Cyclic [G(2′,5′)pA(3′,5′)p] is the metazoan second messenger produced by DNA-activated cyclic GMP-AMP synthase.

Gao, Pu, Ascano, Manuel, Wu, Yang, Barchet, Winfried, Gaffney, Barbara L., Zillinger, Thomas, Serganov, Artem A., Liu, Yizhou, Jones, Roger A., Hartmann, Gunther, Tuschl, Thomas, Patel, Dinshaw J.·2013·Cell

DOI 10.1016/j.cell.2013.04.046

Cited by (1,000)

Items 101–200 of 1,000

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Christopher John Neufeldt, Berati Cerikan, Mirko Cortese, Jamie Frankish, Ji‐Young Lee, Agnieszka Płóciennikowska, Florian Heigwer, Vibhu Ranjan Prasad, Sebastian Joecks, Sandy S. Burkart et al. · 2022 · Communications Biology
Single Nucleotide Polymorphisms of Human STING Can Affect Innate Immune Response to Cyclic Dinucleotides
Guanghui Yi, Volker Brendel, Chang Shu, Pingwei Li, Satheesh Palanathan, C. Cheng Kao · 2013 · PLoS ONE
Inflammasome Activation Triggers Caspase-1-Mediated Cleavage of cGAS to Regulate Responses to DNA Virus Infection
Yutao Wang, Xiaohan Ning, Pengfei Gao, Shuxian Wu, Mengyin Sha, Mengze Lv, Xiang Zhou, Juyi Gao, Run Fang, Guangxun Meng et al. · 2017 · Immunity
HER2 recruits AKT1 to disrupt STING signalling and suppress antiviral defence and antitumour immunity
Shiying Wu, Qian Zhang, Fei Zhang, Fansen Meng, Shengduo Liu, Ruyuan Zhou, Qingzhe Wu, Xinran Li, Li Shen, Jun Huang et al. · 2019 · Nature Cell Biology
Evolutionary Origins of cGAS-STING Signaling
Shally R. Margolis, Stephen C. Wilson, Russell E. Vance · 2017 · Trends in Immunology
Structural mechanism of cGAS inhibition by the nucleosome
Pathare, Ganesh R., Decout, Alexiane, Glück, Selene, Cavadini, Simone, Makasheva, Kristina, Hovius, Ruud, Kempf, Georg, Weiss, Joscha, Kozicka, Zuzanna, Guey, Baptiste et al. · 2020 · Nature
Cytokinesis defects and cancer
Susanne M. A. Lens, René H. Medema · 2018 · Nature reviews. Cancer
Chromatin‐bound cGAS is an inhibitor of DNA repair and hence accelerates genome destabilization and cell death
Hui Jiang, Xiaoyu Xue, Swarupa Panda, Ajinkya S. Kawale, Richard M. Hooy, Fengshan Liang, Jungsan Sohn, Patrick Sung, Nelson O. Gekara · 2019 · The EMBO Journal
The molecular basis of tight nuclear tethering and inactivation of cGAS
Zhao, Baoyu, Xu, Pengbiao, Rowlett, Chesley M., Jing, Tao, Shinde, Omkar, Lei, Yuanjiu, West, A. Phillip, Liu, Wenshe Ray, Li, Pingwei · 2020 · Nature
Listeria monocytogenes induces IFNβ expression through an IFI16‐, cGAS‐ and STING‐dependent pathway
Kathrine Hansen, Thaneas Prabakaran, Anders Laustsen, Sofie E. Jørgensen, Stine H Rahbæk, Søren B. Jensen, Rikke Nielsen, Jess H. Leber, Thomas Decker, Kristy Horan et al. · 2014 · The EMBO Journal
