Nicotinic acetylcholine receptors control encoding and retrieval of associative recognition memory through plasticity in the medial prefrontal cortex
Open accessAbstract
Nicotinic acetylcholine receptors (nAChRs) expressed in the medial prefrontal cortex have critical roles in cognitive function. However, whether nAChRs are required for associative recognition memory and the mechanisms by which nAChRs may contribute to mnemonic processing are not known. We demonstrate that nAChRs in the prefrontal cortex exhibit subtype-specific roles in associative memory encoding and retrieval. We present evidence that these separate roles of nAChRs may rely on bidirectional modulation of plasticity at synaptic inputs to the prefrontal cortex that are essential for associative recognition memory.
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Infusions into the mPFC of methyllycaconitine citrate, before learning, or dihydro-β-erythroidine hydrobromide, before the test trial, did not influence OPP (24 hours) memory.
“In addition, infusions into the mPFC of methyllycaconitine citrate, before learning, or dihydro-β-erythroidine hydrobromide, before the test trial, did not influence OPP (24 hours) memory (Sabec et al., 2018).”
From The medial prefrontal cortex - hippocampus circuit that integrates information of object, place and time to construct episodic memory in rodents: Behavioral, anatomical and neurochemical properties (2020) · cites this paper as Sabec et al., 2018
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- Authors
- Sabec, M. H., Wonnacott, S., Warburton, E. C., & Bashir, Z. I.
- Affiliations
- University of Bristol (GB)
- University of Bath (GB)
- Corresponding author
- Sabec, Marie H.
- Venue
- Cell Reports
- Publisher
- Elsevier BV
- Published
- 2018-03
- Volume
- 22
- Issue
- 13
- Pages
- 3409-3415
- ISSN
- 2211-1247 (ISSN-L)
- PMC
- PMC5896173
- OpenAlex
- W2795260584
- Cited by
- 42
- References
- 39
- Citations by year
- 2026: 5 · 2025: 7 · 2024: 5 · 2023: 3 · 2022: 5 · 2021: 7 · 2020: 7 · 2019: 2 · 2018: 1
- FWCI
- 1.51
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Cell Reports (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- HAL (submittedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Bristol Research (University of Bristol) (submittedVersion, cc-by)
- Explore Bristol Research (submittedVersion, cc-by)
- Funders
- Wellcome Trust (206401/Z/17/Z)
- Biotechnology and Biological Sciences Research Council (BB/L001896/1, BB/J014400/1)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Nicotinic Acetylcholine Receptors Study
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Keywords
- nicotinic acetylcholine receptors, medial prefrontal cortex, associative recognition memory, memory encoding, memory retrieval, synaptic plasticity, cholinergic modulation
- MeSH terms
- Animals, Association Learning, Male, Memory, Neuronal Plasticity, Receptors, Nicotinic, Prefrontal Cortex, Receptors, AMPA, Rats
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