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Astrocyte calcium dysfunction causes early network hyperactivity in Alzheimer’s disease

Shah, Disha, Gsell, Willy, Wahis, Jérôme, Luckett, Emma S., Jamoulle, Tarik, Vermaercke, Ben, Preman, Pranav, Moechars, Daan, Hendrickx, Véronique, Jaspers, Tom, Craessaerts, Katleen, Horré, Katrien, Wolfs, Leen, Fiers, Mark, Holt, Matthew, Thal, Dietmar Rudolf, Callaerts-Vegh, Zsuzsanna, D’Hooge, Rudi, Vandenberghe, Rik, Himmelreich, Uwe, Bonin, Vincent, De Strooper, Bart·2022·Cell Reports
DOI 10.1016/j.celrep.2022.111280PMC PMC9433881

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  • The role of astrocytes in the pathogenesis of FTD and other neurodegenerative diseases is increasingly being recognized.

    “Although most of the research in FTD has been focused on neuronal dysfunction and neuronal cell death, the role of astrocytes in the pathogenesis of FTD and other neurodegenerative diseases is increasingly being recognized [39, 81–83].”

    From A role for astrocytic miR-129-5p in frontotemporal dementia (2025) · cites this paper as [83]

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  1. Adamczuk, 2013, Polymorphism of brain derived neurotrophic factor influences β amyloid load in cognitively intact apolipoprotein e ε4 carriers, Neuroimage. Clin., 2, 512, 10.1016/j.nicl.2013.04.001 · DOI
  2. Aisen, 2017, On the path to 2025: understanding the Alzheimer’s disease continuum, Alzheimer's Res. Ther., 9, 60, 10.1186/s13195-017-0283-5 · DOI · Paper page
  3. Allman, 2001, The anterior cingulate cortex. The evolution of an interface between emotion and cognition, Ann. N. Y. Acad. Sci., 935, 107, 10.1111/j.1749-6632.2001.tb03476.x · DOI
  4. Arranz, 2019, The role of astroglia in Alzheimer’s disease: pathophysiology and clinical implications, Lancet Neurol., 18, 406, 10.1016/S1474-4422(18)30490-3 · DOI · Paper page
  5. Bakker, 2012, Reduction of hippocampal hyperactivity improves cognition in amnestic mild cognitive impairment, Neuron, 74, 467, 10.1016/j.neuron.2012.03.023 · DOI
  6. Beason-Held, 2011, Dementia and the default mode, Curr. Alzheimer Res., 999, 1, 10.2174/1567211212225952050 · DOI
  7. Borges, 2019, Alzheimer’s disease and sleep disturbances: a review, Arq. Neuropsiquiatr., 77, 815, 10.1590/0004-282x20190149 · DOI
  8. Busche, 2015, Neuronal hyperactivity--A key defect in Alzheimer’s disease?, Bioessays, 37, 624, 10.1002/bies.201500004 · DOI · Paper page
  9. Busche, 2012, Critical role of soluble amyloid-β for early hippocampal hyperactivity in a mouse model of Alzheimer’s disease, Proc. Natl. Acad. Sci. USA, 109, 8740, 10.1073/pnas.1206171109 · DOI · Paper page
  10. Busche, 2008, Clusters of hyperactive neurons near amyloid plaques in a mouse model of Alzheimer’s disease, Science, 321, 1686, 10.1126/science.1162844 · DOI · Paper page
  11. Chang, 2014, Anterior cingulate epilepsy: mechanisms and modulation, Front. Integr. Neurosci., 7, 104, 10.3389/fnint.2013.00104 · DOI
  12. Cieri, 2018, Neuroaging through the lens of the resting state networks, BioMed Res. Int., 2018, 5080981, 10.1155/2018/5080981 · DOI
  13. Cramer, 2019, In vivo widefield calcium imaging of the mouse cortex for analysis of network connectivity in health and brain disease, Neuroimage, 199, 570, 10.1016/j.neuroimage.2019.06.014 · DOI
  14. De Meyer, 2020, Comparison of ELISA- and SIMOA-based quantification of plasma Aβ ratios for early detection of cerebral amyloidosis, Alzheimer's Res. Ther., 12, 162, 10.1186/s13195-020-00728-w · DOI
  15. Ding, 2013, α1-Adrenergic receptors mediate coordinated Ca2+ signaling of cortical astrocytes in awake, behaving mice, Cell Calcium, 54, 387, 10.1016/j.ceca.2013.09.001 · DOI
  16. Ewers, 2011, Neuroimaging markers for the prediction and early diagnosis of Alzheimer’s disease dementia, Trends Neurosci., 34, 430, 10.1016/j.tins.2011.05.005 · DOI
  17. Findley, 2019, Amyloid beta-related alterations to glutamate signaling dynamics during alzheimer’s disease progression, ASN Neuro, 11, 10.1177/1759091419855541 · DOI
  18. Goldey, 2014, Removable cranial windows for long-term imaging in awake mice, Nat. Protoc., 9, 2515, 10.1038/nprot.2014.165 · DOI
  19. Grandjean, 2014, Optimization of anesthesia protocol for resting-state fMRI in mice based on differential effects of anesthetics on functional connectivity patterns, Neuroimage, 102, 838, 10.1016/j.neuroimage.2014.08.043 · DOI · Paper page
  20. Habib, 2020, Disease-associated astrocytes in Alzheimer’s disease and aging, Nat. Neurosci., 23, 701, 10.1038/s41593-020-0624-8 · DOI · Paper page
  21. Hafkemeijer, 2012, Imaging the default mode network in aging and dementia, Biochim. Biophys. Acta, 1822, 431, 10.1016/j.bbadis.2011.07.008 · DOI
