Human Gut-Derived Commensal Bacteria Suppress CNS Inflammatory and Demyelinating Disease
Open accessAbstract
The human gut is colonized by a large number of microorganisms (∼10 13 bacteria) that support various physiologic functions. A perturbation in the healthy gut microbiome might lead to the development of inflammatory diseases, such as multiple sclerosis (MS). Therefore, gut commensals might provide promising therapeutic options for treating MS and other diseases. We report the identification of human gut-derived commensal bacteria, Prevotella histicola , which can suppress experimental autoimmune encephalomyelitis (EAE) in a human leukocyte antigen (HLA) class II transgenic mouse model. P. histicola suppresses disease through the modulation of systemic immune responses. P. histicola challenge led to a decrease in pro-inflammatory Th1 and Th17 cells and an increase in the frequencies of CD4 + FoxP3 + regulatory T cells, tolerogenic dendritic cells, and suppressive macrophages. Our study provides evidence that the administration of gut commensals may regulate a systemic immune response and may, therefore, have a possible role in treatment strategies for MS.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
No major legislation changes have been made during or after the period 2011-2015, and major characteristics of patients have not changed between 2015 and 2017.
“No major legislation changes have been made during or after this period, major characteristics of patients have not changed between 2015 and 2017 (article in Dutch).39”
From “Nothing Hurts Less Than Being Dead”: Psychological Pain in Case Descriptions of Psychiatric Euthanasia and Assisted Suicide from the Netherlands: « Rien ne fait moins mal qu’être mort »: La douleur psychologique dans les descriptions de cas d’euthanasie et de suicide assisté psychiatrique aux Pays-Bas (2020) · cites this paper as [39]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Linking long-term dietary patterns with gut microbial enterotypes
Wu, G. D., Chen, J., Hoffmann, C., Bittinger, K., Chen, Y.-Y., Keilbaugh, S. A., Bewtra, M., Knights, D., Walters, W. A., Knight, R., et al. (2011) · Science · doi:10.1126/science.1208344 · Cited by 6,513 · see citing works
PEAR: a fast and accurate Illumina Paired-End reAd mergeR
Zhang, J., Kobert, K., Flouri, T., & Stamatakis, A. (2014) · Bioinformatics · doi:10.1093/bioinformatics/btt593 · Cited by 4,497 · see citing works
Recognition of Commensal Microflora by Toll-Like Receptors Is Required for Intestinal Homeostasis
Rakoff-Nahoum, S., Paglino, J., Eslami-Varzaneh, F., Edberg, S., & Medzhitov, R. (2004) · Cell · doi:10.1016/j.cell.2004.07.002 · Cited by 4,251 · see citing works
Hsiao, E. Y., McBride, S. W., Hsien, S., Sharon, G., Hyde, E. R., McCue, T., Codelli, J. A., Chow, J., Reisman, S. E., Petrosino, J. F., et al. (2013) · Cell · doi:10.1016/j.cell.2013.11.024 · Cited by 3,283 · see citing works
The effect of infections on susceptibility to autoimmune and allergic diseases.
Bach, J. (2002) · New England Journal of Medicine · doi:10.1056/nejmra020100 · Cited by 2,714 · see citing works
Round, J. L., & Mazmanian, S. K. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0909122107 · Cited by 2,233 · see citing works
Are We Really Vastly Outnumbered? Revisiting the Ratio of Bacterial to Host Cells in Humans
Sender, R., Fuchs, S., & Milo, R. (2016) · Cell · doi:10.1016/j.cell.2016.01.013 · Cited by 2,050 · see citing works
The microbiota in adaptive immune homeostasis and disease
Honda, K., & Littman, D. R. (2016) · Nature · doi:10.1038/nature18848 · Cited by 1,846 · see citing works
Alterations of the human gut microbiome in multiple sclerosis
Jangi, S., Gandhi, R., Cox, L. M., Li, N., von Glehn, F., Yan, R., Patel, B., Mazzola, M. A., Liu, S., Glanz, B. L., et al. (2016) · Nature Communications · doi:10.1038/ncomms12015 · Cited by 1,307 · see citing works
The ‘hygiene hypothesis’ for autoimmune and allergic diseases: an update
Okada, H., Kuhn, C., Feillet, H., & Bach, J. (2010) · Clinical & Experimental Immunology · doi:10.1111/j.1365-2249.2010.04139.x · Cited by 1,168 · see citing works
Multiple sclerosis patients have a distinct gut microbiota compared to healthy controls
Chen, J., Chia, N., Kalari, K. R., Yao, J. Z., Novotna, M., Paz Soldan, M. M., Luckey, D. H., Marietta, E. V., Jeraldo, P. R., Chen, X., et al. (2016) · Scientific Reports · doi:10.1038/srep28484 · Cited by 933 · see citing works
Self-citationMiyake, S., Kim, S., Suda, W., Oshima, K., Nakamura, M., Matsuoka, T., Chihara, N., Tomita, A., Sato, W., Kim, S.-W., et al. (2015) · PLoS ONE · doi:10.1371/journal.pone.0137429 · Cited by 809 · see citing works
Ochoa-Repáraz, J., Mielcarz, D. W., Wang, Y., Begum-Haque, S., Dasgupta, S., Kasper, D. L., & Kasper, L. H. (2010) · Mucosal Immunology · doi:10.1038/mi.2010.29 · Cited by 507 · see citing works
Lavasani, S., Dzhambazov, B. M., Nouri, M., Fåk, F., Buske, S., Molin, G., Thorlacius, H., Alenfall, J., Jeppsson, B. W., & Weström, B. R. (2010) · PLoS ONE · doi:10.1371/journal.pone.0009009 · Cited by 450 · see citing works
METAGENassist: a comprehensive web server for comparative metagenomics
Arndt, D., Xia, J., Liu, Y., Zhou, Y. L., Guo, A. C., Cruz, J. A., Sinelnikov, I., Budwill, K., Nesbø, C. L., & Wishart, D. S. (2012) · Nucleic Acids Research · doi:10.1093/nar/gks497 · Cited by 410 · see citing works
Hygiene Hypothesis and Autoimmune Diseases
Rook, G. A. W. (2011) · Clinical Reviews in Allergy & Immunology · doi:10.1007/s12016-011-8285-8 · Cited by 403 · see citing works
Animal models for autoimmune demyelinating disorders of the nervous system
Gold, R., Hartung, H.-P., & Toyka, K. V. (2000) · Molecular Medicine Today · doi:10.1016/s1357-4310(99)01639-1 · Cited by 292 · cited 1× · see citing works
“The hypothesis that MS is an autoimmune disease caused by myelin-specific CD4 T cells comes from experimental autoimmune encephalomyelitis (EAE), an animal model of MS (Gold et al., 2000).”
