The DOI matches its Crossref record; 45 of the 45 references it cites were found in a registry or an index.
Dendritic Cell Amiloride-Sensitive Channels Mediate Sodium-Induced Inflammation and Hypertension
Open accessAbstract
Sodium accumulates in the interstitium and promotes inflammation through poorly defined mechanisms. We describe a pathway by which sodium enters dendritic cells (DCs) through amiloride-sensitive channels including the alpha and gamma subunits of the epithelial sodium channel and the sodium hydrogen exchanger 1. This leads to calcium influx via the sodium calcium exchanger, activation of protein kinase C (PKC), phosphorylation of p47 phox , and association of p47 phox with gp91 phox . The assembled NADPH oxidase produces superoxide with subsequent formation of immunogenic isolevuglandin (IsoLG)-protein adducts. DCs activated by excess sodium produce increased interleukin - 1β (IL-1β) and promote T cell production of cytokines IL-17A and interferon gamma (IFN-γ). When adoptively transferred into naive mice, these DCs prime hypertension in response to a sub-pressor dose of angiotensin II. These findings provide a mechanistic link between salt, inflammation, and hypertension involving increased oxidative stress and IsoLG production in DCs.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Heart Disease and Stroke Statistics—2017 Update: A Report From the American Heart Association
Benjamin, E. J., Blaha, M. J., Chiuve, S. E., Cushman, M., Das, S. R., Deo, R., de Ferranti, S. D., Floyd, J., Fornage, M., Gillespie, C., et al. (2017) · Circulation · doi:10.1161/cir.0000000000000485 · Cited by 12,591
Global burden of hypertension: analysis of worldwide data
Kearney, P. M., Whelton, M., Reynolds, K., Muntner, P., Whelton, P. K., & He, J. (2005) · The Lancet · doi:10.1016/s0140-6736(05)17741-1 · Cited by 8,594
Measuring the global burden of disease
Murray, C. J. L., & Lopez, A. D. (2013) · New England Journal of Medicine · doi:10.1056/nejmra1201534 · Cited by 1,818
Role of the T cell in the genesis of angiotensin II–induced hypertension and vascular dysfunction
Guzik, T. J., Hoch, N. E., Brown, K. A., McCann, L. A., Rahman, A., Dikalov, S., Goronzy, J., Weyand, C., & Harrison, D. G. (2007) · The Journal of Experimental Medicine · doi:10.1084/jem.20070657 · Cited by 1,736
Self-citationSodium chloride drives autoimmune disease by the induction of pathogenic TH17 cells
Kleinewietfeld, M., Manzel, A., Titze, J., Kvakan, H., Yosef, N., Linker, R. A., Muller, D. N., & Hafler, D. A. (2013) · Nature · doi:10.1038/nature11868 · Cited by 1,394
Self-citationInduction of pathogenic TH17 cells by inducible salt-sensing kinase SGK1
Wu, C., Yosef, N., Thalhamer, T., Zhu, C., Xiao, S., Kishi, Y., Regev, A., & Kuchroo, V. K. (2013) · Nature · doi:10.1038/nature11984 · Cited by 1,022
Machnik, A., Neuhofer, W., Jantsch, J., Dahlmann, A., Tammela, T., Machura, K., Park, J.-K., Beck, F.-X., Müller, D. N., Derer, W., et al. (2009) · Nature Medicine · doi:10.1038/nm.1960 · Cited by 963
Self-citationInterleukin 17 Promotes Angiotensin II–Induced Hypertension and Vascular Dysfunction