  22. Haydon, 2001, Glia: listening and talking to the synapse, Nat. Rev. Neurosci., 2, 185, 10.1038/35058528 · DOI
  23. Latif-Hernandez, 2017, Subtle behavioral changes and increased prefrontal-hippocampal network synchronicity in APP NL−G−F mice before prominent plaque deposition, Behav. Brain Res., 364, 431, 10.1016/j.bbr.2017.11.017 · DOI · Paper page
  24. Herrewegen, 2021, Side-by-side comparison of the effects of Gq- and Gi-DREADD-mediated astrocyte modulation on intracellular calcium dynamics and synaptic plasticity in the hippocampal CA1, Mol. Brain, 14, 144, 10.1186/s13041-021-00856-w · DOI
  25. Hoi, 2008, Inactivation of the anterior cingulate cortex blocks expression of remote, but not recent, conditioned taste aversion memory, Learn. Mem., 15
  26. Ingiosi, 2020, A role for astroglial calcium in mammalian sleep and sleep regulation, Curr. Biol., 30, 4373, 10.1016/j.cub.2020.08.052 · DOI
  27. Ju, 2014, Sleep and Alzheimer disease pathology-a bidirectional relationship, Nat. Rev. Neurol., 10, 115, 10.1038/nrneurol.2013.269 · DOI · Paper page
  28. Keszycki, 2019, The hyperactivity-impulsivity-irritiability-disinhibition-aggression-agitation domain in Alzheimer’s disease: current management and future directions, Front. Pharmacol., 10, 1109, 10.3389/fphar.2019.01109 · DOI
  29. Khakh, 2019, The emerging nature of astrocyte diversity, Annu. Rev. Neurosci., 10.1146/annurev-neuro-070918-050443 · DOI
  30. Khakh, 2015, Astrocyte calcium signaling: from observations to functions and the challenges therein, Cold Spring Harbor Perspect. Biol., 10.1101/cshperspect.a020404 · DOI
  31. Kim, 2016, Anterior cingulate cortex inactivation impairs rodent visual selective attention and prospective memory, Behav. Neurosci., 130, 75, 10.1037/bne0000117 · DOI
  32. Klunk, 2015, The Centiloid project: standardizing quantitative amyloid plaque estimation by PET, Alzheimer's Dementia, 11, 10.1016/j.jalz.2014.07.003 · DOI · Paper page
  33. Koike, 2016, Chemogenetic inactivation of dorsal anterior cingulate cortex neurons disrupts attentional behavior in mouse, Neuropsychopharmacology, 41, 1014, 10.1038/npp.2015.229 · DOI
  34. Koole, 2009, Whole-body biodistribution and radiation dosimetry of 18F-GE067: a radioligand for in vivo brain amyloid imaging, J. Nucl. Med., 50, 818, 10.2967/jnumed.108.060756 · DOI
  35. Kuchibhotla, 2009, Synchronous hyperactivity and intercellular calcium waves in astrocytes in Alzheimer mice, Science, 323, 1211, 10.1126/science.1169096 · DOI · Paper page
  36. Kucikova, 2021, Resting-state brain connectivity in healthy young and middle-aged adults at risk of progressive Alzheimer’s disease, Neurosci. Biobehav. Rev., 129, 142, 10.1016/j.neubiorev.2021.07.024 · DOI
  37. Lam, 2017, Silent hippocampal seizures and spikes identified by foramen ovale electrodes in Alzheimer’s disease, Nat. Med., 23, 678, 10.1038/nm.4330 · DOI
  38. Lauderback, 2001, The glial glutamate transporter, GLT-1, is oxidatively modified by 4-hydroxy-2-nonenal in the Alzheimer’s disease brain: the role of Aβ1-42, J. Neurochem., 78, 413, 10.1046/j.1471-4159.2001.00451.x · DOI · Paper page
  39. Lin, 2012, Glutamate transporter EAAT2: a new target for the treatment of neurodegenerative diseases, Future Med. Chem., 4, 1689, 10.4155/fmc.12.122 · DOI
  40. Lines, 2022, Astrocyte-neuronal network interplay is disrupted in Alzheimer’s disease mice, Glia, 70, 368, 10.1002/glia.24112 · DOI
  41. Lines, 2020, Astrocytes modulate sensory-evoked neuronal network activity, Nat. Commun., 11, 3689, 10.1038/s41467-020-17536-3 · DOI
  42. McKee, 2020, Circadian regulation of astrocyte function: implications for Alzheimer’s disease, Cell. Mol. Life Sci., 77, 1049, 10.1007/s00018-019-03314-y · DOI
  43. Michelson, 2019, Comparison between transgenic and AAV-PHP.eB-mediated expression of GCaMP6s using in vivo wide-field functional imaging of brain activity, Neurophotonics, 6, 025014, 10.1117/1.NPh.6.2.025014 · DOI
  44. Osborn, 2016, Astrogliosis: an integral player in the pathogenesis of Alzheimer’s disease, Prog. Neurobiol., 144, 121, 10.1016/j.pneurobio.2016.01.001 · DOI · Paper page
  45. Palop, 2010, Amyloid-Β-induced neuronal dysfunction in Alzheimer’s disease: from synapses toward neural networks, Nat. Neurosci., 13, 812, 10.1038/nn.2583 · DOI · Paper page
  46. Pan, 2020, Transcriptomic profiling of microglia and astrocytes throughout aging, J. Neuroinflammation, 17, 97, 10.1186/s12974-020-01774-9 · DOI · Paper page
  47. Pérez-Alvarez, 2013, Astrocyte-neuron interaction at tripartite synapses, Curr. Drug Targets, 14, 1220, 10.2174/13894501113149990203 · DOI