Cyclic GMP–AMP as an Endogenous Second Messenger in Innate Immune Signaling by Cytosolic DNA
Kazuki Kato, Hiroki Omura, Ryuichiro Ishitani, Osamu Nureki · 2017 · Annual Review of Biochemistry
Structural basis for sequestration and autoinhibition of cGAS by chromatin
Michalski, Sebastian, de Oliveira Mann, Carina C., Stafford, Che A., Witte, Gregor, Bartho, Joseph, Lammens, Katja, Hornung, Veit, Hopfner, Karl-Peter · 2020 · Nature
Emerging role of STING signalling in CNS injury: inflammation, autophagy, necroptosis, ferroptosis and pyroptosis
Xinli Hu, Haojie Zhang, Qianxin Zhang, Xue Xin Yao, Wenfei Ni, Kailiang Zhou · 2022 · Journal of Neuroinflammation
Sequence-specific activation of the DNA sensor cGAS by Y-form DNA structures as found in primary HIV-1 cDNA
Anna‐Maria Herzner, Cristina Amparo Hagmann, Marion Goldeck, Steven Wolter, Kirsten Kübler, Sabine Wittmann, Thomas Gramberg, Liudmila Andreeva, Karl‐Peter Hopfner, Christina Mertens et al. · 2015 · Nature Immunology
Antitumor Activity of cGAMP via Stimulation of cGAS-cGAMP-STING-IRF3 Mediated Innate Immune Response
Tiejun Li, Hao Cheng, Hong Yuan, Qiming Xu, Chang Shu, Yuefan Zhang, Pengbiao Xu, Jason Tan, Yao‐Cheng Rui, Pingwei Li et al. · 2016 · Scientific Reports
Cytosolic DNA Sensing in Organismal Tumor Control
Vanpouille-Box, Claire, Demaria, Sandra, Formenti, Silvia C., Galluzzi, Lorenzo · 2018 · Cancer Cell
Challenges and Opportunities in the Clinical Development of STING Agonists for Cancer Immunotherapy
Leila Motedayеn Aval, James Edward Pease, Rohini Sharma, David James Pinato · 2020 · Journal of Clinical Medicine
Ribonuclease H2 mutations induce a cGAS/STING‐dependent innate immune response
Mackenzie, Karen J, Carroll, Paula, Lettice, Laura, Tarnauskaitė, Žygimantė, Reddy, Kaalak, Dix, Flora, Revuelta, Ailsa, Abbondati, Erika, Rigby, Rachel E, Rabe, Björn et al. · 2016 · The EMBO Journal
Ancient Origin of cGAS-STING Reveals Mechanism of Universal 2′,3′ cGAMP Signaling
Philip J. Kranzusch, Stephen C. Wilson, Amy S.Y. Lee, James M. Berger, Jennifer A. Doudna, Russell E. Vance · 2015 · Molecular Cell
TREX1 Deficiency Triggers Cell-Autonomous Immunity in a cGAS-Dependent Manner
Andrea Ablasser, Inga Hemmerling, Jonathan Leo Schmid-Burgk, Rayk Behrendt, Axel Roers, Veit Hornung · 2014 · The Journal of Immunology
Structural basis for the inhibition of cGAS by nucleosomes
Kujirai, Tomoya, Zierhut, Christian, Takizawa, Yoshimasa, Kim, Ryan, Negishi, Lumi, Uruma, Nobuki, Hirai, Seiya, Funabiki, Hironori, Kurumizaka, Hitoshi · 2020 · Science
Trial watch: TLR3 agonists in cancer therapy
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The interferon response to intracellular DNA: Why so many receptors?
