The DOI matches its Crossref record; 70 of the 70 references it cites were found in a registry or an index.
A Mammalian microRNA Expression Atlas Based on Small RNA Library Sequencing
Open accessAbstract
MicroRNAs (miRNAs) are small noncoding regulatory RNAs that reduce stability and/or translation of fully or partially sequence-complementary target mRNAs. In order to identify miRNAs and to assess their expression patterns, we sequenced over 250 small RNA libraries from 26 different organ systems and cell types of human and rodents that were enriched in neuronal as well as normal and malignant hematopoietic cells and tissues. We present expression profiles derived from clone count data and provide computational tools for their analysis. Unexpectedly, a relatively small set of miRNAs, many of which are ubiquitously expressed, account for most of the differences in miRNA profiles between cell lineages and tissues. This broad survey also provides detailed and accurate information about mature sequences, precursors, genome locations, maturation processes, inferred transcriptional units, and conservation patterns. We also propose a subclassification scheme for miRNAs for assisting future experimental and computational functional analyses.
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In the citing paper
“miR-27a/b are expressed in SN of human midbrain (Additional file 2a) [34–36]”
From miR-27a and miR-27b regulate autophagic clearance of damaged mitochondria by targeting PTEN-induced putative kinase 1 (PINK1) (2016) · cites this paper as [34]
In the citing paper
“Several previous studies showed that miR-27a/b are expressed in human midbrain [34–36].”
From miR-27a and miR-27b regulate autophagic clearance of damaged mitochondria by targeting PTEN-induced putative kinase 1 (PINK1) (2016) · cites this paper as [34]
In the citing paper
“Previous studies have shown that only a small population of miRNAs accounts for a majority of miRNA pool in the brain (Shin et al. 2010, Hu et al. 2011, Landgraf et al. 2007, Berezikov et al. 2006).”
From miR‐186 is decreased in aged brain and suppresses BACE 1 expression (2016) · cites this paper as Landgraf et al. 2007
In the citing paper
“miRNAs often show strong cell typeand tissue-specific regulation of their targets (Landgraf et al., 2007;Jovic ˇic ´et al., 2013).”
From microRNA-33 Regulates ApoE Lipidation and Amyloid-β Metabolism in the Brain (2015) · cites this paper as Landgraf et al., 2007
In the citing paper
“Importantly, miRNAs quite often show cell-type, tissue, and species-specific regulation of their target genes due to the differences in their expression levels and the complexity of interaction with their targets in different cellular contexts (Landgraf et al., 2007;Jovic ˇic ´et al., 2013).”
From microRNA-33 Regulates ApoE Lipidation and Amyloid-β Metabolism in the Brain (2015) · cites this paper as Landgraf et al., 2007
In the citing paper
“Substantial data indicate that microRNA 21 (miR-21) is significantly elevated in glioblastoma (GBM) and in many other tumors of various origins.”
From MicroRNA 21 Promotes Glioma Invasion by Targeting Matrix Metalloproteinase Regulators (2008) · cites this paper as [33]
In the citing paper
“We also found 20 miRNAs that are up-regulated more than 2 fold during differentiation and some were previously identified from rat brain tissues: miR-21, miR-152, miR-142-5p and -3p, miR-338, miR-339 and miR-378 (Landgraf et al., 2007).”
From Identification of Dynamically Regulated MicroRNA and mRNA Networks in Developing Oligodendrocytes (2008) · cites this paper as Landgraf et al., 2007
In the citing paper
“Notably, these included hsa-miR-219a and hsa-miR-338, both known to promote myelin repair 54 , and hsa-miR-23, which enhances oligodendrocyte differentiation and myelin synthesis 55 .”
From Human brain microRNAs exhibit cell-type specificity and age dependence (2026) · cites this paper as [54]
In the citing paper
“both known to promote myelin repair 54 , and hsa-miR-23, which enhances oligodendrocyte differentiation and myelin synthesis 55”
From Human brain microRNAs exhibit cell-type specificity and age dependence (2026) · cites this paper as [54]
In the citing paper
“miR-375, miR-141, and miR-200a in the pituitary (Landgraf et al. 2007);”
From MicroRNA expression in the adult mouse central nervous system (2008) · cites this paper as Landgraf et al. 2007
In the citing paper
“with some being shown to be expressed in a tissue- (16), cell type- (17), or even cell state-specific manner (18)”
From A mouse tissue atlas of small noncoding RNA (2020) · cites this paper as [16]
In the citing paper
“Recent efforts in profiling of the most studied types of small ncRNA, miRNA, across cells and tissues demonstrated the existence of tissue- and cell type-specific short noncoding transcripts (16, 24, 25, 33).”
From A mouse tissue atlas of small noncoding RNA (2020) · cites this paper as [16]
In the citing paper
“We identified both well-described brain-specific miRNAs, such as mir-9, mir-124, mir-219, mir-338 (16, 24, 33), as well as those which are missing from existing catalogs, such as mir-666, mir-878, mir-433, etc.”
