Development and Applications of CRISPR-Cas9 for Genome Engineering

Cited by (173)

Items 101–173 of 173

1. Site-directed mutagenesis in Petunia × hybrida protoplast system using direct delivery of purified recombinant Cas9 ribonucleoproteins
   Subburaj, Saminathan, Chung, Sung Jin, Lee, Choongil, Ryu, Seuk-Min, Kim, Duk Hyoung, Kim, Jin-Soo, Bae, Sangsu, Lee, Geung-Joo · 2016 · Plant Cell Reports
2. Methods and Applications of CRISPR-Mediated Base Editing in Eukaryotic Genomes
   Hess, Gaelen T., Tycko, Josh, Yao, David, Bassik, Michael C. · 2017 · Molecular Cell
3. RNA-guided endonuclease provides a therapeutic strategy to cure latent herpesviridae infection
   Wang, Jianbin, Quake, Stephen R. · 2014 · Proceedings of the National Academy of Sciences
4. Biological plasticity rescues target activity in CRISPR knock outs
   Smits, Arne H., Ziebell, Frederik, Joberty, Gerard, Zinn, Nico, Mueller, William F., Clauder-Münster, Sandra, Eberhard, Dirk, Fälth Savitski, Maria, Grandi, Paola, Jakob, Petra et al. · 2019 · Nature Methods
5. CRISPR-Cas9-based mutagenesis frequently provokes on-target mRNA misregulation
   Tuladhar, Rubina, Yeu, Yunku, Tyler Piazza, John, Tan, Zhen, Rene Clemenceau, Jean, Wu, Xiaofeng, Barrett, Quinn, Herbert, Jeremiah, Mathews, David H., Kim, James et al. · 2019 · Nature Communications
6. Lipid nanoparticle-mediated efficient delivery of CRISPR/Cas9 for tumor therapy
   Zhang, Lingmin, Wang, Peng, Feng, Qiang, Wang, Nuoxin, Chen, Zitian, Huang, Yanyi, Zheng, Wenfu, Jiang, Xingyu · 2017 · NPG Asia Materials
7. Induced pluripotent stem cells: at the heart of cardiovascular precision medicine
   Chen, Ian Y., Matsa, Elena, Wu, Joseph C. · 2016 · Nature Reviews Cardiology
8. Structural Plasticity of PAM Recognition by Engineered Variants of the RNA-Guided Endonuclease Cas9
   Anders, Carolin, Bargsten, Katja, Jinek, Martin · 2016 · Molecular Cell
9. Developmental and epileptic encephalopathies: from genetic heterogeneity to phenotypic continuum
   Guerrini, Renzo, Conti, Valerio, Mantegazza, Massimo, Balestrini, Simona, Galanopoulou, Aristea S., Benfenati, Fabio · 2023 · Physiological Reviews
10. Strategies for nonviral nanoparticle‐based delivery of CRISPR/Cas9 therapeutics
    Chen, Fengqian, Alphonse, Martin, Liu, Qi · 2020 · WIREs Nanomedicine and Nanobiotechnology
11. Transplanting organs from pigs to humans
    Sykes, Megan, Sachs, David H. · 2019 · Science Immunology
12. Viral vectors for therapy of neurologic diseases
    Choudhury, Sourav R., Hudry, Eloise, Maguire, Casey A., Sena-Esteves, Miguel, Breakefield, Xandra O., Grandi, Paola · 2017 · Neuropharmacology
13. A Cas9 Ribonucleoprotein Platform for Functional Genetic Studies of HIV-Host Interactions in Primary Human T Cells
    Hultquist, Judd F., Schumann, Kathrin, Woo, Jonathan M., Manganaro, Lara, McGregor, Michael J., Doudna, Jennifer, Simon, Viviana, Krogan, Nevan J., Marson, Alexander · 2016 · Cell Reports
14. Off-target predictions in CRISPR-Cas9 gene editing using deep learning
    Lin, Jiecong, Wong, Ka-Chun · 2018 · Bioinformatics