Leonie Unterholzner · 2013 · Immunobiology
Structural basis of nucleosome-dependent cGAS inhibition
Boyer, Joshua A., Spangler, Cathy J., Strauss, Joshua D., Cesmat, Andrew P., Liu, Pengda, McGinty, Robert K., Zhang, Qi · 2020 · Science
Viral and metazoan poxins are cGAMP-specific nucleases that restrict cGAS–STING signalling
James B. Eaglesham, Youdong Pan, Thomas Seth Kupper, Philip J. Kranzusch · 2019 · Nature
Phosphorylation and chromatin tethering prevent cGAS activation during mitosis
Tuo Li, Tuozhi Huang, Mingjian Du, Xiang Chen, Fenghe Du, Junyao Ren, Zhijian J. Chen · 2021 · Science
Bacterial origins of human cell-autonomous innate immune mechanisms
Tanita Wein, Rotem Sorek · 2022 · Nature reviews. Immunology
The Impact of Radiation-Induced DNA Damage on cGAS-STING-Mediated Immune Responses to Cancer
Quinn T. Storozynsky, Mary Hitt · 2020 · International Journal of Molecular Sciences
Cyclic Dinucleotides and the Innate Immune Response
Olga Danilchanka, John J. Mekalanos · 2013 · Cell
NEMO–IKKβ Are Essential for IRF3 and NF-κB Activation in the cGAS–STING Pathway
Run Fang, Chenguang Wang, Qifei Jiang, Mengze Lv, Pengfei Gao, Xiaoyu Yu, Ping Mu, Rui Zhang, Sheng Bi, Ji‐Ming Feng et al. · 2017 · The Journal of Immunology
Dengue virus activates cGAS through the release of mitochondrial DNA
Sun, Bo, Sundström, Karin B., Chew, Jun Jie, Bist, Pradeep, Gan, Esther S., Tan, Hwee Cheng, Goh, Kenneth C., Chawla, Tanu, Tang, Choon Kit, Ooi, Eng Eong · 2017 · Scientific Reports
Adenovirus Detection by the cGAS/STING/TBK1 DNA Sensing Cascade
Eric Lam, Saskia Catherina Stein, Erik Falck-Pedersen · 2013 · Journal of Virology
CBASS Immunity Uses CARF-Related Effectors to Sense 3′–5′- and 2′–5′-Linked Cyclic Oligonucleotide Signals and Protect Bacteria from Phage Infection
B. Lowey, Aaron T. Whiteley, Alexander F. A. Keszei, Benjamin R. Morehouse, Ian T. Mathews, Sadie P. Antine, V. Cabrera, Dmitry Kashin, Percy Niemann, Mohit Jain et al. · 2020 · Cell
Glutamylation of the DNA sensor cGAS regulates its binding and synthase activity in antiviral immunity
Pengyan Xia, Buqing Ye, Shuo Wang, Xiaoxiao Zhu, Ying Du, Zhen Xiong, Yong Tian, Zusen Fan · 2016 · Nature Immunology
Innate immune recognition of DNA: A recent history
Alan Dempsey, Andrew Bowie · 2015 · Virology
Intracellular Nucleic Acid Detection in Autoimmunity
John T. Crowl, Elizabeth E. Gray, Kathleen Pestal, Hannah E. Volkman, Daniel B. Stetson · 2017 · Annual Review of Immunology
TRIM56-mediated monoubiquitination of cGAS for cytosolic DNA sensing
Gil Ju Seo, Charlotte Kim, Woo-Jin Shin, Ella H. Sklan, Hyungjin Eoh, Jae Ung Jung · 2018 · Nature Communications
cGAS phase separation inhibits TREX1-mediated DNA degradation and enhances cytosolic DNA sensing
Wen Zhou, Lisa Mohr, John Maciejowski, Philip J. Kranzusch · 2021 · Molecular Cell
Overcoming innate immune barriers that impede AAV gene therapy vectors
Muhuri, Manish, Maeda, Yukiko, Ma, Hong, Ram, Sanjay, Fitzgerald, Katherine A., Tai, Phillip W.L., Gao, Guangping · 2021 · Journal of Clinical Investigation
DNA Sensing in the Innate Immune Response
Benoit Briard, David E. Place, Thirumala‐Devi Kanneganti · 2020 · Physiology
The interactions between cGAS-STING pathway and pathogens
Zhangliang Cheng, Tong Dai, Xuelin He, Zhengkui Zhang, Feng Xie, Shuai Wang, Long Zhang, Fangfang Zhou · 2020 · Signal Transduction and Targeted Therapy
