Diabetes and Cardiovascular Disease Prevention in Older Adults

Cigolle, Christine T.; Blaum, Caroline S.; Halter, Jeffrey B.

doi:10.1016/j.cger.2009.09.001

Cited by 50Diabetes, Cardiovascular Risks, and LipoproteinsDiabetes Treatment and ManagementHealth Promotion and Cardiovascular Prevention

Diabetes and Cardiovascular Disease Prevention in Older Adults

Cigolle, Christine T., Blaum, Caroline S., Halter, Jeffrey B.·2009·Clinics in Geriatric Medicine

DOI 10.1016/j.cger.2009.09.001

Open this paper in CoChat — free account

Abstract

Cardiovascular disease is the major cause of death as well as a leading cause of disability and impaired quality of life in older adults with diabetes. Therefore, preventing cardiovascular events in this population is an important goal of care. Available evidence supports the use of lipid-lowering agents and treatment of hypertension as effective measures to reduce cardiovascular risk in older adults with diabetes. Glucose control, smoking cessation, weight control, regular physical activity, and a prudent diet are also recommended, although data supporting the efficacy of these interventions are limited. While reducing cardiovascular morbidity and mortality remains a primary objective of preventive cardiology in older adults with diabetes, the impact of these interventions on functional well-being, cognition, and other geriatric syndromes requires further study.

Integrity signals

Registry

Crossref · 10.1016/j.cger.2009.09.001

Cites

131 of 131 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Type 2 diabetes is a strong risk factor for cardiovascular disease, and both CVD mortality and the effect of diabetes on CVD risk increase with older age and frailty.
“Type 2 diabetes is a strong risk factor for CVD, and both CVD mortality and the effect of diabetes on the risk of CVD increase sharply with older age and frailty status”
From Inflammageing: chronic inflammation in ageing, cardiovascular disease, and frailty (2018) · cites this paper as [174]
Statin trials for secondary prevention of cardiovascular disease in adults with diabetes have demonstrated comparable relative reductions in recurrent cardiovascular events and mortality by age.
“Statin trials for secondary prevention of cardiovascular disease in adults with diabetes have also demonstrated comparable relative reductions in recurrent cardiovascular events and mortality by age42.”
From Diabetes in Older Adults: A Consensus Report (2012) · cites this paper as [42]