15. Gene-edited human stem cell–derived β cells from a patient with monogenic diabetes reverse preexisting diabetes in mice
    Maxwell, Kristina G., Augsornworawat, Punn, Velazco-Cruz, Leonardo, Kim, Michelle H., Asada, Rie, Hogrebe, Nathaniel J., Morikawa, Shuntaro, Urano, Fumihiko, Millman, Jeffrey R. · 2020 · Science Translational Medicine
16. Marine microalgae for production of biofuels and chemicals
    Maeda, Yoshiaki, Yoshino, Tomoko, Matsunaga, Tadashi, Matsumoto, Mitsufumi, Tanaka, Tsuyoshi · 2018 · Current Opinion in Biotechnology
17. Dual-AAV delivering split prime editor system for in vivo genome editing
    Zhi, Shengyao, Chen, Yuxi, Wu, Guanglan, Wen, Jinkun, Wu, Jinni, Liu, Qianyi, Li, Yang, Kang, Rui, Hu, Sihui, Wang, Jiahui et al. · 2022 · Molecular Therapy
18. TALEN and CRISPR/Cas9-mediated genome editing in the early-branching metazoan Nematostella vectensis
    Ikmi, Aissam, McKinney, Sean A., Delventhal, Kym M., Gibson, Matthew C. · 2014 · Nature Communications
19. CRISPR interference (CRISPRi) for gene regulation and succinate production in cyanobacterium S. elongatus PCC 7942
    Huang, Chun-Hung, Shen, Claire R., Li, Hung, Sung, Li-Yu, Wu, Meng-Ying, Hu, Yu-Chen · 2016 · Microbial Cell Factories
20. Bridge RNAs direct programmable recombination of target and donor DNA
    Durrant, Matthew G., Perry, Nicholas T., Pai, James J., Jangid, Aditya R., Athukoralage, Januka S., Hiraizumi, Masahiro, McSpedon, John P., Pawluk, April, Nishimasu, Hiroshi, Konermann, Silvana et al. · 2024 · Nature
21. Analyzing 2000 in Vivo Drug Delivery Data Points Reveals Cholesterol Structure Impacts Nanoparticle Delivery
    Paunovska, Kalina, Gil, Carmen J., Lokugamage, Melissa P., Sago, Cory D., Sato, Manaka, Lando, Gwyn N., Gamboa Castro, Marielena, Bryksin, Anton V., Dahlman, James E. · 2018 · ACS Nano
22. Structural basis for the altered PAM specificities of engineered CRISPR-cas9
    Hirano, Seiichi, Nishimasu, Hiroshi, Ishitani, Ryuichiro, Nureki, Osamu · 2016 · Molecular Cell
23. Current status and perspectives of genome editing technology for microalgae
    Jeon, Seungjib, Lim, Jong-Min, Lee, Hyung-Gwan, Shin, Sung-Eun, Kang, Nam Kyu, Park, Youn-Il, Oh, Hee-Mock, Jeong, Won-Joong, Jeong, Byeong-ryool, Chang, Yong Keun · 2017 · Biotechnology for Biofuels
24. Large animal models of cardiovascular disease
    Tsang, H. G., Rashdan, N. A., Whitelaw, C. B. A., Corcoran, B. M., Summers, K. M., MacRae, V. E. · 2016 · Cell Biochemistry and Function
25. Nucleus of the Solitary Tract Serotonin 5-HT2C Receptors Modulate Food Intake
    D'Agostino, Giuseppe, Lyons, David, Cristiano, Claudia, Lettieri, Miriam, Olarte-Sanchez, Cristian, Burke, Luke K., Greenwald-Yarnell, Megan, Cansell, Celine, Doslikova, Barbora, Georgescu, Teodora et al. · 2018 · Cell Metabolism
26. Mechanisms of Action and Persistent Neuroplasticity by Drugs of Abuse
    Korpi, Esa R., den Hollander, Bjørnar, Farooq, Usman, Vashchinkina, Elena, Rajkumar, Ramamoorthy, Nutt, David J., Hyytiä, Petri, Dawe, Gavin S. · 2015 · Pharmacological Reviews
27. Hemoglobin switching’s surprise: the versatile transcription factor BCL11A is a master repressor of fetal hemoglobin.