Angiuoli, S. V., Matalka, M. N., Gussman, A., Galens, K., Vangala, M., Riley, D. R. J., Arze, C., White, J. R., White, O. R., & Fricke, W. F. (2011) · BMC Bioinformatics · doi:10.1186/1471-2105-12-356 · Cited by 282 · see citing works
Suppression of Inflammatory Arthritis by Human Gut‐Derived Prevotella histicola in Humanized Mice
Marietta, E. V., Murray, J. A., Luckey, D. H., Jeraldo, P., Lamba, A., Patel, R., Luthra, H. S., Mangalam, A. K., & Taneja, V. (2016) · Arthritis & Rheumatology · doi:10.1002/art.39785 · Cited by 265 · see citing works
Self-citationA microbial perspective of human developmental biology
Charbonneau, M. R., Blanton, L. V., DiGiulio, D. B., Relman, D. A., Lebrilla, C. B., Mills, D. A., & Gordon, J. I. (2016) · Nature · doi:10.1038/nature18845 · Cited by 246 · see citing works
Complex interactions among MHC haplotypes in multiple sclerosis: susceptibility and resistance
Dyment, D. A., Herrera, B. M., Cader, M. Z., Willer, C. J., Lincoln, M. R., Sadovnick, A. D., RISCH, N. J., & Ebers, G. C. (2005) · Human Molecular Genetics · doi:10.1093/hmg/ddi206 · Cited by 243 · see citing works
The yin yang of bacterial polysaccharides: lessons learned from B. fragilis PSA
Surana, N. K., & Kasper, D. L. (2011) · Immunological Reviews · doi:10.1111/j.1600-065x.2011.01075.x · Cited by 153 · see citing works
HLA Class II Transgenic Mice Mimic Human Inflammatory Diseases
Mangalam, A. K., Rajagopalan, G., Taneja, V., & David, C. S. (2008) · Advances in immunology · doi:10.1016/s0065-2776(08)00002-3 · Cited by 85 · see citing works
Self-citationZivadinov, R., Uxa, L., Bratina, A., Bosco, A., Srinivasaraghavan, B., Minagar, A., Ukmar, M., Benedetto, S. Y., & Zorzon, M. (2007) · International review of neurobiology · doi:10.1016/s0074-7742(07)79023-2 · Cited by 75 · see citing works
Luckey, D. H., Bastakoty, D., & Mangalam, A. K. (2011) · Journal of Autoimmunity · doi:10.1016/j.jaut.2011.05.001 · Cited by 51 · see citing works
Self-citationMangalam, A. K., Luckey, D. H., Giri, S., Smart, M. K., Pease, L. R., Rodriguez, M., & David, C. S. (2012) · Journal of Autoimmunity · doi:10.1016/j.jaut.2012.02.004 · Cited by 51 · see citing works
Self-citationDas, P., Drescher, K. M., Geluk, A., Bradley, D. S., Rodriguez, M., & David, C. S. (2000) · Human Immunology · doi:10.1016/s0198-8859(99)00135-4 · Cited by 50 · see citing works
Self-citationMangalam, A. K., Khare, M., Krco, C. J., Rodriguez, M., & David, C. S. (2003) · European Journal of Immunology · doi:10.1002/eji.200324597 · Cited by 41 · see citing works
Self-citationMangalam, A. K., Luckey, D. H., Basal, E., Jackson, M., Smart, M. K., Rodriguez, M., & David, C. S. (2009) · The Journal of Immunology · doi:10.4049/jimmunol.0803918 · Cited by 39 · see citing works
Self-citation
Flagged first, then by citations
Research works printed but not linked: 1
- Mangalam A Luckey D Basal E Jackson M Smart M Rodriguez M David C 2009b HLA-DQ8 (DQB1*0302)-restricted Th17 cells exacerbate experimental autoimmune encephalomyelitis in HLA-DR3-transgenic mice J Immunol 182 5131 5139 19342694 PMC2665933
Cited by
Sorted by citations
The gut microbiota–brain axis in behaviour and brain disorders
Morais, L. H., Schreiber, H. L., & Mazmanian, S. K. (2021) · Nature Reviews Microbiology · doi:10.1038/s41579-020-00460-0 · Cited by 2,149 · see citing works
Multiple Sclerosis: Mechanisms and Immunotherapy
Baecher-Allan, C., Kaskow, B. J., & Weiner, H. L. (2018) · Neuron · doi:10.1016/j.neuron.2018.01.021 · Cited by 938 · see citing works
The pathogenesis of rheumatoid arthritis
Alivernini, S., Firestein, G. S., & McInnes, I. B. (2022) · Immunity · doi:10.1016/j.immuni.2022.11.009 · Cited by 739 · see citing works
Gut barrier disruption and chronic disease
Martel, J., Chang, S.-H., Ko, Y.-F., Hwang, T.-L., Young, J. D., & Ojcius, D. M. (2022) · Trends in Endocrinology & Metabolism · doi:10.1016/j.tem.2022.01.002 · Cited by 514 · see citing works
Fecal Microbiota Transplantation in Neurological Disorders
Vendrik, K. E. W., Ooijevaar, R. E., de Jong, P. R. C., Laman, J. D., van Oosten, B. W., van Hilten, J. J., Ducarmon, Q. R., Keller, J. J., Kuijper, E. J., & Contarino, M. F. (2020) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2020.00098 · Cited by 413 · see citing works