Akt Kinase-Mediated Checkpoint of cGAS DNA Sensing Pathway
Gil Ju Seo, Aerin Yang, Brandon Tan, Sungyoon Kim, Qiming Liang, Younho Choi, Weiming Yuan, Pinghui Feng, Hee-Sung Park, Jae Ung Jung · 2015 · Cell Reports
Human cGAS catalytic domain has an additional DNA-binding interface that enhances enzymatic activity and liquid-phase condensation
Wei Xie, Lodoe Lama, Carolina Adura, Daisuke Tomita, Joseph Fraser Glickman, Thomas Tuschl, Dinshaw J. Patel · 2019 · Proceedings of the National Academy of Sciences
Hippo signalling governs cytosolic nucleic acid sensing through YAP/TAZ-mediated TBK1 blockade
Qian Zhang, Fansen Meng, Shasha Chen, Steven W. Plouffe, Shiying Wu, Shengduo Liu, Xinran Li, Ruyuan Zhou, Junxian Wang, Bin Zhao et al. · 2017 · Nature Cell Biology
BAF restricts cGAS on nuclear DNA to prevent innate immune activation
Baptiste Guey, Marilena Wischnewski, Alexiane C. Decout, Kristina A. Makasheva, Murat Kaynak, Mahmut Selman Sakar, Beat Fierz, Andrea Ablasser · 2020 · Science
Role of the cGAS–STING pathway in cancer development and oncotherapeutic approaches
Khoo, Li Teng, Chen, Liuh‐Yow · 2018 · The EMBO Reports
Molecular evolutionary and structural analysis of the cytosolic DNA sensor cGAS and STING
Xiaomei Wu, Fei-Hua Wu, Xiaoqiang Wang, Lilin Wang, James N. Siedow, Weiguo Zhang, Zhen‐Ming Pei · 2014 · Nucleic Acids Research
Molecular Pathways: Targeting the Stimulator of Interferon Genes (STING) in the Immunotherapy of Cancer
Leticia P. Corrales, Thomas Frank Gajewski · 2015 · Clinical Cancer Research
USP13 negatively regulates antiviral responses by deubiquitinating STING
He Sun, Qiang Zhang, Ying-Ying Jing, Man Zhang, Haiying Wang, Zeng Cai, Tianzi Liuyu, Zhidong Zhang, Tian-Chen Xiong, Yan Wu et al. · 2017 · Nature Communications
Species-Specific Deamidation of cGAS by Herpes Simplex Virus UL37 Protein Facilitates Viral Replication
Junjie Zhang, Jun Zhao, Simin Xu, Junhua Li, Shanping He, Yi Arial Zeng, Linshen Xie, Na Xie, Ting Liu, Katie Lee et al. · 2018 · Cell Host & Microbe
LRRC8A:C/E Heteromeric Channels Are Ubiquitous Transporters of cGAMP
Lauren J. Lahey, Rachel E. Mardjuki, Xianlan Wen, Gaelen T. Hess, Christopher Ritchie, Jacqueline A. Carozza, Volker Böhnert, Merritt C. Maduke, Michael Cory Bassik, Lingyin Li · 2020 · Molecular Cell
Activation of STING by targeting a pocket in the transmembrane domain
Defen Lu, Guijun Shang, Jie Li, Yong De Lu, Xiao‐chen Bai, Xuewu Zhang · 2022 · Nature
Cellular Innate Immunity: An Old Game with New Players
Georg Gasteiger, Andrea D’Osualdo, David A. Schubert, Alexander N.R. Weber, Emanuela M. Bruscia, Dominik Hartl · 2016 · Journal of Innate Immunity
STING orchestrates the crosstalk between polyunsaturated fatty acid metabolism and inflammatory responses
Isabelle K. Vila, Hanane Chamma, Alizée Steer, Mathilde Saccas, Clara Taffoni, Evgenia Turtoi, Line Sinnathamby Reinert, Saqib Hussain, Johanna Marines, Lei Jin et al. · 2022 · Cell Metabolism
The cGAS/STING Pathway: A Novel Target for Cancer Therapy
Yu Gan, Xiaoying Li, Shuangze Han, Qi Liang, Xiaoqian Ma, Pengfei Rong, Wei Wang, Wei Li · 2022 · Frontiers in Immunology
cGAS-like receptors sense RNA and control 3′2′-cGAMP signalling in Drosophila