    Bauer, Daniel E, Orkin, Stuart H · 2015 · Current Opinion in Genetics & Development
28. High-throughput analysis of the activities of xCas9, SpCas9-NG and SpCas9 at matched and mismatched target sequences in human cells
    Kim, Hui Kwon, Lee, Sungtae, Kim, Younggwang, Park, Jinman, Min, Seonwoo, Choi, Jae Woo, Huang, Tony P., Yoon, Sungroh, Liu, David R., Kim, Hyongbum Henry · 2020 · Nature Biomedical Engineering
29. Detection and Identification of Genome Editing in Plants: Challenges and Opportunities
    Grohmann, Lutz, Keilwagen, Jens, Duensing, Nina, Dagand, Emilie, Hartung, Frank, Wilhelm, Ralf, Bendiek, Joachim, Sprink, Thorben · 2019 · Frontiers in Plant Science
30. Biomedical applications of mRNA nanomedicine
    Xiong, Qingqing, Lee, Gha Young, Ding, Jianxun, Li, Wenliang, Shi, Jinjun · 2018 · Nano Research
31. Cell death during crisis is mediated by mitotic telomere deprotection
    Hayashi, Makoto T., Cesare, Anthony J., Rivera, Teresa, Karlseder, Jan · 2015 · Nature
32. Toolboxes for cyanobacteria: recent advances and future direction
    Sun, Tao, Li, Shubin, Song, Xinyu, Diao, Jinjin, Chen, Lei, Zhang, Weiwen · 2018 · Biotechnology Advances
33. Implications of Glycosylation in Alzheimer’s Disease
    Haukedal, Henriette, Freude, Kristine K. · 2021 · Frontiers in Neuroscience
34. Imaging-based pooled CRISPR screening reveals regulators of lncRNA localization
    Wang, Chong, Lu, Tian, Emanuel, George, Babcock, Hazen P., Zhuang, Xiaowei · 2019 · Proceedings of the National Academy of Sciences
35. Current and future perspectives of functional metabolomics in disease studies–A review
    Yan, Min, Xu, Guowang · 2018 · Analytica Chimica Acta
36. Human induced pluripotent stem cells as a platform for personalized and precision cardiovascular medicine
    Matsa, Elena, Ahrens, John H., Wu, Joseph C. · 2016 · Physiological Reviews
37. Human iPSC-derived neuronal model of Tau-A152T frontotemporal dementia reveals tau-mediated mechanisms of neuronal vulnerability
    Silva, M. Catarina, Cheng, Chialin, Mair, Waltraud, Almeida, Sandra, Fong, Helen, Biswas, M. Helal U., Zhang, Zhijun, Huang, Yadong, Temple, Sally, Coppola, Giovanni et al. · 2016 · Stem Cell Reports
38. Extension of the crRNA enhances Cpf1 gene editing in vitro and in vivo
    Park, Hyo Min, Liu, Hui, Wu, Joann, Chong, Anthony, Mackley, Vanessa, Fellmann, Christof, Rao, Anirudh, Jiang, Fuguo, Chu, Hunghao, Murthy, Niren et al. · 2018 · Nature Communications
39. Plasticity in designing PROTACs for selective and potent degradation of HDAC6
    Yang, Haiyan, Lv, Wenxing, He, Ming, Deng, Haiteng, Li, Haitao, Wu, Wei, Rao, Yu · 2019 · Chemical Communications
40. Non-viral Delivery of Zinc Finger Nuclease mRNA Enables Highly Efficient In Vivo Genome Editing of Multiple Therapeutic Gene Targets
    Conway, Anthony, Mendel, Matthew, Kim, Kenneth, McGovern, Kyle, Boyko, Alisa, Zhang, Lei, Miller, Jeffrey C., DeKelver, Russell C., Paschon, David E., Mui, Barbara L. et al. · 2019 · Molecular Therapy
41. Diverse roles for ionotropic glutamate receptors on inhibitory interneurons in developing and adult brain
    Akgül, Gülcan, McBain, Chris J. · 2016 · The Journal of Physiology
42. The SIAH E3 ubiquitin ligases promote Wnt/β-catenin signaling through mediating Wnt-induced Axin degradation
    Ji, Lei, Jiang, Bo, Jiang, Xiaomo, Charlat, Olga, Chen, Amy, Mickanin, Craig, Bauer, Andreas, Xu, Wenqing, Yan, Xiaoxue, Cong, Feng · 2017 · Genes & Development