Microbiota therapy acts via a regulatory T cell MyD88/RORγt pathway to suppress food allergy
Abdel-Gadir, A., Victor, E. S., Gerber, G. K., Rivas, M. N., Wang, S., Harb, H., Wang, L., Li, N., Crestani, E., Spielman, S. C., et al. (2019) · Nature Medicine · doi:10.1038/s41591-019-0461-z · Cited by 392 · see citing works
Gut microbial molecules in behavioural and neurodegenerative conditions
Needham, B. D., Kaddurah-Daouk, R., & Mazmanian, S. K. (2020) · Nature Reviews Neuroscience · doi:10.1038/s41583-020-00381-0 · Cited by 379 · see citing works
The impact of the gut microbiome on extra-intestinal autoimmune diseases
Miyauchi, E., Shimokawa, C., Steimle, A., Desai, M. S., & Ohno, H. (2022) · Nature reviews. Immunology · doi:10.1038/s41577-022-00727-y · Cited by 375 · see citing works
Gut Microbiome in Progressive Multiple Sclerosis
Cox, L. M., Maghzi, A. H., Liu, S., Tankou, S. K., Dhang, F. H., Willocq, V., Song, A., Wasén, C., Tauhid, S., Chu, R., et al. (2021) · Annals of Neurology · doi:10.1002/ana.26084 · Cited by 292 · see citing works
A probiotic modulates the microbiome and immunity in multiple sclerosis
Tankou, S. K., Regev, K., Healy, B. C., Tjon, E. C., Laghi, L., Cox, L. M., Kivisäkk, P., Pierre, I. V., Hrishikesh, L., Gandhi, R., et al. (2018) · Annals of Neurology · doi:10.1002/ana.25244 · Cited by 263 · see citing works
The gut microbiota–brain axis in neurological disorder
Ullah, H., Arbab, S., Tian, Y., Liu, C., Chen, Y., Li, Q., Khan, M. I. U., Hassan, I. U., & Li, K. (2023) · Frontiers in Neuroscience · doi:10.3389/fnins.2023.1225875 · Cited by 278 · see citing works
Impacts of microbiome metabolites on immune regulation and autoimmunity
Haase, S., Haghikia, A., Wilck, N., Müller, D. N., & Linker, R. A. (2018) · Immunology · doi:10.1111/imm.12933 · Cited by 239 · see citing works
The Gut Microbiota: Emerging Evidence in Autoimmune Diseases
Zhang, X., Chen, B.-D., Zhao, L., & Li, H. (2020) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2020.04.001 · Cited by 257 · see citing works
The microbiota-immune axis as a central mediator of gut-brain communication
Fung, T. C. (2019) · Neurobiology of Disease · doi:10.1016/j.nbd.2019.104714 · Cited by 228 · see citing works
The function of gut microbiota in immune-related neurological disorders: a review
Sittipo, P., Choi, J., Lee, S., & Lee, Y. K. (2022) · Journal of Neuroinflammation · doi:10.1186/s12974-022-02510-1 · Cited by 221 · see citing works
Calcinotto, A., Brevi, A., Chesi, M., Ferrarese, R., Garcia Perez, L., Grioni, M., Kumar, S., Garbitt, V. M., Sharik, M. E., Henderson, K. J., et al. (2018) · Nature Communications · doi:10.1038/s41467-018-07305-8 · Cited by 223 · see citing works
Gut Microbiota, Leaky Gut, and Autoimmune Diseases
Christovich, A., & Luo, X. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.946248 · Cited by 206 · see citing works
Microbial dysbiosis in the gut drives systemic autoimmune diseases
Mousa, W. K., Chehadeh, F., & Husband, S. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.906258 · Cited by 207 · see citing works
The intestinal barrier in multiple sclerosis: implications for pathophysiology and therapeutics
Camara-Lemarroy, C. R., Metz, L. M., Meddings, J. B., Sharkey, K. A., & Yong, V. W. (2018) · Brain · doi:10.1093/brain/awy131 · Cited by 188 · see citing works
The "Gut Feeling": Breaking Down the Role of Gut Microbiome in Multiple Sclerosis
Freedman, S. N., Shahi, S. K., & Mangalam, A. K. (2018) · Neurotherapeutics · doi:10.1007/s13311-017-0588-x · Cited by 168 · see citing works
Self-citationHe, B., Hoang, T. K., Tian, X., Taylor, C. M., Blanchard, E., Luo, M., Bhattacharjee, M. B., Freeborn, J., Park, S., Couturier, J. P., et al. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.00385 · Cited by 182 · see citing works
The infant gut microbiome as a microbial organ influencing host well-being
