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Co-transcriptional DNA and RNA Cleavage during Type III CRISPR-Cas Immunity

Samai, Poulami, Pyenson, Nora, Jiang, Wenyan, Goldberg, Gregory W., Hatoum-Aslan, Asma, Marraffini, Luciano A.·2015·Cell
DOI 10.1016/j.cell.2015.04.027PMC PMC4594840
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  • This binding enables Cas10-mediated cleavage of the complementary DNA duplex and Cas7-guided cleavage of the ssRNA molecule in intervals of 6 nucleotides.

    “This binding enables Cas10-mediated cleavage of the complementary DNA duplex and Cas7-guided cleavage of the ssRNA molecule in intervals of 6 nucleotides [47,50].”

    From CRISPR-Cas: Converting A Bacterial Defence Mechanism into A State-of-the-Art Genetic Manipulation Tool (2019) · cites this paper as [50]

    The Results sections report that Cas10 is essential for DNA cleavage and that the Cas10-Csm complex cleaves complementary ssRNA at six-nucleotide intervals, with Csm3 implicated in RNA cleavage (pages not provided). The DNA result is narrower than cleavage of the duplex: the paper reports cleavage of the non-template strand while the template strand was neither cleaved nor degraded. It identifies Csm3, not Cas7, as the RNA-cleavage subunit. (LLM, conf=0.89)

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Research works printed but not linked: 40

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Metadata

Authors
Samai, P., Pyenson, N., Jiang, W., Goldberg, G. W., Hatoum-Aslan, A., & Marraffini, L. A.
Venue
Cell
Publisher
Elsevier BV
Published
2015-05
Volume
161
Issue
5
Pages
1164-1174
ISSN
0092-8674
DOI
10.1016/j.cell.2015.04.027
PMC
PMC4594840
Cited by
426
References
1
Language
en
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