43. Mouse macrophages show different requirements for phosphatidylserine receptor Tim4 in efferocytosis
    Yanagihashi, Yuichi, Segawa, Katsumori, Maeda, Ryota, Nabeshima, Yo-ichi, Nagata, Shigekazu · 2017 · Proceedings of the National Academy of Sciences
44. Somatic Gene Editing of GUCY2D by AAV-CRISPR/Cas9 Alters Retinal Structure and Function in Mouse and Macaque
    McCullough, K. Tyler, Boye, Sanford L., Fajardo, Diego, Calabro, Kaitlyn, Peterson, James J., Strang, Christianne E., Chakraborty, Dibyendu, Gloskowski, Sebastian, Haskett, Scott, Samuelsson, Steven et al. · 2019 · Human Gene Therapy
45. In vivo locus-specific editing of the neuroepigenome
    Yim, Yun Young, Teague, Collin D., Nestler, Eric J. · 2020 · Nature Reviews Neuroscience
46. Highly efficient and genotype-independent barley gene editing based on anther culture
    Han, Yong, Broughton, Sue, Liu, Li, Zhang, Xiao-Qi, Zeng, Jianbin, He, Xiaoyan, Li, Chengdao · 2021 · Plant Communications
47. De novo identification of essential protein domains from CRISPR-Cas9 tiling-sgRNA knockout screens
    He, Wei, Zhang, Liang, Villarreal, Oscar D., Fu, Rongjie, Bedford, Ella, Dou, Jingzhuang, Patel, Anish Y., Bedford, Mark T., Shi, Xiaobing, Chen, Taiping et al. · 2019 · Nature Communications
48. Towards a new era in medicine: therapeutic genome editing
    Porteus, Matthew H. · 2015 · Genome Biology
49. Nanoparticles for CRISPR–Cas9 delivery
    Glass, Zachary, Li, Yamin, Xu, Qiaobing · 2017 · Nature Biomedical Engineering
50. Presenilin 1 deficiency suppresses autophagy in human neural stem cells through reducing γ-secretase-independent ERK/CREB signaling
    Chong, Cheong-Meng, Ke, Minjing, Tan, Yuan, Huang, Zhijian, Zhang, Ke, Ai, Nana, Ge, Wei, Qin, Dajiang, Lu, Jia-Hong, Su, Huanxing · 2018 · Cell Death & Disease
51. IPEX syndrome: genetics and treatment options
    Ben-Skowronek, Iwona · 2021 · Genes
52. Customizing the genome as therapy for the β-hemoglobinopathies.
    Canver, Matthew C., Orkin, Stuart H. · 2016 · Blood
53. Programmable RNA-guided DNA endonucleases are widespread in eukaryotes and their viruses
    Jiang, Kaiyi, Lim, Justin, Sgrizzi, Samantha, Trinh, Michael, Kayabolen, Alisan, Yutin, Natalya, Bao, Weidong, Kato, Kazuki, Koonin, Eugene V., Gootenberg, Jonathan S. et al. · 2023 · Science Advances
54. Crossed wires: 3D genome misfolding in human disease
    Norton, Heidi K., Phillips-Cremins, Jennifer E. · 2017 · Journal of Cell Biology
55. Long QT Syndrome Modelling with Cardiomyocytes Derived from Human-induced Pluripotent Stem Cells
    Sala, Luca, Gnecchi, Massimiliano, Schwartz, Peter J · 2019 · Arrhythmia & Electrophysiology Review
56. In synch but not in step: Circadian clock circuits regulating plasticity in daily rhythms
    Evans, J.A., Gorman, M.R. · 2016 · Neuroscience
57. Blackjack mutations improve the on-target activities of increased fidelity variants of SpCas9 with 5′ G-extended sgRNAs
    Kulcsár, Péter István, Tálas, András, Tóth, Eszter, Nyeste, Antal, Ligeti, Zoltán, Welker, Zsombor, Welker, Ervin · 2020 · Nature Communications
58. CRISPR-Driven Biosensors: A New Frontier in Rapid and Accurate Disease Detection
    Razavi, ZahraSadat, Soltani, Madjid, Souri, Mohammad, Pazoki-Toroudi, Hamidreza · 2026 · Critical Reviews in Analytical Chemistry
59. Genetically modified large animal models for investigating neurodegenerative diseases
    Yang, Weili, Chen, Xiusheng, Li, Shihua, Li, Xiao-Jiang · 2021 · Cell & Bioscience
