Greer, P. L., Lin, Y., Tran, H., Ross, S. E., Mostoslavsky, R., Cohen, H. Y., et al. (2004) · Science · doi:10.1126/science.1094637 · Cited by 3,239

NOX enzymes and the biology of reactive oxygen

Lambeth, J. D. (2004) · Nature Reviews Immunology · doi:10.1038/nri1312 · Cited by 3,125

Mitochondrial free radical generation, oxidative stress, and aging

Cadenas, E., & Davies, K. J. A. (2000) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(00)00317-8 · Cited by 3,010

Premature ageing in mice expressing defective mitochondrial DNA polymerase

Trifunovic, A., Wredenberg, A., Falkenberg, M., Spelbrink, J. N., Rovio, A. T., Bruder, C. E., Bohlooly-Y, M., Gidlöf, S., Oldfors, A., Wibom, R., et al. (2004) · Nature · doi:10.1038/nature02517 · Cited by 2,734

The mitochondrial generation of hydrogen peroxide. General properties and effect of hyperbaric oxygen

Boveris, A., & Chance, B. (1973) · Biochemical Journal · doi:10.1042/bj1340707 · Cited by 2,626

Genes that act downstream of DAF-16 to influence the lifespan of Caenorhabditis elegans

Murphy, C. T., McCarroll, S. A., Bargmann, C. I., Fraser, A., Kamath, R. S., Ahringer, J., Li, H., & Kenyon, C. (2003) · Nature · doi:10.1038/nature01789 · Cited by 2,280

IGF-1 receptor regulates lifespan and resistance to oxidative stress in mice

Holzenberger, M., Dupont, J., Ducos, B., Leneuve, P., Géloën, A., Even, P. C., Cervera, P., & Le Bouc, Y. (2003) · Nature · doi:10.1038/nature01298 · Cited by 2,109

Negative Control of p53 by Sir2α Promotes Cell Survival under Stress

Luo, J., Nikolaev, A. Y., Imai, S.-I., Chen, D., Su, F., Shiloh, A., Guarente, L., & Gu, W. (2001) · Cell · doi:10.1016/s0092-8674(01)00524-4 · Cited by 2,081

Oxidative damage and mitochondrial decay in aging.

Shigenaga, M. K., Hagen, T. M., & Ames, B. N. (1994) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.91.23.10771 · Cited by 2,055

Normal oxidative damage to mitochondrial and nuclear DNA is extensive.

Richter, C., Park, J. W., & Ames, B. N. (1988) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.85.17.6465 · Cited by 1,730

The p66shc adaptor protein controls oxidative stress response and life span in mammals

Migliaccio, E., Giorgio, M., Mele, S., Pelicci, G., Reboldi, P., Pandolfi, P. P., Lanfrancone, L., & Pelicci, P. G. (1999) · Nature · doi:10.1038/46311 · Cited by 1,712

Production of Reactive Oxygen Species by Mitochondria

Chen, Q., Vazquez, E. J., Moghaddas, S., Hoppel, C. L., & Lesnefsky, E. J. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m304854200 · Cited by 1,616

Forkhead transcription factor FOXO3a protects quiescent cells from oxidative stress

Kops, G. J. P. L., Dansen, T. B., Polderman, P. E., Saarloos, I., Wirtz, K. W. A., Coffer, P. J., Huang, T.-T., Bos, J. L., Medema, R. H., & Burgering, B. M. T. (2002) · Nature · doi:10.1038/nature01036 · Cited by 1,580

The cellular production of hydrogen peroxide

Boveris, A., Oshino, N., & Chance, B. (1972) · Biochemical Journal · doi:10.1042/bj1280617 · Cited by 1,549

Topology of superoxide production from different sites in the mitochondrial electron transport chain

St-Pierre, J., Buckingham, J. A., Roebuck, S. J., & Brand, M. D. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m207217200 · Cited by 1,545

The Sir2 Family of Protein Deacetylases

Blander, G., & Guarente, L. (2004) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.73.011303.073651 · Cited by 1,497

Extension of Life-Span by Overexpression of Superoxide Dismutase and Catalase in Drosophila melanogaster

Orr, W. C., & Sohal, R. S. (1994) · Science · doi:10.1126/science.8108730 · Cited by 1,461