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Herpes Simplex Virus 1 Tegument Protein VP22 Abrogates cGAS/STING-Mediated Antiviral Innate Immunity
Jian Hua Huang, Hongjuan You, Chenhe Su, Yangxin Li, Shun‐Hua Chen, Chunfu Zheng · 2018 · Journal of Virology
Structural basis for concerted recruitment and activation of IRF-3 by innate immune adaptor proteins
Baoyu Zhao, Chang Shu, Xinsheng Gao, Banumathi Sankaran, Fenglei Du, Catherine L. Shelton, Andrew B. Herr, Jun‐Yuan Ji, Pingwei Li · 2016 · Proceedings of the National Academy of Sciences
Pharmacological modulation of nucleic acid sensors - therapeutic potential and persisting obstacles
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Structural insights into cGAMP degradation by Ecto-nucleotide pyrophosphatase phosphodiesterase 1
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Immune Sensing Mechanisms that Discriminate Self from Altered Self and Foreign Nucleic Acids
Eva Bartok, Gunther Hartmann · 2020 · Immunity
DNA-stimulated cell death: implications for host defence, inflammatory diseases and cancer
Søren R. Paludan, Line Sinnathamby Reinert, Veit Hornung · 2019 · Nature reviews. Immunology
The cytosolic DNA sensor cGAS recognizes neutrophil extracellular traps
Falko Apel, Liudmila Andreeva, Sebastian Lorenz Knackstedt, Robert Streeck, Christian Karl Frese, Christian Goosmann, Karl‐Peter Hopfner, Arturo Zychlinsky · 2021 · Science Signaling
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Delivery of STING agonists for adjuvanting subunit vaccines
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Rationale, progress and development of vaccines utilizing STING-activating cyclic dinucleotide adjuvants
Thomas Walter Dubensky, David B. Kanne, Meredith L.L. Leong · 2013 · Therapeutic Advances in Vaccines
The cGAS-STING Pathway for DNA Sensing
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Discovery of PF-06928215 as a high affinity inhibitor of cGAS enabled by a novel fluorescence polarization assay
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Crosstalk between cGAS–STING signaling and cell death
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Modified Vaccinia Virus Ankara Triggers Type I IFN Production in Murine Conventional Dendritic Cells via a cGAS/STING-Mediated Cytosolic DNA-Sensing Pathway
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Positive Feedback Regulation of Type I IFN Production by the IFN-Inducible DNA Sensor cGAS
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Clathrin-associated AP-1 controls termination of STING signalling
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Ubiquitination of STING at lysine 224 controls IRF3 activation
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Telomere Stress Potentiates STING-Dependent Anti-tumor Immunity
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A kinase-cGAS cascade to synthesize a therapeutic STING activator
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Structural Biology of Innate Immunity
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cGAS‐cGAMP‐STING: The three musketeers of cytosolic DNA sensing and signaling
Jianli Tao, Xiang Zhou, Zhengfan Jiang · 2016 · IUBMB Life
SENP7 Potentiates cGAS Activation by Relieving SUMO-Mediated Inhibition of Cytosolic DNA Sensing
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