From A mouse tissue atlas of small noncoding RNA (2020) · cites this paper as [16]
In the citing paper
“Consistent with previous reports, we observed that a group of miRNAs known to be brain specific, such as miR-124, miR-29b and miR-9, were highly enriched in all the samples. (Bak et al., 2008, Landgraf et al., 2007).”
From Cell-Type-Based Analysis of MicroRNA Profiles in the Mouse Brain (2012) · cites this paper as Landgraf et al., 2007
In the citing paper
“The most thorough of these microRNA localization projects performed small RNA library sequencing (RNA-seq) on over 250 libraries from 26 organ systems. However, this nascent effort sequenced only ∼1200 reads per library (Landgraf et al. 2007).”
From Toward the human cellular microRNAome (2017) · cites this paper as Landgraf et al. 2007
In the citing paper
“a previous study showed that miR-155 expression was highly specific to cells of hematopoietic origin 51 .”
From Identification of a protective microglial state mediated by miR-155 and interferon-γ signaling in a mouse model of Alzheimer’s disease (2023) · cites this paper as [51]
In the citing paper
“The first and as of now most comprehensive analysis of miRNA abundance in different tissues has been reported by Landgraf et al. in 2007 (3).”
From Distribution of miRNA expression across human tissues (2016) · cites this paper as [3]
In the citing paper
“For canonical miRNAs they found a high concordance of tissue-specific expression in humans and rodents.”
From Distribution of miRNA expression across human tissues (2016) · cites this paper as [3]
In the citing paper
“This sequencing-based study reported 340 miRNAs in 26 organs.”
From Distribution of miRNA expression across human tissues (2016) · cites this paper as [3]
In the citing paper
“Amongst others, Landgraf et al. detected tissue-specific expression of miR-122 in liver, of miR-9, miR-124 and miR 128a/b in brain, of miR-7, miR-375, miR-141 and miR-200a in pituitary gland and of miR-142, miR-144, miR-150, miR-155 and miR-223 in hematopoietic cells.”
From Distribution of miRNA expression across human tissues (2016) · cites this paper as [3]
In the citing paper
“The, as of now, most comprehensive study on tissue-specific miRNAs in humans was published by Landgraf et al. in 2007 (3).”
From Distribution of miRNA expression across human tissues (2016) · cites this paper as [3]
In the citing paper
“They identified 340 mature human miRNAs including 33 novel miRNAs not listed in the miRBase version 9.1, which was the current version at the time of the study (17).”
From Distribution of miRNA expression across human tissues (2016) · cites this paper as [3]
In the citing paper
“MiR-124 (miR-124–3p) was identified as the third most specific miRNA in the nervous system by Landgraf et al.”
From Distribution of miRNA expression across human tissues (2016) · cites this paper as [3]
In the citing paper
“They sequenced 256 small RNA libraries from 26 different organ systems and cell types of humans and rodents, with ∼1000 clone each.”
From Distribution of miRNA expression across human tissues (2016) · cites this paper as [3]
In the citing paper
“MiR-514a-3p belongs to the miR-506 family; the mouse orthologue of miR-506, mmu-201, has been shown to be specifically expressed in reproductive tissues (3).”
From Distribution of miRNA expression across human tissues (2016) · cites this paper as [3]
In the citing paper
“Loss-of-function of the abundant neuronal miRNAs let-7 and miR-124, and of the less abundant miR-125 and miR-132 (Landgraf et al., 2007), caused a marked pruning of the dendritic arbor, as quantified by Sholl analysis (Figure 4A, E).”
From Regulation of Synaptic Structure and Function by FMRP-Associated MicroRNAs miR-125b and miR-132 (2010) · cites this paper as Landgraf et al., 2007
In the citing paper
“The second is that early publications of general miRNA expression focused on tissues, which comprise numerous cell types, and the localization of miRNAs, whether cell specific or ubiquitous, has not been established [8, 9].”
From A curated human cellular microRNAome based on 196 primary cell types (2022) · cites this paper as [9]
In the citing paper
“Notably, five of the top 25 upregulated miRNAs in IS patients were brain-specific or enriched, including hsa-miR-9-3p, hsa-miR-124-3p, hsa-miR-143-3p, hsa-miR-98-5p, and hsa-miR-93-5p.”
From Acute Cerebral Ischemia Increases a Set of Brain-Specific miRNAs in Serum Small Extracellular Vesicles (2022) · cites this paper as Landgraf et al., 2007
In the citing paper
“Likewise, 9 out of the 20 upregulated miRNAs in tMCAO mice are brain-specific or preferentially expressed in brain tissues, including mmu-miR-124-3p, mmu-miR-9-3p, mmu-miR-9-5p, mmu-miR-323-3p, mmu-miR-219b-5p, mmu-miR-129b-3p, mmu-miR-129-5p, mmu-miR-433-3p, and mmu-miR-128-3p (Table 3).”
From Acute Cerebral Ischemia Increases a Set of Brain-Specific miRNAs in Serum Small Extracellular Vesicles (2022) · cites this paper as Landgraf et al., 2007
In the citing paper
“Previous reports have shown that miR-138-5p is highly expressed in the CNS, particularly among brain neurons [45,46,47].”