Extension of Life-Span by Loss of CHICO, a Drosophila Insulin Receptor Substrate Protein

Clancy, D. J., Gems, D., Harshman, L. G., Oldham, S., Stocker, H., Hafen, E., Leevers, S. J., & Partridge, L. (2001) · Science · doi:10.1126/science.1057991 · Cited by 1,436

Oxidant signals and oxidative stress

Finkel, T. (2003) · Current Opinion in Cell Biology · doi:10.1016/s0955-0674(03)00002-4 · Cited by 1,393

Superoxide activates mitochondrial uncoupling proteins

Echtay, K. S., Roussel, D., St-Pierre, J., Jekabsons, M. B., Cadenas, S., Stuart, J. A., Harper, J. A., Roebuck, S. J., Morrison, A., Pickering, S., et al. (2002) · Nature · doi:10.1038/415096a · Cited by 1,382

Generation of reactive oxygen species by the mitochondrial electron transport chain

Liu, Y., Fiskum, G., & Schubert, D. (2002) · Journal of Neurochemistry · doi:10.1046/j.0022-3042.2002.00744.x · Cited by 1,260

Ubisemiquinone is the electron donor for superoxide formation by complex III of heart mitochondria

Turrens, J. F., Alexandre, A., & Lehninger, A. L. (1985) · Archives of Biochemistry and Biophysics · doi:10.1016/0003-9861(85)90293-0 · Cited by 1,214

Extended Longevity in Mice Lacking the Insulin Receptor in Adipose Tissue

Blüher, M., Kahn, B. B., & Kahn, C. R. (2003) · Science · doi:10.1126/science.1078223 · Cited by 1,155

Rates of Behavior and Aging Specified by Mitochondrial Function During Development

Dillin, A., Hsu, A.-L., Arantes-Oliveira, N., Lehrer-Graiwer, J., Hsin, H., Fraser, A. G., Kamath, R. S., Ahringer, J., & Kenyon, C. (2002) · Science · doi:10.1126/science.1077780 · Cited by 1,121

Calorie restriction extends Saccharomyces cerevisiae lifespan by increasing respiration

Lin, S.-J., Kaeberlein, M., Andalis, A. A., Sturtz, L. A., Defossez, P.-A., Culotta, V. C., Fink, G. R., & Guarente, L. (2002) · Nature · doi:10.1038/nature00829 · Cited by 1,057

Mitochondrial superoxide: production, biological effects, and activation of uncoupling proteins

Brand, M. D., Affourtit, C., Esteves, T. C., Green, K., Lambert, A. J., Miwa, S., Pakay, J. L., & Parker, N. (2004) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2004.05.034 · Cited by 1,032

A systematic RNAi screen identifies a critical role for mitochondria in C. elegans longevity

Lee, S. S., Lee, R. Y. N., Fraser, A. G., Kamath, R. S., Ahringer, J., & Ruvkun, G. (2003) · Nature Genetics · doi:10.1038/ng1056 · Cited by 969

Citric acid cycle intermediates as ligands for orphan G-protein-coupled receptors

He, W., Miao, F. J.-P., Lin, D. C.-H., Schwandner, R. T., Wang, Z., Gao, J., Chen, J.-L., Tian, H., & Ling, L. (2004) · Nature · doi:10.1038/nature02488 · Cited by 909

Extension of Drosophila lifespan by overexpression of human SOD1 in motorneurons

Parkes, T. L., Elia, A., Dickinson, D., Hilliker, A. J., Phillips, J. P., & Boulianne, G. L. (1998) · Nature Genetics · doi:10.1038/534 · Cited by 862

Redox Regulation of Forkhead Proteins Through a p66shc -Dependent Signaling Pathway

Nemoto, S., & Finkel, T. (2002) · Science · doi:10.1126/science.1069004 · Cited by 818

Extended Life-Span and Stress Resistance in the Drosophila Mutant methuselah

Lin, Y.-J., Seroude, L., & Benzer, S. (1998) · Science · doi:10.1126/science.282.5390.943 · Cited by 804

Uncoupling to survive? The role of mitochondrial inefficiency in ageing

Brand, M. D. (2000) · Experimental Gerontology · doi:10.1016/s0531-5565(00)00135-2 · Cited by 789