Reduction in the incidence of type 2 diabetes with lifestyle intervention or metformin
(2002) · New England Journal of Medicine · doi:10.1056/nejmoa012512 · Cited by 19,011 · see citing works
Prevention of Type 2 Diabetes Mellitus by Changes in Lifestyle among Subjects with Impaired Glucose Tolerance
Tuomilehto, J., Lindström, J., Eriksson, J. G., Valle, T. T., Hämäläinen, H., Ilanne-Parikka, P., Keinänen-Kiukaanniemi, S., Laakso, M., Louheranta, A., Rastas, M., et al. (2001) · New England Journal of Medicine · doi:10.1056/nejm200105033441801 · Cited by 10,873 · see citing works
Effects of an Angiotensin-Converting–Enzyme Inhibitor, Ramipril, on Cardiovascular Events in High-Risk Patients
(2000) · New England Journal of Medicine · doi:10.1056/nejm200001203420301 · Cited by 8,663 · see citing works
Randomised trial of cholesterol lowering in 4444 patients with coronary heart disease: the Scandinavian Simvastatin Survival Study (4S)
OLSSON, A. G., McMurray, J. J. V., Thorgeirsson, G., Spaulding, C. M., Slattery, J., Pyörälà, K., Færgeman, O., Wright, R. S., Berg, K. M., Wilhelmsen, L., et al. (1994) · The Lancet · Cited by 8,467 · see citing works
Effects of Intensive Glucose Lowering in Type 2 Diabetes
(2008) · New England Journal of Medicine · doi:10.1056/nejmoa0802743 · Cited by 7,888 · see citing works
10-year follow-up of intensive glucose control in type 2 diabetes
Holman, R. R., Paul, S. K., Bethel, M. A., Matthews, D. R., & Neil, H. A. W. (2008) · New England Journal of Medicine · doi:10.1056/nejmoa0806470 · Cited by 7,751 · see citing works
Effects of losartan on renal and cardiovascular outcomes in patients with type 2 diabetes and nephropathy
Brenner, B. M., Cooper, M. E., de Zeeuw, D., Keane, W. F., Mitch, W. E., Parving, H.-H., Remuzzi, G., Snapinn, S. M., Zhang, Z., & Shahinfar, S. (2001) · New England Journal of Medicine · doi:10.1056/nejmoa011161 · Cited by 7,493 · see citing works
The Effect of Pravastatin on Coronary Events after Myocardial Infarction in Patients with Average Cholesterol Levels
Sacks, F. M., Pfeffer, M. A., Moye, L. A., Rouleau, J. L., Rutherford, J. D., Cole, T. G., Brown, L., Warnica, J. W., Arnold, J. M. O., Wun, C.-C., et al. (1996) · New England Journal of Medicine · doi:10.1056/nejm199610033351401 · Cited by 7,439 · see citing works
Intensive blood glucose control and vascular outcomes in patients with type 2 diabetes
(2008) · New England Journal of Medicine · doi:10.1056/nejmoa0802987 · Cited by 7,397 · see citing works
MRC/BHF Heart Protection Study of cholesterol lowering with simvastatin in 20 536 high-risk individuals: a randomised placebocontrolled trial
(2002) · The Lancet · doi:10.1016/s0140-6736(02)09327-3 · Cited by 6,992 · see citing works
Effects of intensive blood-pressure lowering and low-dose aspirin in patients with hypertension: principal results of the hypertension optimal treatment (HOT) randomised trial
Hansson, L., Zanchetti, A., Carruthers, S. G., Dahlöf, B., Elmfeldt, D., Julius, S., Ménard, J., Rahn, K. H., Wedel, H., & Westerling, S. (1998) · The Lancet · doi:10.1016/s0140-6736(98)04311-6 · Cited by 5,728 · see citing works
Major outcomes in high-risk hypertensive patients randomized to angiotensin-converting enzyme inhibitor or calcium channel blocker vs diuretic: the Antihypertensive and Lipid-Lowering Treatment to Prevent Heart Attack Trial (ALLHAT)
The ALLHAT Officers and Coordinators for the ALLHAT Collaborative Research Group (2002) · JAMA: The Journal of the American Medical Association · doi:10.1001/jama.288.23.2981 · Cited by 5,664 · see citing works
Prevention of Cardiovascular Events and Death with Pravastatin in Patients with Coronary Heart Disease and a Broad Range of Initial Cholesterol Levels
(1998) · New England Journal of Medicine · doi:10.1056/nejm199811053391902 · Cited by 5,261 · see citing works
Primary Prevention of Acute Coronary Events With Lovastatin in Men and Women With Average Cholesterol Levels: Results of AFCAPS/TexCAPS
Downs, J. R., Clearfield, M., Weis, S., Whitney, E., Shapiro, D. R., Beere, P. A., Langendorfer, A., Stein, E. A., Kruyer, W., Gotto, Jr., et al. (1998) · JAMA · doi:10.1001/jama.279.20.1615 · Cited by 5,236 · see citing works
Intensive versus Moderate Lipid Lowering with Statins after Acute Coronary Syndromes
Cannon, C. P., Braunwald, E., McCabe, C. H., Rader, D. J., Rouleau, J. L., Belder, R., Joyal, S. V., Hill, K. A., Pfeffer, M. A., & Skene, A. M. (2004) · New England Journal of Medicine · doi:10.1056/nejmoa040583 · Cited by 4,938 · see citing works
Glucose control and vascular complications in veterans with type 2 diabetes
Duckworth, W., Abraira, C., Moritz, T., Reda, D., Emanuele, N., Reaven, P. D., Zieve, F. J., Marks, J., Davis, S. N., Hayward, R., et al. (2009) · New England Journal of Medicine · doi:10.1056/nejmoa0808431 · Cited by 4,762 · see citing works
Multifactorial intervention and cardiovascular disease in patients with type 2 diabetes
Gæde, P., Vedel, P., Larsen, N., Jensen, G. V. H., Parving, H.-H., & Pedersen, O. (2003) · New England Journal of Medicine · doi:10.1056/nejmoa021778 · Cited by 4,378 · see citing works
Effects of diet and exercise in preventing NIDDM in people with impaired glucose tolerance: the Da Qing IGT and Diabetes Study
Pan, X.-R., Li, G.-W., Hu, Y.-H., Wang, J.-X., Yang, W.-Y., An, Z.-X., Hu, Z.-X., Juan-Lin, Xiao, J.-Z., Cao, H.-B., et al. (1997) · Diabetes Care · doi:10.2337/diacare.20.4.537 · Cited by 4,320 · see citing works
Collaborative overview of randomised trials of antiplatelet therapy Prevention of death, myocardial infarction, and stroke by prolonged antiplatelet therapy in various categories of patients
Altman, R., Carreras, L., Díaz, R. S., Figueroa, E. B., Paolasso, E., Parodi, J. C., Cade, J. F., Donnan, G. A., Eadie, M. J., Gavaghan, T. P., et al. (1994) · BMJ · doi:10.1136/bmj.308.6921.81 · Cited by 4,198 · see citing works
Secondary prevention of macrovascular events in patients with type 2 diabetes in the PROactive Study (PROspective pioglitAzone Clinical Trial In macroVascular Events): a randomised controlled trial
Dormandy, J. A., Charbonnel, B., Eckland, D. J., Erdmann, E., Massi-Benedetti, M., Moules, I. K., Skene, A. M., Tan, M. H., Lefèbvre, P. J., Murray, G. D., et al. (2005) · The Lancet · doi:10.1016/s0140-6736(05)67528-9 · Cited by 4,129 · see citing works
Prevention of coronary and stroke events with atorvastatin in hypertensive patients who have average or lower-than-average cholesterol concentrations, in the Anglo-Scandinavian Cardiac Outcomes Trial—Lipid Lowering Arm (ASCOT-LLA): a multicentre randomised controlled trial
Sever, P., Dahlöf, B., Poulter, N. R., Wedel, H., Beevers, G., Caulfield, M. J., Collins, R., Kjeldsen, S. E., Kristinsson, A., McInnes, G. T., et al. (2003) · The Lancet · doi:10.1016/s0140-6736(03)12948-0 · Cited by 3,757 · see citing works
Primary prevention of cardiovascular disease with atorvastatin in type 2 diabetes in the Collaborative Atorvastatin Diabetes Study (CARDS): multicentre randomised placebo-controlled trial
Colhoun, H. M., Betteridge, D. J., Durrington, P. N., Hitman, G. A., W Neil, H. A., Livingstone, S. J., Thomason, M. J., Mackness, M. I., Charlton-Menys, V., & Fuller, J. H. (2004) · The Lancet · doi:10.1016/s0140-6736(04)16895-5 · Cited by 3,755 · see citing works
Intensive Lipid Lowering with Atorvastatin in Patients with Stable Coronary Disease
LaRosa, J. C., Grundy, S. M., Waters, D. D., Shear, C., Barter, P., Fruchart, J.-C., Gotto, A. M., Greten, H., Kastelein, J. J. P., Shepherd, J., et al. (2005) · New England Journal of Medicine · doi:10.1056/nejmoa050461 · Cited by 3,489 · see citing works
Effect of a multifactorial intervention on mortality in type 2 diabetes
Gæde, P., Lund-Andersen, H., Parving, H.-H., & Pedersen, O. (2008) · New England Journal of Medicine · doi:10.1056/nejmoa0706245 · Cited by 3,489 · cited 1× · see citing works
