Student or educator? Sign up with your school email and get 6 months of Pro free.
CoChat
Sign Up
Cited by 646

The DOI matches its Crossref record; 10 of the 10 references it cites were found in a registry or an index.

Gremlin 1 Identifies a Skeletal Stem Cell with Bone, Cartilage, and Reticular Stromal Potential

Open access
Worthley, Daniel L., Churchill, Michael, Compton, Jocelyn T., Tailor, Yagnesh, Rao, Meenakshi, Si, Yiling, Levin, Daniel, Schwartz, Matthew G., Uygur, Aysu, Hayakawa, Yoku, Gross, Stefanie, Renz, Bernhard W., Setlik, Wanda, Martinez, Ashley N., Chen, Xiaowei, Nizami, Saqib, Lee, Heon Goo, Kang, H. Paco, Caldwell, Jon-Michael, Asfaha, Samuel, Westphalen, C. Benedikt, Graham, Trevor, Jin, Guangchun, Nagar, Karan, Wang, Hongshan, Kheirbek, Mazen A., Kolhe, Alka, Carpenter, Jared, Glaire, Mark, Nair, Abhinav, Renders, Simon, Manieri, Nicholas, Muthupalani, Sureshkumar, Fox, James G., Reichert, Maximilian, Giraud, Andrew S., Schwabe, Robert F., Pradere, Jean-Phillipe, Walton, Katherine, Prakash, Ajay, Gumucio, Deborah, Rustgi, Anil K., Stappenbeck, Thaddeus S., Friedman, Richard A., Gershon, Michael D., Sims, Peter, Grikscheit, Tracy, Lee, Francis Y., Karsenty, Gerard, Mukherjee, Siddhartha, Wang, Timothy C.·2015·Cell
DOI 10.1016/j.cell.2014.11.042
Open this paper in CoChat — free account

Abstract

The stem cells that maintain and repair the postnatal skeleton remain undefined. One model suggests that perisinusoidal mesenchymal stem cells (MSCs) give rise to osteoblasts, chondrocytes, marrow stromal cells, and adipocytes, although the existence of these cells has not been proven through fate-mapping experiments. We demonstrate here that expression of the bone morphogenetic protein (BMP) antagonist gremlin 1 defines a population of osteochondroreticular (OCR) stem cells in the bone marrow. OCR stem cells self-renew and generate osteoblasts, chondrocytes, and reticular marrow stromal cells, but not adipocytes. OCR stem cells are concentrated within the metaphysis of long bones not in the perisinusoidal space and are needed for bone development, bone remodeling, and fracture repair. Grem1 expression also identifies intestinal reticular stem cells (iRSCs) that are cells of origin for the periepithelial intestinal mesenchymal sheath. Grem1 expression identifies distinct connective tissue stem cells in both the bone (OCR stem cells) and the intestine (iRSCs).

Overview

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Integrity signals

Registry

Crossref · 10.1016/j.cell.2014.11.042

Cites

10 of 10 references verified0 citation errors · 0 not checkable

Statistics

Verification

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Citations

Cites

Show all 10 references

Cited by

Metadata

Authors
Worthley, D. L., Churchill, M., Compton, J. T., Tailor, Y., Rao, M., Si, Y., Levin, D., Schwartz, M. G., Uygur, A., Hayakawa, Y., Gross, S., Renz, B. W., Setlik, W., Martinez, A. N., Chen, X., Nizami, S., Lee, H. G., Kang, H. P., Caldwell, J.-M., Asfaha, S., Westphalen, C. B., Graham, T., Jin, G., Nagar, K., Wang, H., Kheirbek, M. A., Kolhe, A., Carpenter, J., Glaire, M., Nair, A., Renders, S., Manieri, N., Muthupalani, S., Fox, J. G., Reichert, M., Giraud, A. S., Schwabe, R. F., Pradere, J.-P., Walton, K., Prakash, A., Gumucio, D., Rustgi, A. K., Stappenbeck, T. S., Friedman, R. A., Gershon, M. D., Sims, P., Grikscheit, T., Lee, F. Y., Karsenty, G., Mukherjee, S., & Wang, T. C.
Venue
Cell
Publisher
Elsevier BV
Published
2015-01
Volume
160
Issue
1-2
Pages
269-284
ISSN
0092-8674 (ISSN-L)
DOI
10.1016/j.cell.2014.11.042
OpenAlex
W2003509125
Cited by
646
References
10
FWCI
36.36
Type
journal article
Language
en
Open access
bronze

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Data sources

Bibliographic data: Semantic Scholar, OpenAlex, Crossref.

Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.