From MicroRNA-138-5p Targets Pro-Apoptotic Factors and Favors Neural Cell Survival: Analysis in the Injured Spinal Cord (2022) · cites this paper as [45]
Citations
Cites
Bartel (2004) · doi:10.1016/s0092-8674(04)00045-5 · Cited by 34,714
The C. elegans heterochronic gene lin-4 encodes small RNAs with antisense complementarity to lin-14
Lee, R. C., Feinbaum, R. L., & Ambros, V. (1993) · Cell · doi:10.1016/0092-8674(93)90529-y · Cited by 12,948
Lewis, B. P., Burge, C. B., & Bartel, D. P. (2005) · Cell · doi:10.1016/j.cell.2004.12.035 · Cited by 11,855
Prediction of Mammalian MicroRNA Targets
Lewis, B. P., Shih, I.-H., Jones-Rhoades, M. W., Bartel, D. P., & Burge, C. B. (2003) · Cell · doi:10.1016/s0092-8674(03)01018-3 · Cited by 5,199
Identification of Novel Genes Coding for Small Expressed RNAs
Lagos-Quintana, M., Rauhut, R., Lendeckel, W., & Tuschl, T. (2001) · Science · doi:10.1126/science.1064921 · Cited by 4,956
Self-citationMicroarray analysis shows that some microRNAs downregulate large numbers of target mRNAs
Lim, L. P., Lau, N. C., Garrett-Engele, P., Grimson, A., Schelter, J. M., Castle, J., Bartel, D. P., Linsley, P. S., & Johnson, J. M. (2005) · Nature · doi:10.1038/nature03315 · Cited by 4,755
MicroRNA genes are transcribed by RNA polymerase II
Lee, Y., Kim, M., Han, J., Yeom, K.-H., Lee, S., Baek, S. H., & Kim, V. N. (2004) · The EMBO Journal · doi:10.1038/sj.emboj.7600385 · Cited by 4,556
Wightman, B., Ha, I., & Ruvkun, G. (1993) · Cell · doi:10.1016/0092-8674(93)90530-4 · Cited by 4,292
miRBase: microRNA sequences, targets and gene nomenclature
Griffiths-Jones, S. (2006) · Nucleic Acids Research · doi:10.1093/nar/gkj112 · Cited by 3,950
Silencing of microRNAs in vivo with ‘antagomirs’
Krützfeldt, J., Rajewsky, N., Braich, R., Rajeev, K. G., Tuschl, T., Manoharan, M., & Stoffel, M. (2005) · Nature · doi:10.1038/nature04303 · Cited by 3,949
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Items 2,101–2,200 of 3,637
Seidl, C. I., Lama, L., & Ryan, K. (2012) · Nucleic Acids Research · doi:10.1093/nar/gks1334 · Cited by 25
Circulating miRNAs: Novel Biomarkers of Acute Coronary Syndrome?
Pleister, A. P., Selemon, H., Elton, S. M., & Elton, T. S. (2013) · Biomarkers in Medicine · doi:10.2217/bmm.13.8 · Cited by 27
Epigenetics of Neurological Cancers
Fouse, S. D., & Costello, J. (2009) · Future Oncology · doi:10.2217/fon.09.132 · Cited by 25
Xia, J., & Zhang, W. (2013) · Nucleic Acids Research · doi:10.1093/nar/gkt967 · Cited by 25
Small RNA Regulators of T Cell-Mediated Autoimmunity
Jeker, L. T., & Bluestone, J. A. (2010) · Journal of Clinical Immunology · doi:10.1007/s10875-010-9392-7 · Cited by 27
Mase, Y., Ishibashi, O., Ishikawa, T., Takizawa, T., Kiguchi, K., Ohba, T., Katabuchi, H., Takeshita, T., & Takizawa, T. (2012) · Reproductive Sciences · doi:10.1177/1933719112442245 · Cited by 25
The Effect of RNA Editing and ADARs on miRNA Biogenesis and Function
Heale, B. S. E., Keegan, L. P., & O’Connell, M. A. (2010) · Advances in experimental medicine and biology · doi:10.1007/978-1-4419-7823-3_8 · Cited by 25
Stik, G., Laurent, S., Coupeau, D., Coutaud, B., Dambrine, G., Rasschaert, D., & Muylkens, B. (2010) · RNA · doi:10.1261/rna.2121210 · Cited by 32
MicroRNA-Directed Neuronal Reprogramming as a Therapeutic Strategy for Neurological Diseases
Faravelli, I., & Corti, S. P. (2017) · Molecular Neurobiology · doi:10.1007/s12035-017-0671-7 · Cited by 25
YU, F. Y., Zhou, C., LIU, Y. B., WANG, B., MAO, L., & LI, Y. (2018) · Neoplasma · doi:10.4149/neo_2018_170608n411 · Cited by 25
Hong, X., Chen, R., Yuan, L., & Zha, J. (2018) · The Science of The Total Environment · doi:10.1016/j.scitotenv.2018.08.305 · Cited by 25
Wu, W., Zhai, M., Li, C., Yu, X., Song, X., Gao, S., & Li, B. (2018) · Insect Molecular Biology · doi:10.1111/imb.12539 · Cited by 25
MicroRNA-Attenuated Virus Vaccines
Fay, E. J., & Langlois, R. A. (2018) · Non-Coding RNA · doi:10.3390/ncrna4040025 · Cited by 25
Hecker, M., Boxberger, N., Illner, N., Fitzner, B., Schröder, I., Winkelmann, A., Dudešek, A., Meister, S., Koczan, D., Lorenz, P., et al. (2019) · PLoS Genetics · doi:10.1371/journal.pgen.1007961 · Cited by 26
isomiRs–Hidden Soldiers in the miRNA Regulatory Army, and How to Find Them?