“Follow-up at 10 years found an absolute reduction of 13% in cardiovascular mortality.(21) Odds ratios from proportional hazards models were”
Background
Gemfibrozil for the Secondary Prevention of Coronary Heart Disease in Men with Low Levels of High-Density Lipoprotein Cholesterol
Rubins, H. B., Robins, S. J., Collins, D., Fye, C. L., Anderson, J. W., Elam, M. B., Faas, F. H., Linares, E., Schaefer, E. J., Schectman, G., et al. (1999) · New England Journal of Medicine · doi:10.1056/nejm199908053410604 · Cited by 3,439 · see citing works
Pravastatin in elderly individuals at risk of vascular disease (PROSPER): a randomised controlled trial
Shepherd, J., Blauw, G. J., Murphy, M. B., Bollen, E. L., Buckley, B. M., Cobbe, S. M., Ford, I., Gaw, A., Hyland, M., Jukema, J. W., et al. (2002) · The Lancet · doi:10.1016/s0140-6736(02)11600-x · Cited by 3,378 · see citing works
COLLABORATIVE OVERVIEW OF RANDOMIZED TRIALS OF ANTIPLATELET THERAPY .1. PREVENTION OF DEATH, MYOCARDIAL-INFARCTION, AND STROKE BY PROLONGED ANTIPLATELET THERAPY IN VARIOUS CATEGORIES OF PATIENTS
Altman, R., Carreras, L., Díaz, R. S., Figueroa, E. B., Paolasso, E., Parodi, J. C., Cade, J. F., Donnan, G. A., Eadie, M. J., Gavaghan, T. P., et al. (1994) · Cited by 3,322 · see citing works
Effects of long-term fenofibrate therapy on cardiovascular events in 9795 people with type 2 diabetes mellitus (the FIELD study): randomised controlled trial
(2005) · The Lancet · doi:10.1016/s0140-6736(05)67667-2 · Cited by 3,284 · see citing works
Effects of ramipril on cardiovascular and microvascular outcomes in people with diabetes mellitus: results of the HOPE study and MICRO-HOPE substudy
(2000) · The Lancet · doi:10.1016/s0140-6736(99)12323-7 · Cited by 3,179 · see citing works
Randomised trial of cholesterol lowering in 4444 patients with coronary heart disease: the Scandinavian Simvastatin Survival Study (4S)
Pedersen, T. R. (2004) · Atherosclerosis Supplements · doi:10.1016/j.atherosclerosissup.2004.08.027 · Cited by 3,098 · see citing works
Randomised double-blind comparison of placebo and active treatment for older patients with isolated systolic hypertension
Staessen, J. A., Fagard, R., Thijs, L., Celis, H., Arabidze, G. G., Birkenhäger, W. H., Bulpitt, C. J., de Leeuw, P. W., Dollery, C. T., Fletcher, A. E., et al. (1997) · The Lancet · doi:10.1016/s0140-6736(97)05381-6 · Cited by 2,989 · see citing works
Prevention of Stroke by Antihypertensive Drug Treatment in Older Persons With Isolated Systolic Hypertension: Final Results of the Systolic Hypertension in the Elderly Program (SHEP)
(1991) · JAMA · doi:10.1001/jama.1991.03460240051027 · Cited by 2,953 · see citing works
Prevention of cardiovascular events with an antihypertensive regimen of amlodipine adding perindopril as required versus atenolol adding bendroflumethiazide as required, in the Anglo-Scandinavian Cardiac Outcomes Trial-Blood Pressure Lowering Arm (ASCOT-BPLA): a multicentre randomised controlled trial
Dahlöf, B., Sever, P. S., Poulter, N. R., Wedel, H., Beevers, D. G., Caulfield, M., Collins, R., Kjeldsen, S. E., Kristinsson, A., McInnes, G. T., et al. (2005) · The Lancet · doi:10.1016/s0140-6736(05)67185-1 · Cited by 2,909 · see citing works
MRC/BHF Heart Protection Study of cholesterol-lowering with simvastatin in 5963 people with diabetes: a randomised placebo-controlled trial
(2003) · The Lancet · doi:10.1016/s0140-6736(03)13636-7 · Cited by 2,876 · see citing works
Clinical Practice Guidelines and Quality of Care for Older Patients With Multiple Comorbid Diseases: Implications for Pay for Performance
Boyd, C. M., Darer, J., Boult, C., Fried, L. P., Boult, L., & Wu, A. W. (2005) · JAMA · doi:10.1001/jama.294.6.716 · Cited by 2,581 · see citing works
Acarbose for prevention of type 2 diabetes mellitus: the STOP-NIDDM randomised trial
Chiasson, J.-L., Josse, R. G., Gomis, R., Hanefeld, M., Karasik, A., & Laakso, M. (2002) · The Lancet · doi:10.1016/s0140-6736(02)08905-5 · Cited by 2,543 · see citing works
Standards of Medical Care in Diabetes—2009
American Diabetes Association (2009) · Diabetes Care · doi:10.2337/dc09-s013 · Cited by 2,167 · see citing works
Untitled work
(2000) · PubMed · Cited by 2,095 · see citing works
Effects of a fixed combination of perindopril and indapamide on macrovascular and microvascular outcomes in patients with type 2 diabetes mellitus (the ADVANCE trial): a randomised controlled trial
Patel, A. (2007) · The Lancet · doi:10.1016/s0140-6736(07)61303-8 · Cited by 2,054 · see citing works
XENical in the Prevention of Diabetes in Obese Subjects (XENDOS) Study
Torgerson, J. S., Hauptman, J., Boldrin, M. N., & Sjöström, L. (2004) · Diabetes Care · doi:10.2337/diacare.27.1.155 · Cited by 1,915 · see citing works
The Indian Diabetes Prevention Programme shows that lifestyle modification and metformin prevent type 2 diabetes in Asian Indian subjects with impaired glucose tolerance (IDPP-1)
Ramachandran, A., Snehalatha, C., Mary, S., Mukesh, B., Bhaskar, A. D., Vijay, V., & Indian Diabetes Prevention Programme (IDPP) (2006) · Diabetologia · doi:10.1007/s00125-005-0097-z · Cited by 1,881 · see citing works
Effect of rosiglitazone on the frequency of diabetes in patients with impaired glucose tolerance or impaired fasting glucose: a randomised controlled trial
(2006) · The Lancet · doi:10.1016/s0140-6736(06)69420-8 · Cited by 1,706 · see citing works
Cholesterol Lowering With Simvastatin Improves Prognosis of Diabetic Patients With Coronary Heart Disease: A subgroup analysis of the Scandinavian Simvastatin Survival Study (4S)
Pyörälä, K., Pedersen, T. R., Kjekshus, J., Faergeman, O., Olsson, A. G., Thorgeirsson, G., & The Scandinavian Simvastatin Survival Study (4S) Group (1997) · Diabetes Care · doi:10.2337/diacare.20.4.614 · Cited by 1,623 · see citing works
Reduction in Weight and Cardiovascular Disease Risk Factors in Individuals With Type 2 Diabetes
The Look AHEAD Research Group (2007) · Diabetes Care · doi:10.2337/dc07-0048 · Cited by 1,522 · see citing works
Impaired Fasting Glucose and Impaired Glucose Tolerance
Nathan, D. M., Davidson, M. B., DeFronzo, R. A., Heine, R. J., Henry, R. R., Pratley, R., & Zinman, B. (2007) · Diabetes Care · doi:10.2337/dc07-9920 · Cited by 1,396 · see citing works
The Effect of Nisoldipine as Compared with Enalapril on Cardiovascular Outcomes in Patients with Non-Insulin-Dependent Diabetes and Hypertension
Estacio, R. O., Jeffers, B. W., Hiatt, W. R., Biggerstaff, S. L., Gifford, N., & Schrier, R. W. (1998) · New England Journal of Medicine · doi:10.1056/nejm199803053381003 · Cited by 1,158 · see citing works
Preventing Microalbuminuria in Type 2 Diabetes
Ruggenenti, P. L., Fassi, A., Parvanova, A. I., Bruno, S., Iliev, I. P., Brusegan, V., Rubis, N., Gherardi, G., Arnoldi, F., Ganeva, M. G., et al. (2004) · New England Journal of Medicine · doi:10.1056/nejmoa042167 · Cited by 1,012 · see citing works
Low-dose aspirin and vitamin E in people at cardiovascular risk: a randomised trial in general Practice
Roncaglioni, M. C. (2001) · The Lancet · doi:10.1016/s0140-6736(00)03539-x · Cited by 997 · see citing works
Cardiovascular Events and Their Reduction With Pravastatin in Diabetic and Glucose-Intolerant Myocardial Infarction Survivors With Average Cholesterol Levels: Subgroup Analyses in the Cholesterol And Recurrent Events (CARE) Trial
Goldberg, R. B., Mellies, M. J., Sacks, F. M., Moyé, L. A., Howard, B. V., Howard, W. J., Davis, B. R., Cole, T. G., Pfeffer, M. A., & Braunwald, E. (1998) · Circulation · doi:10.1161/01.cir.98.23.2513 · Cited by 986 · see citing works
Intensified multifactorial intervention in patients with type 2 diabetes mellitus and microalbuminuria: the Steno type 2 randomised study
Gæde, P., Vedel, P., Parving, H.-H., & Pedersen, O. (1999) · The Lancet · doi:10.1016/s0140-6736(98)07368-1 · Cited by 981 · see citing works
