Cited by 124Memory and Neural MechanismsMemory Processes and InfluencesNeuroscience and Neuropharmacology Research

Separate elements of episodic memory subserved by distinct hippocampal-prefrontal connections

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Barker, Gareth R I, Banks, Paul J, Scott, Hannah, Ralph, G Scott, Mitrophanous, Kyriacos A, Wong, Liang-Fong, Bashir, Zafar I, Uney, James B +1 more·2017·Nature Neuroscience

Abstract

Episodic memory formation depends on information about a stimulus being integrated within a precise spatial and temporal context, a process dependent on the hippocampus and prefrontal cortex. Investigations of putative functional interactions between these regions are complicated by multiple direct and indirect hippocampal-prefrontal connections. Here application of a pharmacogenetic deactivation technique enabled us to investigate the mnemonic contributions of two direct hippocampal-medial prefrontal cortex (mPFC) pathways, one arising in the dorsal CA1 (dCA1) and the other in the intermediate CA1 (iCA1). While deactivation of either pathway impaired episodic memory, the resulting pattern of mnemonic deficits was different: deactivation of the dCA1→mPFC pathway selectively disrupted temporal order judgments while iCA1→mPFC pathway deactivation disrupted spatial memory. These findings reveal a previously unsuspected division of function among CA1 neurons that project directly to the mPFC. Such subnetworks may enable the distinctiveness of contextual information to be maintained in an episodic memory circuit.

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Crossref · 10.1038/nn.4472

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Authors
Barker, G. R. I., Banks, P. J., Scott, H., Ralph, G. S., Mitrophanous, K. A., Wong, L.-F., Bashir, Z. I., Uney, J. B., & Warburton, E. C.
Affiliations
  • University of Bristol (GB)
  • Oxford BioMedica (United Kingdom) (GB)
Venue
Nature Neuroscience
Published
2017-01-09
Volume
20
Issue
2
Pages
242-250
ISSN
  • 1097-6256 (ISSN-L)
  • 1546-1726
OpenAlex
W2570448273
Cited by
124
References
52
Citations by year
2026: 11 · 2025: 9 · 2024: 9 · 2023: 10 · 2022: 16 · 2021: 15 · 2020: 17 · 2019: 9 · 2018: 16 · 2017: 12
FWCI
8.49
Type
journal article
Language
en
Locations
  • Nature Neuroscience (publishedVersion)
  • PubMed (publishedVersion)
  • Explore Bristol Research (publishedVersion, other-oa)
  • ORCA Online Research @Cardiff (Cardiff University) (submittedVersion)
Funders
Biotechnology and Biological Sciences Research Council (BB/100310X/1, BB/M017532/1, BB/I00310X/1, BB/L001896/1)
Topics
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Memory Processes and Influences
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Keywords
episodic memory, hippocampus, medial prefrontal cortex, CA1, dorsal CA1, temporal order judgment, spatial memory, contextual information
MeSH terms
Animals, Hippocampus, Male, Nerve Net, Neural Pathways, Neurons, Prefrontal Cortex, Rats, Memory, Episodic, Spatial Memory

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