Glogovitis, I., Yahubyan, G. T., Würdinger, T., Koppers‐Lalic, D., & Baev, V. (2020) · Biomolecules · doi:10.3390/biom11010041 · Cited by 25
Construction of miRNA‐mRNA‐TF Regulatory Network for Diagnosis of Gastric Cancer
Fu, Z., Xu, Y., Chen, Y., Lv, H., Chen, G., & Chen, Y. (2021) · BioMed Research International · doi:10.1155/2021/9121478 · Cited by 25
Langroudi, L., Jamshidi‐Adegani, F., Shafiee, A., Rad, S. M. A. H., Keramati, F., Azadmanesh, K., Arefian, E., & Soleimani, M. (2015) · Tumor Biology · doi:10.1007/s13277-015-3519-7 · Cited by 25
Lutz, C. S., & Cornett, A. L. (2013) · Wiley Interdisciplinary Reviews - RNA · doi:10.1002/wrna.1183 · Cited by 25
Kubo, E., Hasanova, N., Sasaki, H., & Singh, D. P. (2013) · Journal of Cellular and Molecular Medicine · doi:10.1111/jcmm.12094 · Cited by 25
Herdoiza Padilla, E., Crauwels, P., Bergner, T., Wiederspohn, N., Förstner, S., Rinas, R., Ruf, A., Kleemann, M., Handrick, R., Tuckermann, J., et al. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.02210 · Cited by 25
Fine Regulation of MicroRNAs in Gene Regulatory Networks and Pathophysiology
Seida, M., Ogami, K., Yoshino, S., & Suzuki, H. I. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26072861 · Cited by 25
Sheinerman, K. S., Tsivinsky, V. G., & Umansky, S. R. (2013) · Journal of Translational Medicine · doi:10.1186/1479-5876-11-304 · Cited by 24
An Ariadne's thread to the identification and annotation of noncoding RNAs in eukaryotes
Soldà, G., Makunin, I. V., Sezerman, O. U., Corradin, A., Corti, G., & Guffanti, A. (2009) · Briefings in Bioinformatics · doi:10.1093/bib/bbp022 · Cited by 24
Liu, X., Edinger, R. S., Klemens, C. A., Phua, Y. L., Bodnar, A. J., LaFramboise, W. A., Ho, J., & Butterworth, M. B. (2016) · Journal of Cellular Physiology · doi:10.1002/jcp.25599 · Cited by 24
Hepatitis B virus mRNAs functionally sequester let-7a and enhance hepatocellular carcinoma
Deng, M., Hou, J., Hu, J. X., Wang, S., Chen, M., Chen, L., Ju, Y., Li, C., & Meng, S. (2016) · Cancer Letters · doi:10.1016/j.canlet.2016.09.028 · Cited by 24
Oda, S., Takeuchi, M., Akai, S., Shirai, Y., Tsuneyama, K., & Yokoi, T. (2018) · American Journal Of Pathology · doi:10.1016/j.ajpath.2017.12.007 · Cited by 24
The role of microRNA-485 in neurodegenerative diseases
Ryu, I. S., Kim, D. H., Cho, H.-J., & Ryu, J.-H. (2023) · Reviews in the Neurosciences · doi:10.1515/revneuro-2022-0039 · Cited by 25
Diao, W., Yan, J., Wang, X., Qian, Q., & Wang, H. (2022) · Journal of Hazardous Materials · doi:10.1016/j.jhazmat.2022.130297 · Cited by 24
miR-7 controls glutamatergic transmission and neuronal connectivity in a Cdr1as-dependent manner
Cerda, C., Kim, S. J., Thomas, G., Farsi, Z., Zolotarov, G., Dube, G., Deter, A., Bahry, E., Georgii, E., Woehler, A., et al. (2024) · EMBO Reports · doi:10.1038/s44319-024-00168-9 · Cited by 24
Identification and Characterization of Pig Embryo MicroRNAs by Solexa Sequencing
Zhou, Y., Tang, X., Song, Q., Ji, Y., Wang, H., Wang, H., Jiao, H., Ouyang, H., & Pang, D. (2012) · Reproduction in Domestic Animals · doi:10.1111/j.1439-0531.2012.02040.x · Cited by 24
The role of miRNAs in cytokine signaling
McCoy, C. E. (2011) · Frontiers in bioscience · doi:10.2741/3845 · Cited by 24