The effect of aggressive lowering of low-density lipoprotein cholesterol levels and low-dose anticoagulation on obstructive changes in saphenous-vein coronary-artery bypass grafts.
Post Coronary Artery Bypass Graft Trial Investigators (1997) · New England Journal of Medicine · doi:10.1056/nejm199701163360301 · Cited by 953 · see citing works
Effects of Calcium-Channel Blockade in Older Patients with Diabetes and Systolic Hypertension
Tuomilehto, J. O., Rastenytė, D., Birkenhäger, W. H., Thijs, L., Antikaínen, R., Bulpitt, C. J., FLETCHER, A. E., Forette, F., Goldhaber, A., Palatini, P., et al. (1999) · New England Journal of Medicine · doi:10.1056/nejm199903043400902 · Cited by 932 · see citing works
Effect of fenofibrate on progression of coronary-artery disease in type 2 diabetes: the Diabetes Atherosclerosis Intervention Study, a randomised study
Steiner, G. (2001) · The Lancet · doi:10.1016/s0140-6736(00)04209-4 · Cited by 845 · see citing works
Influence of Pravastatin and Plasma Lipids on Clinical Events in the West of Scotland Coronary Prevention Study (WOSCOPS)
(1998) · Circulation · doi:10.1161/01.cir.97.15.1440 · Cited by 791 · see citing works
Low-Dose Aspirin for Primary Prevention of Atherosclerotic Events in Patients With Type 2 Diabetes<subtitle>A Randomized Controlled Trial</subtitle>
Ogawa, H. (2008) · JAMA · doi:10.1001/jama.2008.623 · Cited by 776 · see citing works
Look AHEAD (Action for Health in Diabetes): design and methods for a clinical trial of weight loss for the prevention of cardiovascular disease in type 2 diabetes
The Look AHEAD Research Group (2003) · Controlled Clinical Trials · doi:10.1016/s0197-2456(03)00064-3 · Cited by 767 · see citing works
Long-term follow-up after tight control of blood pressure in type 2 diabetes
Holman, R. R., Paul, S. K., Bethel, M. A., Neil, H. A. W., & Matthews, D. R. (2008) · New England Journal of Medicine · doi:10.1056/nejmoa0806359 · Cited by 762 · see citing works
Effect of fenofibrate on progression of coronary-artery disease in type 2 diabetes: the Diabetes Atherosclerosis Intervention Study, a randomised study
Steiner, G. A. (2001) · Cited by 732 · see citing works
Fluvastatin for Prevention of Cardiac Events Following Successful First Percutaneous Coronary Intervention A Randomized Controlled Trial
Serruys, P. W. J. C. (2002) · JAMA · doi:10.1001/jama.287.24.3215 · Cited by 716 · see citing works
[The Da Qing IGT and Diabetes study].
Ayame, H. (2005) · PubMed · Cited by 658 · see citing works
Prevention of type 2 diabetes by lifestyle intervention: a Japanese trial in IGT males
Kosaka, K., Noda, M., & Kuzuya, T. (2005) · Diabetes Research and Clinical Practice · doi:10.1016/j.diabres.2004.06.010 · Cited by 656 · see citing works
Guidelines for improving the care of the older person with diabetes mellitus
California Healthcare Foundation/American Geriatrics Society, C. (2003) · Journal of the American Geriatrics Society · doi:10.1046/j.1532-5415.51.5s.1.x · Cited by 651 · see citing works
Rationale and Design for the Antihypertensive and Lipid Lowering Treatment to Prevent Heart Attack Trial (ALLHAT)
Davis, B. R. (1996) · American Journal of Hypertension · doi:10.1016/0895-7061(96)00037-4 · Cited by 595 · see citing works
Diabetes, Plasma Insulin, and Cardiovascular Disease: Subgroup Analysis From the Department of Veterans Affairs High-Density Lipoprotein Intervention Trial (VA-HIT)
Rubins, H. B. (2002) · Archives of Internal Medicine · doi:10.1001/archinte.162.22.2597 · Cited by 586 · see citing works
Efficacy and Safety of Atorvastatin in the Prevention of Cardiovascular End Points in Subjects With Type 2 Diabetes
Knopp, R. H., d’Emden, M., Smilde, J. G., Pocock, S. J., & on behalf of the ASPEN Study Group (2006) · Diabetes Care · doi:10.2337/dc05-2415 · Cited by 550 · see citing works
Effect of Lowering LDL Cholesterol Substantially Below Currently Recommended Levels in Patients With Coronary Heart Disease and Diabetes
Shepherd, J., Barter, P., Carmena, R., Deedwania, P., Fruchart, J.-C., Haffner, S., Hsia, J., Breazna, A., LaRosa, J., Grundy, S., et al. (2006) · Diabetes Care · doi:10.2337/dc05-2465 · Cited by 525 · see citing works
Intensive Glycemic Control and the Prevention of Cardiovascular Events: Implications of the ACCORD, ADVANCE, and VA Diabetes Trials
Skyler, J. S., Bergenstal, R. M., Bonow, R. O., Buse, J. B., DEEDWANIA, P. C., Gale, E. A., Howard, B. V., Kirkman, M. S., Kosiborod, M., Reaven, P. D., et al. (2009) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2008.10.008 · Cited by 469 · see citing works
Air Force/Texas Coronary Atherosclerosis Prevention Study
佐々木, 淳. (2008) · Japanese journal of clinical medicine · Cited by 411 · see citing works
Reduction in Cardiovascular Events With Atorvastatin in 2,532 Patients With Type 2 Diabetes
Sever, P. S., Poulter, N. R., Dahlöf, B., Wedel, H., Collins, R., Beevers, G., Caulfield, M., Kjeldsen, S. E., Kristinsson, A., McInnes, G. T., et al. (2005) · Diabetes Care · doi:10.2337/diacare.28.5.1151 · Cited by 390 · see citing works
Reduction of low-density lipoprotein cholesterol in patients with coronary heart disease and metabolic syndrome: analysis of the Treating to New Targets study
Deedwania, P., Barter, P., Carmena, R., Fruchart, J.-C., Grundy, S. M., Haffner, S., Kastelein, J. J., LaRosa, J. C., Schachner, H., Shepherd, J., et al. (2006) · The Lancet · doi:10.1016/s0140-6736(06)69292-1 · Cited by 387 · see citing works
Primary Prevention of Cardiovascular Events With Low-Dose Aspirin and Vitamin E in Type 2 Diabetic Patients
Sacco, M., Pellegrini, F., Roncaglioni, M. C., Avanzini, F., Tognoni, G., Nicolucci, A., & on behalf of the PPP Collaborative Group (2003) · Diabetes Care · doi:10.2337/diacare.26.12.3264 · Cited by 381 · see citing works
The Effect of Pioglitazone on Recurrent Myocardial Infarction in 2,445 Patients With Type 2 Diabetes and Previous Myocardial Infarction
Erdmann, E., Dormandy, J., Charbonnel, B. H., Massi‐Benedetti, M., Moules, I. K., & Skene, A. M. (2007) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2006.12.048 · Cited by 377 · see citing works
Intensive Glycemic Control in the ACCORD and ADVANCE Trials
Dluhy, R. G., & McMahon, G. T. (2008) · New England Journal of Medicine · doi:10.1056/nejme0804182 · Cited by 375 · see citing works
Secondary Prevention of Cardiovascular Events With Long-Term Pravastatin in Patients With Diabetes or Impaired Fasting Glucose
Keech, A., Colquhoun, D., Best, J., Kirby, A., Simes, R. J., Hunt, D., Hague, W., Beller, E., Arulchelvam, M., Baker, J., et al. (2003) · Diabetes Care · doi:10.2337/diacare.26.10.2713 · Cited by 313 · see citing works
Insulin Resistance and Cardiovascular Events With Low HDL Cholesterol
Robins, S. J., Bloomfield, H. E., Faas, F. H., Schaefer, E. J., Elam, M. B., Anderson, J. W., Collins, D. E., & on behalf of the VA-HIT Study Group (2003) · Diabetes Care · doi:10.2337/diacare.26.5.1513 · Cited by 308 · see citing works
Effects of low dose ramipril on cardiovascular and renal outcomes in patients with type 2 diabetes and raised excretion of urinary albumin: randomised, double blind, placebo controlled trial (the DIABHYCAR study)
Marre, M., Lièvre, M. M., Châtellier, G., Mann, J. F. E., Passa, P., & Ménard, J. (2004) · BMJ · doi:10.1136/bmj.37970.629537.0d · Cited by 291 · see citing works
Clinical Outcomes in Antihypertensive Treatment of Type 2 Diabetes, Impaired Fasting Glucose Concentration, and Normoglycemia: Antihypertensive and Lipid-Lowering Treatment to Prevent Heart Attack Trial (ALLHAT)
Whelton, P. K. (2005) · Archives of Internal Medicine · doi:10.1001/archinte.165.12.1401 · Cited by 290 · see citing works
Follow-up study of patients randomized in the scandinavian simvastatin survival study (4S) of cholesterol lowering
Pedersen, T. R., Wilhelmsen, L., Færgeman, O., Strandberg, T. E., Þorgeirsson, G., Troedsson, L., Kristianson, J., Berg, K., Cook, T. J., Haghfelt, T. H., et al. (2000) · The American Journal of Cardiology · doi:10.1016/s0002-9149(00)00910-3 · Cited by 273 · see citing works