60. The Geroscience Hypothesis: Is It Possible to Change the Rate of Aging?
    Austad, Steven N. · 2016 · Advances in Geroscience
61. The AAV-mediated and RNA-guided CRISPR/Cas9 system for gene therapy of DMD and BMD
    Wang, Jing-Zhang, Wu, Peng, Shi, Zhi-Min, Xu, Yan-Li, Liu, Zhi-Jun · 2017 · Brain and Development
62. Genome engineering of stem cell organoids for disease modeling
    Sun, Yingmin, Ding, Qiurong · 2017 · Protein & Cell
63. Large-scale CRISPR screening in primary human 3D gastric organoids enables comprehensive dissection of gene-drug interactions
    Lo, Yuan-Hung, Horn, Hudson T., Huang, Mo-Fan, Yu, Wei-Chieh, Young, Chia-Mei, Liu, Qing, Tomaske, Madeline, Towers, Martina, Dominguez, Antonia, Bassik, Michael C. et al. · 2025 · Nature Communications
64. Non-viral delivery of CRISPR/Cas cargo to the retina using nanoparticles: current possibilities, challenges, and limitations
    Salman, Ahmed, Kantor, Ariel, McClements, Michelle E., Marfany, Gemma, Trigueros, Sonia, MacLaren, Robert E. · 2022 · Pharmaceutics
65. Technical considerations for the use of CRISPR/Cas9 in hematology research
    Gundry, Michael C., Dever, Daniel P., Yudovich, David, Bauer, Daniel E., Haas, Simon, Wilkinson, Adam C., Singbrant, Sofie · 2017 · Experimental Hematology
66. Base editing for reprogramming cyanobacterium Synechococcus elongatus
    Wang, Shu-Yan, Li, Xin, Wang, Shu-Guang, Xia, Peng-Fei · 2023 · Metabolic Engineering
67. Simple and Efficient Targeted Intracellular Protein Delivery with Self‐Assembled Nanovehicles for Effective Cancer Therapy
    He, Xiao, Long, Qipeng, Zeng, Zhiying, Yang, Lan, Tang, Yaqin, Feng, Xuli · 2019 · Advanced Functional Materials
68. Learning to quantify uncertainty in off-target activity for CRISPR guide RNAs
    Özden, Furkan, Minary, Peter · 2024 · Nucleic Acids Research
69. Using hiPSCs to model neuropsychiatric copy number variations (CNVs) has potential to reveal underlying disease mechanisms
    Flaherty, Erin K., Brennand, Kristen J. · 2017 · Brain Research
70. Industry chain and challenges of microalgal food industry-a review
    Chen, Yuanhao, Liang, Honghao, Du, Hong, Jesumani, Valentina, He, Weiling, Cheong, Kit-Leong, Li, Tangcheng, Hong, Ting · 2024 · Critical Reviews in Food Science and Nutrition
71. CRISPR-Cas9 genome editing for cancer immunotherapy: opportunities and challenges
    Chen, Ming, Xu, Jiang, Zhou, Yang, Zhang, Silin, Zhu, Di · 2020 · Briefings in Functional Genomics
72. Chromatin structure and context-dependent sequence features control prime editing efficiency
    Kim, Somang, Yuan, Jimmy B., Woods, Wendy S., Newton, Destry A., Perez-Pinera, Pablo, Song, Jun S. · 2023 · Frontiers in Genetics
73. Human iPSC Models in Drug Discovery: Opportunities and Challenges
    Silva, M.C., Cross, A., Brandon, N.J., Haggarty, S.J. · 2017 · Comprehensive Medicinal Chemistry III