Daubas, P., Crist, C. G., Bajard, L., Relaix, F., Pecnard, E., Rocancourt, D., & BUCKINGHAM, M. E. (2008) · Developmental Biology · doi:10.1016/j.ydbio.2008.11.031 · Cited by 24
Regulatory interplay between miR-21, JAG1 and 17beta-estradiol (E2) in breast cancer cells
Selçuklu, S. D., Donoghue, M. T. A., Kerin, M. J., & Spillane, C. (2012) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2012.05.074 · Cited by 24
MicroRNA-mediated gene regulations in human sarcomas
Subramanian, S., & Kartha, R. V. (2012) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-012-1127-x · Cited by 24
Epigenetics in Traditional Chinese Pharmacy: A Bioinformatic Study at Pharmacopoeia Scale
Hsieh, H.-Y., Chiu, P.-H., & Wang, S.-C. (2010) · Evidence-based Complementary and Alternative Medicine · doi:10.1093/ecam/neq050 · Cited by 24
Dynamic regulation of cancer stem cells and clinical challenges
Ni, C., & Huang, J. (2012) · Clinical & Translational Oncology · doi:10.1007/s12094-012-0927-7 · Cited by 24
Kim, J. M., Lim, K., Hong, J. S., Kang, J., Lee, Y. S., & Hong, K. C. (2014) · Animal Genetics · doi:10.1111/age.12255 · Cited by 24
Qi, F., Huang, M., Pan, Y., Liu, Y., Liu, J., Wen, J., Xie, K., Shen, H., Ma, H., Miao, Y., et al. (2014) · PLoS ONE · doi:10.1371/journal.pone.0085394 · Cited by 24
Defining Plasma MicroRNAs Associated With Cognitive Impairment In HIV‐Infected Patients
Kadri, F., LaPlante, A., Luca, M. D., Doyle, L., Velasco‐Gonzalez, C., Patterson, J., Molina, P. E., Nelson, S., Zea, A. H., Parsons, C. H., et al. (2015) · Journal of Cellular Physiology · doi:10.1002/jcp.25131 · Cited by 24
Qin, H., Chen, G., Liang, M., Rong, J., Yao, J., Liu, H., & Wu, Z. (2013) · Journal of Translational Medicine · doi:10.1186/1479-5876-11-154 · Cited by 24
Quantitative Proteomic Analysis of Gene Regulation by miR-34a and miR-34c
Ebner, O. A., & Selbach, M. (2014) · PLoS ONE · doi:10.1371/journal.pone.0092166 · Cited by 25
Shu, S., Qing, D., Wang, B., Zeng, Q., Chen, Y., Jin, Y., Zeng, C., & Bao, R. (2013) · Journal of Biomedical Science · doi:10.1186/1423-0127-20-9 · Cited by 24
MicroRNAs, HIV and HCV: a complex relation towards pathology
Piedade, D., & Azevedo‐Pereira, J. M. (2016) · Reviews in Medical Virology · doi:10.1002/rmv.1881 · Cited by 24
Apigenin suppresses mouse peritoneal fibrosis by down-regulating miR34a expression
Zhang, Y., Sun, Q., Li, X., Ma, X., Li, Y., Jiao, Z., & Yang, X. (2018) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2018.06.138 · Cited by 24
Age- and sex-dependent changes in levels of circulating brain-enriched microRNAs during normal aging
Sheinerman, K. S., Tsivinsky, V. G., Mathur, A., Kessler, D. A., Shaz, B. H., & Umansky, S. R. (2018) · Aging · doi:10.18632/aging.101613 · Cited by 27
Post-transcriptional tuning of FGF signaling mediates neural crest induction
Copeland, J., & Simoes-Costa, M. (2020) · Proceedings of the National Academy of Sciences of the United States of America · doi:10.1073/pnas.2009997117 · Cited by 22
MicroRNAs in brain cholesterol metabolism and their implications for Alzheimer's disease
Yoon, H., Flores, L. F., & Kim, J. (2016) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2016.04.020 · Cited by 23
“In addition, many miRNAs exhibit temporal and spatial expressions under different cellular contexts and brain has a quite distinct miRNA expression pattern [8, 9, 100, 101].”