Madhur, M. S., Lob, H. E., McCann, L. A., Iwakura, Y., Blinder, Y., Guzik, T. J., & Harrison, D. G. (2010) · Hypertension · doi:10.1161/hypertensionaha.109.145094 · Cited by 827
Self-citationChang, S. S., Grunder, S., Hanukoglu, A., Rösler, A., Mathew, P. M., Hanukoglu, I., Schild, L., Lu, Y., Shimkets, R. A., Nelson-Williams, C., et al. (1996) · Nature Genetics · doi:10.1038/ng0396-248 · Cited by 808
Jakubzick, C., Gautier, E. L., Gibbings, S. L., Sojka, D. K., Schlitzer, A., Johnson, T. E., Ivanov, S., Duan, Q., Bala, S., Condon, T., et al. (2013) · Immunity · doi:10.1016/j.immuni.2013.08.007 · Cited by 783
Inflammation, Immunity, and Hypertensive End-Organ Damage
McMaster, W. G., Kirabo, A., Madhur, M. S., & Harrison, D. G. (2015) · Circulation Research · doi:10.1161/circresaha.116.303697 · Cited by 708
Self-citationDC isoketal-modified proteins activate T cells and promote hypertension
Kirabo, A., Fontana, V., de Faria, A. P. C., Loperena, R., Galindo, C. L., Wu, J., Bikineyeva, A. T., Dikalov, S., Xiao, L., Chen, W., et al. (2014) · Journal of Clinical Investigation · doi:10.1172/jci74084 · Cited by 538
Self-citationKopp, C., Linz, P., Dahlmann, A., Hammon, M., Jantsch, J., Müller, D. N., Schmieder, R. E., Cavallaro, A., Eckardt, K.-U., Uder, M., et al. (2013) · Hypertension · doi:10.1161/hypertensionaha.111.00566 · Cited by 393
Self-citationInduction, function and regulation of IL‐17‐producing T cells
Mills, K. H. G. (2008) · European Journal of Immunology · doi:10.1002/eji.200838535 · Cited by 385
Loffing, J., Zecevic, M., Féraille, E., Kaissling, B., Asher, C., Rossier, B. C., Firestone, G. L., Pearce, D., & Verrey, F. (2001) · American Journal of Physiology-Renal Physiology · doi:10.1152/ajprenal.2001.280.4.f675 · Cited by 383
Glycosaminoglycan polymerization may enable osmotically inactive Na+storage in the skin
Titze, J., Shakibaei, M., Schafflhuber, M., Schulze-Tanzil, G., Porst, M., Schwind, K. H., Dietsch, P., & Hilgers, K. F. (2004) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.01237.2003 · Cited by 330
Self-citationJantsch, J., Schatz, V., Friedrich, D., Schröder, A., Kopp, C., Siegert, I., Maronna, A., Wendelborn, D., Linz, P., Binger, K. J., et al. (2015) · Cell Metabolism · doi:10.1016/j.cmet.2015.02.003 · Cited by 317
Self-citationDikalov, S. I., Nazarewicz, R. R., Bikineyeva, A., Hilenski, L., Lassègue, B., Griendling, K. K., Harrison, D. G., & Dikalova, A. E. (2014) · Antioxidants & Redox Signaling · doi:10.1089/ars.2012.4918 · Cited by 310
Self-citationPharmacology of Brain Na+/Ca2+ Exchanger: From Molecular Biology to Therapeutic Perspectives
Annunziato, L., Pignataro, G., & Di Renzo, G. F. (2004) · Pharmacological Reviews · doi:10.1124/pr.56.4.5 · Cited by 307
Vinh, A., Chen, W., Blinder, Y., Weiss, D., Taylor, W. R., Goronzy, J. J., Weyand, C. M., Harrison, D. G., & Guzik, T. J. (2010) · Circulation · doi:10.1161/circulationaha.109.930446 · Cited by 300
Self-citationInterleukin-17 causes Rho-kinase-mediated endothelial dysfunction and hypertension