  48. Poskanzer, 2018, Functional roles of astrocyte calcium elevations: from synapses to behavior, Front. Cell. Neurosci.
  49. Preman, 2021, Astrocytes in alzheimer’s disease: pathological significance and molecular pathways, Cells, 10, 10.3390/cells10030540 · DOI · Paper page
  50. Ran, 2020, Reproducibility of graph measures at the subject level using resting-state fMRI, Brain Behav., 10, 2336, 10.1002/brb3.1705 · DOI
  51. Reichenbach, 2018, P2Y1 receptor blockade normalizes network dysfunction and cognition in an Alzheimer’s disease model, J. Exp. Med., 215, 1649, 10.1084/jem.20171487 · DOI · Paper page
  52. Reinartz, 2021, Changes in the language system as amyloid-β accumulates, Brain, 10.1093/brain/awab335 · DOI
  53. Roth, 2016, DREADDs for neuroscientists, Neuron, 89, 683, 10.1016/j.neuron.2016.01.040 · DOI · Paper page
  54. Schaeverbeke, 2021, Baseline cognition is the best predictor of 4-year cognitive change in cognitively intact older adults, Alzheimer's Res. Ther., 13, 75, 10.1186/s13195-021-00798-4 · DOI
  55. Schallier, 2011, Region-and age-specific changes in glutamate transport in the AβPP23 mouse model for alzheimer’s disease, J. Alzheimers Dis., 24, 287, 10.3233/JAD-2011-101005 · DOI · Paper page
  56. Shah, 2018, Spatial reversal learning defect coincides with hypersynchronous telencephalic BOLD functional connectivity in APPNL-F/NL-F knock-in mice, Sci. Rep.
  57. Shah, 2016, Resting-state functional MRI and [18F]-FDG PET demonstrate differences in neuronal activity between commonly used mouse strains, Neuroimage, 125, 571, 10.1016/j.neuroimage.2015.10.073 · DOI
  58. Shah, 2016, Early pathologic amyloid induces hypersynchrony of BOLD resting-state networks in transgenic mice and provides an early therapeutic window before amyloid plaque deposition, Alzheimers Dement., 12, 964, 10.1016/j.jalz.2016.03.010 · DOI
  59. Sharp, 1999, Differential cellular expression of isoforms of inositol 1, 4, 5- triphosphate receptors in neurons and glia in brain, J. Comp. Neurol., 406, 207, 10.1002/(SICI)1096-9861(19990405)406:2<207::AID-CNE6>3.0.CO;2-7 · DOI
  60. Sheth, 2012, Human dorsal anterior cingulate cortex neurons mediate ongoing behavioural adaptation, Nature, 488, 218, 10.1038/nature11239 · DOI · Paper page
  61. Shigetomi, 2019, Aberrant calcium signals in reactive astrocytes: a key process in neurological disorders, Int. J. Mol. Sci., 20, E996, 10.3390/ijms20040996 · DOI
  62. Shimada, 2018, Pentylenetetrazole-induced kindling mouse model, J. Vis. Exp., 2018
  63. Stevens, 2011, Anterior cingulate cortex: unique role in cognition and emotion, J. Neuropsychiatry Clin. Neurosci., 23, 121, 10.1176/jnp.23.2.jnp121 · DOI · Paper page
  64. Taylor, 1999, Expression of inositol trisphosphate receptors, Cell Calcium, 26, 237, 10.1054/ceca.1999.0090 · DOI
  65. Tzourio-Mazoyer, 2002, Automated anatomical labeling of activations in SPM using a macroscopic anatomical parcellation of the MNI MRI single-subject brain, Neuroimage, 15, 273, 10.1006/nimg.2001.0978 · DOI · Paper page
  66. Van Erum, 2019, PTZ-induced seizures in mice require a revised Racine scale, Epilepsy Behav., 95, 51, 10.1016/j.yebeh.2019.02.029 · DOI
  67. Vandenberghe, 2010, 18F-flutemetamol amyloid imaging in Alzheimer disease and mild cognitive impairment a phase 2 trial, Ann. Neurol., 68, 319, 10.1002/ana.22068 · DOI
  68. Vanderheyden, 2018, Alzheimer’s disease and sleep–wake disturbances: amyloid, astrocytes, and animal models, J. Neurosci., 38, 2901, 10.1523/JNEUROSCI.1135-17.2017 · DOI
  69. Vogt, 2019, Cingulate cortex in the three limbic subsystems, Handb. Clin. Neurol.
  70. Vossel, 2013, Seizures and epileptiform activity in the early stages of Alzheimer disease, JAMA Neurol., 70, 1158, 10.1001/jamaneurol.2013.136 · DOI
  71. Wang, 2006, Astrocytic Ca2+ signaling evoked by sensory stimulation in vivo, Nat. Neurosci., 9, 816, 10.1038/nn1703 · DOI · Paper page
  72. Weible, 2013, Remembering to attend: the anterior cingulate cortex and remote memory, Behav. Brain Res., 245, 63, 10.1016/j.bbr.2013.02.010 · DOI
  73. Whitesell, 2021, Regional, layer, and cell-type-specific connectivity of the mouse default mode network, Neuron, 109, 545, 10.1016/j.neuron.2020.11.011 · DOI
  74. Xie, 2010, Specific disruption of astrocytic Ca2+ signaling pathway in vivo by adeno-associated viral transduction, Neuroscience, 170, 992, 10.1016/j.neuroscience.2010.08.034 · DOI
  75. Zheng, 2021, Different posterior hippocampus and default mode network modulation in young APOE ε4 carriers: a functional connectome-informed phenotype longitudinal study, Mol. Neurobiol., 58, 2757, 10.1007/s12035-021-02292-2 · DOI