BackgroundMicroRNA-based molecular classification of non-BRCA1/2 hereditary breast tumours
Tanić, M., Andrés, E., Rodríguez-Pinilla, S. M., Márquez‐Rodas, I., Cebollero-Presmanes, M., Fernández, M. V., Osório, A., Benitez, J. J., & Martínez–Delgado, B. (2013) · British Journal of Cancer · doi:10.1038/bjc.2013.612 · Cited by 24
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Chiang, K., & Rice, A. P. (2011) · Future Virology · doi:10.2217/fvl.10.92 · Cited by 23
Self-citationPrecision multidimensional assay for high-throughput microRNA drug discovery
Haefliger, B., Prochazka, L., Angelici, B., & Benenson, Y. (2016) · Nature Communications · doi:10.1038/ncomms10709 · Cited by 23
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Li, C., Wang, Z., Tang, X., Zeng, L., Fan, X., & Li, Z. (2017) · Molecular Medicine Reports · doi:10.3892/mmr.2017.7071 · Cited by 23
Amsel, D., Vilcinskas, A., & Billion, A. (2017) · BMC Bioinformatics · doi:10.1186/s12859-017-1772-z · Cited by 23
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Godínez-Rubí, M., & Ortuño‐Sahagún, D. (2020) · Cells · doi:10.3390/cells9071566 · Cited by 24
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Ke, R., Lv, L., Zhang, S., Zhang, F.-X., & Jiang, Y. (2020) · Cancer Medicine · doi:10.1002/cam4.3557 · Cited by 23
Want, A., Staniak, K., Grabowska, W., Fesiuk, A., Barczak, A. K., Gabryelewicz, T., Kulczyńska‐Przybik, A., Mroczko, B., & Wojda, U. (2023) · Scientific Reports · doi:10.1038/s41598-023-47971-3 · Cited by 31
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Skårn, M., Barøy, T., Stratford, E. W., & Myklebost, O. (2013) · PLoS ONE · doi:10.1371/journal.pone.0079231 · Cited by 23
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Ajay, S. S., Athey, B. D., & Lee, I. (2010) · BMC Genomics · doi:10.1186/1471-2164-11-155 · Cited by 23
miRT: A Database of Validated Transcription Start Sites of Human MicroRNAs
Bhattacharyya, M., Das, M., & Bandyopadhyay, S. (2012) · Genomics Proteomics & Bioinformatics · doi:10.1016/j.gpb.2012.08.005 · Cited by 23
Chen, Y., Zhou, H., Sarver, A. L., Zeng, Y., Roy‐Chowdhury, J., Steer, C. J., & Sahin, B. M. (2010) · Liver Transplantation · doi:10.1002/lt.22111 · Cited by 23
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Mees, S. T., Schleicher, C., Mardin, W. A., Senninger, N. J., Colombo‐Benkmann, M., & Haier, J. (2009) · Journal of Surgical Research · doi:10.1016/j.jss.2009.10.005 · Cited by 23
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Wang, X., Lu, Y., Liang, J.-J., Cao, J., Jin, Y., An, G., Ni, J., Jia, H., & Li, S. (2016) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2016.08.006 · Cited by 23
microRNAs as cancer biomarkers
Flatmark, K., Høye, E., & Fromm, B. (2016) · Scandinavian Journal of Clinical and Laboratory Investigation · doi:10.1080/00365513.2016.1210330 · Cited by 23
The Non-Coding Transcriptome of Prostate Cancer: Implications for Clinical Practice
Bijnsdorp, I. V., van Royen, M. E., Verhaegh, G. W. C. T., & Martens‐Uzunova, E. S. (2017) · Molecular Diagnosis & Therapy · doi:10.1007/s40291-017-0271-2 · Cited by 24
Global mapping of miRNA-target interactions in cattle (Bos taurus)
Scheel, T. K. H., Moore, M. J., Luna, J. M., Nishiuchi, E., Fak, J. J., Darnell, R. B., & Rice, C. M. (2017) · Scientific Reports · doi:10.1038/s41598-017-07880-8 · Cited by 23
Chu, F., Hu, Y., Zhou, Y., Guo, M., Lu, J., Zheng, W., Xu, H., Zhao, J., & Xu, L. (2017) · Clinical & Experimental Immunology · doi:10.1111/cei.13067 · Cited by 23
Bai, S., Xu, B., Guo, Y., Qiu, J., Yu, W. H., & Xie, G. (2018) · Theranostics · doi:10.7150/thno.23852 · Cited by 23
Siracusa, J., Koulmann, N., Sourdrille, A., Chapus, C., Verret, C., Bourdon, S., Goriot, M., & Banzet, S. (2018) · Frontiers in Physiology · doi:10.3389/fphys.2018.00684 · Cited by 23
miR-22-3p is involved in gluconeogenic pathway modulated by 3,5-diiodo-L-thyronine (T2)
Senese, R., Cioffi, F., Petito, G., de Lange, P., Russo, A., Goglia, F., Lanni, A., & Potenza, N. (2019) · Scientific Reports · doi:10.1038/s41598-019-53019-2 · Cited by 23
Pietrzykowski, A. Z., & Spijker, S. (2014) · Frontiers in Neuroscience · doi:10.3389/fnins.2014.00389 · Cited by 23
Das, S. (2009) · Molecular Biology and Evolution · doi:10.1093/molbev/msp035 · Cited by 23
Defining Larger Roles for “Tiny” RNA Molecules: Role of miRNAs in Neurodegeneration Research
Yelamanchili, S. V., & Fox, H. S. (2009) · Journal of Neuroimmune Pharmacology · doi:10.1007/s11481-009-9172-4 · Cited by 23
Glineur, S., Ron, P. D., Hanon, É., Valentin, J., Dremier, S., & da Costa, A. N. (2015) · Toxicological Sciences · doi:10.1093/toxsci/kfv222 · Cited by 23