Turroni, F., Milani, C., Duranti, S., Lugli, G. A., Bernasconi, S., Margollés, A., Pierro, F. D., van Sinderen, D., & Ventura, M. (2020) · The Italian Journal of Pediatrics/Italian journal of pediatrics · doi:10.1186/s13052-020-0781-0 · Cited by 165 · see citing works
Gut microbial co-abundance networks show specificity in inflammatory bowel disease and obesity
Chen, L., Collij, V., Jaeger, M., van den Munckhof, I., Vila, A. V., Kurilshikov, A., Gaćeša, R., Sinha, T., Oosting, M., Joosten, L. A. B., et al. (2020) · Nature Communications · doi:10.1038/s41467-020-17840-y · Cited by 154 · see citing works
Chu, F., Shi, M., Lang, Y., Shen, D., Jin, T., Zhu, J., & Cui, L. (2018) · Mediators of Inflammation · doi:10.1155/2018/8168717 · Cited by 159 · see citing works
Zeng, Q., Gong, J., Liu, X., Chen, C., Sun, X., Li, H., Zhou, Y., Cui, C., Wang, Y., Yang, Y., et al. (2019) · Neurochemistry International · doi:10.1016/j.neuint.2019.104468 · Cited by 156 · see citing works
Investigation of probiotics in multiple sclerosis
Tankou, S. K., Regev, K., Healy, B. C., Cox, L. M., Tjon, E., Kivisakk, P., Vanande, I. P., Cook, S., Gandhi, R., Glanz, B., et al. (2018) · Multiple Sclerosis Journal · doi:10.1177/1352458517737390 · Cited by 156 · see citing works
The multiple sclerosis gut microbiota: A systematic review
Mirza, A., Forbes, J. D., Zhu, F., Bernstein, C. N., Domselaar, G. V., Graham, M., Waubant, E. L., & Tremlett, H. L. (2019) · Multiple Sclerosis and Related Disorders · doi:10.1016/j.msard.2019.101427 · Cited by 152 · see citing works
Correlation between human gut microbiome and diseases
Madhogaria, B., Bhowmik, P., & Kundu, A. (2022) · Infectious Medicine · doi:10.1016/j.imj.2022.08.004 · Cited by 164 · see citing works
Alterations of host-gut microbiome interactions in multiple sclerosis
Cantoni, C., Lin, Q., Dorsett, Y., Ghezzi, L., Liu, Z., Pan, Y., Chen, K., Han, Y., Li, Z., Xiao, H., et al. (2022) · EBioMedicine · doi:10.1016/j.ebiom.2021.103798 · Cited by 149 · see citing works
The role of microbiome in rheumatoid arthritis treatment
Bodkhe, R., Balakrishnan, B., & Taneja, V. (2019) · Therapeutic Advances in Musculoskeletal Disease · doi:10.1177/1759720x19844632 · Cited by 146 · see citing works
Self-citationBist, P., & Choudhary, S. (2022) · Biological Trace Element Research · doi:10.1007/s12011-021-03092-4 · Cited by 132 · see citing works
Shahi, S. K., Freedman, S. N., Murra, A. C., Zarei, K., Sompallae, R. R., Gibson-Corley, K. N., Karandikar, N. J., Murray, J. A., & Mangalam, A. K. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.00462 · Cited by 125 · see citing works
Self-citationBalakrishnan, B., Luckey, D. H., Bodkhe, R., Chen, J., Marietta, E. V., Jeraldo, P., Murray, J. A., & Taneja, V. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.609644 · Cited by 125 · see citing works
Self-citationGut microbiome variation is associated to Multiple Sclerosis phenotypic subtypes
Reynders, T., Devolder, L., Valles‐Colomer, M., Remoortel, A. V., Joossens, M., Keyser, J. D., Nagels, G., D'hooghe, M. B., & Raes, J. (2020) · Annals of Clinical and Translational Neurology · doi:10.1002/acn3.51004 · Cited by 112 · see citing works
Targeting the gut to treat multiple sclerosis
Ghezzi, L., Cantoni, C., Pinget, G. V., Zhou, Y., & Piccio, L. (2021) · Journal of Clinical Investigation · doi:10.1172/jci143774 · Cited by 114 · see citing works
Microbiota-brain interactions: Moving toward mechanisms in model organisms
Nagpal, J. K., & Cryan, J. F. (2021) · Neuron · doi:10.1016/j.neuron.2021.09.036 · Cited by 107 · see citing works
Invited Review: From nose to gut – the role of the microbiome in neurological disease
Bell, J. S., Spencer, J. I., Yates, R. L., Yee, S. A., Jacobs, B. M., & DeLuca, G. C. (2018) · Neuropathology and Applied Neurobiology · doi:10.1111/nan.12520 · Cited by 109 · see citing works
IL-17 controls central nervous system autoimmunity through the intestinal microbiome
Regen, T., Isaac, S., Amorim, A., Núñez, N. G., Hauptmann, J., Shanmugavadivu, A., Klein, M., Sankowski, R., Mufazalov, I. A., Yogev, N., et al. (2021) · Science Immunology · doi:10.1126/sciimmunol.aaz6563 · Cited by 111 · see citing works
Disease-modifying therapies alter gut microbial composition in MS