Uncoupled and surviving: individual mice with high metabolism have greater mitochondrial uncoupling and live longer

Speakman, J. R., Talbot, D. A., Selman, C., Snart, S., McLaren, J. S., Redman, P., Krol, E., Jackson, D. M., Johnson, M. S., & Brand, M. D. (2004) · Aging Cell · doi:10.1111/j.1474-9728.2004.00097.x · Cited by 761

Life-long reduction in MnSOD activity results in increased DNA damage and higher incidence of cancer but does not accelerate aging

Van Remmen, H., Ikeno, Y., Hamilton, M., Pahlavani, M., Wolf, N., Thorpe, S. R., Alderson, N. L., Baynes, J. W., Epstein, C. J., Huang, T.-T., et al. (2003) · Physiological Genomics · doi:10.1152/physiolgenomics.00122.2003 · Cited by 734

Characterization of the human heart mitochondrial proteome

Taylor, S. W., Fahy, E., Zhang, B., Glenn, G. M., Warnock, D. E., Wiley, S. E., Murphy, A. N., Gaucher, S. P., Capaldi, R., Gibson, B. W., et al. (2003) · Nature Biotechnology · doi:10.1038/nbt793 · Cited by 702

Complex I-mediated reactive oxygen species generation: modulation by cytochrome c and NAD(P)+ oxidation–reduction state

Kushnareva, Y., Murphy, A. N., & Andreyev, A. Y. (2002) · Biochemical Journal · doi:10.1042/bj20021121 · Cited by 696

Ras Proteins Induce Senescence by Altering the Intracellular Levels of Reactive Oxygen Species

Lee, A. C., Fenster, B. E., Ito, H., Takeda, K., Bae, N. S., Hirai, T., Yu, Z.-X., Ferrans, V. J., Howard, B. H., & Finkel, T. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.12.7936 · Cited by 691

A mutation in succinate dehydrogenase cytochrome b causes oxidative stress and ageing in nematodes.

Ishii, N., Fujii, M., Hartman, P. S., Tsuda, M., Yasuda, K., Senoo-Matsuda, N., Yanase, S., Ayusawa, D., & Suzuki, K. (1998) · Nature · doi:10.1038/29331 · Cited by 687

Mitochondrial Electron Transport Is a Key Determinant of Life Span in Caenorhabditis elegans

Feng, J., Bussière, F., & Hekimi, S. (2001) · Developmental Cell · doi:10.1016/s1534-5807(01)00071-5 · Cited by 675

The Rate of Living.

Wright, S., & Pearl, R. (1928) · Journal of the American Statistical Association · doi:10.2307/2276751 · Cited by 670

DAF-16 Target Genes That Control C. elegans Life-Span and Metabolism

Lee, S. S., Kennedy, S., Tolonen, A. C., & Ruvkun, G. (2003) · Science · doi:10.1126/science.1083614 · Cited by 669

The potential diagram for oxygen at pH 7

Wood, P. M. (1988) · Biochemical Journal · doi:10.1042/bj2530287 · Cited by 652

Asymmetric Inheritance of Oxidatively Damaged Proteins During Cytokinesis

Aguilaniu, H., Gustafsson, L., Rigoulet, M., & Nyström, T. (2003) · Science · doi:10.1126/science.1080418 · Cited by 639

Sirtuins: Sir2-related NAD-dependent protein deacetylases.

North, B. J., & Verdin, E. M. (2004) · Genome biology · doi:10.1186/gb-2004-5-5-224 · Cited by 586

Long-Lived Drosophila with Overexpressed dFOXO in Adult Fat Body

Giannakou, M. E., Goss, M. W., Jünger, M. A., Hafen, E., Leevers, S. J., & Partridge, L. (2004) · Science · doi:10.1126/science.1098219 · Cited by 577

Detection of catalase in rat heart mitochondria.