Rationale, design, methods and baseline demography of participants of the Anglo-Scandinavian Cardiac Outcomes Trial
Sever, P., Dahlöf, B., Poulter, N. R., Wedel, H., Beevers, G., Caulfield, M. J., Collins, R., Kjeldsen, S. E., McInnes, G. T., Mehlsen, J., et al. (2001) · Journal of Hypertension · doi:10.1097/00004872-200106000-00020 · Cited by 264 · see citing works
Relationship between Number of Medical Conditions and Quality of Care
Higashi, T., Wenger, N. S., Adams, J., Fung, C. H., Roland, M. O., McGlynn, E. A., Reeves, D., Asch, S. M., Kerr, E. A., & Shekelle, P. (2007) · New England Journal of Medicine · doi:10.1056/nejmsa066253 · Cited by 262 · see citing works
Setting the Record Straight
Lewin, L. S., Eckels, T. J., & Miller, L. B. (1988) · New England Journal of Medicine · doi:10.1056/nejm198805053181829 · Cited by 258 · see citing works
MRC/BHF Heart Protection Study of cholesterol-lowering therapy and of antioxidant vitamin supplementation in a wide range of patients at increased risk of coronary heart disease death: early safety and efficacy experience
(1999) · European Heart Journal · doi:10.1053/euhj.1998.1350 · Cited by 256 · see citing works
]. The Influence of Age on the Effects of Lifestyle Modification and Metformin in Prevention of Diabetes
The Diabetes Prevention Program Research Group [Prepared by Jill Crandall, D. S. (2006) · The Journals of Gerontology Series A: Biological Sciences and Medical Sciences · doi:10.1093/gerona/61.10.1075 · Cited by 254 · see citing works
Prevention of Cardiovascular Disease in Persons with Type 2 Diabetes Mellitus: Current Knowledge and Rationale for the Action to Control Cardiovascular Risk in Diabetes (ACCORD) Trial
Goff, D. C., Gerstein, H. C., Ginsberg, H. N., Cushman, W. C., Margolis, K. L., Byington, R. P., Buse, J. B., Genuth, S., Probstfield, J. L., & Simons-Morton, D. G. (2007) · The American Journal of Cardiology · doi:10.1016/j.amjcard.2007.03.002 · Cited by 229 · see citing works
Treating to New Targets (TNT) Study: does lowering low-density lipoprotein cholesterol levels below currently recommended guidelines yield incremental clinical benefit?
Waters, D. D., Guyton, J. R., Herrington, D. M., McGowan, M. P., WENGER, N. K., & Shear, C. L. (2004) · The American Journal of Cardiology · doi:10.1016/j.amjcard.2003.09.031 · Cited by 200 · see citing works
Effects of Ramipril on Coronary Events in High-Risk Persons
Dagenais, G. R., Yusuf, S., Bourassa, M. G., Yi, Q., Bosch, J., Lonn, E., Kouz, S., Grover, J., & on behalf of the HOPE Investigators (2001) · Circulation · doi:10.1161/hc3001.093502 · Cited by 179 · see citing works
The HOPE Study (Heart Outcomes Prevention Evaluation)
Sleight, P. (2000) · Journal of the Renin-Angiotensin-Aldosterone System · doi:10.3317/jraas.2000.002 · Cited by 176 · see citing works
Effects of individual risk factors on the incidence of cardiovascular events in the treated hypertensive patients of the Hypertension Optimal Treatment Study
Zanchetti, A., Hansson, L., Dahlöf, B., Elmfeldt, D., Kjeldsen, S. E., Kolloch, R. E., Larochelle, P. M., McInnes, G. T., Mallion, J.-M., Ruilope, L. M., et al. (2001) · Journal of Hypertension · doi:10.1097/00004872-200106000-00021 · Cited by 165 · see citing works
Design of the cooperative study on glycemic control and complications in diabetes mellitus type 2
Abraira, C., Duckworth, W. C., McCarren, M., Emanuele, N., Arca, D., Reda, D. J., & Henderson, W. G. (2003) · Journal of Diabetes and its Complications · doi:10.1016/s1056-8727(02)00277-5 · Cited by 161 · see citing works
Baseline characteristics of the randomised cohort from the Look AHEAD (Action for Health in Diabetes) study
Bray, G. A. (2006) · Diabetes and Vascular Disease Research · doi:10.3132/dvdr.2006.031 · Cited by 158 · see citing works
Reducing the risk of coronary events: Evidence from the Scandinavian Simvastatin survival study (4S)
Kjekshus, J., & Pedersen, T. R. (1995) · The American Journal of Cardiology · doi:10.1016/s0002-9149(99)80473-1 · Cited by 157 · see citing works
Guidelines for Improving the Care of the Older Person with Diabetes Mellitus
Ickowicz, E. (2003) · Cited by 152 · see citing works
The HOPE (Heart Outcomes Prevention Evaluation) Study: The design of a large, simple randomized trial of an angiotensin converting enzyme inhibitor (ramipril) and vitamin E in patients at high risk of cardiovascular events
Mindlen, F., Nordaby, R. A., Ruiz, M. I. S., Nava-Zavala, A. H., Guzmán, L., Martínez, F., Díaz, R., Mackey, C., Marino, M., Romero, G. S., et al. (1996) · Canadian Journal of Cardiology · Cited by 151 · see citing works
The losartan renal protection study — rationale, study design and baseline characteristics of RENAAL (Reduction of Endpoints in NIDDM with the Angiotensin II Antagonist Losartan)
Brenner, B. M., Cooper, M. E., de Zeeuw, D., Grünfeld, J., Keane, W. F., Kurokawa, K., McGill, J. B., Mitch, W. E., Parving, H. H., Remuzzi, G., et al. (2000) · Journal of the Renin-Angiotensin-Aldosterone System · doi:10.3317/jraas.2000.062 · Cited by 140 · see citing works
Subgroup and Per-Protocol Analysis of the Randomized European Trial on Isolated Systolic Hypertension in the Elderly
Staessen, J. A. (1998) · Archives of Internal Medicine · doi:10.1001/archinte.158.15.1681 · Cited by 134 · see citing works
Appropriate blood pressure control in hypertensive and normotensive type 2 diabetes mellitus: a summary of the ABCD trial
Schrier, R. W., Estacio, R. O., Mehler, P. S., & Hiatt, W. R. (2007) · Nature Reviews Nephrology · doi:10.1038/ncpneph0559 · Cited by 129 · see citing works
Design of the Pravastatin or Atorvastatin Evaluation and Infection Therapy (PROVE IT)—TIMI 22 trial
Cannon, C. P., McCabe, C. H., Belder, R., Breen, J. D., & D, E. B. M. (2002) · The American Journal of Cardiology · doi:10.1016/s0002-9149(02)02201-4 · Cited by 125 · see citing works
Antihypertensive therapy in type 2 diabetes: implications of the appropriate blood pressure control in diabetes (ABCD) trial
Estacio, R. O., & Schrier, R. W. (1998) · The American Journal of Cardiology · doi:10.1016/s0002-9149(98)00750-4 · Cited by 122 · see citing works
Analysis of Efficacy and Safety in Patients Aged 65–75 Years at Randomization
Neil, H. A. W., DeMicco, D. A., Luo, D., Betteridge, D. J., Colhoun, H. M., Durrington, P. N., Livingstone, S. J., Fuller, J., Hitman, G. A., & on behalf of the CARDS Study Investigators (2006) · Diabetes Care · doi:10.2337/dc06-0872 · Cited by 119 · see citing works
Syst-Eur. A multicentre trial on the treatment of isolated systolic hypertension in the elderly: Objectives, protocol, and organization
Amery, A., Birkenhäger, W. H., Bulpitt, C., Clément, D., de Leeuw, P. W., Dollery, C. T., Fagard, R. H., Fletcher, A., Forette, F., Leonetti, G., et al. (1991) · Aging Clinical and Experimental Research · doi:10.1007/bf03324024 · Cited by 116 · see citing works
The Anglo-Scandinavian Cardiac Outcomes Trial: blood pressure-lowering limb: effects in patients with type II diabetes
Östergren, J., Poulter, N. R., Sever, P. S., Dahlöf, B., Wedel, H., Beevers, G., Caulfield, M., Collins, R., Kjeldsen, S. E., Kristinsson, A., et al. (2008) · Journal of Hypertension · doi:10.1097/hjh.0b013e328310e0d9 · Cited by 116 · see citing works
The Diabetes Atherosclerosis Intervention Study (DAIS): a study conducted in cooperation with the World Health Organization
Steiner, G. (1996) · Diabetologia · doi:10.1007/s001250050630 · Cited by 110 · see citing works
Acute coronary syndromes and diabetes: is intensive lipid lowering beneficial? Results of the PROVE IT-TIMI 22 trial
Ahmed, S. (2006) · European Heart Journal · doi:10.1093/eurheartj/ehl220 · Cited by 110 · see citing works
10-Year Follow-up of Subclinical Cardiovascular Disease and Risk of Coronary Heart Disease in the Cardiovascular Health Study