Sand, I. K., Zhu, Y., Ntranos, A., Clemente, J. C., Cekanaviciute, E., Brandstadter, R., Crabtree‐Hartman, E., Singh, S., Bencosme, Y., Debelius, J. W., et al. (2018) · Neurology Neuroimmunology & Neuroinflammation · doi:10.1212/nxi.0000000000000517 · Cited by 106 · see citing works
The Gut Microbiome in Multiple Sclerosis: A Potential Therapeutic Avenue
Kirby, T. O., & Ochoa‐Repáraz, J. (2018) · Medical Sciences · doi:10.3390/medsci6030069 · Cited by 105 · see citing works
Parodi, B., & de Rosbo, N. K. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.718220 · Cited by 105 · see citing works
Role of Gut Microbiota in Neurological Disorders and Its Therapeutic Significance
Tiwari, P., Dwivedi, R., Bansal, M., Tripathi, M., & Dada, R. (2023) · Journal of Clinical Medicine · doi:10.3390/jcm12041650 · Cited by 106 · see citing works
Wang, Z., Chen, K., Wu, C., Chen, J., Pan, H., Liu, Y., Wu, P., Yuan, J., Huang, F., Lang, J., et al. (2021) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/nqab194 · Cited by 99 · see citing works
Fecal Microbiota Transplantation: A New Therapeutic Attempt from the Gut to the Brain
Xu, H., Huang, H., Zhou, Y., Zhao, H., Xu, J., Shou, D., Liu, Y., Zhou, Y., & Nie, Y. (2021) · Gastroenterology Research and Practice · doi:10.1155/2021/6699268 · Cited by 103 · see citing works
Figueroa-Romero, C., Guo, K., Murdock, B. J., Paez-Colasante, X., Bassis, C. M., Mikhail, K. A., Raue, K. D., Evans, M. C., Taubman, G. F., McDermott, A. J., et al. (2019) · Disease Models & Mechanisms · doi:10.1242/dmm.041947 · Cited by 94 · see citing works
Chen, H., Ma, X., Liu, Y., Ma, L., Chen, Z., Lin, X., Si, L., Ma, X., & Chen, X. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.01662 · Cited by 96 · see citing works
Long-term metal exposure changes gut microbiota of residents surrounding a mining and smelting area
Shao, M., & Zhu, Y. (2020) · Scientific Reports · doi:10.1038/s41598-020-61143-7 · Cited by 97 · see citing works
Alleviation of DSS-induced colitis via Lactobacillus acidophilus treatment in mice
Kim, W.-K., Han, D. H., Jang, Y. J., Park, S., Jang, S. J., Lee, G., Han, H. S., & Ko, G. (2020) · Food & Function · doi:10.1039/d0fo01724h · Cited by 92 · see citing works
Microbiome in Multiple Sclerosis: Where Are We, What We Know and Do Not Know
Boziki, M. K., Kesidou, E., Theotokis, P., Mentis, A. A., Karafoulidou, E., Melnikov, M., Sviridova, A. A., Rogovskii, V., Boyко, A., & Grigoriadis, N. (2020) · Brain Sciences · doi:10.3390/brainsci10040234 · Cited by 90 · see citing works
Cutting Edge: Probiotics and Fecal Microbiota Transplantation in Immunomodulation
Zeng, W., Shen, J., Bo, T., Peng, L., Xu, H., Nasser, M. I., Zhuang, Q., & Zhao, M. (2019) · Journal of Immunology Research · doi:10.1155/2019/1603758 · Cited by 89 · see citing works
Cencicchio, M. A., Conte, M. L., Sorini, C., & Falcone, M. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.01937 · Cited by 88 · see citing works
The role of short-chain fatty acids in central nervous system diseases
Dong, Y., & Cui, C. (2022) · Molecular and Cellular Biochemistry · doi:10.1007/s11010-022-04471-8 · Cited by 83 · see citing works
The Gut Microbiome as a Regulator of the Neuroimmune Landscape
Yu, L. W., Agirman, G., & Hsiao, E. Y. (2022) · Annual Review of Immunology · doi:10.1146/annurev-immunol-101320-014237 · Cited by 75 · see citing works
Bianchimano, P., Britton, G. J., Wallach, D. S., Smith, E. M., Cox, L. M., Liu, S., Iwanowski, K., Weiner, H. L., Faith, J. J., Clemente, J. C., et al. (2022) · Microbiome · doi:10.1186/s40168-022-01364-2 · Cited by 81 · see citing works
Good or bad: gut bacteria in human health and diseases
Wang, H., Wei, C.-X., Lu, M., & Zhu, L. (2018) · Biotechnology & Biotechnological Equipment · doi:10.1080/13102818.2018.1481350 · Cited by 84 · see citing works
Bacteroides acidifaciens and its derived extracellular vesicles improve DSS-induced colitis
Zheng, C., Zhong, Y., Xie, J., Wang, Z., Zhang, W., Pi, Y., Zhang, W., Liu, L., Luo, J. F., & Xu, W. (2023) · Frontiers in Microbiology · doi:10.3389/fmicb.2023.1304232 · Cited by 79 · see citing works
