Cited by 1,179Cancer, Hypoxia, and MetabolismCancer Cells and MetastasisAngiogenesis and VEGF in Cancer

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Hypoxia-Inducible Factors, Stem Cells, and Cancer

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Keith, Brian, Simon, M. Celeste·2007·Cell

DOI 10.1016/j.cell.2007.04.019PMC PMC3150586

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Abstract

Regions of severe oxygen deprivation (hypoxia) arise in tumors due to rapid cell division and aberrant blood vessel formation. The hypoxia-inducible factors (HIFs) mediate transcriptional responses to localized hypoxia in normal tissues and in cancers and can promote tumor progression by altering cellular metabolism and stimulating angiogenesis. Recently, HIFs have been shown to activate specific signaling pathways such as Notch and the expression of transcription factors such as Oct4 that control stem cell self renewal and multipotency. As many cancers are thought to develop from a small number of transformed, self-renewing, and multipotent "cancer stem cells," these results suggest new roles for HIFs in tumor progression.

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Authors: Keith, B., & Simon, M. C.
Affiliations: University of Pennsylvania (US)
Howard Hughes Medical Institute (US)
Corresponding author: Keith, Brian
Simon, M. Celeste
ORCID: Keith, Brian
Simon, M. Celeste
Venue: Cell
Publisher: Elsevier BV
Published: 2007-05
Volume: 129
Issue: 3
Pages: 465-472
ISSN: 0092-8674 (ISSN-L)
DOI: 10.1016/j.cell.2007.04.019
PMC: PMC3150586
OpenAlex: W1973541913
Cited by: 1,179
References: 59
Citations by year: 2026: 32 · 2025: 49 · 2024: 54 · 2023: 49 · 2022: 68 · 2021: 62 · 2020: 62 · 2019: 58 · 2018: 62 · 2017: 74 · 2016: 63 · 2015: 81 · 2014: 84 · 2013: 80 · 2012: 72
FWCI: 4.58
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
www.elsevier.com/open-access/userlicense/1.0/ (vor, 2269 d)
doi.org/10.15223/policy-017 (stm-asf)
doi.org/10.15223/policy-037 (stm-asf)
doi.org/10.15223/policy-012 (stm-asf)
doi.org/10.15223/policy-029 (stm-asf)
doi.org/10.15223/policy-004 (stm-asf)
Locations: Cell (publishedVersion)
PubMed (publishedVersion)
Europe PMC (PubMed Central) (acceptedVersion)
PubMed Central (acceptedVersion)
Funders: Howard Hughes Medical Institute
National Institutes of Health
National Heart, Lung, and Blood Institute (HL66130, R01HL066130)
Core Research for Evolutional Science and Technology
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer, Hypoxia, and Metabolism
Health Sciences › Medicine › Oncology › Cancer Cells and Metastasis
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Angiogenesis and VEGF in Cancer
Keywords: hypoxia-inducible factor, tumor hypoxia, cancer stem cells, stem cell self-renewal, tumor angiogenesis, Notch signaling, Oct4, tumor progression, cellular metabolism, transcriptional regulation
MeSH terms: Animals, Hypoxia, Humans, Neoplasms, Stem Cells, Neoplastic Stem Cells, Signal Transduction, Cell Hypoxia, Disease Progression, Basic Helix-Loop-Helix Transcription Factors, Basic Helix-Loop-Helix Proteins

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