Cited by 236Sarcoma Diagnosis and TreatmentImmune cells in cancerCancer Immunotherapy and Biomarkers

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The contribution of immune infiltrates and the local microenvironment in the pathogenesis of osteosarcoma

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Heymann, Marie-Françoise, Lézot, Frédéric, Heymann, Dominique·2019·Cellular Immunology

DOI 10.1016/j.cellimm.2017.10.011

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Abstract

Osteosarcoma is a rare primary bone cancer characterized by cancer cells producing calcified osteoid extracellular matrix and inducing lung metastases with a high frequency. The local microenvironment defined several tumor niches controlling the tumor growth and cell extravasation. The immune infiltrate composes one of these niches. The immune environment of osteosarcoma is mainly composed by T-lymphocytes and macrophages but also contains other subpopulations including B-lymphocytes and mast cells. Osteosarcoma cells control the recruitment and differentiation of immune infiltrating cells and establish a local immune tolerant environment favorable to the tumor growth, drug resistance and the occurrence of metastases. Osteosarcoma cells are able to affect the balance between M1 and M2 macrophage subtypes and so could control the T-lymphocyte responses via the PD-1/PDL-1 system. In addition, mesenchymal stem cells may also contribute to this immune tolerance and strengthen the immune evasion. The present review gives a brief overview of the immune components of osteosarcoma and their most recent therapeutic interests.

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Authors: Heymann, M.-F., Lézot, F., & Heymann, D.
Affiliations: Inserm (FR)
Corresponding author: Heymann, Dominique
ORCID: Heymann, Marie-Françoise
Lézot, Frédéric
Heymann, Dominique
Venue: Cellular Immunology
Publisher: Elsevier BV
Published: 2019-09
Volume: 343
Issue: 1
Pages: 103711
ISSN: 0008-8749 (ISSN-L)
DOI: 10.1016/j.cellimm.2017.10.011
OpenAlex: W2766090242
Cited by: 233
References: 125
Citations by year: 2026: 11 · 2025: 22 · 2024: 33 · 2023: 33 · 2022: 33 · 2021: 42 · 2020: 34 · 2019: 14
FWCI: 2.94
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
www.elsevier.com/open-access/userlicense/1.0/ (am, 372 d)
Locations: Cellular Immunology (acceptedVersion)
PubMed (publishedVersion)
HAL (submittedVersion)
Funders: Bone Cancer Research Trust (144681)
Topics: Health Sciences › Medicine › Oncology › Sarcoma Diagnosis and Treatment
Life Sciences › Immunology and Microbiology › Immunology › Immune cells in cancer
Health Sciences › Medicine › Oncology › Cancer Immunotherapy and Biomarkers
Keywords: osteosarcoma, tumor microenvironment, tumor immune infiltrate, T cells, macrophages, macrophage polarization, PD-1/PD-L1 pathway, immune evasion, mesenchymal stem cells, mast cells, B cells, lung metastasis, drug resistance, immunotherapy
MeSH terms: Animals, Bone Neoplasms, Humans, Macrophages, Osteosarcoma, Lymphocyte Subsets, Tumor Microenvironment, Mesenchymal Stem Cells

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The contribution of immune infiltrates and the local microenvironment in the pathogenesis of osteosarcoma

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