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Berberine alleviates tendinopathy by suppressing the cGAS-STING pathway and Relieving ferroptosis

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PIKfyve Inhibition Induces Antitumor Immunogenicity by Attenuating STING Trafficking and Lysosomal Degradation

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Investigating the Activation Mechanism Differences between Human and Mouse cGAS by Molecular Dynamics Simulations

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NEGATIVE MODULATORS OF THE CGAS-STING PATHWAY

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Exploration of the Binding Mechanism of Cyclic Dinucleotide Analogs to Stimulating Factor Proteins and the Implications for Subsequent Analog Drug Design

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10th anniversary of discovering cGAMP: synthesis and beyond

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One‐Flask Synthesis of Cyclic Diguanosine Monophosphate (c‐di‐GMP)

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Cytosolic DNA sensing unraveled

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Highly Efficient Cyclic Dinucleotide Based Artificial Metalloribozymes for Enantioselective Friedel–Crafts Reactions in Water

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Helicobacter pylori provokes STING immunosurveillance via trans-kingdom conjugationPreprint

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Chloride Homeostasis Regulates cGAS-STING SignalingPreprint

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The regulation of the apoptotic pore—An immunological tightrope walk

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Ein Phosphotriester‐Maskiertes Dideoxy‐cGAMP‐Derivat als Zellpermeabler STING‐Agonist

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Recent Mechanistic Insight into the Immunogenic Properties of Radiation-Induced Micronuclei

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Carriers Multimerize STING Protein Fragments to Activate Type I Interferon Signaling in STING-Deficient Cancer Cells

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cGAS – STING Pathway Activation Enhances Antitumor Effect of Talaporfin Photodynamic Therapy Through ROS Production

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Molecular mechanisms of CBASS-mediated bacteriophage defense

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Aloperine exerts anti-tumor effect and activates the tumor cell-intrinsic STING pathway in gallbladder cancer

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In Silico Discovery and Mechanistic Profiling of Sting Agonists Engaging the Transmembrane Domain

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Interferon‐Like Signaling Pathway in Crustaceans: Structure, Immune Function, and Prospects for Disease Control in Aquaculture

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Activation of STING sensitizes melanoma cells to radiation through ROS-induced NLRP3

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cGAS-STING-driven inflammaging cascade in aging-related retinal diseases: From pathological mechanism to therapeutic potentials

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The role of the cGAS-STING pathway in radiation-induced lung injury: mechanisms and therapeutic perspective

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Cytosolic Immunostimulatory DNA Ligands and DNA Damage Activate the Integrated Stress Response, Stress Granule Formation, and Cytokine Production

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Investigation of the potential anticancer immune response for gold compounds

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Inside Out: How Cellular Localisation Shapes cGAS Functions in Health and Disease

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Targeting Cyclic GMP–AMP Synthase: Novel Therapeutic Inhibitors for Autoimmune Diseases

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cGAS-STING and PANoptosis: Interplay, Underlying Mechanisms, and Therapeutic Targets

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Modular double-stranded DNA recognition defines specificity of the exonuclease TREX1 in cGAS-STING control

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Molecular mechanism of 2′,3′-cGAMP degradation by monkeypox virus poxin-schlafen protein

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Indomethacin restrains cytoplasmic nucleic acid-stimulated immune responses by inhibiting the nuclear translocation of IRF3

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The structural basis for 2′-5′/3′-5′-cGAMP synthesis by cGAS

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Protein-S-nitrosylation of human cytomegalovirus pp65 reduces its ability to undermine cGAS

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Novel telomere-targeting dual-pharmacophore dinucleotide prodrugs for anticancer therapy

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Protein–Ligand Interactions in Scarcity: The Stringent Response from Bacteria to Metazoa, and the Unanswered Questions

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Flash nanoprecipitation for the production of endosomolytic polymersomes for cytosolic drug deliveryPreprint

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Deoxyuridine-rich cytoplasmic DNA antagonizes STING-dependent innate immune responses and sensitizes resistant tumors to anti-PD-L1 therapyPreprint

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New Frontiers on Intracellular cGAS Activation: Molecular Mechanisms, Cellular Signaling, and Therapeutic Strategies

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In Vitro Cleavage Assay to Characterize DENV NS2B3 Antagonism of cGAS

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Vaccination of STING agonists-loaded nanoemulsions for cancer immunotherapy

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Effect of methyl DNA adducts on stimulation of human cytoplasmic DNA ‐sensor cyclic GMP ‐ AMP synthase ( cGAS )