Kuller, L. H. (2006) · Archives of Internal Medicine · doi:10.1001/archinte.166.1.71 · Cited by 110 · see citing works
Fenofibrate Intervention and Event Lowering in Diabetes (FIELD) study: baseline characteristics and short-term effects of fenofibrate [ISRCTN64783481]
The FIELD Study Investigators (2005) · Cardiovascular Diabetology · doi:10.1186/1475-2840-4-13 · Cited by 103 · see citing works
Design features and baseline characteristics of the LIPID (long-term intervention with pravastatin in ischemic disease) study: A randomized trial in patients with previous acute myocardial infarction and/or unstable angina pectoris
* (1995) · The American Journal of Cardiology · doi:10.1016/s0002-9149(99)80133-7 · Cited by 96 · see citing works
Impact of ramipril on the incidence of atrial fibrillation: Results of the Heart Outcomes Prevention Evaluation study
Salehian, O., Healey, J. S., Stambler, B. S., Alnemer, K., Almerri, K., Grover, J., Bata, I. R., Mann, J. F. E., Matthew, J., Pogue, J. M., et al. (2007) · American Heart Journal · doi:10.1016/j.ahj.2007.04.062 · Cited by 92 · see citing works
Prevalence of Clinical and Isolated Subclinical Cardiovascular Disease in Older Adults With Glucose Disorders
Barzilay, J. I., Spiekerman, C. F., Kuller, L. H., Burke, G. L., Bittner, V., Gottdiener, J. S., Brancati, F. L., Orchard, T. J., O’Leary, D. H., & Savage, P. J. (2001) · Diabetes Care · doi:10.2337/diacare.24.7.1233 · Cited by 89 · see citing works
Reduction of cardiovascular events and microvascular complications in diabetes with ACE inhibitor treatment: HOPE and MICRO-HOPE
Gerstein, H. C. (2002) · Diabetes/Metabolism Research and Reviews · doi:10.1002/dmrr.285 · Cited by 89 · see citing works
The Hypertension Optimal Treatment (HOT) Study—Patient Characteristics: Randomization, Risk Profiles, and Early Blood Pressure Results
Hansson, L., & Zanchetti, A. (1994) · Blood Pressure · doi:10.3109/08037059409102281 · Cited by 86 · see citing works
The Scandinavian Simvastatin Survival Study (4S) Subgroup Analysis of Diabetic Subjects: Implications for the Prevention of Coronary Heart Disease
Haffner, S. M. (1997) · Diabetes Care · doi:10.2337/diacare.20.4.469 · Cited by 86 · see citing works
Effects of aggressive cholesterol lowering and low-dose anticoagulation on clinical and angiographic outcomes in patients with diabetes: the Post Coronary Artery Bypass Graft Trial.
Hoogwerf, B. J., Waness, A., Cressman, M. D., Canner, J., CAMPEAU, L. A., Domański, M., Geller, N. L., Herd, A. J., Hickey, A., Hunninghake, D. B., et al. (1999) · Diabetes · doi:10.2337/diabetes.48.6.1289 · Cited by 84 · see citing works
Design & Rationale of the Air Force/Texas Coronary Atherosclerosis Prevention Study (AFCAPS/TexCAPS)
Downs, J. R., Beere, P. A., Whitney, E. J., Clearfield, M. B., Weis, S. E., Rochen, J., Stein, E. A., Shapiro, D. R., Langendörfer, A., & Gotto, A. M. (1997) · The American Journal of Cardiology · doi:10.1016/s0002-9149(97)00347-0 · Cited by 83 · see citing works
Additional Follow-up from the ABCD Trial in Patients with Type 2 Diabetes and Hypertension
Schrier, R. W., & Estacio, R. O. (2000) · New England Journal of Medicine · doi:10.1056/nejm200012283432614 · Cited by 65 · see citing works
Preventing microalbuminuria in type 2 diabetes
Ruggenenti, P. L., Fassi, A., & Ilieva, A. P. (2005) · ACC Current Journal Review · doi:10.1016/j.accreview.2004.12.120 · Cited by 58 · see citing works
Efficacy and Safety of Angiotensin II Receptor Blockade in Elderly Patients With Diabetes
Winkelmayer, W. C., Zhang, Z., Shahinfar, S., Cooper, M. E., Avorn, J., & Brenner, B. M. (2006) · Diabetes Care · doi:10.2337/dc06-0570 · Cited by 57 · see citing works
ALLHAT: Setting the Record Straight
Davis, B. R., Furberg, C. D., Wright, J. T., Cutler, J. A., & Whelton, P. K. (2004) · Annals of Internal Medicine · doi:10.7326/0003-4819-141-1-200407060-00013 · Cited by 56 · see citing works
Effects of aspirin treatment on survival in non-insulin-dependent diabetic patients with coronary artery disease
Harpaz, D., Gottlieb, S., Graff, E., Boyko, V., Kishon, Y., & Behar, S. (1998) · The American Journal of Medicine · doi:10.1016/s0002-9343(98)00328-3 · Cited by 52 · see citing works
The ABCD (Appropriate Blood Pressure Control in Diabetes) trial. Rationale and design of a trial of hypertension control (moderate or intensive) in type II diabetes.
Savage, S., Johnson Nagel, N., Estacio, R., Feig, P. U., MacCarthy, E. P., Lukken, N., Ziegler, R., & Schrier, R. W. (1993) · PubMed · Cited by 45 · see citing works
Adverse effects of left ventricular hypertrophy in the reduction of endpoints in NIDDM with the angiotensin II antagonist losartan (RENAAL) study
RENAAL Investigators, Boner, G., Cooper, M. E., McCarroll, K., Brenner, B. M., de Zeeuw, D., Kowey, P. R., Shahinfar, S., Dickson, T. Z., Crow, R. S., et al. (2005) · Diabetologia · doi:10.1007/s00125-005-1893-1 · Cited by 44 · see citing works
The Non–Insulin-Dependent Diabetes, Hypertension, Microalbuminuria or Proteinuria, Cardiovascular Events, and Ramipril (DIABHYCAR) Study
Lièvre, M. M., Marre, M., Châtellier, G., Plouin, P., Réglier, J.-C., Richardson, L., Bugnard, F., & Vasmant, D. (2000) · Controlled Clinical Trials · doi:10.1016/s0197-2456(00)00060-x · Cited by 43 · see citing works
The HOPE (Heart Outcomes Prevention Evaluation) Study: the design of a large, simple randomized trial of an angiotensin-converting enzyme inhibitor (ramipril) and vitamin E in patients at high risk of cardiovascular events. The HOPE study investigators.
(1996) · PubMed · Cited by 40 · see citing works
Preventing Left Ventricular Hypertrophy by ACE Inhibition in Hypertensive Patients With Type 2 Diabetes
Ruggenenti, P. L., Iliev, I. P., Costa, G. M., Parvanova, A. I., Perna, A., Giuliano, G. A., Motterlini, N., Ene‐Iordache, B., Remuzzi, G., & the BENEDICT Study Group (2008) · Diabetes Care · doi:10.2337/dc08-0371 · Cited by 39 · see citing works
The BErgamo NEphrologic DIabetes Complications Trial (BENEDICT): design and baseline characteristics
The BENEDICT Group (2003) · Controlled Clinical Trials · doi:10.1016/s0197-2456(03)00028-x · Cited by 38 · see citing works
Fluvastatin reduces the impact of diabetes on long-term outcome after coronary intervention—A Lescol Intervention Prevention Study (LIPS) substudy
Arampatzis, C. A., Goedhart, D. M., Serruys, P. W. J. C., Saia, F., Lemos, P. A., & de Feyter, P. J. (2005) · American Heart Journal · doi:10.1016/j.ahj.2004.03.067 · Cited by 32 · see citing works
Differential effects of antihypertensive agents on electrocardiographic voltage: results from the Appropriate Blood Pressure Control in Diabetes (ABCD) trial
Havranek, E. P., Esler, A. L., Estacio, R. O., Mehler, P. S., & Schrier, R. W. (2003) · American Heart Journal · doi:10.1016/s0002-8703(02)94780-0 · Cited by 27 · see citing works
Losartan and end-organ protection-lessons from the renaal study
Kowey, P. R., Dickson, T. Z., Zhang, Z., Shahinfar, S., & Brenner, B. M. (2005) · Clinical Cardiology · doi:10.1002/clc.4960280307 · Cited by 23 · see citing works
Benefit of Antihypertensive Treatment in the diabetic patients enrolled in the Systolic Hypertension in Europe (Syst-Eur) Trial
Gąsowski, J., Birkenhäger, W. H., Staessen, J. A., & de Leeuw, P. W. (2000) · Cardiovascular Drugs and Therapy · doi:10.1023/a:1007891121240 · Cited by 22 · see citing works
Antihypertensive therapy in diabetes mellitus: insights from ALLHAT and the Blood Pressure-Lowering Treatment Trialists’ Collaboration meta-analysis
Varughese, G. I., & Lip, G. Y. H. (2005) · Journal of Human Hypertension · doi:10.1038/sj.jhh.1001926 · Cited by 17 · see citing works
Descriptive Epidemiology of Diabetes
Blaum, C. S. (2007) · CRC Press eBooks · doi:10.3109/9781420019810-1 · Cited by 4 · see citing works
Self-citation
What's in the CARDS?
Plummer, C. (2006) · Diabetic Medicine · doi:10.1111/j.1464-5491.2006.01903.x · Cited by 2 · see citing works