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Metadata

Authors
Shah, D., Gsell, W., Wahis, J., Luckett, E. S., Jamoulle, T., Vermaercke, B., Preman, P., Moechars, D., Hendrickx, V., Jaspers, T., Craessaerts, K., Horré, K., Wolfs, L., Fiers, M., Holt, M., Thal, D. R., Callaerts-Vegh, Z., D’Hooge, R., Vandenberghe, R., Himmelreich, U., Bonin, V., & De Strooper, B.
ORCID
De Strooper, Bart
Venue
Cell Reports
Publisher
Elsevier BV
Published
2022-08
Volume
40
Issue
8
Pages
111280
ISSN
2211-1247
DOI
10.1016/j.celrep.2022.111280
PMC
PMC9433881
Cited by
164
References
13
Language
en
Licence
Funders
  • UK Dementia Research Institute
  • Alzheimer's Association (2019-AARF-640959)
  • European Molecular Biology Organization (12V7519N, 12V7522N, 7806)
  • KU Leuven
  • Vlaams Instituut voor Biotechnologie
  • Vlaamse regering
  • Queen Elisabeth Medical Foundation for Neurosciences
  • MRC
  • European Research Council (CELLPHASE_AD834682)
  • Fonds Wetenschappelijk Onderzoek (12R1122N, G065721N, G0F8516N)
  • European Resuscitation Council

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