Han, G., & Vaishnava, S. (2023) · Experimental & Molecular Medicine · doi:10.1038/s12276-023-01120-y · Cited by 77 · see citing works
Gut Microbial Antigenic Mimicry in Autoimmunity
Garabatos, N., & Santamaría, P. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.873607 · Cited by 74 · see citing works
Radulescu, C. I., Garcia‐Miralles, M., Sidik, H., Bardile, C. F., Yusof, N. A. B. M., Lee, H. U., Ho, E. X. P., Chu, C. W., Layton, E., Low, D., et al. (2019) · Neurobiology of Disease · doi:10.1016/j.nbd.2019.02.011 · Cited by 67 · see citing works
Multiple sclerosis patients have an altered gut mycobiome and increased fungal to bacterial richness
Yadav, M., Ali, S., Shrode, R. L., Shahi, S. K., Jensen, S. N., Hoang, J., Cassidy, S., Olalde, H. M., Guseva, N. V., Paullus, M., et al. (2022) · PLoS ONE · doi:10.1371/journal.pone.0264556 · Cited by 64 · see citing works
Self-citationMicrobiota Analysis Using Two-step PCR and Next-generation 16S rRNA Gene Sequencing
Shahi, S. K., Zarei, K., Guseva, N. V., & Mangalam, A. K. (2019) · Journal of Visualized Experiments · doi:10.3791/59980 · Cited by 83 · see citing works
Self-citationThe Ins and Outs of Central Nervous System Inflammation—Lessons Learned from Multiple Sclerosis
Ramaglia, V., Rojas, O. L., Naouar, I., & Gommerman, J. L. (2021) · Annual Review of Immunology · doi:10.1146/annurev-immunol-093019-124155 · Cited by 69 · see citing works
Multiple sclerosis, the microbiome, TLR2, and the hygiene hypothesis
Wasko, N. J., Nichols, F. C., & Clark, R. B. (2019) · Autoimmunity Reviews · doi:10.1016/j.autrev.2019.102430 · Cited by 63 · see citing works
Gut dysbiosis and multiple sclerosis
Noto, D., & Miyake, S. (2020) · Clinical Immunology · doi:10.1016/j.clim.2020.108380 · Cited by 65 · see citing works
The role of the gut microbiota and microbial metabolites in neuroinflammation
Haase, S., Wilck, N., Haghikia, A., Gold, R., Mueller, D. N., & Linker, R. A. (2020) · European Journal of Immunology · doi:10.1002/eji.201847807 · Cited by 64 · see citing works
Zhai, Q., Wang, J., Cen, S., Zhao, J., Zhang, H., Tian, F., & Chen, W. (2019) · Food & Function · doi:10.1039/c9fo00587k · Cited by 63 · see citing works
Effects of cadmium on organ function, gut microbiota and its metabolomics profile in adolescent rats
Yang, J., Chen, W., Sun, Y., Liu, J., & Zhang, W. (2021) · Ecotoxicology and Environmental Safety · doi:10.1016/j.ecoenv.2021.112501 · Cited by 62 · see citing works
Liu, B., Yu, D., Ge, C., Luo, X., Du, L., Zhang, X., & Hui, C. (2023) · The Science of The Total Environment · doi:10.1016/j.scitotenv.2023.164050 · Cited by 62 · see citing works
Miyamoto, K., Sujino, T., Harada, Y., Ashida, H., Yoshimatsu, Y., Yonemoto, Y., Nemoto, Y., Tomura, M., Melhem, H., Niess, J. H., et al. (2023) · Cell Reports · doi:10.1016/j.celrep.2023.113005 · Cited by 63 · see citing works
The Contribution of Gut Barrier Changes to Multiple Sclerosis Pathophysiology
Buscarinu, M. C., Fornasiero, A., Romano, S., Ferraldeschi, M., Mechelli, R., Reniè, R., Morena, E., Romano, C., Pellicciari, G., Landi, A. C., et al. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.01916 · Cited by 62 · see citing works
Short-Chain Fatty Acid Production by Gut Microbiota Predicts Treatment Response in Multiple Myeloma
Rodríguez-García, A., Arroyo, A., García-Vicente, R., Morales, M. L., Gómez-Gordo, R., Justo, P., Cuéllar, C., Sánchez‐Pina, J. M., López‐Muñoz, N., Alonso, R., et al. (2023) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-23-0195 · Cited by 60 · see citing works
Microbiota-Propelled T Helper 17 Cells in Inflammatory Diseases and Cancer
Bellone, M., Brevi, A., & Huber, S. (2020) · Microbiology and Molecular Biology Reviews · doi:10.1128/mmbr.00064-19 · Cited by 59 · see citing works
Heravi, F. S. (2024) · Current Clinical Microbiology Reports · doi:10.1007/s40588-023-00213-6 · Cited by 65 · see citing works
Ormstad, H., Simonsen, C. S., Broch, L., Maes, M. H. J., Anderson, G., & Celius, E. G. (2020) · Multiple Sclerosis and Related Disorders · doi:10.1016/j.msard.2020.102533 · Cited by 55 · see citing works
Role of the intestinal microbiome in autoimmune diseases and its use in treatments