Nguyen, H., Chiasson, V. L., Chatterjee, P., Kopriva, S. E., Young, K. J., & Mitchell, B. M. (2013) · Cardiovascular Research · doi:10.1093/cvr/cvs422 · Cited by 300
Youn, J.-C., Yu, H. T., Lim, B. J., Koh, M. J., Lee, J., Chang, D.-Y., Choi, Y. S., Lee, S.-H., Kang, S.-M., Jang, Y., et al. (2013) · Hypertension · doi:10.1161/hypertensionaha.113.00689 · Cited by 284
High salt reduces the activation of IL-4– and IL-13–stimulated macrophages
Binger, K. J., Gebhardt, M., Heinig, M., Rintisch, C., Schroeder, A., Neuhofer, W., Hilgers, K., Manzel, A., Schwartz, C., Kleinewietfeld, M., et al. (2015) · Journal of Clinical Investigation · doi:10.1172/jci80919 · Cited by 281
Self-citationDietary Salt Intake and Hypertension
Ha, S. K. (2014) · Electrolytes & Blood Pressure · doi:10.5049/ebp.2014.12.1.7 · Cited by 254
High salt primes a specific activation state of macrophages, M(Na)
Zhang, W.-C., Zheng, X.-J., Du, L.-J., Sun, J.-Y., Shen, Z.-X., Shi, C., Sun, S., Zhang, Z., Chen, X.-Q., Qin, M., et al. (2015) · Cell Research · doi:10.1038/cr.2015.87 · Cited by 242
Rubera, I., Loffing, J., Palmer, L. G., Frindt, G., Fowler-Jaeger, N., Sauter, D., Carroll, T., McMahon, A., Hummler, E., & Rossier, B. C. (2003) · Journal of Clinical Investigation · doi:10.1172/jci16956 · Cited by 210
Kamat, N. V., Thabet, S. R., Xiao, L., Saleh, M. A., Kirabo, A., Madhur, M. S., Delpire, E., Harrison, D. G., & McDonough, A. A. (2015) · Hypertension · doi:10.1161/hypertensionaha.114.04975 · Cited by 206
Self-citationMattson, D. L., Lund, H., Guo, C., Rudemiller, N., Geurts, A. M., & Jacob, H. (2013) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00304.2012 · Cited by 178
Imahashi, K., Pott, C., Goldhaber, J. I., Steenbergen, C., Philipson, K. D., & Murphy, E. (2005) · Circulation Research · doi:10.1161/01.res.0000187456.06162.cb · Cited by 173
Itani, H. A., Xiao, L., Saleh, M. A., Wu, J., Pilkinton, M. A., Dale, B. L., Barbaro, N. R., Foss, J. D., Kirabo, A., Montaniel, K. R., et al. (2016) · Circulation Research · doi:10.1161/circresaha.115.308111 · Cited by 172
Self-citationEPR detection of cellular and mitochondrial superoxide using cyclic hydroxylamines
Dikalov, S. I., Kirilyuk, I. A., Voinov, M., & Grigor'ev, I. A. (2011) · Free Radical Research · doi:10.3109/10715762.2010.540242 · Cited by 171
Self-citationYi, B., Titze, J., Rykova, M., Feuerecker, M., Vassilieva, G., Nichiporuk, I., Schelling, G., Morukov, B., & Choukèr, A. (2015) · Translational Research · doi:10.1016/j.trsl.2014.11.007 · Cited by 166
Self-citationZhang, J., Rudemiller, N. P., Patel, M. B., Karlovich, N. S., Wu, M., McDonough, A. A., Griffiths, R., Sparks, M. A., Jeffs, A. D., & Crowley, S. D. (2015) · Cell Metabolism · doi:10.1016/j.cmet.2015.11.013 · Cited by 151
Sodium sensing in the interstitium and relationship to hypertension
Titze, J. M., & Machnik, A. (2010) · Current Opinion in Nephrology & Hypertension · doi:10.1097/mnh.0b013e32833aeb3b · Cited by 124
Self-citationBonny, O., Chraïbi, A., Loffing, J., Jaeger, N. F., Gründer, S., Horisberger, J., & Rossier, B. C. (1999) · Journal of Clinical Investigation · doi:10.1172/jci6821 · Cited by 116