Lü, J., Gu, H., Tang, Q., Wu, W., Yuan, B., Guo, D., Wei, Y., Sun, H., Xia, Y., Ding, H., et al. (2016) · Scientific Reports · doi:10.1038/srep19825 · Cited by 23
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Liang, D., Zhen, L., Yuan, T., Huang, J. J., Deng, F., Wuyahan, Zhang, H., Pan, L., Liu, Y., The, E., et al. (2014) · PLoS ONE · doi:10.1371/journal.pone.0103097 · Cited by 22
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Zhao, Y., Wei, Q., Hu, L., Chen, F., Hu, Z., Heist, R. S., Su, L., Amos, C. I., Shen, H., & Christiani, D. C. (2014) · Cancer Epidemiology Biomarkers & Prevention · doi:10.1158/1055-9965.epi-14-0389 · Cited by 22
Baulina, N., Osmak, G. J., Сергеевич, К. И., Matveeva, N. A., Kukava, N. G., Shakhnovich, R. M., Кулакова, О. Г., & Favorova, O. O. (2018) · Journal of Molecular and Cellular Cardiology · doi:10.1016/j.yjmcc.2018.07.129 · Cited by 22
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Sabry, R., Williams, M., Werry, N., LaMarre, J., & Favetta, L. A. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23158276 · Cited by 22
Mechanisms of abnormal adult hippocampal neurogenesis in Alzheimer’s disease
Zhou, Y., Wang, X., Liu, Y., Gu, Y., Gu, R., Zhang, G., & Lin, Q. (2023) · Frontiers in Neuroscience · doi:10.3389/fnins.2023.1125376 · Cited by 22
The expression and functional roles of microRNAs in stem cell differentiation
Shim, J., & Nam, J. (2016) · BMB Reports · doi:10.5483/bmbrep.2016.49.1.217 · Cited by 22
MicroRNA regulation of the germinal center response
Baumjohann, D., & Ansel, K. M. (2014) · Current Opinion in Immunology · doi:10.1016/j.coi.2014.01.003 · Cited by 22
miRNAs Stem Cell Reprogramming for Neuronal Induction and Differentiation
Perruisseau-Carrier, C., Jurga, M., Forraz, N., & McGUCKIN, C. P. (2011) · Molecular Neurobiology · doi:10.1007/s12035-011-8179-z · Cited by 22
Autophagy and microRNA dysregulation in liver diseases
Kim, K. M., & Kim, S. G. (2014) · Archives of Pharmacal Research · doi:10.1007/s12272-014-0439-9 · Cited by 22
Bai, Y., Huang, J., Liu, G., Zhang, J., Wang, J., Liu, C., & Fang, M. (2014) · BMC Genomics · doi:10.1186/1471-2164-15-47 · Cited by 25
Discovery of Novel and Differentially Expressed MicroRNAs between Fetal and Adult Backfat in Cattle
Sun, J., Zhou, Y., Cai, H., Lan, X., Lei, C., Zhao, X., Zhang, C., & Chen, H. (2014) · PLoS ONE · doi:10.1371/journal.pone.0090244 · Cited by 22
Das, S. K., Bhutia, S. K., Sokhi, U. K., Dash, R., Azab, B., Sarkar, D., & Fisher, P. B. (2010) · Oncogene · doi:10.1038/onc.2010.572 · Cited by 25
Methods for validation of miRNA sequence variants and the cleavage of their targets
Jeong, D., & Green, P. J. (2012) · Methods · doi:10.1016/j.ymeth.2012.08.005 · Cited by 22
MiR‐492 impairs the angiogenic potential of endothelial cells
Patella, F., Leucci, E., Evangelista, M., Parker, B. J., Wen, J., Mercatanti, A., Rizzo, M., Chiavacci, E., Lund, A. H., & Rainaldi, G. (2013) · Journal of Cellular and Molecular Medicine · doi:10.1111/jcmm.12085 · Cited by 22
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Tan, T., Zhang, Y., Ji, W., & Zheng, P. (2014) · BioMed Research International · doi:10.1155/2014/154251 · Cited by 22
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Roth, W., Hecker, D., & Fava, E. (2015) · Methods in molecular biology · doi:10.1007/978-1-4939-2627-5_21 · Cited by 22
Mamoori, A., Gopalan, V., Lu, C., Chua, T. C., Morris, D. L., Smith, R. A., & Lam, A. K.-Y. (2016) · Journal of Clinical Pathology · doi:10.1136/jclinpath-2016-203972 · Cited by 22
Hsu, A. Y.-H., Wang, D., Gurol, T., Zhou, W., Zhu, X., Lu, H.-Y., & Deng, Q. (2017) · Disease Models & Mechanisms · doi:10.1242/dmm.030791 · Cited by 22
Wang, X., Hao, J., Guo, W., Liao, L., Huang, S.-Y., Guo, X., Bao, X., Esteban, M. A., & Wang, Y. (2017) · Stem Cell Reports · doi:10.1016/j.stemcr.2017.08.027 · Cited by 22
Metadata
- Authors
- Landgraf, P., Rusu, M., Sheridan, R., Sewer, A., Iovino, N., Aravin, A., Pfeffer, S., Rice, A., Kamphorst, A. O., Landthaler, M., Lin, C., Socci, N. D., Hermida, L., Fulci, V., Chiaretti, S., Foà, R., Schliwka, J., Fuchs, U., Novosel, A., Müller, R.-U., Schermer, B., Bissels, U., Inman, J., Phan, Q., Chien, M., Weir, D. B., Choksi, R., De Vita, G., Frezzetti, D., Trompeter, H.-I., Hornung, V., Teng, G., Hartmann, G., Palkovits, M., Di Lauro, R., Wernet, P., Macino, G., Rogler, C. E., Nagle, J. W., Ju, J., Papavasiliou, F. N., Benzing, T., Lichter, P., Tam, W., Brownstein, M. J., Bosio, A., Borkhardt, A., Russo, J. J., Sander, C., Zavolan, M., & Tuschl, T.
