Cited by 962Genetics, Aging, and Longevity in Model OrganismsEpigenetics and DNA MethylationGenomics and Chromatin Dynamics

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Epigenetic Mechanisms of Longevity and Aging

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Sen, Payel, Shah, Parisha P., Nativio, Raffaella, Berger, Shelley L.·2016·Cell

DOI 10.1016/j.cell.2016.07.050PMC PMC5821249

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Abstract

Aging is an inevitable outcome of life, characterized by progressive decline in tissue and organ function and increased risk of mortality. Accumulating evidence links aging to genetic and epigenetic alterations. Given the reversible nature of epigenetic mechanisms, these pathways provide promising avenues for therapeutics against age-related decline and disease. In this review, we provide a comprehensive overview of epigenetic studies from invertebrate organisms, vertebrate models, tissues, and in vitro systems. We establish links between common operative aging pathways and hallmark chromatin signatures that can be used to identify "druggable" targets to counter human aging and age-related disease.

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Authors: Sen, P., Shah, P. P., Nativio, R., & Berger, S. L.
Affiliations: University of Pennsylvania (US)
Corresponding author: Berger, Shelley L.
ORCID: Sen, Payel
Shah, Parisha P.
Nativio, Raffaella
Berger, Shelley L.
Venue: Cell
Publisher: Elsevier BV
Published: 2016-08
Volume: 166
Issue: 4
Pages: 822-839
ISSN: 0092-8674 (ISSN-L)
DOI: 10.1016/j.cell.2016.07.050
PMC: PMC5821249
OpenAlex: W2517275410
Cited by: 956
References: 188
Citations by year: 2026: 76 · 2025: 96 · 2024: 111 · 2023: 116 · 2022: 97 · 2021: 128 · 2020: 113 · 2019: 87 · 2018: 76 · 2017: 51 · 2016: 5
FWCI: 7.31
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/open-access/userlicense/1.0/ (vor, 375 d)
Locations: Cell (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
Funders: American Heart Association
National Institutes of Health (4r01ns078283-05)
National Institute on Aging (P01AG031862)
National Institute of Neurological Disorders and Stroke (R01-NS078283)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Epigenetics and DNA Methylation
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Chromatin Dynamics
Keywords: aging, longevity, epigenetic mechanisms, chromatin signatures, age-related diseases, anti-aging therapeutics, druggable targets, invertebrate models, vertebrate models, tissue aging
MeSH terms: Aging, Animals, Histones, Humans, Longevity, DNA Methylation, Chromatin Assembly and Disassembly, Epigenesis, Genetic

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