Marietta, E. V., Horwath, I. E., Balakrishnan, B., & Taneja, V. (2018) · Cellular Immunology · doi:10.1016/j.cellimm.2018.10.005 · Cited by 54 · see citing works
Self-citationThe Calm after the Storm: Implications of Sepsis Immunoparalysis on Host Immunity
Silva, E. E., Skon-Hegg, C., Badovinac, V. P., & Griffith, T. S. (2023) · The Journal of Immunology · doi:10.4049/jimmunol.2300171 · Cited by 52 · see citing works
Gut microbiome and multiple sclerosis: New insights and perspective
Amini, M. E., Shomali, N., Bakhshi, A., Rezaei, S., Hemmatzadeh, M., Hosseinzadeh, R., Eslami, S., Babaie, F., Aslani, S., Torkamandi, S., et al. (2020) · International Immunopharmacology · doi:10.1016/j.intimp.2020.107024 · Cited by 53 · see citing works
Microbial modulation of the gut microbiome for treating autoimmune diseases
Balakrishnan, B., & Taneja, V. (2018) · Expert Review of Gastroenterology & Hepatology · doi:10.1080/17474124.2018.1517044 · Cited by 51 · see citing works
Self-citationAdesulu-Dahunsi, A. T., Dahunsi, S. O., & Ajayeoba, T. A. (2022) · Frontiers in Microbiology · doi:10.3389/fmicb.2022.684730 · Cited by 54 · see citing works
Shi, Z., Qiu, Y., Wang, J., Fang, Y., Zhang, Y., Chen, H., Du, Q., Zhao, Z., Yan, C., Yang, M., et al. (2019) · Journal of Neuroimmunology · doi:10.1016/j.jneuroim.2019.577126 · Cited by 50 · see citing works
Ertürk-Hasdemir, D., Ochoa‐Repáraz, J., Kasper, D. L., & Kasper, L. H. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.662807 · Cited by 50 · see citing works
Role of Gut Microbiota in Multiple Sclerosis and Potential Therapeutic Implications
Wang, X., Liang, Z., Wang, S., Ma, D., Zhu, M., & Feng, J. (2021) · Current Neuropharmacology · doi:10.2174/1570159x19666210629145351 · Cited by 48 · see citing works
Calvo‐Barreiro, L., Eixarch, H., Alonso, M. P., Castillo, M., Lebrón‐Galán, R., Mestre, L., Guaza, C., Clemente, D., del Campo, R., Montalbán, X., et al. (2020) · Cells · doi:10.3390/cells9040906 · Cited by 48 · see citing works
Impact of Microbiome–Brain Communication on Neuroinflammation and Neurodegeneration
Stolzer, I., Scherer, E., Süß, P., Rothhammer, V., Winner, B., Neurath, M. F., & Günther, C. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms241914925 · Cited by 47 · see citing works
Shahi, S. K., Jensen, S. N., Murra, A. C., Tang, N., Guo, H., Gibson-Corley, K. N., Zhang, J., Karandikar, N. J., Murray, J. A., & Mangalam, A. K. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.578648 · Cited by 46 · see citing works
Self-citationMestre, L., Carrillo-Salinas, F. J., Mecha, M., Feliú, A., Espejo, C., Alvarez-Cermeño, J. C., Villar, L. M., & Guaza, C. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.01374 · Cited by 48 · see citing works
Blais, L. L., Montgomery, T. L., Amiel, E., Deming, P. B., & Krementsov, D. N. (2021) · Gut Microbes · doi:10.1080/19490976.2021.1943289 · Cited by 45 · see citing works
Pandit, L., Cox, L. M., Malli, C., D’Cunha, A., Rooney, T., Lokhande, H. A., Willocq, V., Saxena, S., & Chitnis, T. (2020) · Neurology Neuroimmunology & Neuroinflammation · doi:10.1212/nxi.0000000000000907 · Cited by 42 · see citing works
Calvo‐Barreiro, L., Eixarch, H., Cornejo, T., Costa, C., Castillo, M., Mestre, L., Guaza, C., Martínez‐Cuesta, M. C., Tanoue, T., Honda, K., et al. (2021) · Neurotherapeutics · doi:10.1007/s13311-021-01016-7 · Cited by 45 · see citing works
Autonomic nervous system and neuroimmune interactions
Benarroch, E. E. (2019) · Neurology · doi:10.1212/wnl.0000000000006942 · Cited by 42 · see citing works
The sex-specific interaction of the microbiome in neurodegenerative diseases
Cox, L. M., Abou‐El‐Hassan, H., Maghzi, A. H., Vincentini, J., & Weiner, H. L. (2019) · Brain Research · doi:10.1016/j.brainres.2019.146385 · Cited by 42 · see citing works
Yadav, S. K., Ito, K., & Dhib-Jalbut, S. S. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms241914756 · Cited by 43 · see citing works
Targeting gut microbiota: new therapeutic opportunities in multiple sclerosis
Kujawa, D., Łaczmański, Ł., Budrewicz, S. P., Pokryszko‐Dragan, A., & Podbielska, M. (2023) · Gut Microbes · doi:10.1080/19490976.2023.2274126 · Cited by 44 · see citing works