Radi, R., Turrens, J. F., Chang, L. Y., Bush, K. M., Crapo, J. D., & Freeman, B. A. (1991) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)54740-2 · Cited by 573

Respiratory chain linked H2O2 production in pigeon heart mitochondria

Loschen, G., & Flohé, L. (1971) · FEBS Letters · doi:10.1016/0014-5793(71)80459-3 · Cited by 552

Extended Life-Span Conferred by Cotransporter Gene Mutations in Drosophila

Rogina, B., Reenan, R. A., Nilsen, S. P., & Helfand, S. L. (2000) · Science · doi:10.1126/science.290.5499.2137 · Cited by 506

FLP Recombinase-Mediated Induction of Cu/Zn-Superoxide Dismutase Transgene Expression Can Extend the Life Span of Adult Drosophila melanogaster Flies

Sun, J., & Tower, J. (1999) · Molecular and Cellular Biology · doi:10.1128/mcb.19.1.216 · Cited by 467

Comparing genomic expression patterns across species identifies shared transcriptional profile in aging

McCarroll, S. A., Murphy, C. T., Zou, S., Pletcher, S. D., Chin, C.-S., Jan, Y. N., Kenyon, C., Bargmann, C. I., & Li, H. (2004) · Nature Genetics · doi:10.1038/ng1291 · Cited by 454

A p53-p66Shc signalling pathway controls intracellular redox status, levels of oxidation-damaged DNA and oxidative stress-induced apoptosis

Trinei, M., Giorgio, M., Cicalese, A., Barozzi, S., Ventura, A., Migliaccio, E., Milia, E., Padura, I. M., Raker, V. A., Maccarana, M., et al. (2002) · Oncogene · doi:10.1038/sj.onc.1205513 · Cited by 436

JNK Signaling Confers Tolerance to Oxidative Stress and Extends Lifespan in Drosophila

Wang, M. C., Bohmann, D., & Jasper, H. (2003) · Developmental Cell · doi:10.1016/s1534-5807(03)00323-x · Cited by 422

Transcriptional outputs of the Caenorhabditis elegans forkhead protein DAF‐16

McElwee, J., Bubb, K., & Thomas, J. H. (2003) · Aging Cell · doi:10.1046/j.1474-9728.2003.00043.x · Cited by 416

Low oxygen concentration extends the lifespan of cultured human diploid cells

Packer, L., & FUEHR, K. (1977) · Nature · doi:10.1038/267423a0 · Cited by 393

Role for mitochondrial oxidants as regulators of cellular metabolism

Nemoto, S., Takeda, K., Yu, Z.-X., Ferrans, V. J., & Finkel, T. (2000) · Molecular and Cellular Biology · doi:10.1128/mcb.20.19.7311-7318.2000 · Cited by 393

Peroxiredoxin III, a Mitochondrion-specific Peroxidase, Regulates Apoptotic Signaling by Mitochondria

Chang, T.-S., Cho, C.-S., Park, S., Yu, S., Kang, S. W., & Rhee, S. G. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m407707200 · Cited by 388

Similar gene expression patterns characterize aging and oxidative stress in Drosophila melanogaster

Landis, G. N., Abdueva, D. A., Skvortsov, D., Yang, J., Rabin, B. E., Carrick, J., Tavaré, S., & Tower, J. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0307605101 · Cited by 384

Deletion of the p66 Shc longevity gene reduces systemic and tissue oxidative stress, vascular cell apoptosis, and early atherogenesis in mice fed a high-fat diet

Napoli, C., Martin-Padura, I., de Nigris, F., Giorgio, M., Mansueto, G., Somma, P., Condorelli, M., Sica, G., De Rosa, G., & Pelicci, P. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0336359100 · Cited by 380

Effects of temperature on the life span, vitality and fine structure of Drosophila melanogaster

Miquel, J., Lundgren, P., Bensch, K. G., & Atlan, H. (1976) · Mechanisms of Ageing and Development · doi:10.1016/0047-6374(76)90034-8 · Cited by 342

Hyperoxia increases H2O2 release by lung mitochondria and microsomes

Turrens, J. F., Freeman, B. Α., & Crapo, J. D. (1982) · Archives of Biochemistry and Biophysics · doi:10.1016/0003-9861(82)90519-7 · Cited by 335

Influence of Induced Reactive Oxygen Species in p53-Mediated Cell Fate Decisions

Macip, S., Igarashi, M., Berggren, P., Yu, J., Lee, S. W., & Aaronson, S. A. (2003) · Molecular and Cellular Biology · doi:10.1128/mcb.23.23.8576-8585.2003 · Cited by 331

Structural and Functional Conservation of the Caenorhabditis elegans Timing Gene clk-1

