Spike timing, calcium signals and synaptic plasticity
Abstract
Plasticity at central synapses depends critically on the timing of presynaptic and postsynaptic action potentials. Key initial steps in synaptic plasticity involve the back-propagation of action potentials into the dendritic tree and calcium influx that depends nonlinearly on the action potential and synaptic input. These initial steps are now better understood. In addition, recent studies of processes as diverse as gene expression and channel inactivation suggest that responses to calcium transients depend not only their amplitude, but on their time course and on the location of their origin.
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Bayesian belief propagation and particle filtering are the most successful computer vision algorithms to date.
“Bayesian belief propagation 18 -20 and particle filtering 21,22 are the most successful computer vision algorithms to date.”
From Hierarchical Bayesian inference in the visual cortex (2003) · cites this paper as [20]
Algorithms of this type, with separate sets of particles for bottom-up and top-down messages, constitute one of the most promising techniques for statistical inference in large, multilayered domains.
“Algorithms of this type, although with separate sets of particles for bottom-up and top-down messages, are under active investigation in the computer vision community 19,20,22 and constitute one of the most promising techniques for statistical inference in such large, multilayered domains.”
From Hierarchical Bayesian inference in the visual cortex (2003) · cites this paper as [20]
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- Authors
- Sjöström, P.
- Affiliations
- Brandeis University (US)
- Corresponding author
- Sjöström, P
- ORCID
- Sjöström, P
- Venue
- Current Opinion in Neurobiology
- Publisher
- Elsevier BV
- Published
- 2002-06-01
- Volume
- 12
- Issue
- 3
- Pages
- 305-314
- ISSN
- 0959-4388 (ISSN-L)
- OpenAlex
- W2014900949
- Cited by
- 231
- References
- 5
- Citations by year
- 2026: 5 · 2025: 11 · 2024: 7 · 2023: 1 · 2022: 5 · 2021: 2 · 2020: 7 · 2019: 9 · 2018: 6 · 2017: 2 · 2016: 6 · 2015: 8 · 2014: 7 · 2013: 8 · 2012: 4
- FWCI
- 5.41
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Current Opinion in Neurobiology (publishedVersion)
- PubMed (publishedVersion)
- UCL Discovery (University College London) (submittedVersion)
- Funders
- National Institutes of Health
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Keywords
- spike timing, synaptic plasticity, calcium signaling, dendritic calcium influx, calcium transients, central synapses, gene expression, channel inactivation
- MeSH terms
- Action Potentials, Animals, Humans, Neuronal Plasticity, Synapses, Calcium Signaling
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