Gut microbial factors predict disease severity in a mouse model of multiple sclerosis
Steimle, A., Neumann, M., Grant, E. T., Willième, S., Sciscio, A. D., Parrish, A., Ollert, M. W., Miyauchi, E., Soga, T., Fukuda, S., et al. (2024) · Nature Microbiology · doi:10.1038/s41564-024-01761-3 · Cited by 47 · see citing works
Microbiome, Immunomodulation, and the Neuronal System
Marietta, E. V., Horwath, I. E., & Taneja, V. (2018) · Neurotherapeutics · doi:10.1007/s13311-017-0601-4 · Cited by 41 · see citing works
Self-citationRole of diet in regulating the gut microbiota and multiple sclerosis
Sanchez, J. M. S., DePaula-Silva, A. B., Libbey, J. E., & Fujinami, R. S. (2020) · Clinical Immunology · doi:10.1016/j.clim.2020.108379 · Cited by 42 · see citing works
Mestre, L., Carrillo-Salinas, F. J., Feliú, A., Mecha, M., Alonso, G., Espejo, C., Calvo‐Barreiro, L., Luque-Garcia, J. L., Estévez, H., Villar, L. M., et al. (2020) · Gut Microbes · doi:10.1080/19490976.2020.1813532 · Cited by 41 · see citing works
Equine Fecal Microbiota Changes Associated With Anthelmintic Administration
Kunz, I. G. Z., Reed, K. J., Metcalf, J. L., Hassel, D. M., Coleman, R., Hess, T. M., & Coleman, S. J. (2019) · Journal of Equine Veterinary Science · doi:10.1016/j.jevs.2019.01.018 · Cited by 40 · see citing works
Sell, L. B., Ramelow, C. C., Kohl, H. M., Hoffman, K. R., Bains, J. K., Doyle, W. J., Strawn, K. D., Hevrin, T., Kirby, T. O., Gibson, K. M., et al. (2021) · Clinical Immunology · doi:10.1016/j.clim.2021.108766 · Cited by 40 · see citing works
B Cells and Microbiota in Autoimmunity
Botía-Sánchez, M., Alarcón-Riquelme, M. E., & Galicia, G. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22094846 · Cited by 39 · see citing works
- Authors
- Mangalam, A., Shahi, S. K., Luckey, D., Karau, M., Marietta, E., Luo, N., Choung, R. S., Ju, J., Sompallae, R., Gibson-Corley, K., Patel, R., Rodriguez, M., David, C., Taneja, V., & Murray, J.
- Affiliations
- University of Iowa (US)
- Mayo Clinic (US)
- Corresponding author
- Mangalam, Ashutosh
- ORCID
- Venue
- Cell Reports
- Publisher
- Elsevier BV
- Published
- 2017-08
- Volume
- 20
- Issue
- 6
- Pages
- 1269-1277
- ISSN
- 2211-1247 (ISSN-L)
- PMC
- PMC5763484
- OpenAlex
- W2743852004
- Cited by
- 266
- References
- 29
- Citations by year
- 2026: 12 · 2025: 16 · 2024: 30 · 2023: 41 · 2022: 40 · 2021: 37 · 2020: 36 · 2019: 29 · 2018: 21 · 2017: 4
- FWCI
- 19.33
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Cell Reports (publishedVersion, cc-by-nc-nd)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Iowa Research Online (The University of Iowa) (submittedVersion)
- Iowa Research Online (University of Iowa) (submittedVersion, cc-by-nc-nd)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- Department of Defense (W81XWH-10-1-0254)
- National Multiple Sclerosis Society (RG 5138A1/1T)
- BioFire
- Check-Points
- Curetis
- 3M
- Merck
- Hutchison Biofilm Medical Solutions
- Accelerate Diagnostics
- Allergan
- The Medicines Company
- ASM
- IDSA
- USMLE
- Up-to-Date
- Infectious Diseases Board Review Course
- NIH (GM092993, NS048357, NS073684)
- NIH CTSA (RR024150, TR000135)
- Novartis Pharmaceuticals
- European Regional Development Fund (FNUSA-ICRC CZ.1.05/1.1.00/02.0123)
- Applebaum
- Hilton
- Peterson
- McNeilus Foundations
- Topics
- Health Sciences › Medicine › Pathology and Forensic Medicine › Multiple Sclerosis Research Studies
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
- Keywords
- gut microbiota, commensal bacteria, Prevotella histicola, multiple sclerosis, experimental autoimmune encephalomyelitis, demyelinating disease, neuroinflammation, regulatory T cells, Th17 cells, Th1 cells, tolerogenic dendritic cells, probiotic therapy
- MeSH terms
- Gastrointestinal Microbiome, Animals, Cells, Cultured, Dendritic Cells, Encephalomyelitis, Autoimmune, Experimental, Genes, MHC Class II, Humans, Macrophages, CD4-Positive T-Lymphocytes, Th1 Cells, Prevotella, Probiotics, Mice, Forkhead Transcription Factors, Th17 Cells
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