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A novel nanomicelle based on Rebaudioside A: An oral nanoplatform with enhanced nephroprotective effect of myricetin

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Structural and energetic insights into cGAS-DNA monomer and oligomer formation: an MD and mM/GBSA study

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Dual roles of TRPV2 in the innate immune response to cytosolic DNA: Arresting dormant and boosting activated STING

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Potential and Applications of Mn Complexes in Breast Cancer

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Cucurbitacin B Inhibits Hepatocellular Carcinoma by Inducing Ferroptosis and Activating the cGAS-STING Pathway

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Development and Experimental Validation of a Machine-Learning- and Physics- Based Exhaustive Hexapeptide Screening Model for Target Proteins

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Fueling silence: Metabolic control of latent viral infection

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TIA1-mediated stress granules inhibit the neuroinflammation and neurodegeneration after spinal cord injury through LCN2 signaling

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HSV-2 genome recognition by nuclear cGAS instigates IFN-β production and influences inflammasome activation during de novo infection in HFF cells

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Targeting RNase H2: A dual-mechanism strategy to elevate replication stress, DNA damage, and antitumor immunity in TNBC

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Extracellular cGAMP in health and disease

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Rab26 mitigates ferroptosis in airway epithelium induced by cigarette smoke through suppression of VDAC1 oligomerization-mediated cGAS-STING activation

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Barrier-to-autointegration factor protects against the cGAS-STING response to chromatin bridges

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PKCα-mediated nuclear translocation of cGAS stabilizes β-catenin and drives metastasis

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The NLRP3 inflammasome at the crossroads of innate immune signaling and cell death

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Biomineralized engineered Lactococcus lactis-based in situ vaccination enhances antitumor immunity via sequential activation of chemo-immunotherapy

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Reducing hERG Inhibition in the Design of Potent and Bioavailable Indazole cGAS Inhibitors

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Discovery of the thieno[2,3-b][1,4]thiazin-2(3H)-one STING inhibitors

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The cGAS-STING pathway at the crossroads of neuroimmunology: bridging innate immunity to aging and neurodegeneration

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Multiple Roles of G3BP1 in Regulating STING-Dependent Interferon and Cytokine Induction by Cytosolic dsDNA and HSV-1 Infection

Devale, T., Manivannan, P., & Malathi, K. (2026) · Viruses · doi:10.3390/v18070719 · Cited by 1

Emerging roles of the cGAS/STING pathway in cardiovascular diseases

Saitoh, W., Higashikuni, Y., Bavuu, O., Sata, M., & Fukuda, D. (2026) · Journal of Clinical Investigation · doi:10.1172/jci204551 · Cited by 2

Dysfunctional Mitochondria in Microglia Drive Cognitive Aging and Neurodegeneration via cGAS–STING

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cGAS/STING Signaling in Ulcerative Colitis: Mechanism and Therapeutic Opportunities

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cGAS-STING targeting offers a novel therapeutic paradigm in hemorrhagic stroke

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ENPP1 buffers extracellular cGAMP in brown adipose tissue to limit insulin resistance

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Das Immunsystem der Nukleinsäureerkennung

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Nucleic Acid Innate Immune Receptors

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Organische Chemie 2013

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Site Specific Lysine Acetylation of Histones for Nucleosome Reconstitution using Genetic Code Expansion in Escherichia coli

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CYCLIC DINUCLEOTIDES

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Organelle membrane-associated proteins recruit cGAS via phase separation to facilitate its membrane localizationPreprint

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A choanoflagellate cGLR-STING pathway reveals evolutionary links between bacterial and animal immunityPreprint

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Dissecting the Role of Cytosolic Nucleic Acid Sensors in the Type I Interferon Response to Herpes Simplex Virus-1 and other Ligands: A Dissertation

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Profile of Dinshaw J. Patel

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Revving up cGAS

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Building unique bonds to fight misplaced DNA

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cGAMP‐Synthase als Sensor für invasive DNA

Hille‐Rehfeld, A. (2014) · Chemie in unserer Zeit · doi:10.1002/ciuz.201490008

Structural Biology of Protein Post-transcriptional Modifications and Cellular Signaling

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GEMM-I riboswitch-based fluorescent biosensors for live cell analysis of cyclic dinucleotide signaling

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Advances of cGAS

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Intratumoral STING Activation Sensitizes Poorly Immunogenic Cancers to Checkpoint Blockade Immunotherapy

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