Ewbank, J. J., Barnes, T. M., Lakowski, B., Lussier, M., Bussey, H., & Hekimi, S. (1997) · Science · doi:10.1126/science.275.5302.980 · Cited by 319

Hypoxia-induced endocytosis of Na,K-ATPase in alveolar epithelial cells is mediated by mitochondrial reactive oxygen species and PKC-ζ

Dada, L. A., Chandel, N. S., Ridge, K. M., Pedemonte, C. H., Bertorello, A. M., & Sznajder, J. I. (2003) · Journal of Clinical Investigation · doi:10.1172/jci16826 · Cited by 318

The site of production of superoxide radical in mitochondrial Complex I is not a bound ubisemiquinone but presumably iron–sulfur cluster N2

Genova, M. L., Ventura, B., Giuliano, G., Bovina, C., Formiggini, G., Castelli, G. P., & Lenaz, G. (2001) · FEBS Letters · doi:10.1016/s0014-5793(01)02850-2 · Cited by 301

The Proton-Translocating NADH−Quinone Oxidoreductase in the Respiratory Chain: The Secret Unlocked

Yagi, T., & Matsuno‐Yagi, A. (2003) · Biochemistry · doi:10.1021/bi027158b · Cited by 296

CLK‐1 controls respiration, behavior and aging in the nematode Caenorhabditis elegans

Felkai, S., Ewbank, J. J., Lemieux, J., Labbé, J. ‐., Brown, G. G., & Hekimi, S. (1999) · The EMBO Journal · doi:10.1093/emboj/18.7.1783 · Cited by 295

The Life Span Determinant p66Shc Localizes to Mitochondria Where It Associates with Mitochondrial Heat Shock Protein 70 and Regulates Trans-membrane Potential

Orsini, F., Migliaccio, E., Moroni, M., Contursi, C., Raker, V. A., Piccini, D., Martín-Padura, I., Pelliccia, G., Trinei, M., Bono, M., et al. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m401844200 · Cited by 291

Extracellular superoxide dismutase is a major antioxidant in human fibroblasts and slows telomere shortening

Serra, V., von Zglinicki, T., Lorenz, M., & Saretzki, G. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m207939200 · Cited by 278

A defect in the cytochrome b large subunit in complex II causes both superoxide anion overproduction and abnormal energy metabolism in Caenorhabditis elegans

Senoo-Matsuda, N., Yasuda, K., Tsuda, M., Ohkubo, T., Yoshimura, S., Nakazawa, H., Hartman, P. S., & Ishii, N. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m104718200 · Cited by 271

Integrins engage mitochondrial function for signal transduction by a mechanism dependent on Rho GTPases

Werner, E., & Werb, Z. (2002) · The Journal of Cell Biology · doi:10.1083/jcb.200111028 · Cited by 252

Extension of Life-Span in Caenorhabditis elegans by a Diet Lacking Coenzyme Q

Larsen, P. L., & Clarke, C. F. (2002) · Science · doi:10.1126/science.1064653 · Cited by 249

Cytochrome c Oxidase and the Regulation of Oxidative Phosphorylation

Ludwig, B., Bender, E., Arnold, S., Hüttemann, M., Lee, I., & Kadenbach, B. (2001) · ChemBioChem · doi:10.1002/1439-7633(20010601)2:6 · Cited by 246

A cell-intrinsic timer that operates during oligodendrocyte development

Durand, B., & RAFF, M. C. (2000) · BioEssays · doi:10.1002/(sici)1521-1878(200001)22:1 · Cited by 245

Linking chromatin function with metabolic networks: Sir2 family of NAD+-dependent deacetylases

Denu, J. M. (2003) · Trends in Biochemical Sciences · doi:10.1016/s0968-0004(02)00005-1 · Cited by 210

Metabolic Network Control of Oxidative Phosphorylation

Bose, S., French, S. A., Evans, F. J., Joubert, F., & Balaban, R. S. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m306409200 · Cited by 210

Conditional tradeoffs between aging and organismal performance of Indy long-lived mutant flies

Marden, J. H., Rogina, B., Montooth, K. L., & Helfand, S. L. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0634985100 · Cited by 201

