Separate elements of episodic memory subserved by distinct hippocampal-prefrontal connections
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Episodic memory formation depends on information about a stimulus being integrated within a precise spatial and temporal context, a process dependent on the hippocampus and prefrontal cortex. Investigations of putative functional interactions between these regions are complicated by multiple direct and indirect hippocampal-prefrontal connections. Here application of a pharmacogenetic deactivation technique enabled us to investigate the mnemonic contributions of two direct hippocampal-medial prefrontal cortex (mPFC) pathways, one arising in the dorsal CA1 (dCA1) and the other in the intermediate CA1 (iCA1). While deactivation of either pathway impaired episodic memory, the resulting pattern of mnemonic deficits was different: deactivation of the dCA1→mPFC pathway selectively disrupted temporal order judgments while iCA1→mPFC pathway deactivation disrupted spatial memory. These findings reveal a previously unsuspected division of function among CA1 neurons that project directly to the mPFC. Such subnetworks may enable the distinctiveness of contextual information to be maintained in an episodic memory circuit.
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- Authors
- Barker, G. R. I., Banks, P. J., Scott, H., Ralph, G. S., Mitrophanous, K. A., Wong, L.-F., Bashir, Z. I., Uney, J. B., & Warburton, E. C.
- Affiliations
- University of Bristol (GB)
- Oxford BioMedica (United Kingdom) (GB)
- ORCID
- Venue
- Nature Neuroscience
- Published
- 2017-01-09
- Volume
- 20
- Issue
- 2
- Pages
- 242-250
- ISSN
- 1097-6256 (ISSN-L)
- 1546-1726
- OpenAlex
- W2570448273
- Cited by
- 124
- References
- 52
- Citations by year
- 2026: 11 · 2025: 9 · 2024: 9 · 2023: 10 · 2022: 16 · 2021: 15 · 2020: 17 · 2019: 9 · 2018: 16 · 2017: 12
- FWCI
- 8.49
- Type
- journal article
- Language
- en
- Open access
- Licence
- other-oa
- www.springer.com/tdm (tdm)
- Locations
- Nature Neuroscience (publishedVersion)
- PubMed (publishedVersion)
- Explore Bristol Research (publishedVersion, other-oa)
- ORCA Online Research @Cardiff (Cardiff University) (submittedVersion)
- Funders
- Biotechnology and Biological Sciences Research Council (BB/100310X/1, BB/M017532/1, BB/I00310X/1, BB/L001896/1)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory Processes and Influences
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Keywords
- episodic memory, hippocampus, medial prefrontal cortex, CA1, dorsal CA1, temporal order judgment, spatial memory, contextual information
- MeSH terms
- Animals, Hippocampus, Male, Nerve Net, Neural Pathways, Neurons, Prefrontal Cortex, Rats, Memory, Episodic, Spatial Memory
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