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Shared Principles in NF-κB Signaling
Abstract
The transcription factor NF-kappaB has served as a standard for inducible transcription factors for more than 20 years. The numerous stimuli that activate NF-kappaB, and the large number of genes regulated by NF-kappaB, ensure that this transcription factor is still the subject of intense research. Here, we attempt to synthesize some of the basic principles that have emerged from studies of NF-kappaB, and we aim to generate a more unified view of NF-kappaB regulation.
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“Predominately under IL1β stimulation, negative regulators of AP-1 (Dusp1/2/5/6) and NF-κB signaling (Nfkbia) are upregulated49,50.”
From Clonal hematopoiesis related TET2 loss-of-function impedes IL1β-mediated epigenetic reprogramming in hematopoietic stem and progenitor cells (2023) · cites this paper as [50]
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Metadata
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- Hayden, M. S., & Ghosh, S.
- Venue
- Cell
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- 2008-02
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- 132
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- 3
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- 344-362
- ISSN
- 0092-8674
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- doi.org/10.15223/policy-029 (stm-asf)
- doi.org/10.15223/policy-004 (stm-asf)
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