Investigation of probiotics in multiple sclerosis
Open accessAbstract
None of the disease-modifying therapies (DMTs) currently being used for the management of multiple sclerosis (MS) are 100% effective. In addition, side effects associated with the use of these DMTs have limited the practice of combination therapy. Hence, there is a need for safe immunomodulatory agents to fine-tune the management of MS. The gut microbiome plays an important role in autoimmunity, and several studies have reported alterations in the gut microbiome of MS patients. Studies in animal model of MS have identified members of the gut commensal microflora that exacerbate or ameliorate neuroinflammation. Probiotics represent an oral, non-toxic immunomodulatory agent that could be used in combination with current MS therapy. We designed a pilot study to investigate the effect of VSL3 on the gut microbiome and peripheral immune system function in healthy controls and MS patients. VSL3 administration was associated with increased abundance of many taxa with enriched taxa predominated by Lactobacillus, Streptococcus, and Bifidobacterium species. At the immune level, VSL3 administration induced an anti-inflammatory peripheral immune response characterized by decreased frequency of intermediate monocytes (CD14 high CD16 low ), decreased mean fluorescence intensity (MFI) of CD80 on classical monocytes as well as decreased human leukocyte antigen–antigen D related (HLA-DR) MFI on dendritic cells.
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Probiotic supplementations have therapeutic potential to ameliorate multiple sclerosis, improving disability status, mental health, and some inflammatory and metabolic parameters compared to placebo.
“Moreover, probiotics supplementations have a therapeutic potential to ameliorate MS, improving the disability status, the mental health, and some inflammatory and metabolic parameters, compared to the placebo group (148, 149).”
From The gut-brain axis: how microbiota and host inflammasome influence brain physiology and pathology (2020) · cites this paper as [149]
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- Authors
- Tankou, S. K., Regev, K., Healy, B. C., Cox, L. M., Tjon, E., Kivisakk, P., Vanande, I. P., Cook, S., Gandhi, R., Glanz, B., Stankiewicz, J., & Weiner, H. L.
- Affiliations
- Brigham and Women's Hospital (US)
- Ann Romney Center for Neurologic Diseases, Evergrande Center for Immunologic Diseases, Partners Multiple Sclerosis Center, Brigham and Women’s Hospital and Department of Neurology, Harvard Medical School, Boston, MA, USA
- ORCID
- Venue
- Multiple Sclerosis Journal
- Publisher
- SAGE Publications
- Published
- 2018-01
- Volume
- 24
- Issue
- 1
- Pages
- 58-63
- ISSN
- 1352-4585 (ISSN-L)
- 1477-0970
- OpenAlex
- W2784311706
- Cited by
- 156
- References
- 25
- Citations by year
- 2026: 11 · 2025: 14 · 2024: 19 · 2023: 22 · 2022: 27 · 2021: 24 · 2020: 16 · 2019: 15 · 2018: 7 · 2017: 1
- FWCI
- 14.55
- Type
- journal article
- Language
- en
- Update notices
- correction (2018-11-27)
- Open access
- bronze
- doi.org
- Locations
- Multiple Sclerosis Journal (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Teva Pharmaceutical Industries
- Topics
- Life Sciences › Agricultural and Biological Sciences › Food Science › Probiotics and Fermented Foods
- Health Sciences › Medicine › Pathology and Forensic Medicine › Multiple Sclerosis Research Studies
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Keywords
- multiple sclerosis, probiotics, gut microbiota, immunomodulation, neuroinflammation, monocytes, dendritic cells, Lactobacillus, Streptococcus, Bifidobacterium, disease-modifying therapy, autoimmunity
- MeSH terms
- Gastrointestinal Microbiome, Adult, Female, Humans, Male, Middle Aged, Monocytes, Probiotics, Multiple Sclerosis, Relapsing-Remitting
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