Regulation of cellular response to oncogenic and oxidative stress by Seladin-1

Wu, C., Miloslavskaya, I., Demontis, S., Maestro, R., & Galaktionov, K. I. (2004) · Nature · doi:10.1038/nature03173 · Cited by 195

Effects of Overexpression of Copper-Zinc and Manganese Superoxide Dismutases, Catalase, and Thioredoxin Reductase Genes on Longevity in Drosophila melanogaster

Orr, W. C., Mockett, R. J., Benes, J. J., & Sohal, R. S. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m303095200 · Cited by 190

Superoxide Dismutase 1 Knock-down Induces Senescence in Human Fibroblasts

Blander, G., de Oliveira, R. M., Conboy, C. M., Haigis, M., & Guarente, L. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m307146200 · Cited by 183

Detection of Free Radicals Generated during Enzymic Oxidations by the Initiation of Sulfite Oxidation

Fridovich, I., & Handler, P. (1961) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)63312-0 · Cited by 175

Mitochondrial ROS Metabolism: Modulation by Uncoupling Proteins

Casteilla, L., Rigoulet, M., & Pénicaud, L. (2001) · IUBMB Life · doi:10.1080/15216540152845984 · Cited by 173

Organization of Krebs tricarboxylic acid cycle enzymes in mitochondria.

Robinson, J. B. D., & Srere, P. A. (1985) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)85153-0 · Cited by 168

Are mitochondria a permanent source of reactive oxygen species?

Staniek, K., & Nohl, H. (2000) · Biochimica et Biophysica Acta (BBA) - Bioenergetics · doi:10.1016/s0005-2728(00)00152-3 · Cited by 164

The TCA cycle and tumorigenesis: the examples of fumarate hydratase and succinate dehydrogenase

Pollard, P., Wortham, N., & Tomlinson, I. (2003) · Annals of Medicine · doi:10.1080/07853890310018458 · Cited by 159

Relationship between increased longevity and stress resistance as assessed through gerontogene mutations in Caenorhabditis elegans

Johnson, T. E., de Castro, E., de Castro, S. H., Cypser, J. R., Henderson, S., & Tedesco, P. (2001) · Experimental Gerontology · doi:10.1016/s0531-5565(01)00144-9 · Cited by 153

The reaction between the superoxide anion radical and cytochrome c

Butler, J., Jayson, G. G., & Swallow, A. J. (1975) · Biochimica et Biophysica Acta (BBA) - Bioenergetics · doi:10.1016/0005-2728(75)90124-3 · Cited by 149

Metabolic rate is not reduced by dietary-restriction or by lowered insulin/IGF-1 signalling and is not correlated with individual lifespan in Drosophila melanogaster

Hulbert, A. J., Clancy, D. J., Mair, W. B., Braeckman, B. P., Gems, D., & Partridge, L. (2004) · Experimental Gerontology · doi:10.1016/j.exger.2004.04.006 · Cited by 144

Developmental regulation of energy metabolism in Caenorhabditis elegans

Wadsworth, W. G., & Riddle, D. L. (1989) · Developmental Biology · doi:10.1016/0012-1606(89)90214-5 · Cited by 140

Redox Regulation of Germline and Vulval Development in Caenorhabditis elegans

Shibata, Y., Branicky, R. S., Landaverde, I. O., & Hekimi, S. (2003) · Science · doi:10.1126/science.1087167 · Cited by 121

Rate of aerobic metabolism and superoxide production rate potential in the nematodeCaenorhabditis elegans

Vanfleteren, J. R., & Vreese, A. D. (1996) · Journal of Experimental Zoology · doi:10.1002/(sici)1097-010x(19960201)274:2 · Cited by 117

Mitochondrial Oxidative Phosphorylation Is Defective in the Long-lived Mutant clk-1

Kayser, E., Sedensky, M. M., Morgan, P. G., & Hoppel, C. L. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m403066200 · Cited by 111

A Metabolic Model for Life Span Determination in Caenorhabditis elegans

Rea, S. L., & Johnson, T. E. (2003) · Developmental Cell · doi:10.1016/s1534-5807(03)00242-9 · Cited by 111

Mitochondrial “swirls” induced by oxygen stress and in the Drosophila mutant hyperswirl

Walker, D. W., & Benzer, S. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0403767101 · Cited by 108

The endogenous ligand Stunted of the GPCR Methuselah extends lifespan in Drosophila