Flagged first, then by citations

1 of the 132 references couldn’t be matched to a known paper.

Sorted by citations

Inflammageing: chronic inflammation in ageing, cardiovascular disease, and frailty
Ferrucci, L., & Fabbri, E. (2018) · Nature Reviews Cardiology · doi:10.1038/s41569-018-0064-2 · Cited by 3,690 · see citing works
Diabetes in Older Adults
Kirkman, M. S., Briscoe, V. J., Clark, N., Florez, H., Haas, L. B., Halter, J. B., Huang, E. S., Korytkowski, M. T., Munshi, M. N., Odegard, P. S., et al. (2012) · Diabetes Care · doi:10.2337/dc12-1801 · Cited by 1,274 · see citing works
Self-citation
Diabetes in Older Adults: A Consensus Report
Sue Kirkman, M., Briscoe, V. J., Clark, N., Florez, H., Haas, L. B., Halter, J. B., Huang, E. S., Korytkowski, M. T., Munshi, M. N., Odegard, P. S., et al. (2012) · Journal of the American Geriatrics Society · doi:10.1111/jgs.12035 · Cited by 548 · see citing works
Self-citation
Examining the Evidence: A Systematic Review of the Inclusion and Analysis of Older Adults in Randomized Controlled Trials
Zulman, D. M., Sussman, J. B., Chen, X., Cigolle, C. T., Blaum, C. S., & Hayward, R. A. (2011) · Journal of General Internal Medicine · doi:10.1007/s11606-010-1629-x · Cited by 392 · see citing works
Self-citation
Inflamm-ageing: the role of inflammation in age-dependent cardiovascular disease
Liberale, L., Montecucco, F., Tardif, J., Libby, P., & Camici, G. G. (2020) · European Heart Journal · doi:10.1093/eurheartj/ehz961 · Cited by 347 · see citing works
Diabetes and Cardiovascular Disease in Older Adults: Current Status and Future Directions
Halter, J. B., Musi, N., McFarland Horne, F., Crandall, J. P., Goldberg, A., Harkless, L., Hazzard, W. R., Huang, E. S., Kirkman, M. S., Plutzky, J., et al. (2014) · Diabetes · doi:10.2337/db14-0020 · Cited by 255 · see citing works
Self-citation
Frailty in primary care: a review of its conceptualization and implications for practice
Lacas, A., & Rockwood, K. J. (2012) · BMC Medicine · doi:10.1186/1741-7015-10-4 · Cited by 234 · see citing works
Endothelial Dysfunction and Chronic Inflammation: The Cornerstones of Vascular Alterations in Age-Related Diseases
Pacinella, G., Ciaccio, A. M., & Tuttolomondo, A. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms232415722 · Cited by 172 · see citing works
Network analytics and machine learning for predictive risk modelling of cardiovascular disease in patients with type 2 diabetes
Hossain, M. E., Uddin, S., & Khan, A. M. (2020) · Expert Systems with Applications · doi:10.1016/j.eswa.2020.113918 · Cited by 107 · see citing works
Habitual Intake of Guaraná and Metabolic Morbidities: An Epidemiological Study of an Elderly Amazonian Population
Krewer, C. D. C., Ribeiro, E. E., Ribeiro, E. A. M., Moresco, R. N., da Rocha, M. I. D. U. M., Montagner, G. F. F. D. S., Machado, M. M., Viégas, K., Brito, E., & da Cruz, I. B. M. (2011) · Phytotherapy Research · doi:10.1002/ptr.3437 · Cited by 75 · see citing works
Prevalence of Multiple Chronic Conditions Among Older Adults in Florida and the United States: Comparative Analysis of the OneFlorida Data Trust and National Inpatient Sample
He, Z., Bian, J., Carretta, H. J., Lee, J., Hogan, W. R., Shenkman, E. A., & Charness, N. H. (2018) · Journal of Medical Internet Research · doi:10.2196/jmir.8961 · Cited by 71 · see citing works
Older type 2 diabetic patients are more likely to achieve glycaemic and cardiovascular risk factors targets than younger patients: analysis of a primary care database
la Puente, J. B., Mata‐Cases, M., Franch‐Nadal, J., Mundet, X., Casellas, A., Fernández‐Real, J. M., & Mauricio, D. (2015) · International Journal of Clinical Practice · doi:10.1111/ijcp.12741 · Cited by 67 · see citing works
S2k-Leitlinie Diagnostik, Therapie und Verlaufskontrolle des Diabetes mellitus im Alter
Bahrmann, A., Bahrmann, P., Baumann, J., Bauer, J. M., Brückel, E., Dreyer, M., Freitag, M., Friedl, A., Gölz, S., Grundke, S., et al. (2018) · Diabetologie und Stoffwechsel · doi:10.1055/a-0666-0820 · Cited by 66 · see citing works
Associations of Age at Diagnosis and Duration of Diabetes With Morbidity and Mortality Among Older Adults
Cigolle, C. T., Blaum, C. S., Lyu, C., Ha, J., Kabeto, M. U., & Zhong, J. (2022) · JAMA Network Open · doi:10.1001/jamanetworkopen.2022.32766 · Cited by 62 · see citing works
Self-citation
Cannabinoid receptor 2 activation alleviates diabetes-induced cardiac dysfunction, inflammation, oxidative stress, and fibrosis
Rajesh, M., Mukhopadhyay, P., Bátkai, S., Arif, M., Varga, Z. V., Mátyás, C., Pálóczi, J., Lehocki, A., Haskó, G., & Pacher, P. (2022) · GeroScience · doi:10.1007/s11357-022-00565-9 · Cited by 37 · see citing works
Clinical complexity and mortality in middle-aged and older adults with diabetes
Cigolle, C. T., Kabeto, M. U., Lee, P. G., & Blaum, C. S. (2012) · The Journals of Gerontology Series A: Biological Sciences and Medical Sciences · doi:10.1093/gerona/gls095 · Cited by 34 · see citing works
Self-citation
Interleukin-37 sensitize the elderly type 2 diabetic patients to insulin therapy through suppressing the gut microbiota dysbiosis
Li, T., Li, H., Li, W., Chen, S., Feng, T., Jiao, W., Wu, C., Dong, J., Li, Y., Li, S., et al. (2019) · Molecular Immunology · doi:10.1016/j.molimm.2019.06.008 · Cited by 31 · see citing works
Older adults’ knowledge of pressure ulcer prevention: a prospective quasi‐experimental study
Hartigan, I., Murphy, S., & Hickey, M. T. (2011) · International Journal of Older People Nursing · doi:10.1111/j.1748-3743.2011.00274.x · Cited by 30 · see citing works
Diabetes Mellitus in an Aging Population: The Challenge Ahead
Halter, J. B. (2012) · The Journals of Gerontology Series A · doi:10.1093/gerona/gls201 · Cited by 29 · see citing works
Self-citation
A prospective study of risk factors for cardiovascular events among the elderly
Cabrera, M. A. S., Mesas, A. E., & de Andrade, S. M. (2012) · Clinical Interventions in Aging · doi:10.2147/cia.s37211 · Cited by 27 · see citing works
Relationship between onset age of type 2 diabetes mellitus and vascular complications based on propensity score matching analysis
Huang, L., Wu, P., Zhang, Y., Lin, Y., Shen, X., Zhao, F., & Yan, S. (2022) · Journal of Diabetes Investigation · doi:10.1111/jdi.13763 · Cited by 26 · see citing works
A Framework to Understand the Progression of Cardiovascular Disease for Type 2 Diabetes Mellitus Patients Using a Network Approach
Hossain, M. E., Uddin, S., Khan, A. M., & Moni, M. A. (2020) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph17020596 · Cited by 24 · see citing works
Protective effect of resveratrol on methylglyoxal-induced endothelial dysfunction in aged rats
Taşatargil, A., Tanriover, G., Barutcigil, A., & Turkmen, E. (2018) · Aging Clinical and Experimental Research · doi:10.1007/s40520-018-0986-x · Cited by 21 · see citing works
Multivariate analysis of the population representativeness of related clinical studies
He, Z., Ryan, P. B., Hoxha, J., Wang, S., Carini, S., Sim, I., & Weng, C. (2016) · Journal of Biomedical Informatics · doi:10.1016/j.jbi.2016.01.007 · Cited by 19 · see citing works
Preparation and characterization of novel derivatives of chitosan and trimethyl chitosan conjugated with dipeptides and vitamin B12 as candidates for oral delivery of insulin
Omid, N. J., Babanejad, N., Amini, H., Amini, M., Tehrani, M. R., & Dorkoosh, F. A. (2014) · Journal of Polymer Research · doi:10.1007/s10965-014-0510-8 · Cited by 19 · see citing works
Comparative effectiveness of coronary artery bypass grafting (CABG) surgery and percutaneous coronary intervention (PCI) in elderly patients with diabetes
Shah, R., Yang, Y., Bentley, J. P., & Banahan, B. F. (2016) · Current Medical Research and Opinion · doi:10.1080/03007995.2016.1219708 · Cited by 14 · see citing works
Assessing the comorbidity gap between clinical studies and prevalence in elderly patient populations
He, Z., Charness, N. H., Bian, J., & Hogan, W. R. (2016) · IEEE-EMBS International Conference on Biomedical and Health Informatics (BHI ...) · doi:10.1109/bhi.2016.7455853 · Cited by 14 · see citing works
Ameliorative potential of conditioning on ischemia-reperfusion injury in diabetes.
Rehni, A. K., & Dave, K. R. (2018) · PubMed · Cited by 10 · see citing works
Cardiovascular Disease Risk Factors Profile in Individuals With Diabetes Compared With Non-Diabetic Subjects in North-East of Iran
Niroumand, S., Dadgarmoghaddam, M., Eghbali, B., Abrishami, M., Gholoobi, A., Taghanaki, H. R. B., & Khajedaluee, M. (2016) · Iranian Red Crescent Medical Journal · doi:10.5812/ircmj.29382 · Cited by 9 · see citing works
Aging and Insulin Secretion
Halter, J. B. (2010) · Elsevier eBooks · doi:10.1016/b978-0-12-378638-8.00017-8 · Cited by 8 · see citing works
Self-citation
Depressive Symptoms are Associated with High Levels of Serum Low-Density Lipoprotein Cholesterol in Older Adults with Type 2 Diabetes Mellitus.
Fittipaldi, E. O. D. S., de Andrade, A. D., Santos, A. C. O., Campos, S., Fernandes, J., & Catanho, M. T. J. D. A. (2020) · Arquivos Brasileiros de Cardiologia · doi:10.36660/abc.20190404 · Cited by 8 · see citing works
Age may determine the effect of hypolipidemic agents on plasma adipokine levels in patients with elevated low-density lipoprotein cholesterol levels
Krysiak, R. G., Żmuda, W., Marek, B., & Okopień, B. (2015) · Endokrynologia Polska · doi:10.5603/ep.a2016.0019 · Cited by 6 · see citing works
PPARgamma-2 and ADRB3 polymorphisms in connective tissue diseases and lipid disorders
Grygiel‐Górniak, B., Ziółkowska‐Suchanek, I., Kaczmarek, E., Mosor, M., Nowak, J., & Puszczewicz, M. (2018) · Clinical Interventions in Aging · doi:10.2147/cia.s157186 · Cited by 6 · see citing works
Diabetes Mellitus in Older Women
Lodhi, T. I. (2021) · Clinics in Geriatric Medicine · doi:10.1016/j.cger.2021.06.003 · Cited by 6 · see citing works
Comparing and Contrasting A Priori and A Posteriori Generalizability Assessment of Clinical Trials on Type 2 Diabetes Mellitus.
He, Z., González-Izquierdo, A., Denaxas, S., Sura, A., Guo, Y. M., Hogan, W. R., Shenkman, E. A., & Bian, J. (2017) · PubMed Central · Cited by 5 · see citing works
Nutrition and Lifestyle Change in Older Adults with Diabetes Mellitus and Metabolic Syndrome
Stetson, B. A., & Mokshagundam, S. P. (2009) · Humana Press eBooks · doi:10.1007/978-1-60327-385-5_16 · Cited by 4 · see citing works
Nutrition and Lifestyle Change in Older Adults with Diabetes Mellitus and Metabolic Syndrome
Stetson, B. A., Knight, H., & Mokshagundam, S. P. (2014) · Springer eBooks · doi:10.1007/978-1-4939-1929-1_11 · Cited by 3 · see citing works
DO ALL TRADITIONAL RISK FACTORS ASSOCIATE SAME WITH MORTALITY IN SENIOR POPULATION?
Имаева, А. Э., Shalnova, S. A., Balanova, Y. А., Владимировна, К. А., Аркадьевна, М. Г., Евстифеева, С. Е., Деев, А. Д., & Школьников, В. М. (2017) · CARDIOVASCULAR THERAPY AND PREVENTION · doi:10.15829/1728-8800-2017-5-72-75 · Cited by 3 · see citing works
Performance of Diabetes Self-Management Behaviors by Older Adults in Georgia Senior Centers
Zack, A., Fischer, J. G., Johnson, M. A., & Reddy, S. (2010) · Journal of the American Dietetic Association · doi:10.1016/j.jada.2010.06.446 · Cited by 3 · see citing works
Short-term aerobic exercise does not change kidney function in students of Nnamdi Azikiwe University, Nigeria
Ihim, A. C., Obi, P. C., Udoka, E. J., Osakue, N. O., Ozuruoke, D. F. N., Nwobodo, E. I., Meludu, S., & Okeke, C. O. (2017) · Universa Medicina · doi:10.18051/univmed.2017.v36.166-172 · Cited by 2 · see citing works
Predictive Modelling of the Comorbidity of Chronic Diseases: A Network and Machine Learning Approach
Hossain, E. (2020) · The Sydney eScholarship Repository (The University of Sydney) · Cited by 2 · see citing works
Meta-Analysis on the Efficacy of Novel Glucose-Lowering Agents in Older Patients With Type 2 Diabetes Mellitus
Ahmed, A. B., Imran, L., Naeem, U., Jawed, A., Jawed, A., Khan, Z., Arshad, A. R., & Arshad, M. S. (2022) · The American Journal of Cardiology · doi:10.1016/j.amjcard.2022.10.028 · Cited by 1 · see citing works
Limited preventive care among Medicaid enrollees with HIV in the US South
Kiernan, J. S., Bono, R. S., Mujwara, D., Pan, Z., Dahman, B. A., & Kimmel, A. D. (2025) · Scientific Reports · doi:10.1038/s41598-025-85428-x · Cited by 1 · see citing works
THE RELATIONSHIP BETWEEN PHYSICAL ACTIVITY AND KIDNEY FUNCTION/CHRONIC KIDNEY DISEASE
Hawkins, M. (2010) · D-Scholarship@Pitt (University of Pittsburgh) · doi:10.13016/1lom-zxho
Type 2 diabetes mellitus (T2DM) onset and "remission".
Tangelloju, S. (2016) · doi:10.18297/etd/2515
Current World Literature
(2011) · Current Opinion in Lipidology · doi:10.1097/mol.0b013e3283499d3b
Implantación de la guía de práctica clínica Valoración y manejo de las lesiones por presión para equipos interprofesionales
Navarro, A. R., Gallardo, M. D. Q., Espiñeira, C. H., Barrientos‐Trigo, S., & Pórcel‐Gálvez, A. M. (2023) · Metas de Enfermería · doi:10.35667/metasenf.2023.26.1003082043
The Relationship Between Dietary Fiber Intake and C-reactive Protein Levels in Elderly Diabetic Patients With Cardiovascular Disease RiskPreprint
Yin, B., Wang, T., Wu, Y., & Lv, J. (2024) · Research Square · doi:10.21203/rs.3.rs-5340040/v1
Diabetes and Acute Care Use Among Patients With Metastatic Prostate Cancer Treated With Androgen Receptor Signaling Inhibitors
Liu, M. A., Raghunathan, R. R., Runcie, K. D., Wang, S., Wright, J. D., Wei, A. Z., Stein, M. N., & Hershman, D. L. (2025) · JCO Oncology Practice · doi:10.1200/op-25-00024
Receipt of routine preventive care services among Medicaid enrollees with HIV: the role of physician reimbursement
Kiernan, J. S., Mujwara, D., Pan, Z., Bono, R. S., Dahman, B. A., & Kimmel, A. D. (2025) · AIDS Care · doi:10.1080/09540121.2025.2578655