Mattiello, J. A., Margulies, K. B., Jeevanandam, V., & Houser, S. R. (1998) · Cardiovascular Research · doi:10.1016/s0008-6363(97)00271-x · Cited by 90
(2017) · Circulation · doi:10.1161/cir.0000000000000530 · Cited by 80
Chiasson, V. L., Talreja, D., Young, K. J., Chatterjee, P., Banes‐Berceli, A. K. L., & Mitchell, B. M. (2011) · Hypertension · doi:10.1161/hypertensionaha.110.162917 · Cited by 74
Haase, S., Kissel, J., Manzel, A., Kleinewietfeld, M., Haghikia, A., Gold, R., Müller, D. N., & Linker, R. A. (2016) · Experimental Neurology · doi:10.1016/j.expneurol.2016.03.010 · Cited by 73
Protein kinase C phosphorylates a component of NADPH oxidase of neutrophils
Papini, E., Grzeskowiak, M., Bellavite, P., et al. (1985) · FEBS Letters · doi:10.1016/0014-5793(85)81284-9 · Cited by 71
Sugishita, K., Su, Z. G., Li, F., Philipson, K. D., & Barry, W. H. (2001) · Circulation · doi:10.1161/hc4001.097038 · Cited by 70
Sayeski, P. P., Ali, M., Harp, J. B., Marrero, M. B., & Bernstein, K. E. (1998) · Circulation Research · doi:10.1161/01.res.82.12.1279 · Cited by 60
Dendritic cells and isolevuglandins in immunity, inflammation, and hypertension
Dixon, K. B., Davies, S. S., & Kirabo, A. (2016) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00603.2016 · Cited by 53
Self-citationKirabo, A., Kearns, P. N., Jarajapu, Y. P. R., Sasser, J. M., Oh, S. P., Grant, M. B., Kasahara, H., Cardounel, A. J., Baylis, C., Wagner, K., et al. (2011) · Cardiovascular Research · doi:10.1093/cvr/cvr059 · Cited by 47
Self-citationGarcia, R. C., Whitaker, M., Heyworth, P. G., & Segal, A. W. (1992) · Biochemical Journal · doi:10.1042/bj2860687 · Cited by 39
Cited by
Oxidative Stress and Hypertension
Griendling, K. K., Camargo, L. L., Rios, F. J., Alves-Lopes, R., Montezano, A. C., & Touyz, R. M. (2021) · Circulation Research · doi:10.1161/circresaha.121.318063 · Cited by 573
Immune mechanisms of hypertension
Drummond, G. R., Vinh, A., Guzik, T. J., & Sobey, C. G. (2019) · Nature Reviews Immunology · doi:10.1038/s41577-019-0160-5 · Cited by 428
Pathophysiology of Hypertension: The Mosaic Theory and Beyond
Harrison, D. G., Coffman, T. M., & Wilcox, C. S. (2021) · Circulation Research · doi:10.1161/circresaha.121.318082 · Cited by 365
Self-citationFrąk, W., Wojtasińska, A., Lisińska, W., Młynarska, E., Franczyk, B., & Rysz, J. (2022) · Biomedicines · doi:10.3390/biomedicines10081938 · Cited by 303
The gut microbiome and hypertension
O’Donnell, J. A., Zheng, T., Meric, G., & Marques, F. Z. (2023) · Nature Reviews Nephrology · doi:10.1038/s41581-022-00654-0 · Cited by 281
Metadata
- Authors
- Barbaro, N. R., Foss, J. D., Kryshtal, D. O., Tsyba, N., Kumaresan, S., Xiao, L., Mernaugh, R. L., Itani, H. A., Loperena, R., Chen, W., Dikalov, S., Titze, J. M., Knollmann, B. C., Harrison, D. G., & Kirabo, A.
- Venue
- Cell Reports
- Publisher
- Elsevier BV
- Published
- 2017-10
- Volume
- 21
- Issue
- 4
- Pages
- 1009-1020
- ISSN
- 2211-1247 (ISSN-L)
- OpenAlex
- W2765521509
- Cited by
- 282
- References
- 45
- FWCI
- 13.96
- Type
- journal article
- Language
- en
- Open access
- gold
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