Cvejic, S., Zhu, Z. I., Felice, S. J., Berman, Y. L., & Huang, X. (2004) · Nature Cell Biology · doi:10.1038/ncb1133 · Cited by 95

No reduction of energy metabolism in Clk mutants

Braeckman, B. P., Houthoofd, K., Brys, K., Lenaerts, I., Vreese, A. D., Eygen, S. V., Raes, H., & Vanfleteren, J. R. (2002) · Mechanisms of Ageing and Development · doi:10.1016/s0047-6374(02)00085-4 · Cited by 69

Mitochondrial oxidative stress can lead to nuclear hypermutability

Hartman, P. S., Ponder, R. G., Lo, H., & Ishii, N. (2004) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2004.02.007 · Cited by 55

Murine Models of Life Span Extension

Quarrie, J. K., & Riabowol, K. T. (2004) · Science of Aging Knowledge Environment · doi:10.1126/sageke.2004.31.re5 · Cited by 53

The cytochrome c peroxidase activity of cytochrome oxidase.

Orii, Y. (1982) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)34056-0 · Cited by 51

Is defective electron transport at the hub of aging?

Maklashina, E., & Ackrell, B. A. C. (2003) · Aging Cell · doi:10.1111/j.1474-9728.2003.00078.x · Cited by 43

NADH Enzyme-Dependent Fluorescence Recovery after Photobleaching (ED-FRAP): Applications to Enzyme and Mitochondrial Reaction Kinetics, In Vitro

Joubert, F., Fales, H. M., Wen, H., et al. (2004) · Biophysical Journal · doi:10.1016/s0006-3495(04)74141-7 · Cited by 38

How mitochondria produce reactive oxygen species

Murphy, M. P. (2009) · Biochemical Journal · doi:10.1042/bj20081386 · Cited by 8,207

The NOX Family of ROS-Generating NADPH Oxidases: Physiology and Pathophysiology

Bedard, K., & Krause, K.-H. (2007) · Physiological Reviews · doi:10.1152/physrev.00044.2005 · Cited by 6,989

ROS function in redox signaling and oxidative stress

Schieber, M., & Chandel, N. S. (2014) · Current Biology · doi:10.1016/j.cub.2014.03.034 · Cited by 6,931

Nitric Oxide and Peroxynitrite in Health and Disease

Pacher, P., Beckman, J. S., & Liaudet, L. (2007) · Physiological Reviews · doi:10.1152/physrev.00029.2006 · Cited by 6,390

The senescence-associated secretory phenotype: the dark side of tumor suppression

Coppé, J.-P., Desprez, P.-Y., Krtolica, A., & Campisi, J. (2010) · Annual Review of Pathology: Mechanisms of Disease · doi:10.1146/annurev-pathol-121808-102144 · Cited by 5,206

ИСПОЛЬЗОВAНИЕ ПОТЕНЦИAЛA СОЦИAЛЬНЫХ ПAРТНЕРОВ В ПОДГОТОВКЕ БУДУЩИХ ПЕДAГОГОВ

Атабекова, Б. Б. (2024) · Habaršy. Pedagogika ġylymdary seriâsy · doi:10.51889/2959-5762.2023.80.4.019

Cloning and Characterization of Rat BAT3 cDNA

Ozaki, T., Hanaoka, E., Naka, M., et al. (1999) · DNA and Cell Biology · doi:10.1089/104454999315222 · Cited by 22

EFFECT OF THE NEMATODE PHASMARHABDITIS HERMAPHRODITA ON YOUNG STAGES OF THE PEST SLUG ARION LUSITANICUS

Grimm, B. (2002) · Journal of Molluscan Studies · doi:10.1093/mollus/68.1.25 · Cited by 41

HLA-B-associated transcript 3 (Bat3)/Scythe is essential for p300-mediated acetylation of p53Preprint

Sasaki, T., Gan, E. C., Wakeham, A. C., Kornbluth, S. A., Mak, T. W., & Okada, H. (2007) · Genes & Development · doi:10.1101/gad.1534107 · Cited by 130

Anthoxanthum Mosaic Virus

Catherall, P. L. (1970) · Plant Pathology · doi:10.1111/j.1365-3059.1970.tb00999.x · Cited by 6