Authors: Cigolle, C. T., Blaum, C. S., & Halter, J. B.
Affiliations: University of Michigan (US)
Corresponding author: Cigolle, Christine T.
ORCID: Blaum, Caroline S.
Venue: Clinics in Geriatric Medicine
Publisher: Elsevier BV
Published: 2009-11
Volume: 25
Issue: 4
Pages: 607-641
ISSN: 0749-0690 (ISSN-L)
DOI: 10.1016/j.cger.2009.09.001
OpenAlex: W2033218817
Cited by: 50
References: 132
Citations by year: 2025: 3 · 2024: 1 · 2023: 1 · 2022: 5 · 2021: 1 · 2020: 5 · 2019: 1 · 2018: 6 · 2017: 3 · 2016: 5 · 2015: 2 · 2014: 3 · 2012: 6
FWCI: 0.61
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Clinics in Geriatric Medicine (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Treatment and Management
Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Health Promotion and Cardiovascular Prevention
Keywords: diabetes mellitus, cardiovascular disease prevention, older adults, lipid-lowering drugs, antihypertensive therapy, glycemic control, smoking cessation, weight management, physical activity, diet, geriatric syndromes, cardiovascular risk reduction
MeSH terms: Aged, Aged, 80 and over, Anticholesteremic Agents, Antihypertensive Agents, Blood Glucose, Cardiovascular Diseases, Cause of Death, Diabetes Mellitus, Type 2, Diet, Diabetic, Humans, Life Style, Quality of Life, Risk Factors, Smoking Cessation, Evidence-Based Medicine

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Diabetes and Cardiovascular Disease Prevention in Older Adults

Abstract

Integrity signals

Claims the paper makes

Claims other papers make about this one

Cites

Cited by

Related

Record

About these checks