- Affiliations
- Howard Hughes Medical Institute (US)
- University of Basel (CH)
- Memorial Sloan Kettering Cancer Center (US)
- SIB Swiss Institute of Bioinformatics (CH)
- Sapienza University of Rome (IT)
- German Cancer Research Center (DE)
- Ludwig-Maximilians-Universität München (DE)
- University Medical Center Freiburg (DE)
- Miltenyi Biotec (Germany) (DE)
- J. Craig Venter Institute (US)
- Columbia University (US)
- University of Naples Federico II (IT)
- Düsseldorf University Hospital (DE)
- Rockefeller University (US)
- University of Bonn (DE)
- Albert Einstein College of Medicine (US)
- National Institutes of Health (US)
- Cornell University (US)
- Corresponding author
- Zavolan, Mihaela
- Tuschl, Thomas
- ORCID
- Landgraf, Pablo
- Rusu, Mirabela
- Iovino, Nicola
- Aravin, Alexei
- Pfeffer, Sébastien
- Kamphorst, Alice O.
- Landthaler, Markus
- Lin, Carolina
- Socci, Nicholas D.
- Hermida, Leandro
- Fulci, Valerio
- Chiaretti, Sabina
- Foà, Robin
- Müller, Roman-Ulrich
- Schermer, Bernhard
- Inman, Jason
- Frezzetti, Daniela
- Trompeter, Hans-Ingo
- Hornung, Veit
- Hartmann, Gunther
- Papavasiliou, F. Nina
- Benzing, Thomas
- Tam, Wayne
- Bosio, Andreas
- Borkhardt, Arndt
- Russo, James J.
- Sander, Chris
- Zavolan, Mihaela
- Tuschl, Thomas
- Venue
- Cell
- Publisher
- Elsevier BV
- Published
- 2007-06
- Volume
- 129
- Issue
- 7
- Pages
- 1401-1414
- ISSN
- 0092-8674 (ISSN-L)
- PMC
- PMC2681231
- OpenAlex
- W2149146453
- Cited by
- 3,626
- References
- 70
- Citations by year
- 2026: 42 · 2025: 73 · 2024: 87 · 2023: 104 · 2022: 131 · 2021: 160 · 2020: 152 · 2019: 167 · 2018: 205 · 2017: 185 · 2016: 221 · 2015: 238 · 2014: 275 · 2013: 310 · 2012: 283
- FWCI
- 84.13
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- www.elsevier.com/tdm/userlicense/1.0/ (tdm)
- www.elsevier.com/legal/tdmrep-license (tdm)
- www.elsevier.com/open-access/userlicense/1.0/ (vor, 2274 d)
- doi.org/10.15223/policy-017 (stm-asf)
- doi.org/10.15223/policy-037 (stm-asf)
- doi.org/10.15223/policy-012 (stm-asf)
- doi.org/10.15223/policy-029 (stm-asf)
- doi.org/10.15223/policy-004 (stm-asf)
- Locations
- Cell (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Cold Spring Harbor Laboratory Institutional Repository (Cold Spring Harbor Laboratory) (acceptedVersion)
- HAL (submittedVersion)
- MDC Repository (Max-Delbrueck-Center for Molecular Medicine) (submittedVersion)
- IRIS Research product catalog (Sapienza University of Rome) (submittedVersion)
- MPG.PuRe (Max Planck Society) (submittedVersion)
- Funders
- Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung (105945, 205321)
- National Institute of General Medical Sciences (P01GM073047)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › MicroRNA in disease regulation
- Life Sciences › Agricultural and Biological Sciences › Plant Science › Plant Molecular Biology Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer-related molecular mechanisms research
- Keywords
- microRNA, small RNA sequencing, microRNA precursors, microRNA maturation, miRNA conservation, microRNA target regulation, hematopoietic cells, neurons, cell lineage, miRNA expression profiling
- MeSH terms
- Animals, Base Sequence, Gene Expression Regulation, Hematopoietic Stem Cells, Humans, Molecular Sequence Data, Phylogeny, RNA, Messenger, Sequence Homology, Nucleic Acid, Gene Library, Conserved Sequence, Cell Lineage, Hematologic Neoplasms, Gene Expression Profiling, MicroRNAs, Mice, Rats
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